Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Back to Basics in Palaeontology: 2nd Edition
edited by Hua Stephane
submission deadline 31 Mar 2026 | Viewed by 171 | Submission Open
Keywords: fundamentals; natural history; multidisciplinarity; firsthand bibliography; actualism
(This special issue belongs to the Section Paleobiology)
Fatty Liver Disease: From Molecular Mechanisms to Novel Therapeutics
edited by Stephen Malnick and
submission deadline 31 Mar 2026 | Viewed by 144 | Submission Open
Keywords: fatty liver disease; metabolic-associated liver disease-MAFLD; alcoholic liver disease; non-alcoholic steatohepatitis; alcohol and COVID-19; cytokine storm; microbiome
(This special issue belongs to the Section Medical Research)
New Advances in Natural Product Research for Drug Discovery and Therapeutics submission deadline 31 Mar 2026 | Viewed by 138 | Submission Open
Keywords: plant extract; natural Product; biological activity; chemical profiling; drug discovery; clinical applications
(This special issue belongs to the Section Plant Science)
Water Pollution Solutions: From Ecological Risk Assessment to Biological Restoration
edited by Lei Wang
submission deadline 31 Mar 2026 | Viewed by 134 | Submission Open
Keywords: water pollution; emerging contaminants; biological restoration; ecological risk assessment; microbial bioremediation; phytoremediation; aquatic ecosystem restoration; bio-based technologies; biomimetic technologies
(This special issue belongs to the Section Diversity and Ecology)
Stem Cell Biology, Tissue Formation, Cell Plasticity and Regenerative Medicine
edited by
submission deadline 31 Mar 2026 | Viewed by 105 | Submission Open
Keywords: stem cell biology; development and tissue formation; growth; tissue repair and regeneration; cell plasticity; model organisms and systems; clinical translation; regenerative medicine
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Cellular Responses to Hypoxia
edited by
submission deadline 31 Mar 2026 | Viewed by 77 | Submission Open
Keywords: hypoxia  ; cellular responses  ; molecular mechanisms  ; hypoxia signaling; adaptive pathways
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Neurological Disorders: Pathophysiological Mechanisms, Translational Breakthroughs, and Therapeutic Horizons submission deadline 31 Mar 2026 | Viewed by 68 | Submission Open
Keywords: neurological disorders; pathophysiological mechanisms; translational neuroscience; precision medicine; biomarkers; immunotherapy; digital health; brain– computer interfaces; regenerative medicine; nanomedicine
(This special issue belongs to the Section Medical Research)
Molecular Crossroads: Microbial Interactions and Metabolic Regulation in Livestock Health
edited by and Orsolya Palócz
submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open
Keywords: livestock microbiome; metabolic regulation; host– microbe interactions; animal health; nutrient metabolism; precision livestock farming
(This special issue belongs to the Section Animal Science)
Molecular Epidemiology of Animal Viral Diseases submission deadline 31 Mar 2026 | Viewed by 56 | Submission Open
Keywords: animal health; epidemiology; molecular characterization; virology
(This special issue belongs to the Section Animal Science)
Therapeutic Potential of Natural Products in Chronic Diseases
edited by and Wen-Long Hu
submission deadline 10 Apr 2026 | 1 articles | Viewed by 969 | Submission Open
Keywords: natural products; herbs; chronic disease
(This special issue belongs to the Section Medical Research)
Innovative Soil Amendments for Food Security: Biochar, Nanoparticles and Waste Valorization
edited by
submission deadline 10 Apr 2026 | Viewed by 203 | Submission Open
Keywords: food security; soil– plant-microbiome interactions; soil amendment; waste valorization
(This special issue belongs to the Section Plant Science)
