Nutritional Intervention and Metabolic Health: Multi-Omics Insights

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 730

Special Issue Editors


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Guest Editor
Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave., St. Paul, MN 55108, USA
Interests: nutrition metabolism; lipid oxidation; lipidomics; metabolomics; metabolic diseases; lipids in foods; lipid metabolism
Special Issues, Collections and Topics in MDPI journals
Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave., St. Paul, MN 55108, USA
Interests: sarcopenia; malnutrition; aging; bioactive compounds; phytochemicals; cancer; nutraceuticals; LC–MS; metabolomics

E-Mail Website
Guest Editor
Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave., St. Paul, MN 55108, USA
Interests: nutritional biochemistry; adipocyte biology; metabolic diseases; antioxidants; lipid droplets; natural products; food nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutritional interventions are key to modulating metabolic health, playing a critical role in preventing and managing conditions. The advances in multi-omics technologies—genomics, transcriptomics, proteomics, metabolomics, and lipidomics—provide an integrative framework to uncover the molecular mechanisms driving these nutritional effects.

This Special Issue, “Nutritional Intervention and Metabolic Health: Multi-Omics Insights”, aims to explore the complex interactions between nutrition and metabolism. By leveraging multi-omics approaches, we seek to illuminate how nutrients, dietary active compounds, and dietary patterns influence gene expression, protein activity, and metabolite profiles, offering new insights into key metabolic pathways. This system-level understanding can refine dietary recommendations and therapeutic strategies, advancing the field of personalized nutrition.

Multi-omics technologies also allow us to investigate nutrient–gene interactions, epigenetic modifications, and metabolic signatures associated with various dietary patterns, such as the Mediterranean diet and intermittent fasting. The integration of these data provides potential biomarkers for metabolic health.

We invite original research and reviews that apply multi-omics to investigate the effects of nutrition on metabolic health, especially those focusing on personalized nutrition, nutrient-sensing pathways, and the gut microbiome’s role in mediating dietary effects.

Dr. Qingqing Mao
Dr. Yuyin Zhou
Dr. Hongming Su
Guest Editors

Manuscript Submission Information

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Keywords

  • nutrition metabolism
  • metabolomics
  • metabolic diseases
  • lipidomics
  • proteomics
  • diet and nutrition
  • nutritional intervention
  • diet pattern

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Published Papers (1 paper)

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Research

17 pages, 2303 KB  
Article
A Pilot Multi-Omics Approach Unveils Strong Immune Activation in the First Ten Days of Life in Extremely Preterm Infants
by Laura Burgess, Eva Caamaño Gutiérrez, Brian F. Flanagan, Duncan Alexander Sylvestre, Carolyn M. Slupsky, Mark A. Turner and Colin Morgan
Metabolites 2025, 15(10), 659; https://doi.org/10.3390/metabo15100659 - 7 Oct 2025
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Abstract
Background: Very preterm infants (VPIs) are born with an undeveloped immune system and are more susceptible to infection. Acquired immune responses must develop in a complex nutritional and metabolic environment as these babies transition from parenteral to enteral nutrition. We explored the feasibility [...] Read more.
Background: Very preterm infants (VPIs) are born with an undeveloped immune system and are more susceptible to infection. Acquired immune responses must develop in a complex nutritional and metabolic environment as these babies transition from parenteral to enteral nutrition. We explored the feasibility of a multi-omics approach to investigate the changes in metabolic and molecular profiles between day 3 and day 10 of life. Methods: Blood and plasma samples were collected at day 3 and day 10 of life from eight infants born <29 weeks’ gestation and used to perform microarray transcriptomics and 1H NMR metabolomics. All data were analysed using univariate statistics and mapped to biological pathways and molecular functions using an assortment of databases. Results: We found 1185 genes differentially expressed. The expression patterns found mapped to different immune function, maturation, and development pathways as well as providing mechanistic insights into metabolic changes, notably the downregulation of the metallothionein pathways. We found five metabolites that presented significant differential abundance. These linked to sugar and fat metabolic pathways, known to be altered in the preterm infants. Conclusions: We show that a multi-omics approach is feasible in VPIs and can identify simultaneous changes in the complex metabolic processes and immune adaptation that occur in the first ten days of life. Full article
(This article belongs to the Special Issue Nutritional Intervention and Metabolic Health: Multi-Omics Insights)
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