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New Advances in Keratoplasty
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New Advances in Keratoplasty

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 29 August 2025 | Viewed by 3412

Special Issue Editor

Dr. Cristina Bovone

E-Mail Website
Guest Editor
1. Department of Environmental Sciences and Prevention, University of Ferrara, Ferrara, Italy
2. Department of Ophthalmology, Ospedali Privati Forlì "Villa Igea", Forlì, Italy
Interests: cornea; ophthalmology; keratoplasty; anterior segment surgery

Special Issue Information

Dear Colleagues,

This Special Issue presents an opportunity for ophthalmologists to publish their innovative works focused on the recent advances in keratoplasty surgery. Potential areas of interest include, but are not limited to, the following: lamellar keratoplasty, high-tech intraoperative tools, machine learning and artificial intelligence, and novel surgical techniques. I have the pleasure of inviting you to submit your work for consideration in this Special Issue entitled “New Advances in Keratoplasty". Original research articles (clinical or basic science research), reviews, short communications, and interesting images are welcome. All papers will be fully open access upon publication after peer review.

Dr. Cristina Bovone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lamellar keratoplasty
  • descemet stripping endothelial keratoplasty (DSAEK)
  • descemet membrane endothelial keratoplasty (DMEK)
  • deep anterior lamellar keratoplasty (DALK)
  • keratoconus
  • corneal dystrophies
  • bullous keratopathy
  • anterior segment OCT

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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14 pages, 565 KiB  
Article
Assessment of OCT and Angio-OCT Parameters in Keratoconus Patients with and without Penetrating Keratoplasty
by Anna Maria Gadamer, Piotr Miklaszewski, Dominika Janiszewska-Bil, Anita Lyssek-Boroń, Dariusz Dobrowolski, Edward Wylęgała, Beniamin Oskar Grabarek, Aleksandra Kiełbasińska and Katarzyna Krysik
J. Clin. Med. 2024, 13(17), 5111; https://doi.org/10.3390/jcm13175111 - 28 Aug 2024
Cited by 1 | Viewed by 1412
Abstract
Background/Objectives: Keratoconus (KC) is a bilateral eye disease characterized by corneal thinning and cone-like deformation, leading to visual impairment. This study evaluated the radial peripapillary capillaries (RPCs) in keratoconus patients with and without penetrating keratoplasty (PKP) using OCT and angio-OCT, comparing the results [...] Read more.
Background/Objectives: Keratoconus (KC) is a bilateral eye disease characterized by corneal thinning and cone-like deformation, leading to visual impairment. This study evaluated the radial peripapillary capillaries (RPCs) in keratoconus patients with and without penetrating keratoplasty (PKP) using OCT and angio-OCT, comparing the results to a control group. Methods: This retrospective study included 149 eyes, 97 from patients who underwent PKP between January 2018 and February 2023 and 52 from patients who did not undergo PKP. The control group comprised 72 patients (144 eyes) who were healthy volunteers. Measurements included the best corrected visual acuity (BCVA), the intraocular pressure (IOP), slit-lamp biomicroscopy, a fundus examination, and corneal topography, as well as OCT and angio-OCT assessments of the RPCs, retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and central retinal thickness (CRT). Statistical analyses were performed using Student’s t-test and Pearson’s correlation coefficient. Results: The RNFL was significantly thinner in KC eyes after PKP compared to control eyes (p < 0.001), and the CRT was significantly thicker in KC eyes after PKP compared to control eyes (p = 0.003). However, the GCC was similar across the groups (p = 0.0885). Additionally, RPCs inside the disc were significantly reduced in KC eyes after PKP compared to control eyes (p < 0.0001). A significant positive correlation was found between RPC whole vessel density and RNFL thickness as measured via angio-OCT (r = 0.308, p < 0.0001). Conclusions: This study found that the RPC density inside the disc is significantly reduced in keratoconus patients after penetrating keratoplasty, highlighting RPCs inside the disc as a potential diagnostic tool for further assessment of keratoconus. Full article
(This article belongs to the Special Issue New Advances in Keratoplasty)
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Review

