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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Shoulder Arthroplasty: Clinical Advances and Future Perspectives

edited by Vani J. Sabesan

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1753 | Submission Open

Keywords: shoulder arthroplasty; reverse shoulder arthroplasty; perioperative optimization; multimodal pain management; rehabilitation protocols; outpatient shoulder arthroplasty; implant longevity; complication management; disparities in outcomes

(This special issue belongs to the Section Orthopedics)

Autoimmune Diseases and Multisystem Inflammation: Pathophysiology and Therapeutic Strategies

edited by

Tsuyoshi Shirai

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1468 | Submission Open

Keywords: autoimmune diseases; cardiovascular diseases; cutaneous diseases; gastrointestinal diseases; pulmonary diseases; renal diseases; systemic manifestation; rheumatoid arthritis; systemic lupus erythematosus; vasculitis

(This special issue belongs to the Section Immunology & Rheumatology)

State of the Art in Management of Aortic Aneurysm in Vascular Surgery

edited by Rana O. Afifi and Eanas Yassa

submission deadline 30 Dec 2025 | 3 articles | Viewed by 1310 | Submission Open

Keywords: aortic dissection; complex aortic surgery; endovascular aortic repair; aortic imaging; aortic aneurysm

(This special issue belongs to the Section Vascular Medicine)

Innovations and Challenges in Cardiovascular Surgery

edited by Marc Leon

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1015 | Submission Open

Keywords: cardiovascular surgery; minimally invasive surgery; robotic surgery; hybrid; 3D printing; artificial intelligence; mechanical circulatory support; heart transplantation; valve disease; aortic dissection; ischemic heart disease; heart failure

(This special issue belongs to the Section Cardiovascular Medicine)

Advancing Neonatal Seizures and Epilepsy: New Perspectives and Interventions

edited by

Elena Pavlidis

and Gaetano Cantalupo

submission deadline 30 Dec 2025 | Viewed by 461 | Submission Open

Keywords: neonatal seizures; neonatal epilepsy; neonatal EEG; automated EEG analysis; neonatal brain monitoring; genetic; precision medicine; genetic epilepsies; genome; exome

(This special issue belongs to the Section Clinical Pediatrics)

Interventional Cardiology: Recent Developments and Future Challenges

edited by

Andreas Mitsis

and George Kassimis

submission deadline 30 Dec 2025 | Viewed by 298 | Submission Open

Keywords: percutaneous coronary intervention (PCI); drug-eluting stents (DES); high risk percutaneous coronary intervention (CHIP); chronic total occlusions (CTO); intravascular imaging (IVUS; OCT); coronary physiology (FFR; iFR); antiplatelet therapy; complex coronary interventions; mechanical circulatory support (MCS)

(This special issue belongs to the Section Cardiology)

Current and Emerging Treatment Options in Colorectal Cancer

edited by Michael Osseis

submission deadline 30 Dec 2025 | 1 articles | Viewed by 269 | Submission Open

Keywords: colorectal cancer (CRC); emerging treatment options; targeted therapies; new surgical technologies; precision medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Antiphospholipid Syndrome (APS)

edited by

Ariela Hoxha

submission deadline 30 Dec 2025 | Viewed by 210 | Submission Open

Keywords: thrombosis; pregnancy; antiphospholipid syndrome; lupus anticoagulant; antiphospholipid antibodies

(This special issue belongs to the Section Immunology & Rheumatology)

Plastic and Reconstructive Surgery of the Face: Chances and Challenges

edited by

Cristian Trâmbițaș

and Bogdan Andrei Suciu

submission deadline 30 Dec 2025 | Viewed by 206 | Submission Open

Keywords: facial plastic surgery; facial reconstruction procedures; tissue regeneration; esthetic facial procedures; digital imaging and customization; biomaterials in reconstructive surgery; flap surgery innovations; microsurgical precision techniques

