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Current and Emerging Treatment Options in Colorectal Cancer
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Current and Emerging Treatment Options in Colorectal Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (25 June 2026) | Viewed by 2458

Editor

Dr. Michael Osseis

E-Mail Website
Guest Editor
Department of General Surgery Hôtel-Dieu de France Hospital, Saint Joseph University of Beirut, Beirut 1107 2180, Lebanon
Interests: colorectal cancer; colorectal surgery; robotic surgery; minimally invasive surgery

Special Issue Information

Dear Colleagues,

Colorectal cancer (CRC) remains a major global health challenge, requiring innovative treatment strategies to enhance patient outcomes and improve quality of life. For this Special Issue, we invite original research articles, reviews, and perspectives focusing on current and emerging treatment options for CRC. We welcome contributions addressing topics such as advancements in chemotherapy, immunotherapy, and targeted therapies, as well as the development of combination treatments. Submissions exploring the molecular mechanisms driving CRC progression, novel biomarkers for diagnosis or therapeutic response prediction, and the application of precision medicine are particularly encouraged. Additionally, we invite research on new technologies in CRC surgery, including robotic-assisted procedures, minimally invasive techniques, and intraoperative imaging tools. Studies including clinical trial outcomes, challenges in treatment delivery, and strategies to overcome drug resistance are also within our scope. However, mini-reviews and case reports will not be considered. This Special Issue will advance CRC treatment and foster interdisciplinary collaboration in research and clinical practice.

Dr. Michael Osseis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer (CRC)
  • emerging treatment options
  • targeted therapies
  • new surgical technologies
  • precision medicine

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Published Papers (2 papers)

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10 pages, 226 KB  
Article
Prevalence of BRAF Mutation in Colorectal Cancer Among Lebanese Patients: A Descriptive Study
by Christelle Rahme, Bassil Josianne, Trak Smayra Viviane and Kattan Joseph
J. Clin. Med. 2026, 15(5), 1913; https://doi.org/10.3390/jcm15051913 - 3 Mar 2026
Viewed by 796
Abstract
Background: Although the BRAF gene mutation in colorectal cancer has a prognostic value and a therapeutic interest, very few studies address the prevalence of this mutation in the Middle East, and hardly any among the Lebanese population. Moreover, we studied the correlation [...] Read more.
Background: Although the BRAF gene mutation in colorectal cancer has a prognostic value and a therapeutic interest, very few studies address the prevalence of this mutation in the Middle East, and hardly any among the Lebanese population. Moreover, we studied the correlation between this mutation and other clinical and pathological variables. Methods: In this descriptive, retrospective, single-center study, BRAF mutational status was reviewed in colorectal tumor samples collected from 2015 to 2021 of Lebanese patients with confirmed metastatic colorectal cancer. The genetic analysis was done in two different molecular laboratories. Clinical characteristics were selected from the computerized medical records of included patients. Statistical calculations were performed with SPSS (version 21.0) statistical software. Results: The study included 190 patients. BRAF mutation was detected in 10 patients (5.3%). A positive correlation was observed between the presence of a BRAF mutation and the right-sidedness of the tumor (p = 0.001) as well as with the presence of microsatellite instability (p = 0.004). However, we could not establish a relationship between BRAF mutation and other characteristics such as age (p = 0.682), gender (p = 0.392), the degree of histologic differentiation (p = 0.594), and the presence of peritoneal metastases (p = 0.707). Conclusions: The BRAF mutation was found in 5.3% of colorectal cancers in Lebanon. A positive correlation was suggested with the colon sidedness and the microsatellite instability. However, it was still insufficient to establish statistically significant associations between other variables and the BRAF mutation. Full article
(This article belongs to the Special Issue Current and Emerging Treatment Options in Colorectal Cancer)

Other

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11 pages, 366 KB  
Brief Report
Value of Stool-Based Colorectal Cancer Screening: Integrating Real-World Adherence, Detection, and Prevention in a Cohort-Based Modeling Analysis
by A. Mark Fendrick, Derek W. Ebner, Michael Dore, Chris Estes, Gustavus Aranda and Mohammad Dehghani
J. Clin. Med. 2026, 15(1), 41; https://doi.org/10.3390/jcm15010041 - 20 Dec 2025
Cited by 4 | Viewed by 1242
Abstract
Background/Objectives: Modeling analyses for colorectal cancer (CRC) screening focusing solely on the costs of screening do not fully capture the value of screening programs. We evaluated the clinical and economic effects of CRC stool-based screening tests, including impacts on cancer-related outcomes. Methods: A [...] Read more.
Background/Objectives: Modeling analyses for colorectal cancer (CRC) screening focusing solely on the costs of screening do not fully capture the value of screening programs. We evaluated the clinical and economic effects of CRC stool-based screening tests, including impacts on cancer-related outcomes. Methods: A cohort-based decision-analytic cost-estimator model estimated outcomes for a single round of screening with next-generation multi-target stool DNA (ng mt-sDNA) test or fecal immunochemical test (FIT) from a US payer perspective. Undiagnosed cancers were assumed to become symptomatic (and detected) within 10 years. Clinical assumptions, advanced precancerous lesion and CRC prevalence, and test performance inputs were from clinical trial data. Adherence rates for initial screening and follow-up colonoscopy after a positive result were from real-world data. Input costs included the screening tests, follow-up colonoscopy (with and without polypectomy), and CRC treatment. Results: Compared with FIT, more individuals completed ng mt-sDNA (321,000 vs. 713,000, respectively), leading to the detection of more CRC cases (436 with FIT vs. 2235 with ng mt-sDNA), more advanced precancerous lesions, and more CRC at earlier stages. The cost of screening per patient screened was USD 801 for ng mt-sDNA and USD 124 for FIT. Follow-up colonoscopy cost was USD 149 million with ng mt-sDNA versus USD 22 million with FIT, whereas CRC treatment costs were lower for ng mt-sDNA (USD 1423 million versus USD 1474 million, respectively). When accounting for both direct and CRC averted costs, the total cost of screening and treatment was USD 1383 million with ng mt-sDNA versus USD 1427 million with FIT. Conclusions: Higher screening costs with ng mt-sDNA versus FIT are counterbalanced by savings realized from enhanced CRC prevention and earlier detection due to the superior test performance and better adherence with ng mt-sDNA. Full article
(This article belongs to the Special Issue Current and Emerging Treatment Options in Colorectal Cancer)
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