Innovation in Rheumatology: Advances in Diagnostics, Therapeutics and AI Applications
edited by
submission deadline 10 Apr 2026 | Viewed by 99 | Submission Open
Keywords: innovation; rheumatology; artificial intelligence (AI); new therapeutics; personalised therapy; wearable technologies; electronic health records; gene therapy; nanotechnology
(This special issue belongs to the Section Medical Research)
Stem Cells and Signaling Pathways in Pulmonary Biology
edited by
submission deadline 12 Apr 2026 | Viewed by 89 | Submission Open
Keywords: pulmonary biology; lung progenitor stem cells; signaling pathways; lung repair and regeneration; multi-omics
(This special issue belongs to the Section Physiology and Pathology)
Cutting-Edge Research and Innovation in Gastrointestinal Oncology
edited by Daniela Cornelia Lazar
submission deadline 15 Apr 2026 | Viewed by 184 | Submission Open
Keywords: gastrointestinal oncology; personalized medicine; immunotherapy and targeted treatment; liquid biopsy and molecular biomarkers; artificial intelligence in GI oncology; drug resistance in GI cancer; gut microbiota and cancer progression; endoscopic techniques in GI oncology; modern surgical procedure in GI oncology; multimodal cancer treatment
(This special issue belongs to the Section Physiology and Pathology)
Metabolic Nutrition: Diet–Microbiota Interactions in Obesity and Inflammation submission deadline 16 Apr 2026 | Viewed by 74 | Submission Open
Keywords: nutrition; dietary intake; microbiome; inflammation
(This special issue belongs to the Section Microbiology)
Advances in Endovascular Therapies and Acute Stroke Management
edited by
submission deadline 18 Apr 2026 | 4 articles | Viewed by 4944 | Submission Open
Keywords: mechanical thrombectomy; endovascular reperfusion; stroke intervention technologies; acute ischemic stroke treatment; stroke imaging biomarkers
(This special issue belongs to the Section Medical Research)
Spinal Neuromodulation: From Basic and Translational Research to Clinical Practice submission deadline 18 Apr 2026 | 1 articles | Viewed by 2789 | Submission Open
Keywords: spinal neuromodulation; translational neuroscience; spinal cord injury; neural plasticity; multi-disciplinary rehabilitation
(This special issue belongs to the Section Medical Research)
Bacterial Antibiotic Resistance: From Mechanisms to Strategies for Restoring Antibiotic Efficacy
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 1107 | Submission Open
Keywords: membrane transport; antibiotic resistance; pathogenic bacteria; bacterial defense; therapeutic strategies
(This special issue belongs to the Section Medical Research)
Brain Disease Diagnosis and Image Recognition
edited by Shumao Xu, and Minyan Ge
submission deadline 20 Apr 2026 | Viewed by 161 | Submission Open
Keywords: artificial intelligence; brain disease diagnosis; medical image recognition; neuroimaging; computational neuroscience; deep learning; machine learning; computer vision; signal processing; biomedical image analysis; neurodegenerative disorders; brain– computer interface; sleep disorders; sleep– wake regulation; polysomnography (PSG) analysis; circadian rhythms; sleep staging automation; REM sleep detection; insomnia biomarker identification; sleep apnea detection; neuroinflammation imaging; multimodal data fusion; explainable AI (XAI); federated learning; generative adversarial networks (GANs); edge computing for healthcare; clinical decision support systems; precision neurology; biomarker discovery; sleep-related neurodegeneration; EEG signal processing; functional MRI (fMRI); diffusion tensor imaging (DTI); Alzheimer’ s disease prediction; Parkinson’ s disease biomarkers; brain tumor segmentation; stroke lesion mapping; ethical AI in healthcare; AI-driven sleep medicine; automated sleep scoring
Phase Separation in Biological Regulation and Disease
edited by and Ke Liu
submission deadline 20 Apr 2026 | Viewed by 105 | Submission Open
