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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Brain Barrier Research: Mechanisms, Function, Regulation, and Therapeutic Medicine

edited by

Ana Catarina Duarte

submission deadline 31 Dec 2025 | Viewed by 169 | Submission Open

Keywords: brain barriers; brain homeostasis; neurodegeneration; neuroinflammation; brain drug delivery

(This special issue belongs to the Section Physiology and Pathology)

Understanding Brain Disorders Through EEG and AI

edited by Debashis Das Chakladar and

Giuseppe Augusto Chiarenza

submission deadline 31 Dec 2025 | Viewed by 162 | Submission Open

Keywords: EEG; ADHD; Alzheimer’ s; Parkinson’ s; neurological disorders; machine learning; deep learning

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Artificial Intelligence in Cardiovascular Diseases: Research, Technology and Clinical Practice

edited by

Dimitris Tousoulis

submission deadline 31 Dec 2025 | Viewed by 157 | Submission Open

Keywords: cardiovascular disease; artificial intelligence; atherosclerosis; atrial fibrillation; cardiomyopathy

(This special issue belongs to the Section Medical Research)

Cutting-Edge Research in Rhinology and Allergy: Unraveling Disease Mechanisms and Treatment Innovations

edited by Min-Seok Rha

submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open

Keywords: rhinology; allergy; chronic rhinosinusitis; allergic rhinitis; asthma; precision medicine; clinical immunology; immunopathology; therapeutic innovation

Origin of Life in Chemically Complex Messy Environments: 3rd Edition

edited by

Ranajay Saha

and

Alberto Vázquez-Salazar

submission deadline 31 Dec 2025 | Viewed by 135 | Submission Open

Keywords: origin of life; complex chemical systems ; prebiotic chemistry ; prebiotic metabolisms ; chemical evolution ; prebiotic catalysts

(This special issue belongs to the Section Origin of Life)

Novel Biomaterial-Based Fertilizing Products and Bio-Fertilizers for Sustainable Agricultural Production: 2nd Edition

edited by

and

submission deadline 31 Dec 2025 | Viewed by 127 | Submission Open

Keywords: biomaterials and bio-nanomaterials; bio-based hydrogels and polymers; lignocellulosic biomass and its derivatives; sustainable agriculture; biodegradability; stimuli-responsive fertilizer delivery; controlled-release fertilizers; bio-synthesis processes and characterization; control/sustained fertilizer release mechanisms; bio-fertilizers; plant growth-promoting microbes; fertilizers’ use efficiency; plant physiology; productivity; and quality

(This special issue belongs to the Section Plant Science)

Research Updates in Hematology

edited by

Eleni Gavriilaki

submission deadline 31 Dec 2025 | Viewed by 110 | Submission Open

Keywords: antiphospholipid syndrome; complement; endothelium; hemoglobinopathies; hemophilia; leukemias; lymphomas; multiple myeloma; pediatric hematology; thrombosis

(This special issue belongs to the Section Physiology and Pathology)

Non-Conventional Approaches in Modern Biological Analysis and Medical Diagnostics

edited by

Anna Baraniak

and

Paweł Rudnicki-Velasquez

submission deadline 31 Dec 2025 | Viewed by 108 | Submission Open

Keywords: biological samples; non-conventional analytical techniques; life science; diagnostics; proteins

Update on Clinical Pharmacology

edited by

Ju-Seop Kang

submission deadline 31 Dec 2025 | Viewed by 97 | Submission Open

Keywords: drug efficacy and drug safety; new drug development; therapeutic drug monitoring; clinical trials; pharmacodynamic and pharmacokinetics; pharmacovigilance; clinical toxicology

(This special issue belongs to the Section Pharmaceutical Science)

Impact of Environmental Factors on the Diversity and Structure of Bacterial and Eukaryotic Communities

edited by

Jun Noda

and

Daisuke Tanaka

submission deadline 31 Dec 2025 | Viewed by 95 | Submission Open

Keywords: environmental factors; bacterial and eukaryotic communities; climate adaptation; pollution; microbial resilience; metagenomic analysis; amplicon sequencing; bioinformatics

(This special issue belongs to the Section Microbiology)

Coagulation and Its Disorders: Diagnostics, Therapeutics, and Clinical Management

edited by

Anna Lisa Montemari

submission deadline 31 Dec 2025 | Viewed by 95 | Submission Open

Keywords: coagulation; bleeding disorders; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammation and coagulation disorders; thrombosis; platelet disorders; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations

