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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances in Head and Neck Cancer Diagnostics and Treatment

edited by

Dustin A. Silverman

and Alice L. Tang

submission deadline 20 Feb 2026 | Viewed by 80 | Submission Open

Keywords: head and neck; reconstruction; free flap; surgical margin; biomarker; human papillomavirus (HPV); extranodal extension; immunotherapy; virtual surgical planning

(This special issue belongs to the Section Otolaryngology)

Recent Advances in Gynecologic Surgery

edited by Adam Ostrzenski

submission deadline 20 Feb 2026 | Viewed by 78 | Submission Open

Keywords: gynecologic surgery; pelvic reconstruction surgery; female stress urinary incontinence surgery; cosmetic gynecology surgery; surgical meshes slings; native tissue

(This special issue belongs to the Section Obstetrics & Gynecology)

Mental Disorders, Cognitive Impairment and Dementia Among Older Adults

edited by

Agustín Aibar Almazán

submission deadline 21 Feb 2026 | 3 articles | Viewed by 4852 | Submission Open

Keywords: mental disorders; cognitive decline; dementia; older adults; mental health; exercise; physical function

(This special issue belongs to the Section Geriatric Medicine)

Advances in Plastic and Reconstructive and Aesthetic Surgery of Face, Breast and Body

edited by

Valentin Haug

submission deadline 24 Feb 2026 | 3 articles | Viewed by 6978 | Submission Open

Keywords: reconstructive surgery; academic plastic surgery; research; social media in plastic surgery; breast surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current and Emerging Treatment Options for Aortic Aneurysms

edited by Spyros Ioannis Papadoulas and

Vasileios Leivaditis

submission deadline 24 Feb 2026 | 1 articles | Viewed by 721 | Submission Open

Keywords: thoracic aortic aneurysms; abdominal aortic aneurysm; vascular surgery; cardiac surgery; treatment

(This special issue belongs to the Section Vascular Medicine)

Acute Respiratory Failure: Innovations and Clinical Insights

edited by

Gilda Cinnella

submission deadline 25 Feb 2026 | 3 articles | Viewed by 22845 | Submission Open

Keywords: ARF; mechanical ventilation; VILI; PSILI; NIV; HFNO; weaning; EIT; lung US

(This special issue belongs to the Section Intensive Care)

Interventional Pulmonology: Advances and Future Directions

edited by Martina Ferioli and Piero Candoli

submission deadline 25 Feb 2026 | 7 articles | Viewed by 13630 | Submission Open

Keywords: interventional pulmonology; lung nodule; lung cancer; diagnosis; bronchoscopy; rigid bronchoscopy; airway stent; airway stenosis; mediastinal staging

(This special issue belongs to the Section Respiratory Medicine)

(Recent Advances) Treating Psychiatry Disorders in Children and Adolescents: From Theory to Practice: 2nd Edition

edited by

Pietro Muratori

and

Valentina Levantini

submission deadline 25 Feb 2026 | 5 articles | Viewed by 11257 | Submission Open

Keywords: intervention program; youth psychopathology; internalizing disorders; externalizing disorders; psychiatric disorders

(This special issue belongs to the Section Mental Health)

Interventional and Surgical Treatment of Acute and Chronic Pancreatitis

edited by Chirag Desai

submission deadline 25 Feb 2026 | 5 articles | Viewed by 10386 | Submission Open

Keywords: pancreatitis treatment; endoscopic treatment; pancreatic surgery; Whipple; distal pancreatectomy; islet cell auto trans-plant; total pancreatectomy; TPIAT; laparoscopic treatment of pancreatitis; robotic surgery for pancreatitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advancing Pediatric Sports Medicine: Insights and Innovations

edited by Brian C. Lau

submission deadline 25 Feb 2026 | 4 articles | Viewed by 9526 | Submission Open

Keywords: sport surgery; patellar instability; early sport specialization; triplane fractures; pediatric sports medicine; orthopedic surgery; access to care; arthroscopic

(This special issue belongs to the Section Orthopedics)

Knee Arthroplasty Surgery: Management and Future Opportunities: 2nd Edition

edited by

Joaquín Moya-Angeler

and

Francisco Forriol

submission deadline 25 Feb 2026 | 5 articles | Viewed by 8602 | Submission Open

Keywords: knee; knee replacement; knee arthroplasty; knee alignment technique; robotic knee arthroplasty

