Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.7
3.0
Journals
JCM
Special Issues
Advances in Child Neurology
share announcement

Advances in Child Neurology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Pediatrics".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 6545

Special Issue Editors

Dr. Giuseppina Sgandurra

E-Mail Website
Guest Editor
1. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
2. Department of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, Italy
Interests: telerehabilitation for pediatric neurology; AI in pediatric rehabilitation; cerebral palsy; pediatric movement disorders; developmental coordination disorder (DCD); neurodevelopmental disorders
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marco Carotenuto

E-Mail Website
Guest Editor
Dipartimento di Salute Mentale e Fisica e Medicina Preventiva, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy
Interests: pediatric rehabilitation; pediatric sleep disorders; pediatric polysomnography; pediatric headaches; pediatric epilepsy; pediatric EEG; autism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The prevalence of eurological disorders in pediatric patients is constantly increasing. Researchers and clinicians around the world have an obligation to continually update their knowledge.

The field of pediatric neurology often overlaps with the fields of psychiatric and neuropsychological. Furthermore, at a developmental age, problems in the neurological sphere can become real neurodevelopmental disorders given their important impact on all areas of the functioning of the young patient affected by them.

In this vision, it is necessary to take global responsibility for the patient, their pathology, and their his family; these factors can represent the difference between an effective rehabilitation path and a less than productive one.

New knowledge on the pathophysiology of neuropsychiatric disorders tends to transcend the conceptual separations between different clinical areas, making it easier to identify common mechanisms. Furthermore, there are numerous genetic pathologies with significant neurological disorders such as movement troubles, inattention and epilepsy.

Of particular interest will be demyelinating diseases, PANS, movement disorders, epileptic disorders, and all their comorbidities.

This Special Issue will provide an overview of the recent advancements, challenges, and perspectives in all aspects of pediatric neurology and novel means of conducting outcome assessments and making predictions. The applications of AI to support decision-making and therapeutic processes will be considered, as will the use of robotics in the rehabilitation of patients experiencing pediatric neurological diseases.

Researchers in this field are invited to submit original articles or reviews.

Dr. Giuseppina Sgandurra
Prof. Dr. Marco Carotenuto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric neurological disorders
  • pediatric sleep disorders
  • pediatric epilepsy
  • autoimmune encephalitis
  • pediatric acute-onset neuropsychiatric syndrome (PANS)
  • pediatric headaches
  • RASopathies
  • neurogenetic disorders
  • developmental coordination disorder (DCD)
  • pedaitric neurological rehabilitation
  • AI application for diagnosis and therapeutic management of pediatric neurological diseases

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

12 pages, 1039 KiB  
Article
Behavioral and Electrophysiological Markers of Attention Fluctuations in Children with Hypersomnolence
by Marine Thieux, Julien Lioret, Romain Bouet, Aurore Guyon, Jean-Philippe Lachaux, Vania Herbillon and Patricia Franco
J. Clin. Med. 2024, 13(17), 5077; https://doi.org/10.3390/jcm13175077 - 27 Aug 2024
Viewed by 1116
Abstract
Background. No device is yet available to effectively capture the attentional repercussions of hypersomnolence (HYP). The present study aimed to compare attentional performance of children with HYP, attention deficit hyperactivity disorder (ADHD), and controls using behavioral and electrophysiological (EEG) markers, and to assess [...] Read more.
Background. No device is yet available to effectively capture the attentional repercussions of hypersomnolence (HYP). The present study aimed to compare attentional performance of children with HYP, attention deficit hyperactivity disorder (ADHD), and controls using behavioral and electrophysiological (EEG) markers, and to assess their relationship with conventional sleepiness measurements. Methods. Children with HYP underwent a multiple sleep latency test (MSLT) and completed the adapted Epworth sleepiness scale (AESS). Along with age-matched children with ADHD, they were submitted to a resting EEG followed by the Bron–Lyon Attention Stability Test (BLAST). The control group only performed the BLAST. Multivariate models compared reaction time (RT), error percentage, BLAST-Intensity, BLAST-Stability, theta activity, and theta/beta ratio between groups. Correlations between these measures and conventional sleepiness measurements were conducted in children with HYP. Results. Children with HYP had lower RT and BLAST-Stability than controls but showed no significant difference in BLAST/EEG markers compared to children with ADHD. The AESS was positively correlated with the percentage of errors and negatively with BLAST-Intensity. Conclusions. Children with HYP showed impulsivity and attention fluctuations, without difference from children with ADHD for BLAST/EEG markers. The BLAST–EEG protocol could be relevant for the objective assessment of attentional fluctuations related to hypersomnolence. Full article
(This article belongs to the Special Issue Advances in Child Neurology)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

