Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 856

Special Issue Editor


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Guest Editor
1. Department of Medicine, NYU Long Island School of Medicine, Mineola, New York, NY 11501, USA
2. Division of Cardiology, Department of Medicine, NYU Long Island School of Medicine, Mineola, NY 11501, USA
Interests: inflammation; lipids; cardio-neurologic axis
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Special Issue Information

Dear Colleagues,

Lipid metabolism and homeostasis are critical for the proper functioning of multiple organ systems, particularly for the cardiovascular and nervous systems. Disorders of lipid metabolism may begin early in life or manifest in older people, and the consequences can be devastating. Dysregulated lipid production, processing, and storage can result from specific genetic mutations or complex multifactorial processes and may also be environmentally influenced. This Special Issue accepts submissions on a wide range of topics related to lipid abnormalities spanning organ systems, life stage, and etiology. Articles focused on dyslipidemia, obesity, diabetes, atherosclerosis, and the effects of chronic inflammation on the heart and brain are welcome, as are those covering dysfunction of hepatic lipid metabolism. Papers that focus on mechanistic aspects, molecular pathways, and innovative therapies are of particular interest. Both review articles and original research will be considered.

Dr. Joshua De Leon
Guest Editor

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Keywords

  • lipid metabolism
  • dyslipidemia
  • atherosclerosis

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Published Papers (1 paper)

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Research

13 pages, 253 KiB  
Article
The Effects of SGLT2 Inhibitors on Lipid Profile and Kidney Function in Patients with Chronic Kidney Disease Regardless of Diabetes and Hypertension Status
by Selena Gajić, Stefan Janković, Milorad Stojadinović, Kristina Filić, Ana Bontić, Jelena Pavlović, Ivana Mrđa, Kristina Petrović, Lara Hadži-Tanović, Jelena Žunić, Mihajlo Kostić, Aleksandra Kezić and Marko Baralić
Metabolites 2025, 15(4), 271; https://doi.org/10.3390/metabo15040271 - 13 Apr 2025
Viewed by 408
Abstract
Background: Chronic kidney disease (CKD) is a progressive, irreversible impairment of kidney function due to various etiologies. Numerous studies have shown that sodium-glucose cotransporter-2 inhibitors (SGLT2i) slow the progression of CKD, due to their pleiotropic effects. Therefore, there has been an increase in [...] Read more.
Background: Chronic kidney disease (CKD) is a progressive, irreversible impairment of kidney function due to various etiologies. Numerous studies have shown that sodium-glucose cotransporter-2 inhibitors (SGLT2i) slow the progression of CKD, due to their pleiotropic effects. Therefore, there has been an increase in interest in their effects not only on kidney function but also on other parameters in patients with CKD. The aim of the study was to examine the effects of SGLT2i on serum lipid values and kidney function in patients with CKD undergoing SGLT2i treatment. Methods: This study was a retrospective data analysis of 75 patients with CKD on SGLT2i treatment. We compared the values of biochemical parameters, renal function outcomes, and blood pressure at two time points: baseline and 24 months after. Results: Total cholesterol (Chol) significantly decreased in all patients, while triglyceride (Tg) and low-density lipoprotein cholesterol (LDLc) levels also decreased in all patients. High-density lipoprotein cholesterol (HDLc) levels increased, but this increase was not significant. Creatinine clearance (Ccr) significantly decreased, and serum urea (Sur) significantly increased in all patients. The proteinuria (Prt) levels did not change significantly. The results showed that the diastolic blood pressure (DBP) significantly decreased in all patients. Conclusions: This study showed that the use of SGLT2i reduced total Chol in all patients with CKD during the 24-month follow-up, regardless of diabetes mellitus (DM) status. No significant differences were observed for the Tg, LDLc, and HDLc values. Full article
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