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27 pages, 1405 KiB  
Review
Review of the Literature: Surgery Indications for Fuchs’ Endothelial Corneal Dystrophy
by Moïse Tourabaly, Juliette Knoeri, Cristina Georgeon and Vincent Borderie
J. Clin. Med. 2025, 14(7), 2365; https://doi.org/10.3390/jcm14072365 - 29 Mar 2025
Cited by 1 | Viewed by 594
Abstract
Objectives: To provide an overview of the preoperative indications for endothelial graft in patients with Fuchs endothelial corneal dystrophy (FECD). Methods: A comprehensive database search without date restrictions was performed in PubMed. Keywords included Descemet membrane endothelial keratoplasty (DMEK), Descemet stripping automated endothelial [...] Read more.
Objectives: To provide an overview of the preoperative indications for endothelial graft in patients with Fuchs endothelial corneal dystrophy (FECD). Methods: A comprehensive database search without date restrictions was performed in PubMed. Keywords included Descemet membrane endothelial keratoplasty (DMEK), Descemet stripping automated endothelial keratoplasty (DSAEK), corneal keratoplasty, preoperative visual acuity, preoperative central corneal thickness, and densitometry. Articles aiming to describe or evaluate preoperative indications for endothelial keratoplasty were considered eligible and were included in this review. Results: The indications for surgery in FECD are disparate between the different studies. The tendency is to operate on patients earlier to obtain a better postoperative visual acuity at 1 year. The surgical decision is based on a number of arguments (visual acuity, CCT, densitometry). A preoperative visual acuity worse than 20/40 is generally considered a surgical indication for DMEK, based on current literature. Conclusions: Surgical decisions for Fuchs’ dystrophy should be individualized, guided by preoperative visual acuity, corneal OCT, and advanced imaging, with future risk scores potentially refining the timing of intervention to optimize outcomes. Full article
(This article belongs to the Special Issue New Advances in Keratoplasty)
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Other

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8 pages, 1253 KiB  
Case Report
Therapeutic Keratoplasty for Fusarium Keratitis
by David Oliver-Gutierrez, Liliana Gutuleac, Natalia Anglada-Masferrer, Gloria Segura-Duch, Sara Martin, Laia Bisbe, María Teresa Martín-Gómez, Miguel Ángel Zapata and Javier José Puig
J. Clin. Med. 2024, 13(24), 7775; https://doi.org/10.3390/jcm13247775 - 19 Dec 2024
Viewed by 895
Abstract
Purpose: This study evaluates the effectiveness of therapeutic keratoplasty for Fusarium fungal keratitis and explores the diagnosis and management challenges of this infectious corneal disease. Methods: We retrospectively analyzed therapeutic keratoplasty cases at a tertiary hospital for Fusarium keratitis when standard treatments [...] Read more.
Purpose: This study evaluates the effectiveness of therapeutic keratoplasty for Fusarium fungal keratitis and explores the diagnosis and management challenges of this infectious corneal disease. Methods: We retrospectively analyzed therapeutic keratoplasty cases at a tertiary hospital for Fusarium keratitis when standard treatments failed. Results: Five cases of Fusarium keratitis, unresponsive to typical antifungal treatments, required keratoplasty due to fast progression and diagnostic difficulties. Post-surgery, all patients had infection resolution without recurrence, but some complications like anterior chamber leakage, graft rejection, and ocular hypertension were managed effectively. Final visual acuity ranged from 0.9 to finger counting. Conclusions: Fusarium keratitis, often resistant to conventional therapies, may necessitate keratoplasty for resolution. This intervention is crucial for positive outcomes, emphasizing the need for prompt and effective management to prevent severe surgical measures and preserve ocular health. Full article
(This article belongs to the Special Issue New Advances in Keratoplasty)
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