Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Views on Knee Osteoarthritis: 3rd Edition submission deadline 30 Dec 2025 | Viewed by 152 | Submission Open
Keywords: knee osteoarthritis; metabolic syndrome; obesity; pathogenesis; adipokines; disease-modifying; treatment; personalized medicine
(This special issue belongs to the Section Medical Research)
Advances in the Pathology of Dialysis: Insights into Peritoneal and Hemodialysis-Related Complications
edited by
submission deadline 30 Dec 2025 | Viewed by 71 | Submission Open
Keywords: peritoneal dialysis; hemodialysis; acute kidney injury (AKI); chronic kidney disease; pathology; complication
(This special issue belongs to the Section Physiology and Pathology)
Advances in Neural Stem Cell Medicine
edited by Kiminobu Sugaya
submission deadline 30 Dec 2025 | Viewed by 44 | Submission Open
Keywords: neural stem cell; neurodegenerative diseases; cell therapy; exosomes
(This special issue belongs to the Section Physiology and Pathology)
Plant Biotic and Abiotic Stresses 2024
edited by and
submission deadline 31 Dec 2025 | 21 articles | Viewed by 25989 | Submission Open
Keywords: plant stress; abiotic stress; biotic stress
(This special issue belongs to the Section Plant Science)
Gastrointestinal Health: Clinical Research and Therapeutic Innovations
edited by
submission deadline 31 Dec 2025 | 17 articles | Viewed by 23040 | Submission Open
Keywords: gut microbiota; inflammatory bowel diseases; irritable bowel syndrome; gastroesophageal reflux disease; fatty liver disease; liver cirrhosis; probiotics; mediterranean diet; epidemiology; diagnosis; treatment; artificial intelligence
(This special issue belongs to the Section Medical Research)
New Trends in Otorhinolaryngology submission deadline 31 Dec 2025 | 6 articles | Viewed by 13439 | Submission Open
Keywords: head and neck; otolaryngology; hearing loss; speech disorders; swallowing disorders; cancer; microRNA; nose; plastic surgery
(This special issue belongs to the Section Medical Research)
Clinical Management and Prevention of Adverse Pregnancy Outcomes submission deadline 31 Dec 2025 | 5 articles | Viewed by 10477 | Submission Open
Keywords: pathologic pregnancies; ultrasound; clinical and molecular characteristics; fetal pathologies
(This special issue belongs to the Section Reproductive and Developmental Biology)
New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 8844 | Submission Open
Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA
(This special issue belongs to the Section Medical Research)
Ecology and Conservation of Small Mammals: Exploring Biodiversity, Climate Resilience, and Ecosystem Dynamics Through Small Mammal Monitoring and Research: 2nd Edition submission deadline 31 Dec 2025 | 7 articles | Viewed by 7502 | Submission Open
Keywords: small mammals; biodiversity; indicators; monitoring; assessment; communities
(This special issue belongs to the Section Diversity and Ecology)
New Insights into Breast Cancer: Current Controversies and Future Perspectives
edited by , Angela Bucaro and Flavia de Lauretis
submission deadline 31 Dec 2025 | 7 articles | Viewed by 5989 | Submission Open
Keywords: breast cancer treatment; oncoplastic surgery; conservative mastectomy; breast reconstruction; sentinel node biopsy; chemotherapy; radiotherapy; integrated therapies
(This special issue belongs to the Section Medical Research)
Recent Advances in Functional Genomics
edited by Katerina R. Katsani and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5258 | Submission Open
Keywords: chromatin profiling; CRISPR screens; crop genomics; epigenome editing; epigenomics; interactomes; metagenomics; pharmacogenomics; phenomics
(This special issue belongs to the Section Genetics and Genomics)
Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition submission deadline 31 Dec 2025 | 4 articles | Viewed by 5092 | Submission Open
Keywords: cancer; therapy; cancer drug; molecular mechanism; signaling pathways; targeted therapy; in silico drug response studies; innovative cancer treatment
(This special issue belongs to the Section Medical Research)
Advances in Non-Alcoholic Fatty Liver Disease: Pathophysiology, Diagnosis, and Emerging Therapies submission deadline 31 Dec 2025 | 2 articles | Viewed by 4812 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated fatty liver disease (MAFLD); steatohepatitis; metabolic syndrome; insulin resistance; apoptosis/cell death
(This special issue belongs to the Section Medical Research)
Trends in Clinical Research 2025 submission deadline 31 Dec 2025 | 3 articles | Viewed by 4561 | Submission Open
Keywords: artificial intelligence; biomedical research; digital health; evidence-based medicine; health policy; new therapies; new drugs; patient-centered research; personalized medicine; translational medicine
