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Life
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Advances in Personalized Management in Orthopedics and Traumatology
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Advances in Personalized Management in Orthopedics and Traumatology

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 2295

Special Issue Editors

Prof. Dr. Tudor Sorin Pop

E-Mail Website
Guest Editor
Department of Orthopaedics and Traumatology, Clinical County Hospital, 540139 Tîrgu Mureș, Romania
Interests: hip; knee; bone orthopedics; arthroplasty fracture; knee surgery; hip arthroplasty; hip and knee arthroplasty; knee arthroplasty
Special Issues, Collections and Topics in MDPI journals
Dr. Andrei Marian Feier

E-Mail Website
Guest Editor
Department of Orthopaedics and Traumatology, Clinical County Hospital, 540139 Tîrgu Mureș, Romania
Interests: orthopedics; basic orthopedics science; clinical orthopedics; medical orthopedics; orthopedic surgery; total knee replacement; knee implants; orthopedic sports medicine; sports surgery; stem cells; mesenchymal stem cells; healthcare
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Orthopedics and traumatology are moving toward more personalized care. Patients undergoing treatment related to orthopedic diagnoses differ widely in anatomy, age, activity level, comorbidities, expectations and recovery potential. A “one size fits all” approach is no longer sufficient. This Special Issue in Life aims to highlight practical and research-based approaches that support individualized decision-making in modern orthopedic practice.

The focus is on personalized strategies in hipknee and shoulder pathologies. Contributions addressing patient stratification, functional outcomes, and real-world clinical experience are also welcome.

Both original research and structured reviews with clear clinical relevance are encouraged. The goal of this issue is to bring together clinicians and researchers who are interested in improving outcomes by adapting treatment to the individual patient rather than strictly following standardized protocols. Emphasis will be placed on clinically applicable findings that can directly influence daily orthopedic practice.

Prof. Dr. Tudor Sorin Pop
Dr. Andrei Marian Feier
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized orthopedics
  • hip replacement
  • knee replacement
  • patient-specific treatment
  • clinical outcomes

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Published Papers (4 papers)

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Research

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16 pages, 1086 KB  
Article
Prognostic Value of Intraoperative Distal Radioulnar Joint Instability Grading in Distal Radius and Galeazzi Fractures: A Prospective Multicenter Cohort Study
by Awad Dmour, Yousef Khair, Almuthanna Alyamani, Paul-Dan Sirbu, Bianca-Ana Dmour, Ahmad Al-Zoubi, Yousef Al-Saraireh, Teodor-Stefan Gheorghevici, Stefan-Dragos Tirnovanu, Dragos-Cristian Popescu, Mihaela Pertea, Alexandra Burlui, Hussein Dmour and Bogdan Puha
Life 2026, 16(3), 437; https://doi.org/10.3390/life16030437 - 9 Mar 2026
Viewed by 525
Abstract
Despite anatomically successful fixation of distal radius and Galeazzi fractures, a subset of patients develops persistent pain and functional limitation, suggesting that factors beyond osseous alignment influence recovery. Distal radioulnar joint instability has been implicated in unfavorable outcomes, yet intraoperative assessment remains inconsistently [...] Read more.
Despite anatomically successful fixation of distal radius and Galeazzi fractures, a subset of patients develops persistent pain and functional limitation, suggesting that factors beyond osseous alignment influence recovery. Distal radioulnar joint instability has been implicated in unfavorable outcomes, yet intraoperative assessment remains inconsistently standardized and has rarely been validated as a prognostic variable. This prospective multicenter observational cohort study included 120 consecutive patients with distal radius or Galeazzi fractures treated with plate fixation in two tertiary centers. After fracture reduction and stabilization, intraoperative distal radioulnar joint stability was systematically assessed using a previously published classification system comprising Grades I to III, with patients demonstrating no instability serving as the reference group. The primary outcome was the QuickDASH score at 12 months, while secondary outcomes included pain intensity, grip strength, radiographic distal radioulnar joint gap, and postoperative complications. Multivariable linear regression was used to evaluate the association between intraoperative instability grade and outcomes, adjusting for age, sex, fracture type, and treatment center. Increasing instability grade was independently associated with worse functional outcome, higher pain levels, reduced grip strength, and greater postoperative distal radioulnar joint widening at 12 months, with an adjusted increase of approximately 5 to 6 QuickDASH points per grade. Intraoperative distal radioulnar joint instability grading provides clinically relevant prognostic information and supports postoperative risk stratification following distal radius and Galeazzi fractures. Full article
(This article belongs to the Special Issue Advances in Personalized Management in Orthopedics and Traumatology)
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Review

