Metabolomics Techniques in Nutrition and Pharmacy Research

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1448

Special Issue Editor


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Guest Editor
Department of Nutrition, University of North Carolina-Chapel Hill, Nutrition Research Institute, Kannapolis, NC 28081, USA
Interests: precision oncology; precision health; metabolomics; multi-omics; nutrition; pharmacology; toxicology
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Special Issue Information

Dear Colleagues,

Metabolomics, as a comprehensive tool for studying small molecules in biological systems, is revolutionizing research in nutrition and pharmacy. This Special Issue, “Metabolomics Techniques in Nutrition and Pharmacy Research”, seeks to showcase innovative methodologies and applications that enhance our understanding of metabolism’s role in health, disease, and therapeutic development.

The Special Issue emphasizes cutting-edge metabolomics approaches tailored to nutrition and pharmacy research. This includes, but is not limited to, advancements in mass spectrometry, nuclear magnetic resonance (NMR) spectroscopy, data analysis techniques, and integrated omics approaches for studying metabolic pathways.

Submissions are invited that explore how metabolomics can unravel the molecular underpinnings of nutrition and drug interactions, improve precision nutrition strategies, and aid in the development of precision medicine. Topics of interest include the following:

  • Metabolite profiling for nutritional biomarker discovery.
  • Metabolic impacts of dietary interventions or pharmacological treatments.
  • Studies linking metabolism with gene–environment interactions.
  • Development of novel computational and analytical tools for metabolomics data interpretation.
  • Applications of metabolomics in pharmacokinetics, pharmacodynamics, and personalized therapeutics.

This Special Issue aims to highlight the transformative potential of metabolomics in advancing personalized nutrition and medicine. By bridging gaps between nutrition science, pharmacology, and clinical research, it seeks to provide a platform for novel insights and interdisciplinary collaborations. We encourage contributions that demonstrate the utility of metabolomics in addressing pressing health challenges and in driving innovation in therapeutic and dietary strategies.

We invite researchers, clinicians, and interdisciplinary teams to contribute original research articles, reviews, and methodological advancements that align with these themes. Together, we aim to push the boundaries of knowledge at the interface of metabolomics, nutrition, and pharmacy.

Dr. Blake Rushing
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • precision nutrition
  • precision medicine
  • nutritional biomarkers
  • pharmacometabolomics
  • mass spectrometry
  • metabolic pathways
  • omics integration
  • diet–drug interactions
  • personalized therapeutics

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Published Papers (1 paper)

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Research

16 pages, 2114 KiB  
Article
Untargeted Metabolomics Reveals Dysregulation of Glycine- and Serine-Coupled Metabolic Pathways in an ALDH1L1-Dependent Manner In Vivo
by Grace Fu, Sabrina Molina, Sergey A. Krupenko, Susan Sumner and Blake R. Rushing
Metabolites 2024, 14(12), 696; https://doi.org/10.3390/metabo14120696 - 10 Dec 2024
Viewed by 1041
Abstract
Background: ALDH1L1 plays a crucial role in folate metabolism, regulating the flow of one-carbon groups through the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in a NADP+-dependent reaction. The downregulation of ALDH1L1 promotes malignant tumor growth, and silencing of ALDH1L1 [...] Read more.
Background: ALDH1L1 plays a crucial role in folate metabolism, regulating the flow of one-carbon groups through the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in a NADP+-dependent reaction. The downregulation of ALDH1L1 promotes malignant tumor growth, and silencing of ALDH1L1 is commonly observed in many cancers. In a previous study, Aldh1l1 knockout (KO) mice were found to have an altered liver metabotype, including significant alterations in glycine and serine. Serine and glycine play crucial roles in pathways linked to cancer initiation and progression, including one-carbon metabolism. Objective/Methods: To further investigate the metabolic role of ALDH1L1, an untargeted metabolomic analysis was conducted on the liver and plasma of both KO and wild-type (WT) male and female mice. Since ALDH1L1 affects glycine- and serine-coupled metabolites and metabolic pathways, correlation analyses between liver glycine and serine with other liver or plasma metabolites were performed for both WT and KO mice. Significantly correlated metabolites were input into MetaboAnalyst 5.0 for pathway analysis to uncover metabolic pathways coupled with serine and glycine in the presence or absence of ALDH1L1 expression. Results: This analysis showed substantial alterations in pathways associated with glycine and serine following ALDH1L1 loss, including the amino acid metabolism, antioxidant pathways, fatty acid oxidation, and vitamin B5 metabolism. These results indicate the glycine- and serine-linked metabolic reprogramming following ALDH1L1 loss to support macromolecule biosynthesis and antioxidant defense. Additional research is required to further explore the correlation between specific alterations in these pathways and tumor growth, as well as to identify potential dietary interventions to mitigate the detrimental effects of ALDH1L1 loss. Full article
(This article belongs to the Special Issue Metabolomics Techniques in Nutrition and Pharmacy Research)
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