47 pages, 488 KiB  
Review
Autism Spectrum Disorder and Epilepsy: Pathogenetic Mechanisms and Therapeutic Implications
by Alessandra Giliberti, Adele Maria Frisina, Stefania Giustiniano, Ylenia Carbonaro, Michele Roccella and Rosaria Nardello
J. Clin. Med. 2025, 14(7), 2431; https://doi.org/10.3390/jcm14072431 - 2 Apr 2025
Viewed by 661
Abstract
The co-occurrence of autism spectrum disorder (ASD) and epilepsy is a complex neurological condition that presents significant challenges for both patients and clinicians. ASD is a group of complex developmental disorders characterized by the following: (1) Social communication difficulties: challenges in understanding and [...] Read more.
The co-occurrence of autism spectrum disorder (ASD) and epilepsy is a complex neurological condition that presents significant challenges for both patients and clinicians. ASD is a group of complex developmental disorders characterized by the following: (1) Social communication difficulties: challenges in understanding and responding to social cues, initiating and maintaining conversations, and developing and maintaining relationships. (2) Repetitive behaviors: engaging in repetitive actions, such as hand-flapping, rocking, or lining up objects. (3) Restricted interests: focusing intensely on specific topics or activities, often to the exclusion of other interests. (4) Sensory sensitivities: over- or under-sensitivity to sensory input, such as sounds, touch, tastes, smells, or sights. These challenges can significantly impact individuals’ daily lives and require specialized support and interventions. Early diagnosis and intervention can significantly improve the quality of life for individuals with ASD and their families. Epilepsy is a chronic brain disorder characterized by recurrent unprovoked (≥2) seizures that occur >24 h apart. Single seizures are not considered epileptic seizures. Epilepsy is often idiopathic, but various brain disorders, such as malformations, strokes, and tumors, can cause symptomatic epilepsy. While these two conditions were once considered distinct, growing evidence suggests a substantial overlap in their underlying neurobiology. The prevalence of epilepsy in individuals with ASD is significantly higher than in the general population. This review will explore the epidemiology of this comorbidity, delve into the potential mechanisms linking ASD and epilepsy, and discuss the implications for diagnosis, treatment, and management. Full article
(This article belongs to the Special Issue Advances in Child Neurology)
12 pages, 774 KiB  
Review
Multiple Subpial Transection for the Treatment of Landau–Kleffner Syndrome—Review of the Literature
by Piotr Duda, Natalia Duda, Katarzyna Kostelecka, Filip Woliński, Joanna Góra, Michał Granat, Łukasz Bryliński, Barbara Teresińska, Robert Karpiński, Wojciech Czyżewski and Jacek Baj
J. Clin. Med. 2024, 13(24), 7580; https://doi.org/10.3390/jcm13247580 - 13 Dec 2024
Viewed by 795
Abstract
As speech-related symptoms of Landau–Kleffner syndrome (LKS) are often refractory to pharmacotherapy, and resective surgery is rarely available due to the involvement of the vital cortex, multiple subpial transection (MST) was suggested to improve patient outcome and preserve cortical functions. Here, we analyze [...] Read more.
As speech-related symptoms of Landau–Kleffner syndrome (LKS) are often refractory to pharmacotherapy, and resective surgery is rarely available due to the involvement of the vital cortex, multiple subpial transection (MST) was suggested to improve patient outcome and preserve cortical functions. Here, we analyze the reports about MST use in LKS, regarding its impact on seizures, language, behavior, EEG, cognition, and reported adverse effects. In conditions like LKS, surgery is not a popular treatment option and presumably should be considered sooner. Candidates for MST should be selected carefully, optimally with the unilateral onset of epileptic activity. Laterality can be assessed using a methohexital suppression test (MHXT), electrical intracarotid amobarbital test, or magnetoencephalography. After MST, a significant percentage of LKS patients present seizure-free status, normalization of EEG patterns, and rapid behavior improvement. Data comprising language outcomes are mixed, with improvement reported in 23.8–100% of cases, and no superiority was found in the only study comparing MST with a non-surgical group. Cognitive outcomes are not well described. The risk linked to MST is described as low, with cerebral edema and transient neurological deficits being the most common complications. MST successfully improves seizure, EEG, and behavioral outcomes in LKS patients. However, its beneficial impact on language and cognition is not well proven. It is generally a safe neurological operation. Full article
(This article belongs to the Special Issue Advances in Child Neurology)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