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14 pages, 2509 KB  
Review
Talocalcaneal Coalition: Current Concepts, Clinical Implications, and Management Strategies
by Antonio Mascio, Chiara Comisi, Virginia Cinelli, Federico Moretti, Gloria Assegbede, Giulio Maccauro, Tommaso Greco and Carlo Perisano
Life 2026, 16(3), 495; https://doi.org/10.3390/life16030495 - 18 Mar 2026
Viewed by 770
Abstract
Talocalcaneal coalition is a frequent cause of painful rigid flatfoot in adolescents and young adults, resulting from congenital failure of segmentation with fibrous, cartilaginous, or osseous bridging of the subtalar joint. Clinical presentation typically coincides with skeletal maturation and includes hindfoot pain, recurrent [...] Read more.
Talocalcaneal coalition is a frequent cause of painful rigid flatfoot in adolescents and young adults, resulting from congenital failure of segmentation with fibrous, cartilaginous, or osseous bridging of the subtalar joint. Clinical presentation typically coincides with skeletal maturation and includes hindfoot pain, recurrent ankle sprains, progressive stiffness, and characteristic planovalgus deformity. Although prevalence is likely underestimated, advances in imaging have improved recognition and characterization. Diagnosis relies on the integration of clinical findings with imaging, where computed tomography (CT) remains the reference standard, while magnetic resonance imaging (MRI) enables accurate detection of both osseous and non-osseous coalitions and associated soft-tissue changes. This narrative review aims to provide a comprehensive and updated synthesis of current concepts in talocalcaneal coalition, with specific focus on its clinical implications and contemporary management strategies. We critically analyze diagnostic pathways, including emerging modalities such as weight-bearing CT, and discuss evidence-based indications for conservative treatment, coalition resection, and arthrodesis. Particular attention is devoted to patient selection, prognostic factors, and evolving minimally invasive techniques. Current limitations and areas of controversy are highlighted, emphasizing the need for standardized imaging criteria and optimized treatment algorithms to improve long-term functional outcomes. Full article
(This article belongs to the Special Issue Advances in Personalized Management in Orthopedics and Traumatology)
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Other

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11 pages, 24014 KB  
Case Report
Surgical Treatment of Juvenile Hip Chondroblastoma Using Mosaicplasty: A Case Report
by György Márk Hangody, László Rudolf Hangody, János Kiss, Miklós Attila Keszég, Gyula Ferenc Szőcs and László Hangody
Life 2026, 16(5), 752; https://doi.org/10.3390/life16050752 - 1 May 2026
Viewed by 124
Abstract
Chondroblastoma is a generally benign tumor occurring at a young age; however, its location near a joint and its tendency to recur make the treatment particularly challenging. This is especially true in the case of its occurrence in the hip joint. Surgical removal—curettage—is [...] Read more.
Chondroblastoma is a generally benign tumor occurring at a young age; however, its location near a joint and its tendency to recur make the treatment particularly challenging. This is especially true in the case of its occurrence in the hip joint. Surgical removal—curettage—is the primary method, but the remaining defect can be filled with several methods depending on the size of the tumor. The approach to the lesion is another difficulty. There are several available options, but due to the characteristics of the blood supply to the joint, this is a significant risk. In our case, we used an open autologous osteochondral graft transplantation (mosaicplasty) to treat juvenile hip chondroblastoma in a young female patient, for which the ipsilateral knee joint served as the donor area. The patient was followed up for 3 years after surgery, and, in addition to physical examinations, numerous imaging studies were performed to exclude local recurrence or avascular necrosis in the femoral head and to ensure that the congruence of the implanted osteochondral grafts was maintained. Full article
(This article belongs to the Special Issue Advances in Personalized Management in Orthopedics and Traumatology)
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35 pages, 778 KB  
Systematic Review
Is Exercise Enough? Evidence from Controlled Clinical Trials on Rehabilitation with and Without Adjunct Modalities for Musculoskeletal Disorders
by Bindiya Rawat, Yajuvendra Singh Rajpoot, Sohom Saha, Vasile-Cătălin Ciocan, Alina-Mihaela Cristuta, Suchishrava Choudhary, Prashant Kumar Choudhary, Carmina-Mihaela Gorgan, Constantin Sufaru and Nicolae Lucian Voinea
Life 2026, 16(4), 608; https://doi.org/10.3390/life16040608 - 7 Apr 2026
Viewed by 619
Abstract
Background: Musculoskeletal disorders (MSDs) are a major contributor to global disability. Exercise-based rehabilitation is widely recommended as first-line management; however, in clinical practice, it is frequently combined with adjunct therapeutic modalities, and the incremental effectiveness of these approaches remains unclear. The present review [...] Read more.
Background: Musculoskeletal disorders (MSDs) are a major contributor to global disability. Exercise-based rehabilitation is widely recommended as first-line management; however, in clinical practice, it is frequently combined with adjunct therapeutic modalities, and the incremental effectiveness of these approaches remains unclear. The present review addressed the research question: Do adjunct modalities provide additional benefits beyond exercise-based rehabilitation alone in individuals with musculoskeletal disorders? Methods: This systematic review was conducted according to PRISMA 2020 guidelines and prospectively registered in the PROSPERO database (registration number CRD420261309183). Electronic searches were performed in PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials to identify controlled clinical trials evaluating exercise-based rehabilitation delivered alone or combined with adjunct modalities. Outcomes included pain, functional disability, physical performance, strength, structural or imaging-based measures, biomechanical variables, injury risk, and work-related outcomes. Due to methodological heterogeneity across studies, a structured narrative and tabular synthesis were performed. Results: Twenty-one controlled clinical trials were included, encompassing tendinopathies (n = 7), knee osteoarthritis (n = 5), post-ACL reconstruction (n = 2), chronic spinal pain (n = 3), sarcopenia (n = 2), low bone mass (n = 2), and occupational musculoskeletal conditions (n = 1), with sample sizes ranging from 22 to 823 participants. Pain outcomes were reported in 18 studies (86%) and functional outcomes in 16 studies (76%). Exercise-based rehabilitation consistently produced clinically meaningful improvements across studies, whereas adjunct modalities demonstrated short-term advantages in a limited number of trials but rarely showed sustained long-term superiority. Conclusions: Evidence from controlled clinical trials indicates that exercise-based rehabilitation is an effective primary intervention for improving pain, functional capacity, and physical performance across diverse musculoskeletal conditions. Adjunct modalities may provide condition-specific or short-term benefits but do not consistently enhance long-term outcomes beyond structured exercise programs. Full article
(This article belongs to the Special Issue Advances in Personalized Management in Orthopedics and Traumatology)
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