The Role of Diet and Nutrition in Relation to Metabolic Health

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 226

Special Issue Editors


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Guest Editor
Group for Nutrition and Metabolism, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia
Interests: nutrition and metabolism; pathophysiology of metabolic syndrome; lipid metabolism in obesity, metabolic syndrome, and diabetes; vitamin D in metabolic health; diet and reproduction; metabolic syndrome and reproductive disorders in both genders; gender differences in metabolism, menopause, and metabolism; role of selenium, fatty acids, probiotics, and antioxidants in metabolic and reproductive health

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Guest Editor
Group for Nutritional Biochemistry and Dietology, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia
Interests: anti-inflammatory nutrition; diet and supplementation in prevention and treatment of metabolic syndrome, diabetes, cardiovascular diseases, and non-alcoholic fatty liver disease; cancer research focusing on nutritional influences; impact of diet and supplementation on systemic inflammation, oxidative stress, and lipid metabolism; nutritional biochemistry; dietary habits assessment; bioactivity of antioxidants and polyphenols in food; functional foods and nutraceuticals and their role in health promotion; dietotherapy and chronic disease prevention and management

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Guest Editor
Group for Nutrition and Metabolism, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia
Interests: analysis of fatty acid profiles of circulation and tissues as a biomarker of their dietary intake and endogenous metabolism in different pathophysiological conditions; dietary antioxidants—polyphenols; protein—human serum albumin (HSA) and ligands—fatty acids, metals, polyphenol interactions, and influences of these ligand bindings on the reactivity of the Cys34 thiol group of HSA
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Special Issue Information

Dear Colleagues,

In recent decades, research on the impact of diet, dietary patterns, specific foods, nutrients, and their metabolites on metabolic health has significantly increased. However, many issues remain unresolved, and controversies persist. Furthermore, the question of personalized nutrition and the interactions between diet, lifestyle, genetics, and epigenetics is still unresolved.

This Special Issue, titled ‘The Role of Diet and Nutrition in Relation to Metabolic Health,’ aims to present the latest knowledge and research regarding how diet and nutrients can either promote or hinder metabolic health. The overall focus of this Special Issue is to explore the effects of specific foods, dietary patterns, and various food components (including micro- and macronutrients and other protective bioactive compounds) on metabolic health.

We encourage contributions that cover a wide range of topics, including, but not limited to, the role of diet, dietary patterns, and nutritional interventions in the prevention and management of metabolic diseases (such as obesity, metabolic syndrome, dyslipidemia, diabetes, and fatty liver disease), the effects of specific dietary components (specific foods and separate nutrients) on the risk for metabolic diseases and biomarkers of metabolic health (e.g., body composition, lipidomics and metabolomics, insulin resistance and inflammation biomarkers), and the genetic and environmental factors (including chrono-nutrition) influencing the complex relationship between nutrition, metabolism, and health.

Particularly, there is a need for research focused on the effect of specific dietary patterns (e.g., hyper-protein low-carb, low-fat diets vs. classic high-fat keto diets), meal timing (e.g., intermittent fasting with different meal timings: morning or evening), and nutrients (e.g., various proteins or bioactive peptides from distinct animal or vegetable sources) on glycemic control, intestinal and hepatic gluconeogenesis, insulin resistance markers, lipid metabolism, appetite control, hormonal responses, adipokine and myokine production, metabolic rate, and fat distribution.

We invite original research studies and review articles (including narrative reviews, systematic reviews, standard and network meta-analyses, and umbrella reviews). Submissions are welcome from studies conducted in vitro, in animals, and in humans.

Dr. Ivana Šarac
Dr. Marija Paunovic
Dr. Marija Takić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary patterns
  • nutrients
  • metabolic syndrome
  • diet
  • metabolic health
  • nutritional biochemistry
  • dietotherapy
  • functional food
  • nutraceuticals

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Published Papers (1 paper)

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41 pages, 2569 KB  
Systematic Review
Harnessing Metabolomics to Advance Nutrition-Based Therapeutics for Inflammation: A Systematic Review of Randomized Clinical Trials
by Belén Carlino, Gerardo N. Guerrero-Flores, Camila Niclis, Gina Segovia-Siapco and Martín L. Mayta
Metabolites 2025, 15(11), 705; https://doi.org/10.3390/metabo15110705 - 29 Oct 2025
Abstract
Background/Objectives: The association between plasma metabolites derived from dietary substrates and inflammatory processes remains underexplored, despite its potential relevance in the prevention of non-communicable diseases. This systematic review aimed to examine the relationship between blood metabolites and the modulation of inflammatory biomarkers. Methods: [...] Read more.
Background/Objectives: The association between plasma metabolites derived from dietary substrates and inflammatory processes remains underexplored, despite its potential relevance in the prevention of non-communicable diseases. This systematic review aimed to examine the relationship between blood metabolites and the modulation of inflammatory biomarkers. Methods: A total of 25 randomized controlled trials, published between 2019 and 2024, were included from an initial pool of 111 records. These studies investigated the effects of dietary patterns, specific food groups, or nutritional supplements on the human metabolome and their potential links to inflammation. Results: Metabolomic analyses were predominantly performed using mass spectrometry (MS)-based platforms (17 out of 25), with liquid chromatography–mass spectrometry as the most frequently employed method. Both targeted (n = 14) and untargeted (n = 11) approaches were represented, and samples were drawn from plasma, urine, and feces. Across the interventions, 64 metabolites were modulated, including fatty acyls, glycerolipids, benzenoids, and organic acids, reflecting potential changes in pathways related to oxidative stress, lipid and carbohydrate metabolism, and inflammatory signaling. Several studies also assessed classical inflammatory biomarkers such as C-reactive protein (CRP), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Interventions involving healthy traditional dietary patterns, improvements in dietary fat quality, or the use of specific probiotic strains were often associated with favorable immunometabolic outcomes. In contrast, some interventions, such as Mohana Choorna, elicited upregulation of immune-related gene expression in adipose tissue without improvements in glucose or lipid metabolism. Conclusions: While metabolomic responses varied across studies, the evidence highlights the value of dietary interventions in modulating systemic metabolism and inflammation. These findings support the integration of metabolomics into clinical nutrition to define more personalized and effective dietary strategies for inflammation-related chronic disease prevention. Full article
(This article belongs to the Special Issue The Role of Diet and Nutrition in Relation to Metabolic Health)
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