(This special issue belongs to the Section Orthopedics)

New Advances in Total Knee Arthroplasty

edited by

Carlo Biz

submission deadline 25 Feb 2026 | 5 articles | Viewed by 8310 | Submission Open

Keywords: artificial intelligence; bone tumors; knee joint; knee pain; knee replacement; knee surgery; orthopedic surgery; osteoarthritis; prognostic markers; radiological evaluation

(This special issue belongs to the Section Orthopedics)

Acute Coronary Syndromes: From Diagnosis to Treatment

edited by

Andreas Mitsis

and Christos Eftychiou

submission deadline 25 Feb 2026 | 4 articles | Viewed by 7725 | Submission Open

Keywords: acute coronary syndrome; diagnosis; biomarkers; interventional cardiology; imaging; pharmacotherapy; patient management; health systems; special populations; clinical trials

(This special issue belongs to the Section Cardiology)

New Advances in Keratoplasty

edited by Cristina Bovone

submission deadline 25 Feb 2026 | 3 articles | Viewed by 6475 | Submission Open

Keywords: lamellar keratoplasty; descemet stripping endothelial keratoplasty (DSAEK); descemet membrane endothelial keratoplasty (DMEK); deep anterior lamellar keratoplasty (DALK); keratoconus; corneal dystrophies; bullous keratopathy; anterior segment OCT

(This special issue belongs to the Section Ophthalmology)

Advances in the Management of Cardiac Amyloidosis and Hypertrophic Cardiomyopathy

edited by Ahmed Abuzaid

submission deadline 25 Feb 2026 | 3 articles | Viewed by 5585 | Submission Open

Keywords: cardiac amyloidosis; hypertrophic cardiomyopathy; left ventricular hypertrophy; non-invasive cardiac imaging; heart failure; clinical manifestations

(This special issue belongs to the Section Cardiology)

Alzheimer’s Disease and Related Disorders: Recent Advances in Prevention, Diagnosis and Therapy

edited by

Daniel H. S. Silverman

submission deadline 25 Feb 2026 | 2 articles | Viewed by 5344 | Submission Open

Keywords: cognition; prodromal; Alzheimer’ s; Alzheimer; dementia; mild cognitive impairment; mild decline in cognition; disease-modifying; amyloid; tau; neuroinflammation; biomarkers; neuroimaging; PET; PET/CT; PET/MRI

(This special issue belongs to the Section Clinical Neurology)

New Insights into Cardiorenal Metabolic Syndrome

edited by

Caterina Carollo

submission deadline 25 Feb 2026 | 3 articles | Viewed by 5319 | Submission Open

Keywords: cardiorenal medicine; diabetes; chronic renal failure; heart failure; cardiorenal syndrome; nephrocardiology

(This special issue belongs to the Section Cardiovascular Medicine)

Obesity Surgery—State of the Art

edited by Anna Casajoana

submission deadline 25 Feb 2026 | 2 articles | Viewed by 4739 | Submission Open

Keywords: obesity; bariatric surgery; metabolic surgery; diabetes mellitus type 2; GLP-1

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Aspects and Outcomes in Contemporary Colorectal Surgery

edited by

Lior Segev

submission deadline 25 Feb 2026 | 4 articles | Viewed by 3812 | Submission Open

Keywords: colorectal surgery; colorectal cancer; Crohn’ s disease; ulcerative colitis; coloproctology; minimally invasive surgery

(This special issue belongs to the Section General Surgery)

Recent Advances in Reconstructive Oral and Maxillofacial Surgery

edited by

Luciano Maria Catalfamo

submission deadline 25 Feb 2026 | 2 articles | Viewed by 3663 | Submission Open

Keywords: oral surgery; maxillofacial surgery; new technologies; free flap; reconstructive surgery; artificial intelligence

(This special issue belongs to the Section General Surgery)

Clinical Research in Palliative Care

edited by Cosimo Chelazzi

submission deadline 25 Feb 2026 | 2 articles | Viewed by 3198 | Submission Open

Keywords: cancer palliative care; total pain; advanced care planning; spiritual care; financial toxicity; cancer-related pain

