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New Insights into Cardiorenal Metabolic Syndrome
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New Insights into Cardiorenal Metabolic Syndrome

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 508

Special Issue Editor

Dr. Caterina Carollo

E-Mail Website
Guest Editor
Unit of Nephrology and Dialysis, Hypertension Excellence Centre, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, Italy
Interests: nephrocardiology; chronic renal failure; hypertension
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The relationships between the heart and kidneys are complex and interesting. A promising field of research is focusing our attention on these relationships, especially if they are explored in the framework of the intriguing topic of metabolic syndrome. In fact, the so-called "cardiorenal–metabolic syndrome" deserves particular attention for its serious implications in pathophysiology, clinics, and pharmacological treatment. The availability of new "smart" drugs, which cover all these three specialties, allows us to extend our zone of interest to better investigate and, further, to better treat such complex and frail patients.

Dr. Caterina Carollo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiorenal medicine
  • diabetes
  • chronic renal failure
  • heart failure
  • cardiorenal syndrome
  • nephrocardiology

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Published Papers (1 paper)

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Research

10 pages, 2855 KiB  
Communication
Mission and One-Year Experience of a Kidney–Heart Outpatient Service: A Patient-Centered Management Model
by Caterina Carollo, Salvatore Evola, Alessandra Sorce, Emanuele Cirafici, Miriam Bennici, Giuseppe Mulè and Giulio Geraci
J. Clin. Med. 2025, 14(6), 2102; https://doi.org/10.3390/jcm14062102 - 19 Mar 2025
Viewed by 351
Abstract
Background: Cardiorenal Syndrome (CRS) represents a growing global health challenge due to the increasing prevalence of coexisting kidney and heart disease. The complex pathophysiology of CRS demands an integrated, multidisciplinary approach involving both nephrology and cardiology. However, specialized care models remain limited, [...] Read more.
Background: Cardiorenal Syndrome (CRS) represents a growing global health challenge due to the increasing prevalence of coexisting kidney and heart disease. The complex pathophysiology of CRS demands an integrated, multidisciplinary approach involving both nephrology and cardiology. However, specialized care models remain limited, leading to fragmented management and suboptimal outcomes. Methods: A Kidney–Heart Outpatient Service was established at "Paolo Giaccone" University Hospital in Palermo in May 2023 to provide coordinated, multidisciplinary care for non-hospitalized patients with CRS. The service involves structured patient assessments, including medical history, physical examinations, laboratory tests, imaging, and a collaborative therapeutic plan formulated by nephrologists and cardiologists. Preliminary patient data were collected and analysed to assess demographic characteristics, comorbidities, and clinical outcomes. Results: Among the first 115 patients evaluated, most were male and over 70 years old. Hypertension (91%) and diabetes were the leading comorbidities, with CKD stage G3b being the most prevalent. Cardiovascular conditions such as atrial fibrillation (18%), prior myocardial infarction (17%), and heart failure (15%) were frequently observed. Three patient deaths occurred, and one progressed to hemodialysis. Conclusions: The Kidney–Heart Outpatient Service represents a novel, patient-centered model for CRS management, aiming to improve clinical outcomes and reduce hospital admissions through multidisciplinary collaboration. Longitudinal follow-up and expanded data collection are essential to validate the long-term efficacy of this approach and refine management strategies for CRS patients. Ongoing research efforts will focus on tracking patient outcomes over extended periods, optimizing therapeutic strategies, and further integrating nephrology and cardiology training. The goal is to establish a sustainable and scalable framework for CRS management that enhances patient care and reduces the healthcare burden. Full article
(This article belongs to the Special Issue New Insights into Cardiorenal Metabolic Syndrome)
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