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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Carbon and Nitrogen Cycles in Terrestrial Ecosystems

edited by

Naiqing Pan

submission deadline 29 Apr 2026 | 4 articles | Viewed by 8826 | Submission Open

Keywords: process-based modeling and machine learning; field experiments and meta-analysis; terrestrial carbon and nitrogen cycles; role of living organisms in biogeochemical cycles

(This special issue belongs to the Section Diversity and Ecology)

Musculoskeletal Pain and Disorders: Diagnosis, Treatment and Management

edited by

Antonio Stecco

and

Carmelo Pirri

submission deadline 30 Apr 2026 | 3 articles | Viewed by 13441 | Submission Open

Keywords: pain; connective tissue; musculoskeletal disorders; fascia; muscles; tendons; ligaments

(This special issue belongs to the Section Physiology and Pathology)

Cardiovascular–Kidney–Metabolic (CKM) Syndrome

edited by Chien Yu Lin and

Ching-Chung Hsiao

submission deadline 30 Apr 2026 | 3 articles | Viewed by 12567 | Submission Open

Keywords: cardiovascular-kidney-metabolic (CKM) syndrome; mortality; biomarkers; epidemiology; environmental pollutants; gut microbiome; oxidative stress; metabolic syndrome; coronary heart disease; chronic renal failure; cardiovascular disease; cardiorenal syndrome; metabolic disorders; heart failure; diabetes and CKD; inflammation and CKM syndrome; multi-organ interaction; translational research in CKM

(This special issue belongs to the Section Medical Research)

Health Management of Farm Animals: Physiological and Pathological Aspects

edited by

Vasileios Papatsiros

submission deadline 30 Apr 2026 | 3 articles | Viewed by 4530 | Submission Open

Keywords: cattle; small ruminants; pig; poultry; veterinary medicine; health; disease; welfare

(This special issue belongs to the Section Animal Science)

Advanced Heart Failure and Transplant Cardiology

edited by David Dobarro

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3974 | Submission Open

Keywords: heart failure; heart transplantation; cardiology; ventricular assist devices

(This special issue belongs to the Section Medical Research)

Kidney Transplantation: What’s Hot and What’s New—2nd Edition

edited by

Giuseppe Ietto

and Caterina Di Bella

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2933 | Submission Open

Keywords: kidney transplantation; immunosuppression; graft quality; machine perfusion (MP); living-donor kidney transplantation

(This special issue belongs to the Section Medical Research)

From Pathophysiology to Pathology—an Update on Diabetic Kidney Disease

edited by Sharma Prabhakar

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2860 | Submission Open

Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system; sodium glucose transporter 2; albuminuria

(This special issue belongs to the Section Physiology and Pathology)

Physiological Responses and Adaptation Mechanisms of Plants to Stress

edited by

Jie Luo

and Bassam T. Yasseen

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2307 | Submission Open

Keywords: biotechnology; chemical composition; growth processes; heavy metals; hormonal balance; improving growth variables; mechanisms of osmotic stress; pollution; photosynthesis; stomatal behaviors

(This special issue belongs to the Section Plant Science)

Minimally Invasive Neuroendoscopy

edited by Stefan Linsler

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1612 | Submission Open

Keywords: spinal neuroendoscopy; spine and brain surgery; endonasal endoscopic skull base surgery; intraventricular neuroendoscopy

(This special issue belongs to the Section Medical Research)

Research and Management in Autoimmune Rheumatic Diseases

edited by

Panagiotis Athanassiou

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1593 | Submission Open

Keywords: autoimmune rheumatic diseases; rheumatoid arthritis; systemic lupus erythematosus; systemic sclerosis; Sjogren's syndrome; biologic agents; JAK inhibitors

(This special issue belongs to the Section Medical Research)

An Update on Diabetic Kidney Disease: Epidemiology, Diagnosis, Treatment

edited by Sharma Prabhakar

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1331 | Submission Open

Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system sodium glucose transporter 2; albuminuria

(This special issue belongs to the Section Medical Research)