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

New Developments in Hematopoietic Stem Cell Transplantation in Clinical Practice

edited by Mattia Algeri

submission deadline 30 Dec 2025 | Viewed by 187 | Submission Open

Keywords: hematopoietic stem cell transplantation; graft-versus-host disease (GVHD); conditioning regimens; immune reconstitution; donor selection; post-transplant complications; long-term survivorship

(This special issue belongs to the Section Hematology)

Challenges and Opportunities in Colorectal Cancer

edited by

Naim Abu-Freha

submission deadline 30 Dec 2025 | Viewed by 139 | Submission Open

Keywords: colorectal cancer; screening; staging; treatment of colorectal cancer (CRC); high-risk patients; fecal occult testing; colonoscopy; lynch syndrome

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cutting-Edge Technologies and Unconventional Therapies in Heart Failure

edited by

Gonzalo Luis Alonso Salinas

and Pablo Díez-Villanueva

submission deadline 30 Dec 2025 | Viewed by 133 | Submission Open

Keywords: heart failure; new technologies; artificial intelligence; treatment; advanced heart failure

(This special issue belongs to the Section Cardiology)

Advances in Diagnosis and Treatment of Amyloidosis

edited by Michael Rosenzweig

submission deadline 31 Dec 2025 | 9 articles | Viewed by 23233 | Submission Open

Keywords: amyloidosis; transthyretin (TTR); autologous stem cell transplantation (ASCT); chemotherapy; immunotherapy; cardiomyopathy; nephropathy; neuropathy

(This special issue belongs to the Section Cardiology)

Interdisciplinary Approach on the Oral Cavity Management Due to Musculoskeletal Conditions

edited by Cosmin Sinescu,

Elena Amaricai

and

Virgil-Florin Duma

submission deadline 31 Dec 2025 | 5 articles | Viewed by 21109 | Submission Open

Keywords: rehabilitation medicine; biomechanics; bruxism assessment; general medicine; dental medicine; biomedical imaging; musculoskeletal disorders; shoulder girdle; cervical region; physical therapy; therapeutic exercise; postural correction; dynamic balance; pediatric rehabilitation; sports medicine; quality of life research; general conditions with resonance in the oro-maxillo-facial sphere

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Symptoms and Treatment of Parkinson’s Disease

edited by

Christos Koros

and Nikolaos Papagiannakis

submission deadline 31 Dec 2025 | 6 articles | Viewed by 20748 | Submission Open

Keywords: Parkinson’ s disease; non-motor symptoms; clinical progression; cognitive assessment; genetics; remote monitoring; biomarkers; personalized medicine; device-aided treatments; disease-modifying therapies

(This special issue belongs to the Section Clinical Neurology)

Clinical Management of Prosthetic Joint Infection (PJI)

edited by Daniel Pérez-Prieto

submission deadline 31 Dec 2025 | 7 articles | Viewed by 13363 | Submission Open

Keywords: prosthetic joint infection; debridement; biofilm; wound healing; multidisciplinary team; osteomyelitis

(This special issue belongs to the Section Orthopedics)

Oral Health and Dental Care: Current Advances and Future Options

edited by

Massimo Amato

Federica Di Spirito

and Alessia Bramanti

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10824 | Submission Open

Keywords: oral health; dental care; technologies; innovation; dental materials

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Challenges in the Field of Psycho-Oncology: Insights from Research

edited by

Ana Bartolo

Sara Monteiro

, Tânia Brandão and Ricardo Teixeira

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7116 | Submission Open

Keywords: cancer; psycho-oncology; survivorship care; psychological distress; quality of life; sustainable development goals; global health; health disparities

(This special issue belongs to the Section Oncology)

New Trends and Challenges in Critical Care Management

edited by

Anna Wrzosek

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5015 | Submission Open

Keywords: critical care; intensive care; extracorporeal organ support; mechanical ventilation; personalized medicine; artificial intelligence; infections; antimicrobial resistance; COVID-19

