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New Clinical Insights into Acute Respiratory Failure
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New Clinical Insights into Acute Respiratory Failure

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Intensive Care".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 603

Special Issue Editor

Dr. Christophe Guervilly

E-Mail Website
Guest Editor
1. Service de Médecine Intensive Réanimation, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille, Marseille, France
2. Centre d’Etudes et de Recherches sur les Services de Santé et Qualité de vie EA 3279, Aix-Marseille Université, Marseille, France
Interests: mechanical ventilation and respiratory physiology; advanced respiratory monitoring (esophageal manometry, EIT); veno-venous ECMO; ARDS

Special Issue Information

Dear Colleagues,

We are pleased to invite submissions for a Special Issue of the Journal of Clinical Medicine entitled “New Clinical Insights into Acute Respiratory Failure.” This Special Issue aims to bring together high-quality original research that enhances our understanding of the mechanisms, monitoring, and management of acute respiratory failure in both critical care and emergency settings.

We welcome original research articles addressing topics of acute respiratory failure, including mechanisms of lung injury and patient–ventilator asynchrony. Studies involving advanced monitoring, respiratory mechanics, respiratory drive assessment, electrical impedance tomography (EIT), lung and diaphragm ultrasound, and esophageal manometry are highly encouraged.

We also invite studies focusing on respiratory support strategies, including high-flow nasal oxygen therapy (HFNO), non-invasive ventilation (NIV), conventional and non-conventional modes of invasive mechanical ventilation, the effects of body positioning, and studies involving patients on veno-venous ECMO.

This Special Issue aims to provide clinicians and researchers with new insights that may contribute to improved patient care. We warmly encourage you to submit your latest work and to disseminate this invitation within your networks.

Dr. Christophe Guervilly
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute respiratory failure
  • pathophysiology
  • advances respiratory monitoring
  • respiratory support strategies
  • respiratory mechanics
  • mechanical ventilation
  • respiratory drive
  • patient-ventilator asynchrony

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Published Papers (1 paper)

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Research

13 pages, 1567 KB  
Article
Urine Metanephrine Concentration Can Early and Accurately Predict Etiology of Acute Respiratory Failure in Critically Ill Patients with Subarachnoid Hemorrhage: A Prospective Single-Center Pilot Study
by Mateusz N. Zachura, Natalia Kopcińska, Michał P. Pluta, Mateusz Gołdyn, Bartosz Blada, Dominika Krupnik, Magdalena Kwiatkowska and Łukasz J. Krzych
J. Clin. Med. 2026, 15(4), 1557; https://doi.org/10.3390/jcm15041557 - 16 Feb 2026
Viewed by 391
Abstract
Background: Subarachnoid hemorrhage (SAH) can cause remote organ failure through complex systemic reactions. Acute respiratory failure (ARF) in the course of SAH may have a diverse etiology, including cardiogenic origin. The aim of the study was to evaluate the utility of urine metanephrine [...] Read more.
Background: Subarachnoid hemorrhage (SAH) can cause remote organ failure through complex systemic reactions. Acute respiratory failure (ARF) in the course of SAH may have a diverse etiology, including cardiogenic origin. The aim of the study was to evaluate the utility of urine metanephrine measurement in identifying the ARF phenotype in patients with SAH. Methods: A prospective single-center study was conducted between January 2022 and February 2023. The study included consecutive adult patients admitted to the Intensive Care Unit (ICU) within 24 h of SAH diagnosis and requiring mechanical ventilation due to ARF within the first 48 h of stay. Demographic and clinical data were collected. Metanephrine (MET) was determined in 24-h urine collection. The inflammatory profile was assessed by measuring serum levels of interleukin-6 (IL-6), CRP, and PCT. Cardiogenic ARF phenotype was diagnosed when concomitant elevation of hsTpI, CK-MB, and NT-proBNP was observed upon admission. Results: The study group consisted of 18 patients. The cardiogenic etiology group (n = 4) was characterized by higher MET concentrations (249 vs. 63.5 ng/mL; p = 0.007) and a lower oxygenation index (190 vs. 296 mmHg; p < 0.05) on admission. In the non-cardiogenic etiology group (n = 14), higher levels of IL-6 were found (34 vs. 8.3 pg/mL; p = 0.013). MET significantly correlated with the oxygenation index (R = −1.0; p < 0.001) on day 1 and with lactate levels on days 2 and 3 of stay (R = 1.0; p < 0.001). Baseline MET concentration accurately predicted the ARF phenotype (AUC 0.93; 95% CI 0.786–1.000, p = 0.008). Conclusions: Urine metanephrine levels show potential in differentiating the etiology of ARF and correlate with severity markers in critically ill SAH patients at an early stage. These preliminary results highlight the importance of a targeted approach to ARF diagnostics after SAH, which could support appropriate therapeutic decisions, although further validation in larger cohorts is required. Full article
(This article belongs to the Special Issue New Clinical Insights into Acute Respiratory Failure)
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