Translational Perspectives on Cancer Energy Metabolism: From Metabolic Mechanisms to Clinical Applications
A Special Issue of Metabolites (ISSN 2218-1989) belonging to the section "Cell Metabolism".
Deadline for manuscript submissions: 15 November 2026 | Viewed by 449
Editors
Interests: cancer metabolism; energy metabolism; ketogenic diet; Warburg effect
Interests: signal transduction via cation channels in mast cells; environmental impacts on TRP channels and inflammation; mast cell alterations in chronic diseases; therapeutics from non-western pharmacopeias; pain and inflammation therapies; stem education and workforce development
Special Issue Information
Dear Colleagues,
Cancer cells undergo profound metabolic reprogramming to support rapid growth, evasion of cell death, and adaptation to harsh microenvironments, with energy metabolism serving as a central hallmark. This Special Issue of Metabolites solicits original research and reviews that delve into the energy metabolism of cancer cells. The Special Issue will emphasize translational perspectives grounded in metabolomics and metabolic biochemistry, and spanning the bench-to-bedside-to-population research continuum. At the foundational level, we invite studies on key pathways such as aerobic glycolysis (Warburg effect), mitochondrial oxidative phosphorylation, glutaminolysis, and lipid metabolism, utilizing advanced omics technologies, flux analysis, and computational modeling to elucidate metabolite dynamics and regulatory networks. Progressing to clinical translational research (CTR), contributions may explore metabolic biomarkers for early detection, prognostic assessment, and therapeutic monitoring in patient samples, including non-invasive imaging and profiling methods that quantify metabolite alterations in tumors. We encourage investigations into targeted interventions, such as inhibitors of metabolic enzymes or nutrient-modulating therapies, evaluated through preclinical models and clinical trials for safety, efficacy, and personalization based on metabolic phenotypes. To bridge to broader applications, submissions should address how these insights inform practice, guidance and policy recommendations, including integration into diagnostic protocols and treatment guidelines for metabolic diseases like cancer. At the population level, we welcome epidemiological metabolomics studies that examine metabolite profiles in diverse cohorts, especially where disparities are evident. All submissions must maintain a substantial focus on the measurement, analysis, or biological roles of metabolites and pathways. By integrating these layers, this issue aims to advance metabolomics-driven innovations in oncology.
Dr. Michael Weichhaus
Prof. Dr. Helen Turner
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer metabolism
- Warburg effect
- metabolic reprogramming
- metabolic flux analysis
- biomarkers
- targeted therapies
- clinical translation
- population metabolomics
- health disparities
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