(This special issue belongs to the Section Intensive Care)

Rare Respiratory Diseases: A Personal and a Public Health Problem: 3rd Edition

edited by

Francisco Dasí

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4383 | Submission Open

Keywords: rare diseases; rare respiratory diseases; alpha-1 antitrypsin deficiency; primary ciliary dyskinesia; cystic fibrosis; idiopathic pulmonary fibrosis; lymphangioleiomyomatosis; interstitial lung diseases; pulmonary arterial hypertension

(This special issue belongs to the Section Respiratory Medicine)

Acute Kidney Injury: Latest Advances and Prospects

edited by

Emanuele de Simone

and Kianoush Kashani

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4160 | Submission Open

Keywords: acute kidney injury (AKI); sepsis; septic shock; renal replacement therapy; intensive care; specialized interventions; biomarkers; risk factors; “ Green Practice” ; nephrology; epidemiology; multidisciplinary approach

(This special issue belongs to the Section Nephrology & Urology)

Clinical Updates on Knee and Hip Arthroplasty

edited by Amarildo Smakaj and Elena Gasbarra

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3982 | Submission Open

Keywords: knee arthroplasty; hip arthroplasty; total joint replacement; minimally invasive arthroplasty; implant durability; postoperative rehabilitation; revision arthroplasty; prosthesis-related complications; periprosthetic joint infection; implant loosening

(This special issue belongs to the Section Orthopedics)

Advances in Clinical Approaches to Breast Cancer Diagnosis and Treatment

edited by

Lorenzo Scardina

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3930 | Submission Open

Keywords: breast cancer; diagnosis; precision medicine; molecular profiling; targeted therapy; breast-conserving surgery; minimally invasive techniques; artificial intelligence; personalized medicine; radiation therapy

(This special issue belongs to the Section Oncology)

Clinical Therapeutic Advances in Bone Fractures

edited by Simon Hackl and Eva Simone Steinhausen

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3448 | Submission Open

Keywords: stem cells; biomechanics; fracture fixation; orthobiologics; rehabilitation; personalized medicine; 3D printing; im-plant coating; nonunion; fracture-related infection

(This special issue belongs to the Section Orthopedics)

Emerging Clinical Insights into Adolescent Behavioral Development and Mental Health

edited by

Ainzara Favini

and Anne-Marie Iselin

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2626 | Submission Open

Keywords: adolescence; behavioral development; clinical maladjustment; adolescents’ mental health; innovative clinical approach; adolescents’ emotional problems; clinical settings; innovative developmental research; adolescents’ symptoms

(This special issue belongs to the Section Mental Health)

Pregnancy Complications and Maternal-Perinatal Outcomes

edited by

Angelo Sirico

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2194 | Submission Open

Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Updates on Prenatal Diagnosis

edited by Valentina D'Ambrosio

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1658 | Submission Open

Keywords: fetal anomalies; twin pregnancy; fetal therapy; prenatal genetic testing; genome sequencies

(This special issue belongs to the Section Obstetrics & Gynecology)

Novel Advanced Imaging in Cardiology: Current Status and Future Directions

edited by

Moshe Rav-Acha

and

Arik Wolak

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1640 | Submission Open

Keywords: cardiac imaging; cardiac magnetic resonance; echocardiography; computed tomography; trans-thoracic echocardiography global longitudinal strain (GLS) analyses; radiomics

(This special issue belongs to the Section Cardiovascular Medicine)

Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions

edited by Pietro C. Dattolo and

Aris Tsalouchos

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1599 | Submission Open

Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology

(This special issue belongs to the Section Nephrology & Urology)

Children and Adolescent Mood Disorders: Risks and Treatment

edited by

Angelo Fraschetti

and

Emanuela Mari

submission deadline 31 Dec 2025 | Viewed by 1549 | Submission Open

Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs

(This special issue belongs to the Section Mental Health)

