Biochemical Modulators in Chronic Diseases: The Antioxidant/Anti-Inflammatory Interdependence—2nd Edition
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 15
Special Issue Editor
Interests: lung diseases; chronic obstructive pulmonary disease; oxidative stress biomarkers; pulmonary rehabilitation; sleep disorders and sleep medicine; ozone
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Increasing evidence suggests that inflammation and oxidative stress play a key role in the pathogenesis of many chronic diseases. In fact, oxidative stress underpins the molecular mechanisms responsible for the development of many chronic inflammatory diseases, such as atherosclerosis, diabetes mellitus, chronic obstructive pulmonary diseases, rheumatoid arthritis, and neurodegeneration. Whilst oxidative stress is known to result in an inflammatory response, it has also been suggested that inflammation itself may elicit free radical formation. Reactive oxygen species (ROS) are generated by phagocytic cells, neutrophils, and macrophages during the inflammatory reaction, and chronic infections and inflammatory disorders also provoke an increased production of free radicals. Thus, a close connection has been found to exist between oxidative and inflammatory systems and the development and progression of chronic diseases. It is clear that inflammation and oxidative stress act in unison, exacerbating each other’s effects, leading to a further progression of organ damage. However, the interdependence between these two biochemical pathways is more complex than it appears, as suggested by the lack of clinical trials showing beneficial health effects following the antioxidant treatment of chronic diseases, and by the discovery of the antioxidant paradox. The selection of biochemical agents able to modulate the antioxidant/anti-inflammatory interdependence appears to be a challenge in the prevention and treatment of chronic diseases. This Special Issue provides an overview of the future perspectives of biochemical modulators that act as selective inhibitors along inflammatory and oxidative pathways, as well as the appropriate quantification of both redox and inflammatory status before, during, and after antioxidant or anti-inflammatory therapy. This Special Issue welcomes original research articles, reviews, and short reports on various aspects of antioxidants/anti-inflammatory interdependence in chronic diseases, in addition to the predictions of future trends in related fields.
For access to our previous publications, please visit:
The first volume of this Special Issue: (https://www.mdpi.com/journal/life/special_issues/antioxidant_inflammatory).
Dr. Emma Borrelli
Guest Editor
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Keywords
- oxidative stress
- inflammation
- redox modulator
- anti-inflammatory agents
- chronic diseases
- antioxidant paradox
- reactive oxygen species
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