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Interventional and Surgical Treatment of Acute and Chronic Pancreatitis
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Interventional and Surgical Treatment of Acute and Chronic Pancreatitis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 410

Special Issue Editor

Dr. Chirag Desai

E-Mail Website
Guest Editor
Department of Surgery, Division of Abdominal Transplantation, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Interests: hepatobiliary and pancreatic surgery; auto islet cell transplantation; liver transplantation; islet cell transplants; advanced liver; bile duct, and pancreatic surgery; chronic pancreatitis

Special Issue Information

Dear Colleagues,

The field of pancreatitis management has seen remarkable progress in recent years, particularly in interventional treatments. Conditions ranging from acute pancreatitis to recurrent acute pancreatitis and the challenging transition to chronic pancreatitis have historically been associated with significant morbidity and mortality. However, advancements in radiological, endoscopic, and surgical approaches have transformed the management of this complex disease, significantly improving patient outcomes and quality of life.

Patients now benefit from a spectrum of treatment options, including percutaneous interventions, endoscopic techniques, laparoscopic and robotic procedures, and various surgical strategies such as drainage procedures, parenchyma-preserving resections, and total pancreatectomy with or without islet autotransplantation. Despite these advancements, there remains a critical need for high-quality data to further refine and optimize treatment strategies. This Special Issue invites original research, reviews, and case series on the interventional management and outcomes of pancreatitis. Submissions may cover a wide range of topics, including but not limited to:

  • Percutaneous radiological interventions.
  • Endoscopic techniques for acute and chronic pancreatitis.
  • Minimally invasive surgical approaches, including laparoscopic and robotic procedures.
  • Open surgical techniques, such as the Whipple procedure, distal pancreatectomy, or total pancreatectomy with or without islet autotransplant.
  • Innovations in islet cell transplantation and outcomes after pancreatic surgeries.
  • Short- and long-term outcome-focused data around these treatment strategies.

We encourage authors to contribute cutting-edge studies and comprehensive reviews that highlight advancements in the field and address the existing gaps in the literature. Join us in advancing the understanding and management of pancreatitis through this Special Issue.

Dr. Chirag Desai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pancreatitis treatment
  • endoscopic treatment
  • pancreatic surgery
  • Whipple
  • distal pancreatectomy
  • islet cell auto trans-plant
  • total pancreatectomy
  • TPIAT
  • laparoscopic treatment of pancreatitis
  • robotic surgery for pancreatitis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

14 pages, 4372 KiB  
Article
Association of Visceral Adiposity and Sarcopenia with Geospatial Analysis and Outcomes in Acute Pancreatitis
by Ankit Chhoda, Manisha Bohara, Anabel Liyen Cartelle, Matthew Antony Manoj, Marco A. Noriega, Miriam Olivares, Jill Kelly, Olga Brook, Steven D. Freedman, Abraham F. Bezuidenhout and Sunil G. Sheth
J. Clin. Med. 2025, 14(9), 3005; https://doi.org/10.3390/jcm14093005 - 26 Apr 2025
Viewed by 255
Abstract
Background: Radiological imaging has improved our insight into how obesity and sarcopenia impacts acute pancreatitis via several measured variables. However, we lack understanding of the association between social determinants of health and these variables within the acute pancreatitis population. Methods: This study included [...] Read more.
Background: Radiological imaging has improved our insight into how obesity and sarcopenia impacts acute pancreatitis via several measured variables. However, we lack understanding of the association between social determinants of health and these variables within the acute pancreatitis population. Methods: This study included patients at a single tertiary care center between 1 January 2008 and 31 December 2021. Measurements of visceral adiposity (VA), subcutaneous adiposity (SA), the ratio of visceral to total adiposity (VA/TA), and degree of sarcopenia via psoas muscle Hounsfield unit average calculation (HUAC) were obtained on CT scans performed at presentation. Using geocoded patient data, we calculated the social vulnerability index (SVI) from CDC metrics. Descriptive and regression analyses were performed utilizing clinical and radiological data. Results: In 484 patients with 592 acute pancreatitis-related hospitalization, median (IQR) VA was 176 (100–251), SA was 209.5 (138.5–307), VA/TA ratio was 43.5 (32.3–55.3), and HUAC was 51.3 (44.4–58.9). For our primary outcome, geospatial analyses showed a reverse association between VA and SVI with a coefficient of −9.0 (p = 0.04) after adjustment for age, health care behaviors (i.e., active smoking and drinking), and CCI, suggesting residence in areas with higher SVI is linked to lower VA. However, VA/TA, SA, and HUAC showed no significant association with SVI. The SVI subdomain of socioeconomic status had significant association with VA (−39.78 (95% CI: −75.88–−3.70), p = 0.03) after adjustments. For our secondary outcome, acute pancreatitis severity had significant association with higher VA (p ≤ 0.001), VA/TA (p ≤ 0.001), and lower HUAC (p ≤ 0.001). When comparing single vs. recurrent hospitalization patients, there was significantly higher median VA with recurrences (VA-single acute pancreatitis: 149 (77.4–233) vs. VA-recurrent acute pancreatitis: 177 (108–256); p = 0.04). Conclusions: In this study we found that patients residing in more socially vulnerable areas had lower visceral adiposity. This paradoxical result potentially conferred a protective effect against severe and recurrent acute pancreatitis; however, this was not found to be statistically significant. Full article
(This article belongs to the Special Issue Interventional and Surgical Treatment of Acute and Chronic Pancreatitis)
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