Implications of Bioactive Compounds in Lifelong Disorders: 2nd Edition

edited by

Guillermo Cásedas

and

Francisco Les

submission deadline 30 Apr 2026 | 1 articles | Viewed by 696 | Submission Open

Keywords: phytochemicals; functional food; oxidative stress; metabolic syndrome; neuroinflammation; antioxidant; polyphenols; diabetes; inflammatory bowel disease; natural products; neurodegenerative disease

Breakthroughs in Radiotherapy for Cancer

edited by

Kai Ding

and

Hamed Hooshangnejad

submission deadline 30 Apr 2026 | 1 articles | Viewed by 589 | Submission Open

Keywords: radiotherapy; radioimmunotherapy; AI-enhanced radiotherapy; bio-guided radiotherapy

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Phytochemicals in Focus: Bioactivity, Safety, and Therapeutic Potential

edited by Naeem Khan

submission deadline 30 Apr 2026 | 1 articles | Viewed by 409 | Submission Open

Keywords: phytochemicals; antioxidant activity; antimicrobial properties; toxicity evaluation; natural products; medicinal plants and bioactivity; oxidative stress plant extracts; therapeutic potential; safety assessment; bioactive compounds

(This special issue belongs to the Section Plant Science)

Advanced Research in Plant Physiology, Metabolism and Signal Transduction

edited by Xiaomin Wang

submission deadline 30 Apr 2026 | 1 articles | Viewed by 333 | Submission Open

Keywords: plant development; plant– environment interaction; plant– microbe interactions; signaling transduction; stress adaptation

(This special issue belongs to the Section Plant Science)

Advances in Binocular Vision Assessment and Management: From Anomalies to Oculomotor Norms

edited by

Mario Cantó-Cerdán

submission deadline 30 Apr 2026 | Viewed by 232 | Submission Open

Keywords: binocular vision; oculomotor control vergence; accommodation; strabismus; amblyopia; convergence insufficiency; eye-tracking; visual rehabilitation; normative oculomotor behavior

(This special issue belongs to the Section Medical Research)

Multi-Omics Insights into Traditional Fermented Foods: Microbial Ecology, Metabolite Profiles, and Functional Applications

edited by

Chia-Wen Hsieh

, Lan-Szu Chou, Chih-Yu Lo and

Brian Bor-Chun Weng

submission deadline 30 Apr 2026 | Viewed by 218 | Submission Open

Keywords: traditional fermented foods; omics analysis; fermentation biotechnology; bioactive metabolites

(This special issue belongs to the Section Microbiology)

Rumen Microbiome and Fermentation Function Research

edited by

Xingzhou Tian

submission deadline 30 Apr 2026 | Viewed by 199 | Submission Open

Keywords: rumen; in vivo; in vitro; microbe; fermentation; multi-omics

(This special issue belongs to the Section Animal Science)

Updates in Pancreas and Colorectal Adenocarcinoma

edited by

Radu Virgil Costea

submission deadline 30 Apr 2026 | Viewed by 198 | Submission Open

Keywords: pancreatic and colorectal carcinoma; pancreatic cancer; colorectal cancer

(This special issue belongs to the Section Medical Research)

Advances in Sustainable Animal Nutrition: Impacts on Physiology, Health, and Production

edited by

Christos Eliopoulos

and

Dimitrios Arapoglou

submission deadline 30 Apr 2026 | Viewed by 190 | Submission Open

Keywords: animal nutrition; alternative feedstuffs; physiology; gut health; nutrient metabolism; immune function; animal performance; sustainable livestock production

(This special issue belongs to the Section Animal Science)

Developmental Programming in Cats and Dogs

edited by

Franck Péron

Virginie Gaillard

and Sylvie Chastant

submission deadline 30 Apr 2026 | Viewed by 171 | Submission Open

Keywords: dog; cat; growth; health; prevention; development; susceptibility; environment; risk factors; nutrition; neutering

(This special issue belongs to the Section Animal Science)

15th Anniversary of Life—Emerging Plant-Based Materials and Bioactive Compounds in Biomedical Applications

edited by

Stefania Lamponi

submission deadline 30 Apr 2026 | Viewed by 163 | Submission Open

Keywords: plant-derived materials; bioactive compounds; phytochemicals; biomedical applications; natural products; plant-based polymers; drug delivery; tissue engineering

(This special issue belongs to the Section Plant Science)

Novel Diagnostics and Therapeutics for Ophthalmic Diseases

edited by

Chris H. L. Lim

submission deadline 30 Apr 2026 | Viewed by 161 | Submission Open

Keywords: clinical ophthalmology; ophthalmic innovations; diagnostic technologies; therapeutic advancements; surgical techniques; disparity in global eye health; personalized medicine

(This special issue belongs to the Section Medical Research)

Behavioral Manifestations and Neural Regulation of Movements

edited by

Luca Puce

and

Nicola Luigi Bragazzi

submission deadline 30 Apr 2026 | Viewed by 156 | Submission Open

Keywords: motor control; movement behavior; sensorimotor integration; neurophysiology; emotion and movement; cognitive-motor interaction; temperament; neurotechnology; rehabilitation; performance

(This special issue belongs to the Section Physiology and Pathology)

Genetic Drivers in Endocrine Disorders: From Rare Variants to Aggressive Malignancies

edited by

Sorina Schipor

Mihai Constantin Ceausu

and

Mihai Publik

submission deadline 30 Apr 2026 | Viewed by 139 | Submission Open

Keywords: endocrine tumors; rare variants; somatic variants; next-generation sequencing; molecular pathology; differentially expressed genes; aggressive tumor phenotype; novel genetic tests

(This special issue belongs to the Section Genetics and Genomics)

Advances in Tissue Engineering in Reproduction

edited by

Rodrigo Da Silva Nunes Barreto

submission deadline 30 Apr 2026 | Viewed by 128 | Submission Open

Keywords: translational regenerative medicine; bioengineered scaffolds; organoids and organ-on-a-chip; in vitro models; extracellular matrix on reproduction and regeneration

(This special issue belongs to the Section Animal Science)

Cortical Development and Neurotransmission

edited by Christine Hohmann and Joanne Berger-Sweeney

submission deadline 30 Apr 2026 | Viewed by 126 | Submission Open

Keywords: cerebral cortex; neurotransmission; neuromodulatory neurotransmitters; developmental brain disorders; molecular mechanism

(This special issue belongs to the Section Medical Research)

Research and Management of Endocrine Tumors

edited by

Ifigenia Kostoglou-Athanassiou

submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open

Keywords: thyroid cancer; papillary thyroid cancer; anaplastic thyroid cancer; radioiodine; multiple kinase and angiogenetic factor inhibitors; adrenal cancer; pituitary adenomas

(This special issue belongs to the Section Medical Research)

Advances in Disease Mechanisms and Treatment Innovations in Rhinology and Allergy

edited by

Chien-Chia Huang

submission deadline 30 Apr 2026 | Viewed by 108 | Submission Open

Keywords: sinonasal disorder ; chronic rhinosinusitis ; rhinitis ; empty nose syndrome ; nasal septal deviation ; obstructive sleep apnea ; sinonasal tumor ; skull base surgery ; pediatric otorhinolaryngology

(This special issue belongs to the Section Medical Research)

Current Challenges in Prognostic Assessment and Intervention Strategies in Acute and Critical Care

edited by

Hidetaka Onda

submission deadline 30 Apr 2026 | Viewed by 104 | Submission Open

Keywords: acute and critical care; prognostic assessment; biomarkers; therapeutic strategies; sepsis; trauma; cardiac arrest; respiratory failure/ARDS; neurocritical care; implementation; patient-centered outcomes keyword

(This special issue belongs to the Section Medical Research)

Research on the Pathogenesis and Association of Diabetes and Metabolic Syndrome

edited by Gwo-Ping Jong

submission deadline 30 Apr 2026 | Viewed by 99 | Submission Open

Keywords: diabetes mellitus; insulin resistance; metabolic syndrome; obesity; coronary artery disease; endothelial dysfunction; stroke; hypertension; peripheric arterial disease; metabolic dysfunction; hyperlipidemia