Keywords: biomolecular condensates; liquid– liquid phase separation (LLPS); gene regulation; disease pathogenesis; aberrant phase separation
(This special issue belongs to the Section Physiology and Pathology)
Cardiovascular Diseases: From Basic Research to Clinical Application—3rd Edition submission deadline 24 Apr 2026 | 4 articles | Viewed by 2855 | Submission Open
Keywords: CVDs; risk factors; prevention; treatment; novelties in research; artificial intelligence
(This special issue belongs to the Section Medical Research)
Chronic Respiratory Comorbidities in Sleep-Disordered Breathing: A Holistic Approach submission deadline 24 Apr 2026 | Viewed by 511 | Submission Open
Keywords: sleep-disordered breathing (SDB); obstructive sleep apnoea (OSA); asthma; chronic obstructive pulmonary disease (COPD); interstitial lung diseases (ILDs); sleep physiology; pathophysiological traits; cardio-metabolic outcomes; treatment adherence and response
(This special issue belongs to the Section Physiology and Pathology)
Body Fluid-Based Biomarkers for Cognitive Impairment
edited by Wei Li
submission deadline 24 Apr 2026 | Viewed by 485 | Submission Open
Keywords: Alzheimer’ s disease and related dementia (ADRD); body fluid-based biomarkers; cognitive impairments; early diagnosis; treatment; prognosis
(This special issue belongs to the Section Medical Research)
The Impact of Onconutraceutics as Potential Oncological Strategy submission deadline 24 Apr 2026 | Viewed by 158 | Submission Open
Keywords: nutraceuticals; oncological therapies; onconutraceuticals; molecular pathways modulated by onconutraceuticals; chemotherapy; radiotherapy; personalized therapies; non-invasive approaches
(This special issue belongs to the Section Physiology and Pathology)
The 15th Anniversary of Life: Endothelial Glycocalyx—a Determinant of Endothelial Function and Vascular Reactivity submission deadline 24 Apr 2026 | Viewed by 121 | Submission Open
Keywords: endothelial glycocalyx; cardiovascular system; oxidative stress; inflammation; nutrition
(This special issue belongs to the Section Physiology and Pathology)
Advances in Research on Phytohormones
edited by
submission deadline 25 Apr 2026 | Viewed by 204 | Submission Open
Keywords: stress tolerance; plant hormones; secondary metabolites; biostimulants; nanoparticles; transcriptomics; genome-wide analysis; biochemical pathways; stress defense responses
(This special issue belongs to the Section Plant Science)
Recent Trends in Prebiotic Chemistry
edited by Maheen Gull
submission deadline 26 Apr 2026 | 1 articles | Viewed by 1357 | Submission Open
Keywords: early earth; prebiotic chemistry; meteorites; molecules of life; phosphorylation; challenges in prebiotic chemistry; chirality; condensation; wet– dry cycles; RNA world; hydrothermal systems; mineral catalysis
(This special issue belongs to the Section Origin of Life)
Transformative Frontiers in Mental Health Treatment: Advances in Neuropsychopharmacology submission deadline 27 Apr 2026 | Viewed by 325 | Submission Open
Keywords: neuropsychopharmacology; mental health; novel drug therapies; biomarkers; personalized medicine; psychiatric conditions; treatment innovation; pharmacogenomics; synaptic plasticity; neuroinflammation; neuroendocrine systems
(This special issue belongs to the Section Pharmaceutical Science)
Gynecological Cancer: Etiologic, Diagnostic, Prognostic, and Therapeutic Research submission deadline 27 Apr 2026 | Viewed by 259 | Submission Open
Keywords: gynecological cancer; chemotherapy in gynecological cancers; radiation therapy in gynecological oncology; gynecological cancer biomarkers; cancer prevention; gynecological cancer immunotherapy
(This special issue belongs to the Section Medical Research)
Clinical Update for Resuscitation Science: 2nd Edition
edited by Mitsuaki Nishikimi
submission deadline 27 Apr 2026 | Viewed by 163 | Submission Open
