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Multifactorial Causation and Therapies of Myopia: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 26 December 2025 | Viewed by 694

Special Issue Editors


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Guest Editor
Department of Pharmacy, Biotechnology, Nutrition, Optics and Optometry, Faculty of Biomedical and Health Sciences, European University of Madrid, 28670 Villaviciosa de Odón, Spain
Interests: myopia control; irregular cornea; optical quality of the eye; refractive surgery
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Guest Editor
Department of Optometry and Vision, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28037 Madrid, Spain
Interests: myopia; sport vision; optometry; visual health; refractive errors; contact lenses
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain
Interests: cornea; refractive surgery; cataract; ocular surface; ocular imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are excited to announce the release of the second volume of the Special Issue titled “Multifactorial Causation and Therapies of Myopia”. On this occasion, we would also like to invite you to visit our website to access the first volume of this Special Issue, available at https://www.mdpi.com/journal/jcm/special_issues/VUTU61AW2J.

The prevalence of myopia continues to increase, aligning with the forecasts set out years ago. According to these data, we are facing a pandemic with enormous clinical and research interest, since its comorbidities have a negative impact on public health and its financing.

This Special Issue aims to review the current situation and future prospects for myopia, from its causes to its current management and possible control.

The topics of interest include the following:

  • The epidemiology of myopia;
  • Theories about myopia, the role of accommodation, the retina, the choroid, and the sclera;
  • Myopia and genetics;
  • Premyopia, simple myopia, and pathological myopia;
  • The prevention of atropine, sunlight, and myopia progression risk;
  • Efficacy, predictability, and safety in short-, medium-, and long-term pharmacological and optical treatments (ophthalmic lenses, orthokeratology, and soft contact lenses) and rebound effects, application protocols, and predictors of success;
  • Light and myopia (blue light and red light in myopia control), as well as other treatments used for simple and pathological myopia;
  • New and emerging myopia management strategies;
  • Binocular vision (phorias, AC/A, accommodative LAG, etc.) and ocular optics (axial length, anterior and vitreous chamber, high-order aberrations, etc.) in myopia;
  • Artificial intelligence applied to myopia.

Prof. Dr. César Villa Collar
Dr. Cristina Alvarez-Peregrina
Prof. Dr. David Piñero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epidemiology
  • genetics
  • premyopia
  • simple and pathological myopia
  • orthokeratology
  • lenses for myopia control
  • blue light and red light
  • binocular vision and ocular optics
  • artificial intelligence

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Published Papers (1 paper)

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Research

12 pages, 846 KB  
Article
The Influence of Highly Aspherical Lenslets on Choroidal Thickness and Axial Length
by Larissa Paulasto, Céline Carré and Martin Loertscher
J. Clin. Med. 2025, 14(19), 7059; https://doi.org/10.3390/jcm14197059 - 6 Oct 2025
Viewed by 511
Abstract
Objectives: Recent studies have shown that highly aspheric lenslets (HAL) are effective in slowing myopia progression. Moreover, research indicates that an enhancement in choroidal thickness might serve as a biomarker for evaluating the efficacy of myopia control treatments. Therefore, this study examined the [...] Read more.
Objectives: Recent studies have shown that highly aspheric lenslets (HAL) are effective in slowing myopia progression. Moreover, research indicates that an enhancement in choroidal thickness might serve as a biomarker for evaluating the efficacy of myopia control treatments. Therefore, this study examined the short-term effects of HAL and full-field +3.00 diopters (D) myopic defocus on sub-foveal choroidal thickness (SFCHR). Design: Prospective experimental study. Participants: Twenty-five participants aged 20–30 (mean 24.56 ± 2.467) years with a refraction error of emmetropia to −5.0 D (mean −2.255 ± 1.514 D). The contralateral non-dominant eye was used as control for each participant. Methods: The participants watched a movie projected at 6 m for 90 min on two separate occasions while wearing HAL or +3 D full-field myopic defocus lenses on their dominant eye. The control eye wore only a single-vision contact lens with the best-corrected distance vision. Three measurements of AL and SFCHR were captured before defocus, and after 60 and 90 min of defocus for both eyes. The main outcome measures were changes in SFCHR and AL over time. Results: Exposure to HAL and +3 D myopic defocus significantly increased SFCHR in the defocused eyes compared to the baseline (p < 0.001). The increase in SFCHR was 6.62 ± 6.32 µm with the HAL intervention and 7.36 ± 8.83 µm with the +3 D intervention. The difference between the two interventions was not statistically significant (p = 0.595). A significant mean difference of 3.176 ± 1.318 µm in SFCHR increase was observed with +3.00 D full-field defocus in the defocused eyes compared to the control eyes over the measurement period (p = 0.020). Conclusions: Short-term exposure to full-field myopic defocus increased choroidal thickness, which was comparable with that observed in peripheral myopic defocus with HAL, although the effect appears less pronounced. Full article
(This article belongs to the Special Issue Multifactorial Causation and Therapies of Myopia: 2nd Edition)
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