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Clinical Outcomes in Bipolar and Depressive Disorders
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Clinical Outcomes in Bipolar and Depressive Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: 30 January 2026 | Viewed by 824

Special Issue Editors

Dr. Luca J. Steardo

E-Mail Website
Guest Editor
Department of Physiology and Pharmacology, University of Catanzaro “Magna Graecia”, 88100 Catanzaro, Italy
Interests: bipolar disorder; lithium; psychopharmacology; sleep disturbance; high risk; mood disorders; psychological trauma
Special Issues, Collections and Topics in MDPI journals
Dr. Francesco Monaco

E-Mail Website
Guest Editor
1. Department of Mental Health, Azienda Sanitaria Locale Salerno, Salerno, Italy
2. European Biomedical Research Institute of Salerno (EBRIS), Salerno, Italy
Interests: schizophrenia; depression
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue “Clinical Outcomes in Bipolar and Depressive Disorders” aims to gather high-quality contributions exploring the complex interplay between clinical pathophysiological mechanisms, clinical phenomenology, and treatment outcomes in mood disorders. Bipolar and depressive disorders represent a major global burden, with substantial personal, social, and economic consequences. Despite advances in diagnostic frameworks and therapeutic options, heterogeneity in clinical presentation and variability in treatment response remain critical challenges.

We welcome original research articles, systematic reviews, and meta-analyses that investigate clinical, biological, psychological, and social factors influencing the course and prognosis of mood disorders. Studies addressing clinical neurobiological underpinnings, including genetic, epigenetic, and neuroimaging findings, are encouraged, as are contributions exploring transdiagnostic features, early markers of vulnerability, and longitudinal outcomes.

Submissions may also focus on pharmacological, psychotherapeutic, and integrative interventions, evaluating real-world effectiveness, predictors of response, adverse effects, and long-term adherence.

Of particular interest are works examining gender differences, comorbidities (e.g., substance use, anxiety, personality disorders), and the impact of life events, trauma, and affective temperament on treatment trajectories.

Our goal is to foster an inclusive, interdisciplinary dialogue that bridges research and clinical practice, providing a platform for innovative approaches to understanding and improving outcomes in bipolar and depressive disorders.

Dr. Luca J. Steardo
Dr. Francesco Monaco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mood disorders
  • clinical outcomes
  • treatment response
  • psychopathology
  • pathophysiology

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Published Papers (1 paper)

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Research

10 pages, 572 KB  
Article
Improvement in Depressive Symptoms Is Not Associated with the Severity of Autobiographical Amnesia Following Electroconvulsive Therapy—A Preliminary Report from Naturalistic Prospective Observational Study
by Albert Stachura, Stefan Sawicki and Łukasz Święcicki
J. Clin. Med. 2025, 14(21), 7663; https://doi.org/10.3390/jcm14217663 - 28 Oct 2025
Viewed by 635
Abstract
Background/Objectives: Electroconvulsive therapy (ECT) is used for treatment-resistant depression (TRD). Despite high effectiveness, its most prevalent side effect is memory loss, particularly autobiographical memory deficits. Some patients and physicians might associate post-ECT improvement in depressive symptoms with a higher risk of autobiographical [...] Read more.
Background/Objectives: Electroconvulsive therapy (ECT) is used for treatment-resistant depression (TRD). Despite high effectiveness, its most prevalent side effect is memory loss, particularly autobiographical memory deficits. Some patients and physicians might associate post-ECT improvement in depressive symptoms with a higher risk of autobiographical amnesia or even consider this side effect ECT’s mechanism of action. Here, we aimed to study the association between improvement in depressive symptoms and the severity of autobiographical amnesia, as well as identify factors associated with the degree of memory loss. Methods: In this prospective naturalistic observational pilot study, we included 20 patients who underwent ECT for TRD. Attending psychiatrists decided on the electrode placement. Electrical dosage was based on the seizure-titration procedure. Depressive symptoms (Hamilton Depression Scale-21) and autobiographical memory (AMI-SF) were assessed before and after the full course of ECT. The correlation between symptomatic improvements and severity of memory loss was studied using Spearman’s correlation. Demographic and clinical baseline data were examined to look for associations with the decline in autobiographical memory. Results: Symptomatic improvement was not correlated with autobiographical memory loss (r = −0.14, p = 0.58) or any of its domains. Suicidal ideation at baseline was associated with a stronger decline in autobiographical memory (r = −0.53, p = 0.016). Patients treated with bilateral electrode placement had worse amnesia than those treated with right unilateral treatment, though the difference was not significant (MD = −17.4 vs. −13.1, p = 0.2). Conclusions: ECT improved depressive symptoms irrespective of autobiographical amnesia severity. Patients with suicidal ideation at baseline might experience worse post-ECT amnesia than those without. Full article
(This article belongs to the Special Issue Clinical Outcomes in Bipolar and Depressive Disorders)
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