An Integrated Approach on Diagnosis and Treatment of Cerebral Veins and Intracranial Dural Sinuses Thrombosis (CVT)

edited by

Dragos Catalin Jianu

and

Dafin Fior Muresanu

submission deadline 31 Dec 2025 | Viewed by 88 | Submission Open

Keywords: cerebral veins and intracranial dural sinuses thrombosis (CVT); thrombophilia; intracranial hypertension; non-enhanced computer tomography (NECT) of the head; computer tomography venography (CTV); magnetic resonance imaging (MRI) of the head; magnetic resonance venography (MRV); anticoagulation

(This special issue belongs to the Section Medical Research)

Recent Advances in Left Ventricular Unloading Therapy

edited by Mehmet Oezkur

submission deadline 31 Dec 2025 | Viewed by 80 | Submission Open

Keywords: left ventricular unloading therapy; cardiovascular medicine; heart failure; acute myocardial infarction

(This special issue belongs to the Section Medical Research)

Research on Female Reproductive Health and Metabolism

edited by

Alice Bongrani

submission deadline 31 Dec 2025 | Viewed by 73 | Submission Open

Keywords: female reproduction; metabolism; nutrition; adipose tissue; hypothalamus– pituitary– gonadal axis; insulin resistance; adipocytokines; reproductive disorders; PCOS

(This special issue belongs to the Section Physiology and Pathology)

Language Models in Lab Coats: AI-Powered Biomedical Interpretation

edited by Sebastian Sanduleanu

submission deadline 31 Dec 2025 | Viewed by 72 | Submission Open

Keywords: radiology; large language models; artificial intelligence; radiobiology

(This special issue belongs to the Section Medical Research)

Biochemical Modulators in Chronic Diseases: The Antioxidant/Anti-Inflammatory Interdependence—2nd Edition

edited by

Emma Borrelli

submission deadline 31 Dec 2025 | Viewed by 62 | Submission Open

Keywords: oxidative stress; inflammation; redox modulator; anti-inflammatory agents; chronic diseases; antioxidant paradox; reactive oxygen species

(This special issue belongs to the Section Pharmaceutical Science)

Topographical Anatomy and Physiological Mechanics of the Musculoskeletal System

edited by

Michael L. Pretterklieber

submission deadline 31 Dec 2025 | Viewed by 33 | Submission Open

Keywords: muscle; bone; joint; peripheral nerve; motor innervation; proprioception; anatomical variant; radiologic imaging; development; comparative anatomy

(This special issue belongs to the Section Medical Research)

Human Infertility and Reproductive Endocrinology: 2nd Edition

edited by

Giuseppe Grande

submission deadline 6 Jan 2026 | 3 articles | Viewed by 4656 | Submission Open

Keywords: infertility; reproduction; reproductive endocrinology; male infertility; female infertility

(This special issue belongs to the Section Reproductive and Developmental Biology)

Blood Rheology: Insights & Innovations

edited by Nadia Antonova

submission deadline 15 Jan 2026 | 1 articles | Viewed by 2884 | Submission Open

Keywords: hemorheology ; microfluidics ; blood viscosity ; mechanobiology ; cellular mechanics

(This special issue belongs to the Section Medical Research)

Innovations in Dairy Cattle Health and Nutrition Management

edited by Rasa Želvytė and Ingrida Monkevičienė

submission deadline 15 Jan 2026 | 2 articles | Viewed by 1730 | Submission Open

Keywords: innovations; dairy cattle; health; nutrition; rumen; metabolism; biomarkers

(This special issue belongs to the Section Animal Science)

Research Progress in Kidney Diseases

edited by Ane Claudia Fernandes Nunes

submission deadline 15 Jan 2026 | 2 articles | Viewed by 1258 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; hemodialysis; nephrology; renal failure; hypertension; diabetes; molecular genetics

(This special issue belongs to the Section Physiology and Pathology)

Aspects of the Biology of Populations in Northern Africa and the Middle East

edited by

Kanya Godde

and Shomarka Keita

submission deadline 15 Jan 2026 | Viewed by 125 | Submission Open

Keywords: biodiversity in the Middle East; biodiversity in Northern Africa; population genetics in the Middle East; ecology in the Middle East; ecology in Northern Africa; skeletal variation in the Middle East; skeletal variation in Northern Africa; dental variation in the Middle East; dental variation in Northern Africa

New Insights into Allergic Eye Diseases

edited by

De Gaulle I. Chigbu

and

Livio Vitiello

submission deadline 16 Jan 2026 | 2 articles | Viewed by 15734 | Submission Open

Keywords: allergy; IgE; IL-4; IL-5; IL-13; TNF-alpha; mast cells; eosinophils; Th1 cells; Th2 cells; therapeutics; immunopathogenesis; immunopathology; conjunctivitis; keratoconjunctivitis