Recent Progress and Future Directions in Orthopedic Oncology

edited by

Giuseppe Papalia

and Carmine Zoccali

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1002 | Submission Open

Keywords: orthopedic oncology; bone tumors; limb-sparing surgery; reconstruction techniques; 3D-printed implants; navigation and robotics; precision medicine in musculoskeletal oncology

(This special issue belongs to the Section Orthopedics)

Innovations in Psychosis and Schizophrenia: New Findings and Implications

edited by

Gabriele Nibbio

submission deadline 31 Dec 2025 | 1 articles | Viewed by 863 | Submission Open

Keywords: schizophrenia; psychosis; psychopathology; neurobiology; assessment; pharmacological treatment; psychosocial interventions

(This special issue belongs to the Section Mental Health)

Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction

edited by

Salvatore Troisi

and

Livio Vitiello

submission deadline 31 Dec 2025 | 1 articles | Viewed by 734 | Submission Open

Keywords: dry eye disease; ocular surface; corneal disease; conjunctival disease; ocular biomarkers; patient-centered care; advanced diagnostics; regenerative medicine; artificial intelligence; therapeutic innovations

(This special issue belongs to the Section Ophthalmology)

Paradigms, Advances and Future Directions in Oral Medicine

edited by

Pia Lopez-Jornet

submission deadline 31 Dec 2025 | 1 articles | Viewed by 565 | Submission Open

Keywords: oral medicine; oral potentially malignant disorders; leukoplakia; oral lichen planus; orofacial pain; biopsy and liquid biopsy; biomarkers

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Gene Therapy for Retinal Diseases

edited by Tahreem Aman Mir

submission deadline 31 Dec 2025 | Viewed by 239 | Submission Open

Keywords: gene therapy; inherited retinal degenerations; age-related macular degeneration; diabetic retinopathy

(This special issue belongs to the Section Ophthalmology)

Clinical Trends in Diagnostic Radiology

edited by Wolfram Schwindt, Benjamin Noto and Anne Helfen

submission deadline 31 Dec 2025 | Viewed by 213 | Submission Open

Keywords: diagnostic imaging; radiology; nuclear medicine; hybrid imaging; artificial intelligence; radiomics; quantitative imaging; theranostics; imaging biomarkers; clinical applications

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Progress in the Multimodal Treatment of Pancreatic Disease

edited by

Gennaro Nappo

submission deadline 31 Dec 2025 | Viewed by 168 | Submission Open

Keywords: pancreatic diseases; pancreatic cancer; multimodal treatment; neoadjuvant therapy; imaging techniques; minimally invasive surgery; immunotherapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Optimizing Outcomes in Deep Vein Thrombosis: A Focus on Interventional Management

edited by Adam Gwozdz

submission deadline 31 Dec 2025 | Viewed by 133 | Submission Open

Keywords: deep vein thrombosis; post-thrombotic syndrome; venous patency; emerging technology; vascular surgery

(This special issue belongs to the Section Vascular Medicine)

Broadening the Knowledge of Autism Spectrum Disorder in Adulthood: Advances in Diagnosis, Assessment and Treatment

edited by

Camilla Gesi

submission deadline 5 Jan 2026 | 1 articles | Viewed by 3097 | Submission Open

Keywords: autism spectrum disorder; adulthood; autism; comorbidity; gender; age-adjusted

(This special issue belongs to the Section Mental Health)

Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition

edited by

Francesca Lodato

submission deadline 9 Jan 2026 | 3 articles | Viewed by 3641 | Submission Open

Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Clinical Advances in Pancreatobiliary Diseases

edited by

Kyong Joo Lee

submission deadline 9 Jan 2026 | 1 articles | Viewed by 1157 | Submission Open

Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advance in Chronic Total Occlusion Percutaneous Coronary Intervention

edited by Anbukarasi Maran and Kevin Croce

submission deadline 9 Jan 2026 | Viewed by 146 | Submission Open

Keywords: chronic total occlusion (CTO); percutaneous coronary intervention (PCI); innovative techniques; guidewire technology; retrograde PCI; interventional cardiology