(This special issue belongs to the Section Medical Research)
Advances in Non-Invasive Brain Stimulation submission deadline 31 Dec 2025 | 2 articles | Viewed by 4169 | Submission Open
Keywords: translational neuroscience; clinical neurophysiology; neurodegeneration; neural plasticity; neurosonology; sleep disorders; cognitive decline; non-invasive brain stimulation; nutraceuticals; neurogenetics; transcranial magnetic stimulation; dementia; vascular cognitive impairment; stroke; depression; metaplasticity; motor cortex; motor learning; neurotrophins; transcranial-focused ultrasound
(This special issue belongs to the Section Medical Research)
Plant Physiology: From Omic Analysis Toward Physiological Mechanism Research: 2nd Edition
edited by and Fang He
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2683 | Submission Open
Keywords: plant physiology; transcriptome; proteomics; gene regulatory network; bioinformation; omics; molecular mechanisms
(This special issue belongs to the Section Plant Science)
Molecular Mechanisms of Preeclampsia
edited by Feng Li
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2662 | Submission Open
Keywords: preeclampsia; hypertension; proteinuria; placenta; fetal growth restriction; pregnancy com-plications; implantation
(This special issue belongs to the Section Reproductive and Developmental Biology)
Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition submission deadline 31 Dec 2025 | 4 articles | Viewed by 2548 | Submission Open
Keywords: obstetrics; gynecology; translational research; translational medicine
(This special issue belongs to the Section Medical Research)
Mechanism, Diagnostic and Therapeutic Novelties in Dermatology: 3rd Edition
edited by Jose Carlos Armario Hita, and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2266 | Submission Open
Keywords: physiopathology; skin sonography; dermoscopy; innovation; confocal microscopy; biological treatment; psoriasis; atopic dermatitis; inmmunomediated diseases; urticaria; laser CO2
(This special issue belongs to the Section Medical Research)
Antimicrobial Innovations
edited by and Miho Nakamura
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1943 | Submission Open
Keywords: antimicrobial resistance; biopreservation; lactic acid bacteria; bacteriocins; bacteriophages; natural antimicrobials; antimicrobial peptides; foodborne pathogens; antimicrobial biomaterials; race for the surface; microbial growth models; food safety
(This special issue belongs to the Section Microbiology)
Feature Papers in Animal Science: 4th Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1560 | Submission Open
Keywords: fish; microbial ecology; lipid nutrition; electron microscopy; gut microbiota; proteomics; next-generation sequencing; arthropod parasites; protease inhibitors; disease vectors; cystatin; serpin; Kunitz; tick; insect; vector– host interaction; innate immunity; shellfish immunology; bivalve molluscs; transcriptomics; diseases; hemocytes; microscopy
(This special issue belongs to the Section Animal Science)
From Muscle to Fascia: Current Trends and Future Perspectives submission deadline 31 Dec 2025 | 1 articles | Viewed by 1552 | Submission Open
Keywords: connective tissue; deep fascia; superficial fascia; retinacula; muscle stiffness; hyaluronan; densification; biomechanics; therapies
(This special issue belongs to the Section Physiology and Pathology)
Molecular Biomarkers in Inflammatory Disease
edited by Stelvio Tonello
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1354 | Submission Open
Keywords: cytokines; chemokines; and immune mediators as pharmacodynamic biomarkers; genomic and epigenomic contributions to drug response variability; proteomic and metabolomic profiling to guide pharmacotherapy in inflammation; biomarker-driven strategies for drug development and personalized treatment; mechanistic studies on drug– biomarker interactions and their clinical relevance; novel biomarkers for predicting adverse drug reactions in inflammatory diseases
(This special issue belongs to the Section Medical Research)
The Emerging Clinical Relevance of Artificial Intelligence, Data Science, and Wearable Devices in Headache
edited by , , Muneto Tatsumoto and Shingo Shimoda
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1321 | Submission Open
Keywords: headache; migraine; tension-type headache; trigeminal autonomic cephalalgias; medication-overuse headache; primary headaches; secondary headaches; raising awareness; calcitonin gene-related peptide (CGRP) monoclonal antibodies; artificial intelligence; wearable devices; data sciences
(This special issue belongs to the Section Medical Research)
Neurobiological and Neuroepigenetic Factors in Childhood Disorders: Autism Spectrum Disorder and Obesity
