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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Refractive Surgery and Intraocular Lens Implantation
edited by Antonio Leccisotti
submission deadline 15 Feb 2026 | Viewed by 193 | Submission Open
Keywords: refractive surgery; intraocular lens implantation; keratectomy; cornea; ocular surgery; optical coherence tomography; laser surgery; KLEx (keratorefractive lenticule extraction); femtolasik
(This special issue belongs to the Section Ophthalmology)
Kidney Transplantation: Current Challenges and Future Perspectives: 2nd Edition
edited by Alberto Piana and Angelo Territo
submission deadline 15 Feb 2026 | Viewed by 190 | Submission Open
Keywords: kidney transplantation; urologic cancers; organ preservation; surgical challenges; donor selection; long-term outcomes; complications; post-transplant care; technology
(This special issue belongs to the Section Nephrology & Urology)
State of the Art in Bladder Cancer: Diagnostics and Treatment Strategies
edited by
submission deadline 15 Feb 2026 | Viewed by 112 | Submission Open
Keywords: bladder cancer; photodynamic diagnosis (PDD); bladder-sparing strategies; robotic-assisted surgery; single-port robotic cystectomy; older patients; immunotherapy; intravesical therapy; bladder preservation; minimally invasive urology; advanced bladder cancer; diagnostic innovation
(This special issue belongs to the Section Nephrology & Urology)
Clinical Perspectives in Amyotrophic Lateral Sclerosis: Diagnosis, Management and Future Opportunities
edited by
submission deadline 15 Feb 2026 | Viewed by 110 | Submission Open
Keywords: amyotrophic lateral sclerosis; early diagnosis; neuroimaging; biomarkers; treatment
(This special issue belongs to the Section Clinical Neurology)
Eosinophilic Esophagitis: Clinical Advances in Diagnosis, Treatment, and Monitoring
edited by Pierfrancesco Visaggi, Edoardo Vincenzo Savarino and
submission deadline 18 Feb 2026 | 4 articles | Viewed by 6799 | Submission Open
Keywords: eosinophilic esophagitis (EoE); diagnosis  ; treatment  ; monitoring; disease assessment; precision medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Endocrine Malignancies: Current Surgical Therapeutic Approaches: 2nd Edition
edited by , and Marco Bononi
submission deadline 18 Feb 2026 | 4 articles | Viewed by 5689 | Submission Open
Keywords: endocrine malignancies; thyroid cancer; adrenocortical cancer; parathyroid; men
(This special issue belongs to the Section Endocrinology & Metabolism)
Sepsis: Current Updates and Perspectives submission deadline 20 Feb 2026 | 8 articles | Viewed by 21470 | Submission Open
Keywords: sepsis biomarkers; diagnostic tools; cytokines; inflammation; infection; antibiotherapy; blood purification; novel therapies
(This special issue belongs to the Section Intensive Care)
Traumatic Brain Injury: Emergency Management, Prevention of Secondary Injury, and Rehabilitation
edited by and Lori Shutter
submission deadline 20 Feb 2026 | 6 articles | Viewed by 20477 | Submission Open
Keywords: traumatic brain injury; neuromonitoring; neurocritical care; neurorehabilitation; secondary injury; outcome; prognostication
(This special issue belongs to the Section Brain Injury)
Recent Developments in Gynecological Endocrinology submission deadline 20 Feb 2026 | 8 articles | Viewed by 20442 | Submission Open
Keywords: amenorrhea; puberty; PCOS; premature ovarian insufficiency; endometriosis; infertility; pregnancy; hormones; menopause
(This special issue belongs to the Section Obstetrics & Gynecology)
Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions
edited by Mauro Zaccarelli and
submission deadline 20 Feb 2026 | 6 articles | Viewed by 17624 | Submission Open
Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex
(This special issue belongs to the Section Infectious Diseases)
Endodontic and Periodontal Medicine: Systemic Implications of Oral Infections submission deadline 20 Feb 2026 | 10 articles | Viewed by 17179 | Submission Open
Keywords: dentistry; endodontics; apical periodontitis; endodontic medicine; periodontal disease; periodontal medicine; pulpitis; systemic diseases; root canal treatment
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Blood Disorders: Diagnosis, Management, and Future Opportunities submission deadline 20 Feb 2026 | 4 articles | Viewed by 14677 | Submission Open