10 pages, 1602 KiB  
Case Report
Isolated Intracranial Hypertensions as Onset of Myelin Oligodendrocyte Glycoprotein Antibody Disease
by Laura Papetti, Giulia Moltoni, Daniela Longo, Gabriele Monte, Francesco Dellepiane, Stefano Pro, Giorgia Bracaglia, Claudia Ruscitto, Alberto Verrotti and Massimiliano Valeriani
J. Clin. Med. 2024, 13(15), 4468; https://doi.org/10.3390/jcm13154468 - 30 Jul 2024
Cited by 1 | Viewed by 1832
Abstract
Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is characterized by multiple phenotypic conditions such as acute disseminated encephalomyelitis, optic neuritis, and myelitis. MOGAD’s spectrum is expanding, with potential symptoms of increased intracranial pressure that are similar to idiopathic intracranial hypertension (IIH). We report a [...] Read more.
Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is characterized by multiple phenotypic conditions such as acute disseminated encephalomyelitis, optic neuritis, and myelitis. MOGAD’s spectrum is expanding, with potential symptoms of increased intracranial pressure that are similar to idiopathic intracranial hypertension (IIH). We report a boy with new-onset continuous headache and a brain MRI at onset suggesting idiopathic intracranial hypertension (IIH). The patient showed resistance to treatment with acetazolamide and, after one month, developed optic neuritis in the left eye. Laboratory tests documented positive MOG antibodies (anti-MOG) in the serum. The final diagnosis was MOGAD, with the initial symptoms resembling IIH. Full article
(This article belongs to the Special Issue Advances in Child Neurology)
►▼ Show Figures

Figure 1

18 pages, 2087 KiB  
Study Protocol
TABLET TOSCANA to Develop Innovative Organizational Models for Tele-Rehabilitation in Subjects with Congenital and Acquired Developmental Disabilities: A Wait-List Control Group Trial Protocol
by Veronica Barzacchi, Gloria Mangani, Benedetta Del Lucchese, Valentina Menici, Clara Bombonato, Elena Beani, Enrico Biagioni, Ilaria Palla, Federico Posteraro, Leopoldo Trieste, Giuseppe Turchetti, Giuseppina Sgandurra, Giovanni Cioni and on behalf of Tablet Toscana Consortium
J. Clin. Med. 2024, 13(14), 4159; https://doi.org/10.3390/jcm13144159 - 16 Jul 2024
Cited by 1 | Viewed by 1473
Abstract
Background/Objectives: In recent years, the advent of new technologies has fostered their application in neuro-psychomotor and language rehabilitation, particularly since the COVID-19 pandemic. Tele-rehabilitation has emerged as an innovative and timely solution, enabling personalized interventions monitored by clinicians. TABLET TOSCANA project aims to [...] Read more.
Background/Objectives: In recent years, the advent of new technologies has fostered their application in neuro-psychomotor and language rehabilitation, particularly since the COVID-19 pandemic. Tele-rehabilitation has emerged as an innovative and timely solution, enabling personalized interventions monitored by clinicians. TABLET TOSCANA project aims to develop innovative tele-rehabilitation organizational models in children, adolescents and young adults with congenital and acquired developmental disabilities, using the Virtual Reality Rehabilitation System (VRRS) Home Kit and the MedicoAmico APP. Methods: The trial is designed according to the CONSORT statement guidelines. The project encompasses three phases: adapting the technologies for pediatric use, validating them through a wait-list study, and analyzing feasibility and effectiveness data to define new organizational models. A randomized wait-list-control study with 100 subjects aged 6 to 30 years will compare tele-rehabilitation versus prosecution of standard care. Discussion: Although literature highlights tele-rehabilitation benefits such as improved access, cost savings, and enhanced treatment adherence, practical implementation remains limited (i.e., the definition of standardized procedures). TABLET TOSCANA project seeks to address these gaps by focusing on multi-domain treatments for neurodevelopmental disabilities and emphasizing the integration of tele-rehabilitation into local health services. Conclusion: The project aims to improve the continuity and intensity of care through innovative models that integrate tele-rehabilitation into local health services. The results could inform healthcare policies and promote the development of innovative and collaborative models of care, paving the way for more effective and widespread tele-rehabilitation solutions and fostering collaborative networks among professionals. Full article
(This article belongs to the Special Issue Advances in Child Neurology)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop