Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)
edited by
submission deadline 30 Sep 2025 | Viewed by 92 | Submission Open
Keywords: chronic kidney disease; vascular dysfunction; endothelial cells
(This special issue belongs to the Section Medical Research)
Advances in Microvascular Research: 2nd Edition submission deadline 30 Sep 2025 | Viewed by 91 | Submission Open
Keywords: microvascular injury; microvascular dysfunction; microcirculation; vascular inflammation; hypertension; cardiovascular diseases
(This special issue belongs to the Section Physiology and Pathology)
Updates on Cancer Immunology and Immunotherapy
edited by Parnian Jabbari
submission deadline 30 Sep 2025 | Viewed by 82 | Submission Open
Keywords: cancer immunology; immunotherapy; immune checkpoints; tumor microenvironment; chimeric antigen receptor T-cell (CAR-T) therapy; cancer vaccines; immune evasion; tumor immunity; personalized immunotherapy; immune oncology; combination therapy; immune-related adverse events; neoantigens; adoptive cell transfer; oncolytic viruses; targeted immunotherapy; tumor-associated antigens; cancer immunosurveillance; resistance mechanisms; clinical trials in immunotherapy
(This special issue belongs to the Section Medical Research)
Research Progress of Cultivation of Edible Fungi: 2nd Edition
edited by Yajie Zou
submission deadline 30 Sep 2025 | Viewed by 82 | Submission Open
Keywords: edible fungi; cultivation; domesticate; substrate; biological efficiency; nutritional properties; functional compounds; sustainability; commercialization; emerging species
(This special issue belongs to the Section Microbiology)
Autoimmune Disorders: From Pathophysiology to Therapeutics
edited by and Chiara Mura
submission deadline 30 Sep 2025 | Viewed by 80 | Submission Open
Keywords: autoimmunity; autoimmune diseases; polyglandular autoimmune syndromes; thyroid autoimmune disease; type 1 diabetes
(This special issue belongs to the Section Physiology and Pathology)
Computational Approaches in Breast Cancer Diagnosis and Prognosis
edited by Elham Pashaei and
submission deadline 30 Sep 2025 | Viewed by 77 | Submission Open
Keywords: bioinformatics; machine learning; artificial intelligence; breast cancer
(This special issue belongs to the Section Physiology and Pathology)
Advances in Congenital Diaphragmatic Hernia: From Clinical Features to Management
edited by Przemysław Kosinski
submission deadline 30 Sep 2025 | Viewed by 65 | Submission Open
Keywords: congenital diaphragmatic hernia; prenatal diagnosis; fetal interventions; neonatal management; pulmonary hypoplasia; surgical techniques; imaging techniques; genetic testing; FETO; comprehensive care protocols  
(This special issue belongs to the Section Medical Research)
Cell-Free DNA as a Biomarker in Metabolic Diseases
edited by
submission deadline 20 Oct 2025 | Viewed by 58 | Submission Open
Keywords: cell-free DNA (cfDNA); liquid biopsy; metabolic diseases; obesity; type 2 diabetes; non-alcoholic fatty liver disease (NAFLD); methylation; mutations
(This special issue belongs to the Section Medical Research)
New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases
edited by
submission deadline 20 Oct 2025 | Viewed by 51 | Submission Open
Keywords: chronic liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); drug-induced liver injury (DILI); hepatocellular carcinoma; biomarkers of liver fibrosis; imaging of liver fibrosis; CEUS; novel therapeutic strategies for CLDs
(This special issue belongs to the Section Medical Research)
Diversity and Evolution of Pathogenic Viruses
edited by
submission deadline 20 Oct 2025 | Submission Open
Keywords: pathogenic viruses; biologic diversity; evolution
(This special issue belongs to the Section Medical Research)
Sensitization via Skin Exposure
edited by
submission deadline 20 Oct 2025 | Submission Open
Keywords: contact dermatitis; patch test; epidemiology; occupation; prevention
Cancer Epidemiology
edited by Daniela-Cristina Stefan and Honoré K. Mitonga
submission deadline 24 Oct 2025 | 4 articles | Viewed by 4220 | Submission Open
Keywords: cancer disparities; specific populations; methodological advances; cancer trends; cancer causes; prevention strategies
(This special issue belongs to the Section Epidemiology)
Dive into Myopia
edited by
submission deadline 24 Oct 2025 | Viewed by 108 | Submission Open
Keywords: myopia; hyperopia; myopia control; axial length; axial length retardation; axial length elongation; myopia complications; refraction measurement; atropine; rebound effect; orthokeratology; missight; defocus incorporated multiple segments (DIMSs); highly aspherical lenslets (HALs); red light; repeated low-level red light (RLRL) therapy; enhance myopia control; customized myopia control; peripheral refraction; peripheral myopia; refractive surgery; PRK; LASIK; smile; contact lens; spectacles
(This special issue belongs to the Section Medical Research)
Neuroimaging and Integrative Analyses in Psychiatry and Addictive Disorders
edited by Arkadiusz Komorowski
submission deadline 25 Oct 2025 | Viewed by 107 | Submission Open
Keywords: psychiatry; neuroimaging; forensic psychiatry; fMRI; PET; EEG; addiction; substance use disorders (SUD); psychotherapy; treatment-resistant depression (TRD); attention deficit hyperactivity disorder (ADHD)
(This special issue belongs to the Section Physiology and Pathology)
Laparoscopy and Treatment: An All-Encompassing Solution for Surgeons
edited by Niculae Iordache and Claudiu-Octavian Ungureanu
submission deadline 26 Oct 2025 | 1 articles | Viewed by 534 | Submission Open
Keywords: oncological; staging laparoscopy; tool; radical surgery; diagnostic
(This special issue belongs to the Section Medical Research)
Therapeutic Effects of Natural Products on Human Diseases: 2nd Edition
edited by
submission deadline 27 Oct 2025 | 8 articles | Viewed by 11224 | Submission Open
Keywords: natural products; natural extracts; cancer; neurodegenerative diseases; immunological disorders; metabolic diseases; oriental medicine; microorganisms; algae; functional foods
(This special issue belongs to the Section Pharmaceutical Science)
Role of Machine and Deep Learning in Drug Screening
edited by and
submission deadline 29 Oct 2025 | Viewed by 430 | Submission Open
Keywords: machine learning in drug screening; deep learning in drug discovery; virtual screening; molecular docking and dynamics; personalized medicine
(This special issue belongs to the Section Pharmaceutical Science)
Soil–Plant–Microbe Interactions: The Role of Biostimulants and Agro-Environmental Implications
edited by Regina Gabilondo and
submission deadline 30 Oct 2025 | 3 articles | Viewed by 3783 | Submission Open
Keywords: soil– plant– microbe system; biostimulants; rhizosphere; fertilizers; availability of mineral nutrients; microfaunal grazing; protozoa; nematode; mycorrhizae; microbial loop
(This special issue belongs to the Section Plant Science)
Advances in Integrative Omics Data Analysis for Cancer Research
edited by , Jianli Dai and Guangyi Niu
submission deadline 30 Oct 2025 | 1 articles | Viewed by 2326 | Submission Open
Keywords: cancer research; omics; bioinformatics; translational medicine
(This special issue belongs to the Section Genetics and Genomics)
Advances in Dryland Agriculture Science
edited by and Hangyu Dong
submission deadline 30 Oct 2025 | 2 articles | Viewed by 1488 | Submission Open
Keywords: dry farming; climate smart agriculture; soil and water protection; conservation tillage; intercropping; crop rotation; saving irrigation
(This special issue belongs to the Section Plant Science)
Optogenetics and Light-Induced Processes in Synthetic Biology
edited by
submission deadline 30 Oct 2025 | Viewed by 577 | Submission Open
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Advances in Anesthesia and Critical Care
edited by
submission deadline 30 Oct 2025 | Viewed by 43 | Submission Open
Keywords: anesthesia; intensive care training; updates in anesthesia; machine learning
(This special issue belongs to the Section Medical Research)
Resistance Training Is Medicine submission deadline 31 Oct 2025 | 4 articles | Viewed by 9000 | Submission Open
Keywords: resistance training; resistance exercise; physical activity; sedentary behavior; strength training; chronic disease; risk factors; obesity; physical health
(This special issue belongs to the Section Epidemiology)
Algae—a Step Forward in the Sustainability of Resources: 2nd Edition submission deadline 31 Oct 2025 | 7 articles | Viewed by 8103 | Submission Open
Keywords: macroalgae; microalgae; cyanobacteria; bioactive compounds; biomass production; pharmaceuticals; nutraceuticals; cosmetics; food/feed; CO2 sequestrations; water treatment; IMTA; ecosystem services; biofuels; biopesticides; green extraction methods
(This special issue belongs to the Section Microbiology)
Physical Rehabilitation for Musculoskeletal Disorders
edited by You Gyoung Yi
submission deadline 31 Oct 2025 | 5 articles | Viewed by 6255 | Submission Open
Keywords: physical rehabilitation; musculoskeletal disorders; pain management; range of motion; muscle strengthening; mobility enhancement; physical therapy; manual therapy; AI in rehabilitation
(This special issue belongs to the Section Medical Research)
Ecotoxicity Effects of Metals and Microplastics on Aquatic Organisms
edited by Chiara Martino
submission deadline 31 Oct 2025 | 4 articles | Viewed by 3822 | Submission Open
Keywords: aquatic organisms; emerging contaminants; metals; microplastics; defense strategies; cell stress; heavy metals; environmental stress; pollution; ecotoxicology
(This special issue belongs to the Section Animal Science)
Unlocking New Biochemical Pathways: A Bridge for Drug Development in Human and Animal Diseases submission deadline 31 Oct 2025 | 1 articles | Viewed by 2507 | Submission Open
Keywords: drug discovery; omics sciences; veterinary sciences; oxidative stress; bioactive compounds; inflammation; cancer; neurodegeneration; cell death
(This special issue belongs to the Section Pharmaceutical Science)
Recent Advances in Physiotherapy for Musculoskeletal submission deadline 31 Oct 2025 | 2 articles | Viewed by 1738 | Submission Open
Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery
(This special issue belongs to the Section Physiology and Pathology)
Advances in Neuroimaging and Functional Brain Analysis
edited by Gianvincenzo Sparacia
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1722 | Submission Open
Keywords: magnetic resonance imaging; resting-state functional magnetic resonance imaging; connectomics; functional connectivity; brain networks; brain diseases assessment
(This special issue belongs to the Section Medical Research)
Coronary Artery Disease: Pathophysiological Mechanisms, Imaging Modalities and Therapeutic Implications
edited by Michele Russo and Filippo Luca Gurgoglione
submission deadline 31 Oct 2025 | 3 articles | Viewed by 1718 | Submission Open
Keywords: coronary artery disease; coronary atherosclerosis; atherosclerotic plaque progression; coronary imaging; cardiovascular risk factors and coronary atherosclerosis-associated diseases
(This special issue belongs to the Section Medical Research)
Bone and Cartilage Fractures: Types, Diagnosis, Complications, Prevention and Treatment
edited by Massimiliano Leigheb, Gabriele Colò and
submission deadline 31 Oct 2025 | 2 articles | Viewed by 779 | Submission Open
Keywords: fracture; traumatology; diagnosis; surgery; osteosynthesis; reduction; cartilage; chondral; lesion; injury; rehabilitation; complication
(This special issue belongs to the Section Medical Research)
Microalgae and Their Biotechnological Potential
edited by , Yi Xin and Yuanxue Liang
submission deadline 31 Oct 2025 | Viewed by 421 | Submission Open
Keywords: microalgae; biofuels; bioproducts; lipid metabolism; synthetic biology; system engineering
(This special issue belongs to the Section Microbiology)
Diagnosis and Treatment of Orthopedic Diseases: Advancing Arthroscopy submission deadline 31 Oct 2025 | 1 articles | Viewed by 363 | Submission Open
Keywords: arthroscopy; knee; hip; shoulder; arthroscopic surgery
(This special issue belongs to the Section Medical Research)
Pediatric Cardiology Frontiers: Innovations in Diagnosis and Treatment submission deadline 31 Oct 2025 | 1 articles | Viewed by 301 | Submission Open
Keywords: congenital heart disease; cardiovascular imaging; minimally invasive interventions; fetal cardiology; transcatheter therapies; artificial intelligence in cardiology; 3D echocardiography; cardiac MRI; personalized medicine; genetic heart disorders; heart failure in children; robotic-assisted surgery; cardiovascular biomarkers; electrophysiology in pediatrics; innovative surgical techniques; early diagnosis of heart disease; emerging therapies in cardiology
(This special issue belongs to the Section Medical Research)
Opportunistic Infections in the Immunocompromised Patient
edited by and Luca Navarini
submission deadline 31 Oct 2025 | Viewed by 141 | Submission Open
Keywords: immunocompromised patients; opportunistic infections; infectious diseases; HIV; immunological mechanisms; epidemiology
(This special issue belongs to the Section Medical Research)
Orthopedic Disease Treatment and Management: Innovations, Challenges, and Future Directions
edited by Mihnea Ioan Gabriel Popa
submission deadline 31 Oct 2025 | Viewed by 134 | Submission Open
Keywords: orthopedic surgery; musculoskeletal regeneration; biomaterials and implants; minimally invasive techniques; periprosthetic joint infections; regenerative medicine; biomechanics and implant design; orthopedic trauma and reconstruction; rehabilitation and functional recovery; AI and robotics in orthopedics
(This special issue belongs to the Section Medical Research)
The Management and Prognosis of Open-Angle Glaucoma
edited by
submission deadline 31 Oct 2025 | Viewed by 127 | Submission Open
Keywords: open-angle glaucoma; cataracts; visual impairment
(This special issue belongs to the Section Medical Research)
Health Management of Farm Animals: Physiological and Pathological Aspects submission deadline 31 Oct 2025 | Viewed by 99 | Submission Open
Keywords: cattle; small ruminants; pig; poultry; veterinary medicine; health; disease; welfare
(This special issue belongs to the Section Animal Science)
Advances and Applications of Sport Physiology: 2nd Edition
edited by and
submission deadline 31 Oct 2025 | Viewed by 92 | Submission Open
Keywords: sports medicine; strength and conditioning; diagnostics; sport injuries; performance analysis
(This special issue belongs to the Section Physiology and Pathology)
Molecular Muscle Adaptations Across the Lifespan
edited by S. Kyle Traivs and
submission deadline 31 Oct 2025 | Viewed by 91 | Submission Open
Keywords: muscle tissue; muscle physiology; molecular pathways; therapeutics
(This special issue belongs to the Section Physiology and Pathology)
Research on Gastrointestinal Cancer and Nutritional Health
edited by , Adam Mylonakis and Dimitrios Tsapralis
submission deadline 31 Oct 2025 | Viewed by 85 | Submission Open
Keywords: dietary patterns; gastrointestinal cancer; clinical nutrition; nutritional status; nutritional assessment; metabolism; gastric cancer; esophageal cancer; pancreatic cancer; colorectal cancer
(This special issue belongs to the Section Medical Research)
Natural Products for the Management of Acute and Chronic Kidney Disease
edited by Noori S. D. Al-Waili
submission deadline 31 Oct 2025 | Viewed by 74 | Submission Open
Keywords: kidney; diseases; management; natural products; proteinuria; bee products
(This special issue belongs to the Section Pharmaceutical Science)
Skin Care and Innovation from the Perspective of Molecular Dermatology submission deadline 31 Oct 2025 | Viewed by 74 | Submission Open
Keywords: molecular dermatology; personalised skincare; ageing; natural ingredients
(This special issue belongs to the Section Physiology and Pathology)
Advances in the Epidemiology, Physiology, Diagnosis and Treatment of Breast Cancer
edited by , Traian Pǎtraşcu, Petronel Mustatea and
submission deadline 31 Oct 2025 | Viewed by 70 | Submission Open
Keywords: epidemiology; physiology; conservative breast surgery; sentinel lymph node biopsy; artificial intelligence in breast cancer
(This special issue belongs to the Section Medical Research)
Advanced Research in Obstetrics and Gynecology
edited by Vasileios Pergialiotis
submission deadline 31 Oct 2025 | Viewed by 69 | Submission Open
Keywords: obstetrics; gynecology; gynecologic oncology
(This special issue belongs to the Section Medical Research)
Cutting-Edge Research and Innovation in Gastrointestinal Oncology
edited by Daniela Cornelia Lazar
submission deadline 31 Oct 2025 | Viewed by 47 | Submission Open
Keywords: gastrointestinal oncology; personalized medicine; immunotherapy and targeted treatment; liquid biopsy and molecular biomarkers; artificial intelligence in GI oncology; drug resistance in GI cancer; gut microbiota and cancer progression; endoscopic techniques in GI oncology; modern surgical procedure in GI oncology; multimodal cancer treatment
(This special issue belongs to the Section Physiology and Pathology)
Research on Viral Infections and Immune Regulation Mechanisms
edited by Moses Turkle Bility
submission deadline 31 Oct 2025 | Viewed by 45 | Submission Open
Keywords: virus infections; virus– host interaction; virome– host interactions; innate immunity; adaptive immunity; host factors in viral infection and immune regulation; acute and chronic infections; restriction factors; viral-vectored strategies; immunotherapeutic strategies against viral infections
(This special issue belongs to the Section Microbiology)
Management of Ischemia and Heart Failure—3rd Edition
edited by
submission deadline 31 Oct 2025 | Viewed by 36 | Submission Open
Keywords: heart failure; myocardial ischemia; left ventricular remodeling; prognosis
(This special issue belongs to the Section Medical Research)
Therapeutic Approaches of Natural Products in Health and Disease submission deadline 31 Oct 2025 | Viewed by 35 | Submission Open
Keywords: natural products; bioactive compounds; isolation; analysis; metabolism; in vitro and in vivo experiments; pharmacological activity
(This special issue belongs to the Section Pharmaceutical Science)
Physiological Responses and Adaptation Mechanisms of Plants to Stress
edited by and Bassam T. Yasseen
submission deadline 31 Oct 2025 | Viewed by 32 | Submission Open
Keywords: biotechnology; chemical composition; growth processes; heavy metals; hormonal balance; improving growth variables; mechanisms of osmotic stress; pollution; photosynthesis; stomatal behaviors
(This special issue belongs to the Section Plant Science)
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