The Role of Biomarkers in Cardiovascular Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 25 July 2025 | Viewed by 267

Special Issue Editor


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Guest Editor
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
Interests: cardiac amyloidosis; hypertrophic cardiomyopathy; cardiomyopathies; heart failure; multimodal imaging; translational medicine; clinical cardiology

Special Issue Information

Dear Colleagues,

As is well known, cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality worldwide, underscoring the urgent need for innovative diagnostic and therapeutic strategies. Biomarkers have emerged as critical elements in addressing these challenges, offering valuable insights into disease mechanisms, risk stratification, and treatment response. The advent of omics technologies has further facilitated the identification of thousands of potential biomarkers, significantly expanding the opportunities for improving early detection and predicting outcomes across a broad range of CVDs. However, despite this promise, the journey from biomarker discovery to clinical application is often full of challenges that impede validation and implementation.

The scope of this Special Issue, "The Role of Biomarkers in Cardiovascular Diseases”, is to explore the multifaceted role of both traditional and non-traditional biomarkers in enhancing our understanding of CVDs, improving early detection, and guiding personalized treatment approaches.

We invite researchers and clinicians to submit original research and comprehensive reviews focused on novel and established cardiovascular biomarkers, their pathophysiological relevance, and their use in precision medicine for cardiovascular care. Your contributions are essential to bridge the gap between research and clinical applications, ultimately improving patient outcomes.

Thank you for your participation, and we look forward to your submissions!

Dr. Giorgia Panichella
Guest Editor

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Keywords

  • biomarkers
  • cardiovascular diseases
  • heart failure
  • ischemic heart disease
  • cardiomyopathy
  • risk stratification
  • diagnosis
  • prognosis
  • inflammation

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Published Papers (1 paper)

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Research

16 pages, 1700 KiB  
Article
Association Between Plasma Homocysteine, Folate, Vitamin B12 Levels, and Metabolic Dysfunction Indices in Elderly with Arterial Stiffness
by Jintana Sirivarasai, Prapimporn Chattranukulchai Shantavasinkul, Manasid Thitiwiwatkul, Wutarak Monsuwan, Pachara Panpunuan and Piyamitr Sritara
J. Clin. Med. 2025, 14(9), 2998; https://doi.org/10.3390/jcm14092998 - 26 Apr 2025
Viewed by 120
Abstract
Background/Objectives: Arterial stiffness is a prevalent age-related condition that can significantly increase the risk of cardiovascular disease and mortality in older adults. Understanding the factors that contribute to vascular health, including metabolic dysfunction and hyperhomocysteinemia, alongside vitamin B status, is [...] Read more.
Background/Objectives: Arterial stiffness is a prevalent age-related condition that can significantly increase the risk of cardiovascular disease and mortality in older adults. Understanding the factors that contribute to vascular health, including metabolic dysfunction and hyperhomocysteinemia, alongside vitamin B status, is essential for developing effective interventions. This study aimed to explore the relationship between plasma levels of homocysteine, folate, and vitamin B12, as well as various indices of metabolic dysfunction, in elderly individuals with arterial stiffness. Methods: We conducted a cross-sectional analysis involving 884 participants aged 65 and older, assessing arterial stiffness using the cardio/ankle vascular index method. Additionally, we collected fasting blood samples to evaluate plasma homocysteine, folate, vitamin B12 levels, and other relevant biochemical markers. Results: Higher plasma homocysteine levels are significantly correlated with elevated CAVI scores and increased indices of metabolic dysfunction (p < 0.05). Furthermore, a multivariate logistic regression analysis demonstrated that elevated plasma homocysteine levels, along with higher levels of lipid accumulation product (LAP), triglyceride/glucose index (TyG), and visceral adiposity index (VAI), are associated with increased arterial stiffness. Conclusions: These findings suggest that monitoring and optimizing homocysteine, folate, and vitamin B12 levels may be beneficial for preventing or managing arterial stiffness and related metabolic disorders in the elderly population. Full article
(This article belongs to the Special Issue The Role of Biomarkers in Cardiovascular Diseases)
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