edited by Elisa Na
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1124 | Submission Open
Keywords: obesity; autism spectrum disorder; hypothalamus; cerebellum; frontal cortex; epigenetics
(This special issue belongs to the Section Physiology and Pathology)
Effects of Exercise and Functional Interventions on Musculoskeletal Health
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 938 | Submission Open
Keywords: musculoskeletal health; exercise; physical function; joint stability; fall prevention; rehabilitation science
(This special issue belongs to the Section Medical Research)
Diagnosis and Treatment of Erectile Dysfunction
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 931 | Submission Open
Keywords: erectile dysfunction; non-invasive methods; surgical strategies
(This special issue belongs to the Section Physiology and Pathology)
Advances in Research on Motor Deficits Caused by Neurological Disorders: From Mechanism to Treatment
edited by and Hans Hultborn
submission deadline 31 Dec 2025 | 1 articles | Viewed by 807 | Submission Open
Keywords: neurological disorders; neurodegenerative diseases; brain injury; spinal cord injury; stroke; cerebral palsy; peripheral nerve injury; paralysis; spasticity; contracture; muscle weakness; postural asymmetry; gate pattern changes; uncontrolled movements
(This special issue belongs to the Section Medical Research)
Conservation Ecology and Management of Mammalian Predators submission deadline 31 Dec 2025 | Viewed by 667 | Submission Open
Keywords: mammalian predators; mesocarnivores; terrestrial predators; predator– prey interactions
(This special issue belongs to the Section Animal Science)
Pain: New Insights into Mechanisms, Diagnosis, Therapy, and Management
edited by and I-Han Hsiao
submission deadline 31 Dec 2025 | Viewed by 574 | Submission Open
Keywords: pain; mechanisms; signaling pathways; diagnosis
(This special issue belongs to the Section Physiology and Pathology)
Advances in Artificial Intelligence for Medical Image Analysis: 2nd Edition
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 448 | Submission Open
Keywords: artificial intelligence; medical imaging; deep learning for medical imaging; histopathological image analysis; medical diagnosis; visualization in biomedical imaging; magnetic resonance imaging (MRI); X-ray computed tomography (CT); positron emission tomography (PET); medical image fusion
(This special issue belongs to the Section Medical Research)
Advancing Cancer Radiodiagnostics Through Artificial Intelligence: Techniques, Applications, and Challenges
edited by Pei-Ju Chao, , and
submission deadline 31 Dec 2025 | Viewed by 447 | Submission Open
Keywords: artificial intelligence; cancer radiodiagnostics; machine learning; tumor detection; radiomics integration
(This special issue belongs to the Section Medical Research)
The Interactions Between Cells and Their Microenvironment
edited by and
submission deadline 31 Dec 2025 | Viewed by 386 | Submission Open
Keywords: cell microenvironment; extracellular matrix; interstitial cells
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Characterization, Bioactivity Evaluation and Utilization of Plant Polysaccharides
edited by and
submission deadline 31 Dec 2025 | Viewed by 313 | Submission Open
Keywords: plant polysaccharides; identification; characterization; functional property; biological activity; health benefit; food packaging
(This special issue belongs to the Section Pharmaceutical Science)
Radiological Diagnosis of Cervical Spondylosis and Carotid Artery Disease
edited by Anusha Vaddi
submission deadline 31 Dec 2025 | Viewed by 306 | Submission Open
Keywords: carotid artery disease; atherosclerosis; cervical spondylosis; c-spine; radiological diagnosis; diagnostic accuracy; AI in radiology
(This special issue belongs to the Section Medical Research)
Sustainable Agroforestry: Molecular Strategies for Integrated Pest and Disease Management
edited by Gothandapani Sellamuthu and Kanakachari Mogilicherla
submission deadline 31 Dec 2025 | Viewed by 246 | Submission Open
Keywords: sustainable agroforestry; integrated pest management; genomics; transcriptomics; CRISPR technology; RNAi; plant– microbe interactions; biopesticides
(This special issue belongs to the Section Plant Science)
Move to Thrive: Pioneering Health and Resilience Through Physical Activity submission deadline 31 Dec 2025 | Viewed by 223 | Submission Open
Keywords: physical activity; inflammation modulation; chronic disease prevention; immune system adaptation; biomechanics; rehabilitation strategies; sports medicine; aging and physical activity; disability and movement; environmental and regional influences on exercise
(This special issue belongs to the Section Physiology and Pathology)
