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Diagnosis and Management of Corneal Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 25 June 2026 | Viewed by 846

Special Issue Editor


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Guest Editor
Section of Ophthalmology, Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari, 70124 Bari, Italy
Interests: glaucoma; retina; cataract surgery; OCT; retinal diseases; optical coherence tomography; macular degeneration; retinal degeneration; phacoemulsification; retinal imaging

Special Issue Information

Dear Colleagues,

Corneal surgery has evolved rapidly through advances in imaging, biomaterials, and regenerative medicine, offering unprecedented opportunities for restoring corneal transparency and visual function. Novel lamellar techniques, bioengineered grafts, and cell-based therapies are transforming both surgical precision and long-term outcomes.

This Special Issue aims to present current innovations shaping the future of corneal surgery by technology development and clinical evaluation. Emphasis will be placed on elucidating biological mechanisms of corneal repair, improving graft survival, and optimizing patient selection through multimodal diagnostics.

We invite contributions addressing:

  • Novel surgical and imaging techniques;
  • Regenerative and bioengineered corneal substitutes;
  • Mechanisms of wound healing and immune modulation;
  • Clinical outcomes.

Our goal is to foster a scientific dialogue that advances understanding and promotes the clinical development of emerging technologies in corneal surgery.

Dr. Nicola Cardascia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • corneal surgery
  • lamellar keratoplasty
  • bioengineered corneal grafts
  • regenerative medicine
  • cell-based therapies
  • tissue-based therapies
  • Intraoperative imaging
  • corneal wound healing
  • lmmune modulation
  • graft survival
  • translational research
  • multimodal diagnostics
  • clinical outcomes
  • corneal transparency restoration
  • ophthalmic surgical innovation

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Published Papers (1 paper)

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8 pages, 2417 KB  
Case Report
Amniotic Membrane-Assisted Corneal Transplantation in Ocular Perforation Due to GVHD: A Case Report
by Nicola Cardascia, Maria Gabriella La Tegola, Francesco D’Oria, Giacomo Boscia, Francesco Boscia and Giovanni Alessio
J. Clin. Med. 2026, 15(2), 548; https://doi.org/10.3390/jcm15020548 - 9 Jan 2026
Viewed by 648
Abstract
Background/Objectives: Ocular graft-versus-host disease (oGVHD) is a chronic, immune-mediated complication of allogeneic hematopoietic stem cell transplantation that can progress to corneal ulceration or perforation. These cases are often refractory to standard therapy and present a high risk of graft failure after keratoplasty. We [...] Read more.
Background/Objectives: Ocular graft-versus-host disease (oGVHD) is a chronic, immune-mediated complication of allogeneic hematopoietic stem cell transplantation that can progress to corneal ulceration or perforation. These cases are often refractory to standard therapy and present a high risk of graft failure after keratoplasty. We report a case of oGVHD-related corneal perforation successfully managed with a novel amniotic membrane-assisted “envelope” technique during corneal transplantation. Case Report: A 42-year-old man with chronic oGVHD and a full-thickness corneal perforation underwent urgent repair with a lamellar patch graft completely wrapped in cryopreserved amniotic membrane, followed by penetrating keratoplasty (PKP) using an amniotic membrane envelope surrounding the donor lenticule. Results: The amniotic membrane provided a 360° biological barrier that isolated graft antigens from the inflammatory environment while supporting epithelial healing and stromal remodeling. Despite recurrent inflammatory episodes and multiple procedures—including cataract extraction, pars plana vitrectomy, and multilayer amniotic membrane transplantation—the graft remained clear and stable at 12-month follow-up, achieving a best-corrected visual acuity of 20/40. Conclusions: The amniotic membrane envelope technique may represent a valuable adjunct in managing high-risk corneal perforations secondary to oGVHD. By combining immune modulation and regenerative support, this approach can enhance tectonic stability, reduce rejection risk, and promote durable surface recovery, potentially delaying or avoiding keratoprosthesis in refractory cases. Full article
(This article belongs to the Special Issue Diagnosis and Management of Corneal Diseases)
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