Keywords: blood disorders; biomarkers; personalized medicine; diagnosis; NGS; metabolomics; digital droplet PCR (ddPCR)
(This special issue belongs to the Section Hematology)
Pediatric Critical Care: Clinical Recognition, Management, and Outcomes
edited by Janet Hume
submission deadline 20 Feb 2026 | 6 articles | Viewed by 14018 | Submission Open
Keywords: pediatric critical care medicine; sepsis; pediatric acute respiratory distress syndrome; mechanical ventilation; renal replacement therapy; chronic critical illness; post-intensive care syndrome
(This special issue belongs to the Section Clinical Pediatrics)
Cystic Fibrosis: Diagnosis and Treatment
edited by Corrado Tagliati and Gian Marco Giuseppetti
submission deadline 20 Feb 2026 | 6 articles | Viewed by 13886 | Submission Open
Keywords: cystic fibrosis; diagnosis; treatment; management
(This special issue belongs to the Section Respiratory Medicine)
Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management
edited by , and Mohamed Ahmed Mostafa Aboellail
submission deadline 20 Feb 2026 | 5 articles | Viewed by 11731 | Submission Open
Keywords: preeclampsia; pregnancy complications; early intervention; diagnosis of pregnancy complications; management of pregnancy complications; sexual dysfunctions in pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Orthopedic Surgery: Recent Advances and Prospects
edited by Mitchell K. Ng
submission deadline 20 Feb 2026 | 4 articles | Viewed by 10489 | Submission Open
Keywords: orthopedic surgery; clinical updates; joint reconstruction; spine surgery; trauma; elective surgery; peri-operative management
(This special issue belongs to the Section Orthopedics)
Management of Pituitary Tumors: Current and Future Treatment Options—2nd Edition
edited by
submission deadline 20 Feb 2026 | 6 articles | Viewed by 10206 | Submission Open
Keywords: pituitary; cushing syndrome; acromegaly; prolactinoma; non-functioning pituitary adenoma; hypopituitarism; hypophysitis
(This special issue belongs to the Section Endocrinology & Metabolism)
Neuroendocrine Tumors: Challenges and Future Perspectives (Second Edition) submission deadline 20 Feb 2026 | 6 articles | Viewed by 9885 | Submission Open
Keywords: neuroendocrine tumors; clinical challenges; innovative biomarkers; novel agents; personalized oncology
(This special issue belongs to the Section Oncology)
Navigating Pregnancy and Its Complications: Challenges and Innovations in Maternal–Fetal Medicine submission deadline 20 Feb 2026 | 3 articles | Viewed by 9183 | Submission Open
Keywords: pregnancy; obstetrics; diabetes; high risk; preeclampsia; labor; delivery; hypertension; hemorrhage; embryo; screening
(This special issue belongs to the Section Obstetrics & Gynecology)
Targeted Treatment in Chronic Inflammatory Arthritis
edited by , and Simone Perniola
submission deadline 20 Feb 2026 | 4 articles | Viewed by 9093 | Submission Open
Keywords: rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; spondyloarthritis; disease-modifying antirheumatic drugs (DMARDs); personalized medicine; immunomodulatory therapies; patient outcomes; combination therapies
(This special issue belongs to the Section Immunology & Rheumatology)
Optimizing Present and Future Therapeutic Choices for Treatment and Management of Chronic Inflammatory Bowel Diseases—2nd Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 7032 | Submission Open
Keywords: Inflammatory Bowel Diseases(IBD); JAK inhibitors; mucosal healing
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Innovative Approaches to the Challenges of Neurodegenerative Disease
edited by Brian T. Bicknell and
submission deadline 20 Feb 2026 | 4 articles | Viewed by 6802 | Submission Open
Keywords: neurodegenerative disease; Parkinson’ s disease; Alzheimer’ s disease; multiple sclerosis; amyotrophic lateral sclerosis
(This special issue belongs to the Section Clinical Neurology)
Clinical Updates on Hereditary Hemorrhagic Telangiectasia (HHT) and Other Vascular Diseases
edited by Tamás Major
submission deadline 20 Feb 2026 | 5 articles | Viewed by 6790 | Submission Open
Keywords: hereditary hemorrhagic telangiectasia (HHT); arteriovenous malformations; embolization; VEGF; capillary malformation-arteriovenous malformation