(This special issue belongs to the Section Medical Research)

Multi-Omics Approaches for Gut Microbiota Research: Implications for Human Nutrition

edited by

Georgia Saxami

and Antonio Benedetti

submission deadline 16 Jan 2026 | Viewed by 595 | Submission Open

Keywords: gut microbiota; multi-omics; metagenomics; metabolomics; host– microbiome interactions; precision nutrition; dietary interventions

(This special issue belongs to the Section Microbiology)

Advances in Bioprinting, Tissue Engineering, and Regenerative Medicine

edited by

Adrian Neagu

submission deadline 18 Jan 2026 | 3 articles | Viewed by 6060 | Submission Open

Keywords: model tissues; scaffolds; biocompatible materials; biodegradable materials; tissue-on-a-chip; organoids

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Advances in Vascular Health and Metabolism

edited by Ana Blazquez-Medela

submission deadline 18 Jan 2026 | 3 articles | Viewed by 2493 | Submission Open

Keywords: cardiovascular; cardiometabolic disease; adipogenesis; atherosclerosis; obesity; overweight; peripheral artery disease

(This special issue belongs to the Section Medical Research)

Knee Bracing in Human Movement: Biomechanics, Artificial Intelligence, and Optimization

edited by

Zixiang Gao

and Liangliang Xiang

submission deadline 20 Jan 2026 | Viewed by 133 | Submission Open

Keywords: knee bracing; sports biomechanics; neuromechanical mechanisms; gait analysis; functional movement adaptation; AI in orthotics; AI for brace performance; musculoskeletal modeling; finite element simulation; real-time monitoring of knees; human-in-the-loop control; robotic exoskeleton integration; human– machine interaction; rehabilitation or injury prevention

(This special issue belongs to the Section Medical Research)

Nutritional Supplements and Cardiovascular Function in Athletes and Sedentary People

edited by

Ines Drenjančević

submission deadline 23 Jan 2026 | 6 articles | Viewed by 10773 | Submission Open

Keywords: athletes; sedentary; eating habits; nutrition; endothelium; microcirculation; vascular function; nutritional supplements; oxidative stress; antioxidants; NRF2-signaling pathway; functional food; cardiovascular function; prevention; physical activity

(This special issue belongs to the Section Medical Research)

Microbial Diversity and Function in Aquatic Environments

edited by Xianglong Chen and

Liang Guo

submission deadline 30 Jan 2026 | 3 articles | Viewed by 4127 | Submission Open

Keywords: aquatic environment; microbial diversity and function; element biogeochemical cycle; interaction between microorganisms and aquatic environments; metaomic approaches

(This special issue belongs to the Section Microbiology)

Advancing Nanotechnology in Cancer Theranostics

edited by

Yulia Merkher

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2162 | Submission Open

Keywords: nanotechnology; cancer; nanoscale materials; nanoparticles; diagnostic accuracy; therapeutic efficacy; metastasis detection and prediction; targeted drug delivery; personalized cancer therapy

(This special issue belongs to the Section Medical Research)

Physical Medicine and Rehabilitation: Trends and Applications—4th Edition

edited by

and

submission deadline 30 Jan 2026 | 2 articles | Viewed by 1370 | Submission Open

Keywords: clinical physical medicine and rehabilitation; neurorehabilitation; cardiopulmonary rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; geriatric rehabilitation; cancer rehabilitation; musculoskeletal pain management; physical therapy; occupational therapy; speech and swallowing therapy

(This special issue belongs to the Section Epidemiology)

Nutrition–Physiology Interactions in Aquatic Species

edited by

Dizhi Xie

Songlin Li

and

Kangle Lu

submission deadline 30 Jan 2026 | 2 articles | Viewed by 849 | Submission Open

Keywords: aquatic animal nutrition; fish physiology; sustainable aquaculture; alternative lipid sources; alternative protein sources; gut– microbiota interactions

(This special issue belongs to the Section Animal Science)

3D Imaging and Facial Reconstruction

edited by Marios Papadakis

submission deadline 30 Jan 2026 | 1 articles | Viewed by 710 | Submission Open

Keywords: 3D imaging; facial plastic surgery; reconstructive surgery; virtual surgical planning; custom implants; preoperative planning; intraoperative navigation

(This special issue belongs to the Section Medical Research)

Metabolic Research in Animal Nutrition

edited by

Sylwia Szymańczyk

Marek Bienko

and

Radosław P. Radzki

submission deadline 30 Jan 2026 | Viewed by 430 | Submission Open

Keywords: nutrition; supplementation; microbiota; obesity; metabolic syndrome; metabolic disorders and diseases; hormonal factors; development and metabolism; metabolomics; nutrigenomics