(This special issue belongs to the Section Clinical Rehabilitation)

Updates in the Orthopedic Management of Foot Disorders: 2nd Edition

edited by

Carlo Biz

and

Pietro Ruggieri

submission deadline 25 Feb 2026 | 2 articles | Viewed by 2715 | Submission Open

Keywords: foot pathologies; diabetic feet; forefoot deformities; oncology surgery; foot tumors; minimally invasive surgery; percutaneous surgery; foot joint arthroscopy; stress fractures

(This special issue belongs to the Section Orthopedics)

Innovations in Advanced Echocardiography

edited by Rebecca T. Hahn and Alexandros Papachristidis

submission deadline 25 Feb 2026 | 1 articles | Viewed by 2303 | Submission Open

Keywords: advanced echocardiography; ultrafast ultrasound; contrast echocardiography; subharmonic aided pressure estima-tion; artificial intelligence; 3D echocardiography

(This special issue belongs to the Section Cardiology)

Non-Small-Cell Lung Cancer: Screening, Diagnosis and Treatment Options in the AI and Omics Era

edited by Miljana Tanić

submission deadline 25 Feb 2026 | 2 articles | Viewed by 1631 | Submission Open

Keywords: lung cancer; NSCLC; radiomics; digital pathology; electronic health records; tumor profiling; AI; machine learning; deep learning; liquid biopsy; early detection; diagnosis; prognosis; therapy; biomarkers; management

(This special issue belongs to the Section Respiratory Medicine)

Advancing Clinical Medicine Through Artificial Intelligence (AI) and Digital Technology: 2nd Edition

edited by

Antonio Jorge Forte

Syed Ali Haider

and

Mark Lifson

submission deadline 25 Feb 2026 | 2 articles | Viewed by 1202 | Submission Open

Keywords: artificial intelligence; clinical medicine; medical imaging; precision medicine; clinical decision support systems; patient care; healthcare practices; early disease detection; patient outcomes

(This special issue belongs to the Section Intensive Care)

Helicobacter pylori-Associated Intestinal Diseases and Beyond

edited by

Antonio Facciorusso

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1135 | Submission Open

Keywords: IBD; Hp; stomach; celiac disease; diverticulosis; diverticulitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Advances in Clinical Pharmacology Based on Pharmacokinetics

edited by

Magdalena Cuciureanu

Cristina Ghiciuc

and

Nina Filip

submission deadline 25 Feb 2026 | Viewed by 1032 | Submission Open

Keywords: PK/PD modeling; dose optimization; clinical decision-making tools; therapeutic drug monitoring; personalized medicine

(This special issue belongs to the Section Pharmacology)

Hospital-Acquired Infections: Evolving Threats and Epidemiological Insights

edited by

Amir Nutman

submission deadline 25 Feb 2026 | 1 articles | Viewed by 870 | Submission Open

Keywords: hospital-acquired infections; healthcare-associated infections; antimicrobial resistance; multidrug-resistant organisms (MDRO); infection prevention and control; outbreak investigation; patient safety; healthcare epidemiology

(This special issue belongs to the Section Infectious Diseases)

Clinical Advances of Retinal and Vitreous Diseases: Current Status and Prospect

edited by Lorenzo De Angelis, Francesco Barca and Stanislao Rizzo

submission deadline 25 Feb 2026 | 1 articles | Viewed by 679 | Submission Open

Keywords: vitreoretinal surgery; retinal multimodal imaging; gene therapy; retinal diseases; age-related macular degeneration; vascular retinal disease; imaging technologies in ophthalmology

(This special issue belongs to the Section Ophthalmology)

Application of Echocardiography in Clinical Practice

edited by

Shemy Carasso

submission deadline 25 Feb 2026 | 1 articles | Viewed by 516 | Submission Open

Keywords: echocardiography; three-dimensional imaging; mechanical imaging; strain; artificial intelligence; interventional echocardiography; POCUS; hand-held echocardiography; cancer therapy and cardiotoxicity

