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(Recent Advances) Treating Psychiatry Disorders in Children and Adolescents: From...
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(Recent Advances) Treating Psychiatry Disorders in Children and Adolescents: From Theory to Practice: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 3270

Special Issue Editors

Prof. Dr. Pietro Muratori

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Guest Editor
IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, 56018 Pisa, Italy
Interests: children and adolescents with emotional and behavioral difficulties; children with disruptive behavior disorder; cognitive psychotherapy
Special Issues, Collections and Topics in MDPI journals
Dr. Valentina Levantini

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Guest Editor
Department of Languages and Literatures, Communication, Education and Society, University of Udine, 33100 Udine, Italy
Interests: youths with disruptive behavior disorder; children with aggressive behavioral problems; emotional problems in children
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to this Special Issue entitled “(Recent Advances) Treating Psychiatry Disorders in Children and Adolescents: From Theory to Practice: 2nd Edition”. In our previous Special Issue entitled “(Recent Advances) Treating Psychiatry Disorders in Children and Adolescents: From Theory to Practice”, we collected high-standard original articles and review papers covering a wide range of topics. This is a continuation of the previous series.

Psychiatric disorders in children and adolescents are relevant both in terms of their prevalence and their impact on the quality of life of the child/adolescent and their family. Psychiatric disorders include emotional symptoms (i.e., anxiety, emotional dysregulation, and peer problems) and/or behavioral symptoms (hyperactivity, oppositional, and conduct problems), which frequently lead to persistent adverse outcomes. An especially relevant topic is represented by neurodevelopmental disorders (ADHD and autism). Even though their characteristics might change across time, their symptoms and consequences echo for the whole lifespan. Often, children and adolescents present a co-morbidity of psychiatric disorders; therefore, they require a specific approach integrating contributions from different professionals (e.g., pediatricians, psychiatrists, psychologists, and therapists of different sorts). Therefore, the current Special Issue aims to gather original and exciting articles presenting the latest news about the treatment of youths’ psychiatric disorders. We will also consider articles exploring the protective and risk factors for psychiatric symptoms in children and adolescents.

We invite both empirical studies and conceptual/theoretical contributions related to the above-described topics for this Special Issue. We are open to various theoretical, practical, and methodological perspectives and hope that this Special Issue will be a multifaceted and stimulating collection of works with multiple perspectives. We strongly hope that this Special Issue will collect contributions from experts from different backgrounds, and we also highly encourage researchers from all subdisciplines in psychology and medicine to join.

Prof. Dr. Pietro Muratori
Dr. Valentina Levantini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intervention program
  • youth psychopathology
  • internalizing disorders
  • externalizing disorders
  • psychiatric disorders

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Related Special Issue

Published Papers (3 papers)