(This special issue belongs to the Section Physiology and Pathology)

Diabetes, Microbiome, and Inflammation: Mechanisms and Therapeutic Perspectives

edited by

Gratiela Pircalabioru

and

Octavian Savu

submission deadline 30 Apr 2026 | Viewed by 99 | Submission Open

Keywords: diabetes mellitus; microbiome; microbiota metabolites; metabolic disease; dysbiosis

(This special issue belongs to the Section Medical Research)

Targeting DEK and TGF-β Signaling in Gynecologic Disease and Cancer: Diagnostic and Therapeutic Perspectives

edited by

Hung-Chi Cheng

and Anastasia Tsigkou

submission deadline 30 Apr 2026 | Viewed by 89 | Submission Open

Keywords: DEK oncogene; TGF-β signaling; cervical cancer; endometriosis; uterine myomas; cancer biomarkers; epithelial– mesenchymal transition (EMT); SMAD2/3 phosphorylation; LY364947; targeted therapy

(This special issue belongs to the Section Medical Research)

Novel Biomarkers for Lymphoma Diagnosis and Prognosis: Translating Research into Practice

edited by Dominic Kaddu-Mulindwa

submission deadline 30 Apr 2026 | Viewed by 85 | Submission Open

Keywords: lymphoma; biomarker; minimal residual disease (MRD); circulating tumor DNA (ctDNA); molecular profiling; tumor microenvironment; epigenetic markers; predictive diagnostics

(This special issue belongs to the Section Physiology and Pathology)

Decoding Helicobacter pylori: Genetic Secrets, Flagellar Motility, and Biofilm Mechanisms

edited by Xiaolin Liu and Shuai Hu

submission deadline 30 Apr 2026 | Viewed by 73 | Submission Open

Keywords: virulence genes; motility; flagella; biofilm; antibiotic resistance; colonization; Helicobacter pylori

(This special issue belongs to the Section Microbiology)

Ultrasound-Guided Interventions and Advances in Musculoskeletal Disorders

edited by Chih-Ya Chang

submission deadline 5 May 2026 | Viewed by 135 | Submission Open

Keywords: ultrasound-guided interventions; regenerative medicine; platelet-rich plasma (PRP); musculoskeletal disorders; shoulder and knee osteoarthritis; peripheral nerve injuries

(This special issue belongs to the Section Medical Research)

Exploration of Gene Regulation and Therapeutic Targets in Refractory Cancers

edited by Wei-Chieh Huang

submission deadline 6 May 2026 | Viewed by 77 | Submission Open

Keywords: refractory cancers; gene regulation; targeted therapy; drug resistance

(This special issue belongs to the Section Medical Research)

Melatonin Signaling: Therapeutic Implications and Molecular Mechanisms

edited by

Yen-Sung Huang

and

Chia-Chao Wu

submission deadline 15 May 2026 | Viewed by 720 | Submission Open

Keywords: melatonin; AANAT; HIOMT; MTNR1A; MTNR1B; circadian rhythms

(This special issue belongs to the Section Physiology and Pathology)

Recent Advances in Crop Genetics and Breeding: 2nd Edition

edited by

Tianxiao Chen

Xiangjin Wei

Baohua Feng

and Long Chen

submission deadline 15 May 2026 | Viewed by 91 | Submission Open

Keywords: crop; high-throughput genotyping; genetic resources; favorable haplotype; marker-assisted selection; genome editing; CRISPR-Cas9; genomic selection

(This special issue belongs to the Section Plant Science)

Microvascular Dynamics: Insights and Applications

edited by

Aristotle G. Koutsiaris

and Friedrich Jung

submission deadline 18 May 2026 | 6 articles | Viewed by 16500 | Submission Open

Keywords: microvessels; dynamics; velocity; flow; rheology; in vitro; animals; humans; biomarkers; imaging; simulations; models; preclinical; clinical

(This special issue belongs to the Section Physiology and Pathology)