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Updates of Diagnosis and Treatment in Chronic Kidney Disease (CKD)

edited by

Juan F. Navarro-González

, Carmen Mora-Fernández and

Javier Donate-Correa

submission deadline 25 Feb 2026 | 1 articles | Viewed by 424 | Submission Open

Keywords: CKD; CKD progression; biomarkers; disease-modifying treatments; diabetic kidney disease; cardiorenal disease; glomerunephritis; genetic kidney diseases

(This special issue belongs to the Section Nephrology & Urology)

Evidence-Based Physiotherapy: Prospects and Challenges

edited by Roman Nowobilski and

Maciej Płaszewski

submission deadline 25 Feb 2026 | Viewed by 268 | Submission Open

Keywords: evidence-based practice; physiotherapy; critique; certainty of evidence; clinical practice guidelines; implementa-tion; clinical settings; clinical practice; clinical processing

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Research Progress in Diabetes and Cardiovascular Diseases

edited by

Ken-ichi Aihara

submission deadline 25 Feb 2026 | Viewed by 170 | Submission Open

Keywords: diabetes; cardiovascular diseases; risk factor; vascular function; diagnosis; treatment

(This special issue belongs to the Section Cardiovascular Medicine)

Plastic and Reconstructive Surgery: Clinical Advances and Future Opportunities

edited by Rami S Kantar

submission deadline 25 Feb 2026 | Viewed by 150 | Submission Open

Keywords: plastic surgery; reconstructive surgery; cleft lips; palates; post-traumatic reconstruction; facial transplantation; craniofacial surgery; cleft surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current Advances and Future Perspectives of Sepsis and Septic Shock

edited by Filippo Mearelli and Gianni Biolo

submission deadline 25 Feb 2026 | Viewed by 141 | Submission Open

Keywords: sepsis; epidemiology; biomarkers; diagnosis; predictive models; prognostication

(This special issue belongs to the Section Emergency Medicine)

Allergic and Eosinophilic Diseases: Diagnosis, Treatment and Management (Second Edition)

edited by Aikaterini Detoraki

submission deadline 25 Feb 2026 | Viewed by 133 | Submission Open

Keywords: allergy; eosinophilic diseases; immunology; clinical immunology; asthma; diagnosis; treatment; management

(This special issue belongs to the Section Immunology & Rheumatology)

Segmentectomy and Lobectomy in Early-Stage Lung Cancer Management

edited by Yujin Kudo

submission deadline 25 Feb 2026 | Viewed by 125 | Submission Open

Keywords: lung cancer; segmentectomy; lobectomy; thoracic surgery; early-stage NSCLC; oncologic outcomes; pulmonary function; surgical planning

(This special issue belongs to the Section Respiratory Medicine)

Spinal Surgery: Recent Advances and Future Perspectives

edited by

Yoshiharu Kawaguchi

submission deadline 25 Feb 2026 | Viewed by 123 | Submission Open

Keywords: spine surgery; diagnostic technology; AI; images; biomarkers; genetics; robotic surgery; minimum invasive surgery; pain control; VR

(This special issue belongs to the Section Orthopedics)

Clinical Update on the Diagnosis and Treatment of Heart Failure

edited by Giulia Nardi and Alessio Mattesini

submission deadline 26 Feb 2026 | 5 articles | Viewed by 14440 | Submission Open

Keywords: ejection fraction; acute heart failure; multidisciplinary management; right heart failure; left ventricle remodeling systems; HF percutaneous treatment; pharmacotherapy; HF prevention; cardiomyopathies

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Arrhythmia Diagnosis and Management

edited by Zoltán Csanádi

submission deadline 26 Feb 2026 | 7 articles | Viewed by 11776 | Submission Open

Keywords: catheter ablation; atrial fibrillation; ventricular tachycardia; conduction system pacing; cardiac resynchronization; sudden cardiac death

(This special issue belongs to the Section Cardiology)

Pancreatic Cancer: Novel Strategies of Diagnosis and Treatment

edited by

Camelia Cristina Diaconu

and

Gina Gheorghe

submission deadline 26 Feb 2026 | 2 articles | Viewed by 3146 | Submission Open

Keywords: pancreatic cancer; chronic pancreatitis; pancreatic intraepithelial neoplasia; gastroenterology; clinical innovative diagnostic; clinical treatment strategies