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Research

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14 pages, 1100 KiB  
Article
Screening of Neurodevelopmental and Psychiatric Disorders in School-Aged Children from Sahrawi Refugee Camp: A Cross-Sectional Observational Study
by Ilaria Accorinti, Linda Bonezzi, Gianluca Sesso, Simona Pipino, Francesca Pignatelli, Alessandra De Angelis, Annarita Milone and Roberta Battini
J. Clin. Med. 2025, 14(6), 2080; https://doi.org/10.3390/jcm14062080 - 18 Mar 2025
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Abstract
Background/Objectives: The prevalence of neurodevelopmental and psychiatric disorders in children is a growing concern in developed countries. However, data from low- and middle-income countries (LMICs) remain scarce. The objective of this study was to ascertain the prevalence of such conditions in the [...] Read more.
Background/Objectives: The prevalence of neurodevelopmental and psychiatric disorders in children is a growing concern in developed countries. However, data from low- and middle-income countries (LMICs) remain scarce. The objective of this study was to ascertain the prevalence of such conditions in the school-aged children residing in Sahrawi refugee camps. In particular, the objective was to develop a bespoke screening instrument for the collection of epidemiological data and the examination of the impact of these disorders on academic performance and school life. Methods: A cross-sectional observational study was conducted in 13 primary schools within Sahrawi refugee camps, with a target sample size of 3425 children aged 7–14. The Strengths and Difficulties Questionnaire (SDQ) was administered to teachers to identify any neurodevelopmental issues. Results: A total of 74 (2.2% [95% CI: 1.7–2.7%]) of the 3425 children displayed positive SDQ results for neurodevelopmental or psychiatric difficulties. The most frequently identified issues were emotional and conduct problems, which often co-occurred. Boys exhibited higher hyperactivity rates than girls. Conclusions: This study’s findings revealed significant neurodevelopmental and psychiatric challenges in Sahrawi children, with implications for their academic and social development. The results emphasize the necessity of enhancing teacher training and mental health interventions to facilitate early identification and support. Full article
(This article belongs to the Special Issue (Recent Advances) Treating Psychiatry Disorders in Children and Adolescents: From Theory to Practice: 2nd Edition)
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13 pages, 1170 KiB  
Article
Gender Differences in Alexithymia, Emotion Regulation, and Impulsivity in Young Individuals with Mood Disorders
by Luca Di Benedetto, Mario Pinto, Valentina Ieritano, Francesco Maria Lisci, Laura Monti, Elisa Marconi, Daniela Pia Rosaria Chieffo, Silvia Montanari, Georgios D. Kotzalidis, Gabriele Sani and Delfina Janiri
J. Clin. Med. 2025, 14(6), 2030; https://doi.org/10.3390/jcm14062030 - 17 Mar 2025
Viewed by 781
Abstract
Background/Objectives: Alexithymia, emotion regulation, and impulsivity are key factors in youths with mood disorders. However, gender differences within these dimensions remain insufficiently studied in this population. This study seeks to explore these dimensions in a sample of adolescents and young adults with mood [...] Read more.
Background/Objectives: Alexithymia, emotion regulation, and impulsivity are key factors in youths with mood disorders. However, gender differences within these dimensions remain insufficiently studied in this population. This study seeks to explore these dimensions in a sample of adolescents and young adults with mood disorders, aiming to identify gender-specific characteristics with important clinical implications. Methods: We assessed 115 outpatients aged 13 to 25 years with a DSM-5 diagnosis of mood disorder. The evaluation included the Toronto Alexithymia Scale (TAS-20), the Difficulties in Emotion Regulation Scale (DERS), and the UPPS-P Impulsive Behavior Scale. The associations with suicidal ideation were tested using two different multivariate models. Results were controlled for age and intelligence measures. Results: The first model (Wilks’ Lambda = 0.720, p < 0.001) revealed significantly higher scores in women than men for TAS-20 (p < 0.001), DERS (p < 0.001), and the UPPS-P subscales “Lack of Premeditation” (p = 0.004) and “Lack of Perseverance” (p = 0.001). Regression analyses confirmed gender as a significant predictor of these variables, also controlling for age and intelligence. Furthermore, intelligence measure influenced Lack of Premeditation and age influenced Lack of Perseverance. Conclusions: Women with mood disorders exhibit greater alexithymia, emotional dysregulation, and impulsivity, particularly in difficulties with planning and task persistence. These findings highlight the need for gender-sensitive interventions that address emotional awareness and impulse control to improve clinical outcomes. Full article
(This article belongs to the Special Issue (Recent Advances) Treating Psychiatry Disorders in Children and Adolescents: From Theory to Practice: 2nd Edition)
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9 pages, 217 KiB  
Study Protocol
Extended-Release Lithium Treatment for Adolescents with Bipolar Disorder with or Without Comorbid Autism Spectrum Disorder: Protocol of a Longitudinal Prospective Naturalistic Study for the Assessment of Efficacy and Tolerability
by Gianluca Sesso, Francesca Bargnesi, Giulia Mutti, Stefano Berloffa, Valentina Viglione, Pamela Fantozzi, Greta Tolomei, Fulvio Guccione, Pietro Muratori, Annarita Milone and Gabriele Masi
J. Clin. Med. 2024, 13(20), 6196; https://doi.org/10.3390/jcm13206196 - 17 Oct 2024
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Abstract
Background: Lithium is the gold-standard treatment for Bipolar Disorder (BD) in both adults and adolescents, effectively managing mood episodes and reducing suicide risk. While its efficacy in neurotypical youth is well established, its use in adolescents with Autism Spectrum Disorder (ASD) and [...] Read more.
Background: Lithium is the gold-standard treatment for Bipolar Disorder (BD) in both adults and adolescents, effectively managing mood episodes and reducing suicide risk. While its efficacy in neurotypical youth is well established, its use in adolescents with Autism Spectrum Disorder (ASD) and comorbid BD remains under-researched. Here, we present the protocol for a study aiming to evaluate the efficacy and tolerability of Extended-Release Lithium Salts in treating adolescents with BD and comorbid ASD compared to neurotypical BD patients. Methods: This longitudinal prospective naturalistic comparative study will enroll lithium-naïve adolescents aged 12–18 with BD, with or without comorbid ASD, from the Department of Child and Adolescent Psychiatry and Psychopharmacology. Participants will be followed for six months while receiving Extended-Release Lithium Salts treatment. Primary outcomes will include mood instability, suicidality, emotional dysregulation, and aggression, assessed through a range of clinical rating scales and diagnostic tools at baseline, three months, and six months. Secondary outcomes will focus on the safety and tolerability of Extended-Release Lithium Salts, with measures including side effect ratings, physical exams, and laboratory tests. Results: We hypothesize that Extended-Release Lithium Salts will demonstrate non-inferiority in treating BD symptoms in adolescents with comorbid ASD compared to those without ASD. Conclusions: This study is poised to fill a significant gap in the literature by providing critical data on the use of lithium for adolescents with BD and ASD. Findings will inform clinical practice and future research, potentially guiding more personalized treatment approaches for this complex and vulnerable population. Full article
(This article belongs to the Special Issue (Recent Advances) Treating Psychiatry Disorders in Children and Adolescents: From Theory to Practice: 2nd Edition)
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