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JCM
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Pregnancy Complications and Maternal-Perinatal Outcomes
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Pregnancy Complications and Maternal-Perinatal Outcomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 167

Special Issue Editor

Dr. Angelo Sirico

E-Mail Website
Guest Editor
Institute of Gynaecology and Obstetrics, University of Campania “Luigi Vanvitelli”, Caserta, Italy
Interests: gestational diabetes; macrosomia; preeclampsia; ultrasound; Doppler; placenta; immunohistochemistry; fetal growth restriction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pregnancy is a dynamic and complex physiological process that can be affected by a wide range of maternal and fetal complications. Conditions such as gestational diabetes mellitus (GDM), preeclampsia, fetal growth restriction (FGR), and other high-risk pregnancy factors continue to represent major causes of maternal and perinatal morbidity and mortality worldwide. The aim of this Special Issue is to gather high-quality original research articles, systematic reviews, and clinical studies focusing on the clinical pathophysiology, diagnosis, prevention, and management of pregnancy-related complications. Particular attention will be given to studies exploring the role of the placenta, maternal metabolic status, and the use of ultrasound and other diagnostic tools in monitoring maternal and fetal health. We welcome submissions that enhance the understanding of mechanisms underlying high-risk pregnancies and that propose innovative strategies to improve outcomes for both mothers and newborns.

Dr. Angelo Sirico
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pregnancy
  • high-risk
  • GDM
  • preeclampsia
  • fetal growth restriction
  • diabetes
  • placenta
  • ultrasound

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Published Papers (1 paper)

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18 pages, 2151 KiB  
Systematic Review
Clinical Scores of Peripartum Patients Admitted to Maternity Wards Compared to the ICU: A Systematic Review and Meta-Analysis
by Jennifer A. Walker, Natalie Jackson, Sudha Ramakrishnan, Claire Perry, Anandita Gaur, Anna Shaw, Saad Pirzada and Quincy K. Tran
J. Clin. Med. 2025, 14(14), 5113; https://doi.org/10.3390/jcm14145113 - 18 Jul 2025
Viewed by 55
Abstract
Background/Objectives: Hospitalized peripartum patients who later decompensate and require an upgrade to the intensive care unit (ICU) may have an increased risk for poor outcomes. Most of the literature regarding the need for ICU involves Modified Early Warning Scores in already hospitalized [...] Read more.
Background/Objectives: Hospitalized peripartum patients who later decompensate and require an upgrade to the intensive care unit (ICU) may have an increased risk for poor outcomes. Most of the literature regarding the need for ICU involves Modified Early Warning Scores in already hospitalized patients or the evaluation of specific comorbid conditions or diagnoses. This systematic review and meta-analysis aimed to assess the differences in clinical scores at admission among adult peripartum patients to identify the later need for ICU. Methods: We systematically searched Ovid-Medline, PubMed, EMBASE, Web of Science and Google Scholar for randomized and observational studies of adult patients ≥18 years of age who were ≥20 weeks pregnant or up to 40 days post-partum, were admitted to the wards from the emergency department and later required critical care services. The primary outcome was the Sequential Organ Failure Assessment (SOFA) score. Secondary outcomes included other clinical scores, the hospital length of stay (HLOS) and mortality. The Newcastle–Ottawa Scale was utilized to grade quality. Descriptive analyses were performed to report demographic data, with means (±standard deviation [SD]) for continuous data and percentages for categorical data. Random-effects meta-analyses were performed for all outcomes when at least two studies reported a common outcome. Results: Seven studies met the criteria, with a total of 1813 peripartum patients. The mean age was 27.2 (±2.36). Patients with ICU upgrades were associated with larger differences in mean SOFA scores. The pooled difference in means was 2.76 (95% CI 1.07–4.46, p < 0.001). There were statistically significant increases in Sepsis in Obstetrics Scores, APACHE II scores, and HLOS in ICU upgrade patients. There was a non-significantly increased risk of mortality in ICU upgrade patients. There was high overall heterogeneity between patient characteristics and management in our included studies. Conclusions: This systematic review and meta-analysis demonstrated higher SOFA or other physiologic scores in ICU upgrade patients compared to those who remained on the wards. ICU upgrade patients were also associated with a longer HLOS and higher mortality compared with control patients. Full article
(This article belongs to the Special Issue Pregnancy Complications and Maternal-Perinatal Outcomes)
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