Postharvest Softening, Flavor and Quality of Fruits: Molecular Mechanisms and Regulatory Approaches
edited by Qinggang Zhu and Yaxiu Xu
submission deadline 31 Dec 2025 | 1 articles | Viewed by 211 | Submission Open
Keywords: fruit softening; fruit quality; fruit flavor; molecular mechanisms; regulatory approaches
(This special issue belongs to the Section Plant Science)
Animal Reproduction and Health
edited by and
submission deadline 31 Dec 2025 | Viewed by 197 | Submission Open
Keywords: animal; reproduction; genetics; heritability; disease; fertility; sperm; health; pregnancy; neonatal health and development; microbiome health and development
(This special issue belongs to the Section Animal Science)
Plant Adaptation Mechanisms to Abiotic Stresses
edited by Sunchung Park and Ezekiel Ahn
submission deadline 31 Dec 2025 | Viewed by 169 | Submission Open
Keywords: abiotic stress; plant adaptation mechanisms; cold; heat; drought; salinity; flooding; waterlogging; transcription factors
(This special issue belongs to the Section Plant Science)
Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations
edited by Manuel Gil Lozano and Marina Romaní-Pérez
submission deadline 31 Dec 2025 | Viewed by 163 | Submission Open
Keywords: gastrointestinal peptides; adipokines; food intake regulation; hypothalamus; orexigenic; anorexigenic; adipocytes; pancreatic islets; leptin; insulin
(This special issue belongs to the Section Physiology and Pathology)
Bioactive Compounds for Medicine and Health submission deadline 31 Dec 2025 | Viewed by 154 | Submission Open
Keywords: phytochemistry; bioactive compounds; cancer; immune modulation; heart disease; diabetes; obesity; neurodegenerative diseases; neuroprotection
(This special issue belongs to the Section Pharmaceutical Science)
Airway Management in Emergency and Intensive Care Medicine
edited by Prashant Nasa and Tonny V. Veenith
submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open
Keywords: airway management; critical care; laryngoscopy; intubation; intratracheal; emergency treatment
(This special issue belongs to the Section Medical Research)
Brain Barrier Research: Mechanisms, Function, Regulation, and Therapeutic Medicine submission deadline 31 Dec 2025 | Viewed by 136 | Submission Open
Keywords: brain barriers; brain homeostasis; neurodegeneration; neuroinflammation; brain drug delivery
(This special issue belongs to the Section Physiology and Pathology)
Artificial Intelligence in Cardiovascular Diseases: Research, Technology and Clinical Practice
edited by
submission deadline 31 Dec 2025 | Viewed by 131 | Submission Open
Keywords: cardiovascular disease; artificial intelligence; atherosclerosis; atrial fibrillation; cardiomyopathy
(This special issue belongs to the Section Medical Research)
The Biology and Functions of Platelets: Emerging Challenges
edited by and Miriam Andrea Duque
submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open
Keywords: platelet; hemostasis; toll-like receptor; immunity; phagocytosis; transfusions; von Willebrand factor; thrombocyte
(This special issue belongs to the Section Medical Research)
Leveraging the Power of Enzymes in Biotechnological Applications
edited by
submission deadline 31 Dec 2025 | Viewed by 115 | Submission Open
Keywords: enzyme; 3D structure; function/activity; enzyme engineering; beneficial variants; industrial application
Origin of Life in Chemically Complex Messy Environments: 3rd Edition submission deadline 31 Dec 2025 | Viewed by 110 | Submission Open
Keywords: origin of life; complex chemical systems  ; prebiotic chemistry  ; prebiotic metabolisms  ; chemical evolution  ; prebiotic catalysts
(This special issue belongs to the Section Origin of Life)
Cutting-Edge Research in Rhinology and Allergy: Unraveling Disease Mechanisms and Treatment Innovations
edited by Min-Seok Rha
submission deadline 31 Dec 2025 | Viewed by 109 | Submission Open
Keywords: rhinology; allergy; chronic rhinosinusitis; allergic rhinitis; asthma; precision medicine; clinical immunology; immunopathology; therapeutic innovation
Novel Biomaterial-Based Fertilizing Products and Bio-Fertilizers for Sustainable Agricultural Production: 2nd Edition submission deadline 31 Dec 2025 | Viewed by 98 | Submission Open
Keywords: biomaterials and bio-nanomaterials; bio-based hydrogels and polymers; lignocellulosic biomass and its derivatives; sustainable agriculture; biodegradability; stimuli-responsive fertilizer delivery; controlled-release fertilizers; bio-synthesis processes and characterization; control/sustained fertilizer release mechanisms; bio-fertilizers; plant growth-promoting microbes; fertilizers’ use efficiency; plant physiology; productivity; and quality
(This special issue belongs to the Section Plant Science)
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