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Clinical Aspects and Outcomes in Contemporary Colorectal Surgery
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Clinical Aspects and Outcomes in Contemporary Colorectal Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 28 August 2025 | Viewed by 481

Special Issue Editor

Dr. Lior Segev

E-Mail Website
Guest Editor
Head of Colorectal Cancer Surgery Service, Division of Surgery, Sheba Medical Center, Tel Hashomer, Israel Faculty of Medicine, Tel Aviv University, Tel Aviv 6329302, Israel
Interests: colorectal surgery; colorectal cancer; IBD (inflammatory bowel disease) surgery

Special Issue Information

Dear Colleagues,

Over the last several years, along with the gradual rise in colorectal cancer and Crohn’s disease incidence, the field of colorectal surgery has been rapidly evolving and growing. We, as colorectal surgeons, feel this increase in the volumes of patients with colorectal diseases being referred to us on a daily basis. The aim of the present Topical Collection is to serve as a forum for addressing core issues in colorectal surgery, including, but not limited to, surgical techniques, perioperative management, postoperative recovery, and surgical outcomes. We invite the submission of manuscripts in all areas of colorectal surgery. Priority will be given to high-quality, original studies, but well-designed and conducted systematic reviews (with or without metanalysis) giving a comprehensive overview of the state of the art on a specific topic are also welcome. In summary, this Topical Collection will increase clinicians’ knowledge of poorly explored areas of coloproctology, as well as providing a balanced, sound, and evidence-based overview of advances and potential perspectives in the field of colorectal surgery.

Dr. Lior Segev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal surgery
  • colorectal cancer
  • Crohn’s disease
  • ulcerative colitis
  • coloproctology
  • minimally invasive surgery

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Published Papers (1 paper)

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Research

14 pages, 573 KiB  
Article
Predictors and Long-Term Outcomes of Pathological Complete Response Following Neoadjuvant Treatment and Radical Surgery for Locally Advanced Rectal Cancer
by Dan Assaf, Yaacov Lawrence, Ofer Margalit, Einat Shacham-Shmueli, Lior Bear, Nadav Elbaz, Alexander Lebedayev, Edward Ram, Yasmin Anderson, Ofir Gruper, Michael Goldenshluger and Lior Segev
J. Clin. Med. 2025, 14(12), 4251; https://doi.org/10.3390/jcm14124251 - 15 Jun 2025
Viewed by 320
Abstract
Background: Pathological complete response (pCR) following neoadjuvant therapy and surgery for locally advanced rectal cancer is associated with improved prognosis. Accurately predicting who will achieve pCR could theoretically eliminate the need for surgery for these patients. We aimed to compare pCR and non-pCR [...] Read more.
Background: Pathological complete response (pCR) following neoadjuvant therapy and surgery for locally advanced rectal cancer is associated with improved prognosis. Accurately predicting who will achieve pCR could theoretically eliminate the need for surgery for these patients. We aimed to compare pCR and non-pCR rectal cancer patients following neoadjuvant therapy, searching for clinical predictors for pCR and comparing oncological outcomes between these groups. Methods: This is a single-center retrospective analysis of all patients who underwent a curative-intent rectal resection between 2010 and 2020 for primary non-metastatic rectal cancer following neoadjuvant therapy. The cohort (263 patients) was divided into two groups according to the pathological results from surgery: the pCR group (53 patients) and the non-pCR group (210 patients). Results: The groups were similar in terms of baseline characteristics, clinical presentation, and staging, but tumors of the pCR group were significantly higher in the rectum (mean distance from the anal verge 7.92 cm versus 6.9 cm respectively, p = 0.04), and more of them were located at the posterior rectal wall (37.7% versus 24.3%, p = 0.049). Multivariate analysis found posterior location and tumor height to be significantly associated with pCR (OR 2.23, 95% CI 1.11–4.45, p = 0.023), (OR 1.14, 95% CI 1.03–1.27, p = 0.015). The 5-year overall survival was 95.6% in the pCR group compared with 87.5% in the non-pCR group (p = 0.09), and the 5-year disease-free survival was 92.7% versus 64.5%, respectively (p < 0.001). Conclusions: Tumor location at the posterior wall of the rectum and higher tumor location were found to be associated with pCR. Patients achieving pCR demonstrate improved prognosis compared with non-pCR patients. Full article
(This article belongs to the Special Issue Clinical Aspects and Outcomes in Contemporary Colorectal Surgery)
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