Headache Disorders: New Advances in Management and Treatment Strategies: 2nd Edition

Dear Colleagues,

We are pleased to invite you to contribute to the second edition of the Special Issue “Headache Disorders: New Advances in Management and Treatment Strategies: 2nd Edition” in the Journal of Clinical Medicine. The success of the first edition “Headache Disorders: New Advances in Management and Treatment Strategies” has prompted us to continue this important academic discussion with a new volume featuring both original research articles and comprehensive reviews.

Headache disorders—including migraine, cluster headache, tension-type headache, and post-traumatic headache—are among the most prevalent neurological conditions encountered in clinical practice. In recent years, significant progress has been made in understanding and treating these disorders. Notably, monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway (e.g., erenumab, fremanezumab, galcanezumab, and eptinezumab) have demonstrated efficacy in migraine prevention. Meanwhile, small-molecule CGRP receptor antagonists (gepants) and 5-HT1F receptor agonists (ditans) have expanded the options for acute treatment.

Despite these advances, a substantial number of patients continue to experience suboptimal responses, underscoring the need for more effective and personalized therapeutic strategies. Ongoing research efforts are focused on optimizing existing treatments, investigating novel targets such as PACAP inhibitors, and elucidating the complex pathophysiology of headache disorders to improve clinical outcomes.

This Special Issue seeks to highlight recent developments in the diagnosis, management, and treatment of headache disorders. We welcome submissions that offer new insights into clinical practices, novel therapeutic approaches, and the underlying biological mechanisms of these conditions. Thank you in advance for your contributions to this Special Issue. We firmly believe that your work will play a vital role in advancing knowledge and improving patient care in this important field.

Dr. Andreas A. Argyriou
Dr. Emmanouil V. Dermitzakis
Dr. Vikelis Michail
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.