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Orthodontics: State of the Art and Perspectives

edited by

Camelia Szuhanek

and

Irina Nicoleta Zetu

submission deadline 27 Feb 2026 | 10 articles | Viewed by 16029 | Submission Open

Keywords: orthodontics; digital orthodontics; intraoral scanners; facial scanners; treatment planning; interdisciplinary treatment; orthodontic implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Unraveling Myopia: Current Science, Clinical Impact, and Future Horizons

edited by Neeraj K Singh and Pablo De Gracia

submission deadline 27 Feb 2026 | 2 articles | Viewed by 3776 | Submission Open

Keywords: accommodation; contact lenses; ophthalmic lenses; myopia progression; epidemiology; myopia control interventions; pharmaceutical treatments; environmental and behavioral risk factors; imaging innovations in myopia

(This special issue belongs to the Section Ophthalmology)

Harnessing Photobiomodulation Light for Therapeutic or Prevention of Human Diseases

edited by

Reem Hanna

submission deadline 28 Feb 2026 | 6 articles | Viewed by 29432 | Submission Open

Keywords: neurorehabilitation; supportive care for cancer; reproductive health; dental and oral diseases; viral and bacterial diseases; wound care; dermatology; sports rehabilitation; bone and musculoskeletal diseases; PBM mechanism; ophthalmology; stem cells and regenerative medicine; pain and addiction management; PBM-tissue interaction

Advances in Child Neurology

edited by

Giuseppina Sgandurra

and

Marco Carotenuto

submission deadline 28 Feb 2026 | 7 articles | Viewed by 19127 | Submission Open

Keywords: pediatric neurological disorders; pediatric sleep disorders; pediatric epilepsy; autoimmune encephalitis; pediatric acute-onset neuropsychiatric syndrome (PANS); pediatric headaches; RASopathies; neurogenetic disorders; developmental coordination disorder (DCD); pedaitric neurological rehabilitation; AI application for diagnosis and therapeutic management of pediatric neurological diseases

(This special issue belongs to the Section Clinical Pediatrics)

Headache Disorders: New Advances in Management and Treatment Strategies: 2nd Edition

edited by

Andreas A. Argyriou

Emmanouil V. Dermitzakis

and

Vikelis Michail

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2399 | Submission Open

Keywords: headache; migraine; cluster headache; tension-type headache; post-traumatic headache; calcitonin gene-related peptide; monoclonal antibodies; preventive therapy; acute treatment; pathophysiology; neuromodulation; pain management; drug development; gepants; ditan

(This special issue belongs to the Section Clinical Neurology)

New Insights into Head and Neck Surgery—2nd Edition

edited by

Gábor Dénes Répássy

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1720 | Submission Open

Keywords: otorhinolaryngology; head and neck surgery; ear surgery; sinonasal surgery; skull base surgery; salivary gland surgery; thyroid gland surgery; head and neck cancer surgery

(This special issue belongs to the Section General Surgery)

Tumor Microenvironment—Current Status and Therapeutic Targets

edited by

Rashi Kalra

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1613 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; immune checkpoint inhibitors; cancer biology; targeted therapies

(This special issue belongs to the Section Oncology)

Towards a New Paradigm: Opioid-Free and Opioid-Sparing Strategies in Modern Anesthesia

edited by

Kassiani Theodoraki

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1468 | Submission Open

Keywords: opioid-free anesthesia; opioid-sparing strategies; multimodal analgesia; regional anesthesia; non-opioid analgesics; enhanced recovery after surgery (ERAS); perioperative pain management; postoperative analgesia; anesthesia innovation; chronic pain prevention; patient-centered anesthesia; clinical outcomes in anesthesia

(This special issue belongs to the Section Anesthesiology)

Clinical Updates in Cardiovascular Computed Tomography (CT)

edited by

Antonella Meloni

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1433 | Submission Open

Keywords: cardiovascular CT; coronary CTA; plaque imaging; artificial intelligence; low-dose imaging; structural heart disease; cardiac imaging; high-risk plaque; atherosclerosis; coronary artery disease; valve calcification; thrombus detection

(This special issue belongs to the Section Cardiovascular Medicine)

Displaying special issue 551-600 on page 12 of 32.

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