Keywords: resuscitation science; cardiac arrest; acute respiratory failure; acute circulatory failure; trauma
(This special issue belongs to the Section Medical Research)
Life in Space: From Molecules to Extremophiles
edited by Alessia Cassaro and
submission deadline 27 Apr 2026 | Viewed by 95 | Submission Open
Keywords: astrobiology; life in space; extreme environments; extremophiles; adaptation mechanisms; ground-based simulation; planetary protection; life detection strategies; spaceflight experiments; synthetic biology
(This special issue belongs to the Section Astrobiology)
Current Trends in Obstructive Sleep Apnea
edited by Kimberly A. Hardin
submission deadline 28 Apr 2026 | 4 articles | Viewed by 12423 | Submission Open
Keywords: obstructive sleep apnea  ; diagnosis and biomarkers  ; personalized treatment strategies  ; clinical phenotypes  ; innovative therapies
(This special issue belongs to the Section Medical Research)
Cardiorenal Disease: Pathogenesis, Diagnosis, and Treatments
edited by Pedro Caravaca-Pérez and Jose Jesus Broseta
submission deadline 28 Apr 2026 | 3 articles | Viewed by 3068 | Submission Open
Keywords: heart failure; kidney disease; cardiorenal syndrome; diagnosis; treatment
(This special issue belongs to the Section Medical Research)
New Developments in Mycology submission deadline 28 Apr 2026 | 1 articles | Viewed by 1064 | Submission Open
Keywords: fungal diversity; population genetics; phylogeography; mycorrhizae; biotechnology
(This special issue belongs to the Section Microbiology)
Neurodegenerative Diseases: From Risk Factors to Treatments
edited by
submission deadline 28 Apr 2026 | Viewed by 156 | Submission Open
Keywords: immune regulation (e.g.; chronic inflammation) of NDs; cardiocerebral vascular disease and NDs; the effects of emotional and affective dimensions on cognitive reserve decline; the multidimensional screening of NDs; the interventions of NDs; gene polymorphism on the efficacy of pharmacological treatments in NDs; cognitive and functional rehabilitation for patients with NDs; technology innovation in the integrated approach to the patients with NDs
(This special issue belongs to the Section Medical Research)
Reviewing the Landscape of Psychopharmacology
edited by
submission deadline 28 Apr 2026 | Viewed by 111 | Submission Open
Keywords: psychopharmacology; mood disorders; neurobiology; drug safety; translational psychiatry
(This special issue belongs to the Section Pharmaceutical Science)
Carbon and Nitrogen Cycles in Terrestrial Ecosystems
edited by
submission deadline 29 Apr 2026 | 4 articles | Viewed by 7948 | Submission Open
Keywords: process-based modeling and machine learning; field experiments and meta-analysis; terrestrial carbon and nitrogen cycles; role of living organisms in biogeochemical cycles
(This special issue belongs to the Section Diversity and Ecology)
Musculoskeletal Pain and Disorders: Diagnosis, Treatment and Management submission deadline 30 Apr 2026 | 3 articles | Viewed by 11860 | Submission Open
Keywords: pain; connective tissue; musculoskeletal disorders; fascia; muscles; tendons; ligaments
(This special issue belongs to the Section Physiology and Pathology)
Cardiovascular–Kidney–Metabolic (CKM) Syndrome
edited by Chien Yu Lin and
submission deadline 30 Apr 2026 | 3 articles | Viewed by 11477 | Submission Open
Keywords: cardiovascular-kidney-metabolic (CKM) syndrome; mortality; biomarkers; epidemiology; environmental pollutants; gut microbiome; oxidative stress; metabolic syndrome; coronary heart disease; chronic renal failure; cardiovascular disease; cardiorenal syndrome; metabolic disorders; heart failure; diabetes and CKD; inflammation and CKM syndrome; multi-organ interaction; translational research in CKM
(This special issue belongs to the Section Medical Research)
Health Management of Farm Animals: Physiological and Pathological Aspects submission deadline 30 Apr 2026 | 3 articles | Viewed by 4041 | Submission Open