(This special issue belongs to the Section Cardiovascular Medicine)

Heart Disease and Chronic Inflammatory Conditions: New Insights

edited by Ofer Kobo and Gilad Margolis

submission deadline 10 Jan 2026 | 4 articles | Viewed by 14735 | Submission Open

Keywords: heart diseases; chronic inflammatory; rheumatoid arthritis; cardiovascular disease; inflammatory bowel disease

(This special issue belongs to the Section Cardiology)

Clinical Guidelines in Critical Care Medicine

edited by

Ana Vujaklija Brajković

Andrej Markota

and Daniela Bandic-Pavlovic

submission deadline 10 Jan 2026 | 3 articles | Viewed by 7202 | Submission Open

Keywords: critical illness; immunocompromised host; biomarkers; thrombocytopenia; blood coagulation disorders; multiple trauma; diagnostic imaging

(This special issue belongs to the Section Intensive Care)

Heart Failure and Coronary Artery Diseases: Cardiovascular Complications and Comorbidities

edited by

Dhrubajyoti Bandyopadhyay

Vikash Jaiswal

and

Adrija Hajra

submission deadline 10 Jan 2026 | 3 articles | Viewed by 5112 | Submission Open

Keywords: heart failure; acute myocardial infarction; coronary artery diseases; cardiac imaging; biomarkers; artificial intelligence

(This special issue belongs to the Section Cardiovascular Medicine)

From Acute Injury to Personalized Prevention—Developing Modern Strategies

edited by

Markus Gesslein

and

Eduard Kurz

submission deadline 10 Jan 2026 | 2 articles | Viewed by 2585 | Submission Open

Keywords: orthopedics; acute injury; personalized prevention; innovative methodologies; musculoskeletal disorders; musculoskeletal injury; conservative therapy; functional testing; intervention

(This special issue belongs to the Section Orthopedics)

Advancements in Spinal Oncology: The Current Landscape

edited by Aladine Elsamadicy and

Daniel M. Sciubba

submission deadline 10 Jan 2026 | 2 articles | Viewed by 2162 | Submission Open

Keywords: spinal oncology; patient outcomes; primary bone tumor; spine metastases; intradural tumors

(This special issue belongs to the Section Clinical Neurology)

Pelvic Organ Prolapse: Clinical Advances and Challenges

edited by

Barbara Bodner-Adler

submission deadline 10 Jan 2026 | 1 articles | Viewed by 572 | Submission Open

Keywords: pelvic organ prolapse; pessary treatment; uterus-preserving prolapse surgery; clinical management; clinical treatment

(This special issue belongs to the Section Obstetrics & Gynecology)

Advanced Physiotherapy Practice in Patients with Musculoskeletal Disorders

edited by

Filippo Maselli

and

Firas Mourad

submission deadline 10 Jan 2026 | 1 articles | Viewed by 382 | Submission Open

Keywords: differential diagnosis; physiotherapy; rehabilitation; multidisciplinary; effectiveness; musculoskeletal disorders; screening for referral; manual therapy; exercise; cognitive behavioral therapy; pain neuroscience

(This special issue belongs to the Section Clinical Rehabilitation)

Advances in Vascular and Endovascular Surgery: Second Edition

edited by

Fadi Taher

and Afshin Assadian

submission deadline 11 Jan 2026 | 4 articles | Viewed by 4140 | Submission Open

Keywords: vascular surgery; endovascular surgery; aortic surgery; peripheral arterial disease; vascular imaging; EVAR; FEVAR; vascular access; vascular education; aneurysms

(This special issue belongs to the Section Vascular Medicine)

Displaying special issue 101-150 on page 3 of 32.

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