Cancer Epidemiology

edited by Daniela-Cristina Stefan and Honoré K. Mitonga

submission deadline 18 May 2026 | 8 articles | Viewed by 11851 | Submission Open

Keywords: cancer disparities; specific populations; methodological advances; cancer trends; cancer causes; prevention strategies

(This special issue belongs to the Section Epidemiology)

Vestibular Disorders: Pathogenesis and Modern Diagnostic Approaches

edited by Kazimierz Niemczyk and Agnieszka Jasińska-Nowacka

submission deadline 18 May 2026 | Viewed by 86 | Submission Open

Keywords: vestibular disorders; Mé niè re’ s disease; vestibular migraine; vertigo; perilymph; endolymph

(This special issue belongs to the Section Medical Research)

Emerging Applications of Nanobiotechnology in Medicine and Health

edited by Roshanak Khandanlou

submission deadline 19 May 2026 | 2 articles | Viewed by 1359 | Submission Open

Keywords: nanobiotechnology; targeted drug-delivery; tissue engineering; cancer treatment; regenerative medicine; medical applications

(This special issue belongs to the Section Medical Research)

Wildlife Shifts: Species, Space, and Survival

edited by Nikolay D. Natchev

submission deadline 19 May 2026 | Viewed by 86 | Submission Open

Keywords: ecological transitions; behavior; adaptation; organisms; habitat specifics

(This special issue belongs to the Section Animal Science)

Environmental Contaminants: Impacts on Reproduction and Embryonic Development

edited by

Elena Maria Scalisi

submission deadline 20 May 2026 | 1 articles | Viewed by 1031 | Submission Open

Keywords: environmental contaminants; embryonic development; fertility; toxicity; chemicals

(This special issue belongs to the Section Reproductive and Developmental Biology)

Diagnosis and Management of Maternal Medical Diseases in Pregnancy: Current Practice and Future Perspectives

edited by

Alexandra Arvanitaki

and

Ioannis Tsakiridis

submission deadline 20 May 2026 | Viewed by 123 | Submission Open

Keywords: maternal medical disease; maternal cardiac disease; maternal thyroid disease; gestational diabetes; gestational hypertension; pre-eclampsia; diagnosis; management; maternal and fetal outcomes

(This special issue belongs to the Section Medical Research)

Clinical and Radiological Perspectives in Rhinosinusal Pathology

edited by

Alin Horatiu Nedelcu

Ancuta Lupu

and

Vasile Valeriu Lupu

submission deadline 20 May 2026 | Viewed by 76 | Submission Open

Keywords: chronic rhinosinusitis; CBCT; CT; acute rhinosinusitis; maxillary rhinosinusitis; ethmoidal air cells variants; maxillary sinus; Haller cells; Onodi cells; concha bullosa; Agger nasi cells

(This special issue belongs to the Section Medical Research)

Advances in Cardiac Arrhythmias: Mechanisms, Diagnostics and Therapeutics

edited by

Paschalis Karakasis

submission deadline 22 May 2026 | 1 articles | Viewed by 2034 | Submission Open

Keywords: cardiac electrophysiology; arrhythmias; inherited channelopathies

(This special issue belongs to the Section Medical Research)

From Animal Models to Clinical Innovations: Translating Research into Medicine

edited by

Mihaela-Claudia Spataru

and

Manuela Ciocoiu

submission deadline 22 May 2026 | 1 articles | Viewed by 812 | Submission Open

Keywords: animal models; animal research; biomedical research; ethics of animal experimentation; experimentation on animals; interspecies differences; translational medicine; human clinical medicine

(This special issue belongs to the Section Animal Science)

Progress and Challenges in Emerging Therapies for Alzheimer’s Disease and Its Comorbidities

edited by

Gabriela Dumitrița Stanciu

submission deadline 22 May 2026 | Viewed by 58 | Submission Open

Keywords: Alzheimer’ s disease; emerging therapies/novel treatments; multimorbidity/comorbidities; translational research; cognitive decline; drug development; innovative approaches

(This special issue belongs to the Section Medical Research)

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