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Metabolites
Special Issues
Metabolic Signatures in Human Health and Disease
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Metabolic Signatures in Human Health and Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Integrative Metabolomics".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 63

Special Issue Editor

Dr. Samantha Lodge

E-Mail Website
Guest Editor
1. Australian National Phenome Centre, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia
2. Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA 6150, Australia
Interests: inflammation; disease biomarkers; metabolomic health; healthy ageing; obesity; chronic disease; metabolic phenotyping
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolomics is a significant branch of systems biology, which monitors perturbations in small-molecule substrates (amino acids, lipids, lipoproteins, nucleotides, sugars, etc.) and products of metabolic reactions. It is a valuable tool for disease diagnosis and monitoring, drug discovery, toxicology, personalized medicine, and dietary intervention studies.

This Special Issue aims to use metabolomic approaches that contribute to a better understanding of metabolism in health and perturbations that occur with disease. This will aid in defining metabolic signatures, both in healthy and disease states, in order to improve disease diagnosis and prognosis. Any submissions related to these topics are encouraged and reviews and original articles involving human, animal, or cell models will be considered.

I look forward to receiving your contributions.

Dr. Samantha Lodge
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • disease biomarkers
  • metabolomic health
  • healthy ageing
  • obesity
  • chronic disease
  • metabolic phenotyping

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Published Papers (1 paper)

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Research

21 pages, 1109 KB  
Article
Herbal Weight Loss Supplements Induce Metabolomic In Vitro Changes Indicative of Oxidative Stress
by Emily C. Davies, Garth L. Maker, Ian F. Musgrave and Samantha Lodge
Metabolites 2025, 15(9), 587; https://doi.org/10.3390/metabo15090587 (registering DOI) - 1 Sep 2025
Abstract
Background/Objectives: The prevalence of obesity continues to rise globally, and with this an increase in the use of herbal weight loss supplements (WLS). At present, there is limited evidence to support the efficacy and safety of WLS, and there have been growing [...] Read more.
Background/Objectives: The prevalence of obesity continues to rise globally, and with this an increase in the use of herbal weight loss supplements (WLS). At present, there is limited evidence to support the efficacy and safety of WLS, and there have been growing reports of adverse events associated with their use. We aimed to determine those WLS that caused toxicity in vitro and to use 1H nuclear magnetic spectroscopy (NMR) to examine the metabolomic changes induced by these WLS in human hepatic and intestinal cells. Materials and Methods: This study used in vitro methods and 1H NMR spectroscopy to analyse the metabolomic changes in vitro of WLS available for purchase in Australia. Ten WLS were selected, nine WLS caused significant toxicity in HepG2 human liver cells, and of these, six met the criteria for 1H NMR analysis, which was based on a 25–50% reduction in cell viability. Results: All 10 WLS caused a significant reduction in viability of Caco-2 human intestinal cells, with seven selected for metabolic profiling. Orthogonal partial least squares discriminant analysis (O-PLS-DA) of 1H NMR spectral data was used to characterise the metabolites that differed between the untreated and treated cells and the fold changes of the metabolites were determined. The results showed alterations to key metabolites such as amino acids, glucose, carboxylic acids, and amines in all treatment groups compared to untreated controls across both cell lines. Conclusions: Collectively, these biochemical changes represent disturbances to intracellular proteins, energy metabolism, and membrane lipids suggestive of oxidative stress. This study highlights the need for further investigations into the actions of these WLS in vivo, and, as these products were regulated by the Therapeutic Goods Administration (TGA) at the time of purchase, this study suggests improved pre-market screening to ensure consumer health is protected. Full article
(This article belongs to the Special Issue Metabolic Signatures in Human Health and Disease)
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