(This special issue belongs to the Section Animal Science)

Targeting Hormonal Regulation in Prostate Cancer

edited by Marília Figueira

submission deadline 30 Jan 2026 | Viewed by 298 | Submission Open

Keywords: prostate cancer; castrate resistant prostate cancer (CRPC); metastatic prostate cancer; estrogens; estrogen receptors; drug resistance

(This special issue belongs to the Section Medical Research)

New Advances in Neuroimaging and Brain Functions: 2nd Edition

edited by

Ming-Chang Chiang

and

Chiahui Yen

submission deadline 31 Jan 2026 | 4 articles | Viewed by 16844 | Submission Open

Keywords: neuroimaging; brain functions; neurological diseases; humanities and social sciences; noninvasive methods; AI deep learning

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Pain and Therapy: Historical Perspectives and Future Directions

edited by

Francesco Scaglione

and

Arianna Pani

submission deadline 31 Jan 2026 | 6 articles | Viewed by 7785 | Submission Open

Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment

(This special issue belongs to the Section Medical Research)

Pancreatic Cancer: Long Survivals

edited by Francesco Leonardi and

Ingrid Garajova

submission deadline 31 Jan 2026 | 1 articles | Viewed by 7107 | Submission Open

Keywords: pancreatic cancer; long survival; outcome; pancreatic adenocarcinoma; long-term survival; surgical resection; chemotherapy; NGS

(This special issue belongs to the Section Physiology and Pathology)

Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition

edited by

Marzena Tylicka

Joanna Kamińska

and

Olga Koper-Lenkiewicz

submission deadline 31 Jan 2026 | 4 articles | Viewed by 2320 | Submission Open

Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases

(This special issue belongs to the Section Physiology and Pathology)

Natural Products and Modern Drug Discovery: Emerging Strategies Targeting Cancer- and Disease-Related Molecular Mechanisms

edited by

Chia-Jui Weng

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1298 | Submission Open

Keywords: natural products; phytochemicals; drug discovery; bioactivity profiling; pharmacophore modeling; synthetic biology; cancer therapy; microbial metabolites

(This special issue belongs to the Section Medical Research)

Recent Advances in Valve Therapy: Clinical and Molecular Perspectives

edited by

Panayotis Vlachakis

, Konstantinos Toutouzas and Constantina Aggeli

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1244 | Submission Open

Keywords: transcatheter aortic valve implantation (TAVI); valve-in-valve; long-term outcomes; aortic stenosis; molecular mechanisms in valve disease; structural heart disease

(This special issue belongs to the Section Medical Research)

Microbiome–Gut–Brain Connections: New Windows into Health and Disease

edited by

Yating Wan

and Qi Su

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1101 | Submission Open

Keywords: gut microbes; gut– brain axis; neuroscience

(This special issue belongs to the Section Microbiology)

Advances in Cardiac Arrest: Prognostic Performance and Management

edited by

Kei Hayashida

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1046 | Submission Open

Keywords: cardiac arrest; resuscitation; emergency medicine; critical care medicine

(This special issue belongs to the Section Medical Research)

Advances in the Rehabilitation of Stroke

edited by

Chia Huei Lin

submission deadline 31 Jan 2026 | 1 articles | Viewed by 912 | Submission Open

Keywords: stroke; acute stroke; chronic stroke; post-acute stroke; functional recovery; rehabilitation

(This special issue belongs to the Section Medical Research)

Plant–Soil Interactions Under Global Change

edited by

Tao Zhang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 768 | Submission Open

Keywords: plant– soil interactions; biodiversity; ecosystem; agroecosystem; natural ecosystem; sustainable development

(This special issue belongs to the Section Plant Science)

Prevention, Diagnosis, and Treatment of Gestational Diseases

edited by

Andrea Suranyi

submission deadline 31 Jan 2026 | 2 articles | Viewed by 761 | Submission Open

Keywords: gestational diseases; gestational diabetes; preeclampsia; pregnancy complications

(This special issue belongs to the Section Medical Research)

Pig Microbiota Metabolism and Intestinal Health

edited by

Qi-Ye Wang

submission deadline 31 Jan 2026 | 1 articles | Viewed by 640 | Submission Open

Keywords: pig microbiota; metabolism; intestinal health; gut microbiome; functional genomics; microbiome-host interactions; animal nutrition; disease resistance; gut barrier function; omics technologies; immune function; antibiotic reduction; feed efficiency; pathogen control; gastrointestinal health

(This special issue belongs to the Section Animal Science)

Advances in Emergency and Critical Care Medicine

edited by