The Metabolic Genesis of Cardiovascular Disease
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 18
Special Issue Editor
Interests: cardiovascular disease; hypertension; vascular aging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, exerting a significant burden on public health systems and economies. In parallel, the world is facing an unprecedented epidemic of metabolic disorders—including obesity, insulin resistance, type 2 diabetes, and dyslipidemia—which are emerging at alarming rates, particularly among younger populations. A key driver of this trend is an increasing dietary imbalance characterized by excessive consumption of carbohydrates and simple sugars, leading to chronic overstimulation of the insulin axis. This hyperinsulinemic state contributes to systemic inflammation, endothelial dysfunction, and metabolic disturbances that collectively accelerate cardiovascular damage.
Increasing evidence implicates metabolic dysfunction as a central driver of chronic low-grade inflammation and immune dysregulation, both of which play pivotal roles in the pathogenesis and progression of CVD. A growing body of research has unveiled intricate links between metabolic derangements and cardiovascular risk, revealing how alterations in metabolites, metabolic pathways, and signaling networks contribute directly to vascular injury, atherosclerosis, and cardiac dysfunction.
This Special Issue, “The Metabolic Genesis of Cardiovascular Disease”, focuses on exploring the emerging concept that metabolic disorders are not merely risk factors but may represent fundamental causative events in cardiovascular disease. We welcome contributions that provide novel insights into dietary influences, metabolomic profiles, inflammatory pathways, immune system interactions, and metabolic networks involved in cardiovascular pathology, as well as studies proposing innovative strategies for early detection, prevention, and treatment of metabolic-driven cardiovascular diseases.
Dr. Davide Agnoletti
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolic disorder
- insulin resistance
- inflammation
- immune system
- cardiovascular disease
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