Keywords: cattle; small ruminants; pig; poultry; veterinary medicine; health; disease; welfare
(This special issue belongs to the Section Animal Science)
Advanced Heart Failure and Transplant Cardiology
edited by David Dobarro
submission deadline 30 Apr 2026 | 3 articles | Viewed by 3528 | Submission Open
Keywords: heart failure; heart transplantation; cardiology; ventricular assist devices
(This special issue belongs to the Section Medical Research)
Kidney Transplantation: What’s Hot and What’s New—2nd Edition
edited by and Caterina Di Bella
submission deadline 30 Apr 2026 | 1 articles | Viewed by 2612 | Submission Open
Keywords: kidney transplantation; immunosuppression; graft quality; machine perfusion (MP); living-donor kidney transplantation
(This special issue belongs to the Section Medical Research)
From Pathophysiology to Pathology—an Update on Diabetic Kidney Disease
edited by Sharma Prabhakar
submission deadline 30 Apr 2026 | 2 articles | Viewed by 2337 | Submission Open
Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system; sodium glucose transporter 2; albuminuria
(This special issue belongs to the Section Physiology and Pathology)
Physiological Responses and Adaptation Mechanisms of Plants to Stress
edited by and Bassam T. Yasseen
submission deadline 30 Apr 2026 | 2 articles | Viewed by 1948 | Submission Open
Keywords: biotechnology; chemical composition; growth processes; heavy metals; hormonal balance; improving growth variables; mechanisms of osmotic stress; pollution; photosynthesis; stomatal behaviors
(This special issue belongs to the Section Plant Science)
Minimally Invasive Neuroendoscopy
edited by Stefan Linsler
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1488 | Submission Open
Keywords: spinal neuroendoscopy; spine and brain surgery; endonasal endoscopic skull base surgery; intraventricular neuroendoscopy
(This special issue belongs to the Section Medical Research)
An Update on Diabetic Kidney Disease: Epidemiology, Diagnosis, Treatment
edited by Sharma Prabhakar
submission deadline 30 Apr 2026 | 1 articles | Viewed by 1176 | Submission Open
Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system sodium glucose transporter 2; albuminuria
(This special issue belongs to the Section Medical Research)
Research and Management in Autoimmune Rheumatic Diseases submission deadline 30 Apr 2026 | 1 articles | Viewed by 837 | Submission Open
Keywords: autoimmune rheumatic diseases; rheumatoid arthritis; systemic lupus erythematosus; systemic sclerosis; Sjogren's syndrome; biologic agents; JAK inhibitors
(This special issue belongs to the Section Medical Research)
Implications of Bioactive Compounds in Lifelong Disorders: 2nd Edition submission deadline 30 Apr 2026 | 1 articles | Viewed by 568 | Submission Open
Keywords: phytochemicals; functional food; oxidative stress; metabolic syndrome; neuroinflammation; antioxidant; polyphenols; diabetes; inflammatory bowel disease; natural products; neurodegenerative disease
Multi-Omics Insights into Traditional Fermented Foods: Microbial Ecology, Metabolite Profiles, and Functional Applications
edited by , Lan-Szu Chou, Chih-Yu Lo and
submission deadline 30 Apr 2026 | Viewed by 201 | Submission Open
Keywords: traditional fermented foods; omics analysis; fermentation biotechnology; bioactive metabolites
(This special issue belongs to the Section Microbiology)
Advances in Binocular Vision Assessment and Management: From Anomalies to Oculomotor Norms submission deadline 30 Apr 2026 | Viewed by 199 | Submission Open
Keywords: binocular vision; oculomotor control vergence; accommodation; strabismus; amblyopia; convergence insufficiency; eye-tracking; visual rehabilitation; normative oculomotor behavior
(This special issue belongs to the Section Medical Research)
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