Clinical Advances in Antiphospholipid Syndrome (APS)
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: 30 December 2025 | Viewed by 10
Special Issue Editor
Interests: anti-phospholipid antibodies; lupus anticoagulant; antinuclear antibodies; autoimmune disease; arthritis; autoantibodies; obstetrics; rheumatic diseases; clinical rheumatology; anti-phospholipid syndrome; autoimmune disorders; systemic lupus erythematosus; congenital autoimmune heart block
Special Issue Information
Dear Colleagues,
Antiphospholipid syndrome (APS) is a thrombo-inflammatory disorder characterized by recurrent thrombo-embolic occurrences and pregnancy complications linked to the presence of circulating antiphospholipid antibodies (aPL). With an estimated incidence of 50 patients per 10,000 person-years, APS predominantly affects young female adults aged 15 to 50 years, conferring significant morbidity. The condition includes arterial or venous thrombosis, microvascular thrombosis, or recurrent thrombosis resistant to anticoagulants, as well as severe pregnancy complications, up to catastrophic APS, which is a life-threatening condition. APS can affect various organs, leading to a significantly higher rate of damage accrual and disability burden in this young population. The recent ACR/EULAR 2023 classification criteria have increased specificity to 99% to improve patient identification in clinical trials and research, but the potential impact of APS on this young population underscores the need for a high-priority APS research program to guide future updates.
This Special Issue, entitled “Clinical Advances in Antiphospholipid Syndrome (APS)”, will provide an in-depth exploration of the latest clinical research, challenges, and developments in the understanding and management of APS. As APS continues to pose significant challenges in clinical practice, this Special Issue will highlight diverse perspectives and recent findings in this field.
Dr. Ariela Hoxha
Guest Editor
Manuscript Submission Information
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Keywords
- thrombosis
- pregnancy
- antiphospholipid syndrome
- lupus anticoagulant
- antiphospholipid antibodies
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