(This special issue belongs to the Section Vascular Medicine)
Novel Therapeutic Targets with Inflammatory Bowel Diseases
edited by Konstantinos H. Katsanos and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 6437 | Submission Open
Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; colorectal; intestinal bowel disease; mucosal im-munology; molecular endoscopy; fibrosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Non-Invasive Respiratory Support: Current Insights and Future Directions
edited by Giovanni Misseri and
submission deadline 20 Feb 2026 | 3 articles | Viewed by 6280 | Submission Open
Keywords: respiratory failure; high-flow nasal cannula (HFNC); noninvasive ventilation (NIV); noninvasive positive pressure ventilation (NPPV); hypoxia; perioperative care; weaning; ICU; respiratory care; respiratory physiology; pneumology; home-care ventilation; artificial intelligence; personalized medicine
(This special issue belongs to the Section Respiratory Medicine)
Recent Advances in Immunotherapy of Cancer submission deadline 20 Feb 2026 | 3 articles | Viewed by 6214 | Submission Open
Keywords: immunotherapy; immunology; cancer; oncology; tumor immune microenvironment; artificial intelligence; immune-related adverse events
(This special issue belongs to the Section Oncology)
Gastrointestinal Diseases: Clinical Challenges and Management
edited by Anusha Shirwaikar Thomas and
submission deadline 20 Feb 2026 | 3 articles | Viewed by 6207 | Submission Open
Keywords: GI bleed; nutrition; obstructive jaundice; drug-induced liver injury; GI motility; clostridium difficile infection; large bowel obstruction; colon cancer prevention and surveillance
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The Complex Interplay Between Physical Activity, Sleep, Diet, and Obesity: Clinical Insights for Treatment and Prevention submission deadline 20 Feb 2026 | 5 articles | Viewed by 6047 | Submission Open
Keywords: body mass; body composition; nutrition; sleep patterns; weight management; lifestyle interventions; sedentary behavior; adiposity; obesity prevention; dietary habits
(This special issue belongs to the Section Clinical Rehabilitation)
Cardiopulmonary Resuscitation in Emergency Care Units submission deadline 20 Feb 2026 | 4 articles | Viewed by 5673 | Submission Open
Keywords: cardiopulmonary resuscitation; emergency care; cardiac arrest; CPR techniques; resuscitation devices; post-resuscitation care; survival outcomes
(This special issue belongs to the Section Emergency Medicine)
Alcohol-Related Liver Disease: Diagnosis, Treatment, and Management submission deadline 20 Feb 2026 | 4 articles | Viewed by 5594 | Submission Open
Keywords: alcohol-related liver disease; gut– liver axis; hepatic fibrosis; liver cirrhosis; micro-RNA; inflammatory pathways; liver transplantation; steatohepatitis; fecal microbiota transplantation in liver cirrhosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Updates on Lumbar Spine Surgery for Degenerative Diseases
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5376 | Submission Open
Keywords: degenerative disease; lumbar spine surgery; fusion; decompressive surgery; sagittal alignment; complications; outcomes
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Gastrointestinal Inflammation
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4998 | Submission Open
Keywords: Helicobacter pylori; antibiotic resistance; COVID-19 pandemic; post-COVID era; inflammatory bowel diseases; acute gastrointestinal infections; SARS-COV-2 infection; celiac disease
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Interstitial Lung Disease: From Diagnosis to Treatment
edited by and Tomohisa Baba
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4813 | Submission Open
Keywords: interstitial pneumonia; diagnosis; virus infection; collagen vascular disease-related interstitial pneumonia; differen-tial diagnosis; lung sounds
(This special issue belongs to the Section Respiratory Medicine)
Intraocular Lenses for Cataract Surgery: Clinical Advances and Perspectives
edited by Choul Yong Park
submission deadline 20 Feb 2026 | 5 articles | Viewed by 4376 | Submission Open
Keywords: cataract surgery; intraocular lens; IOL formula; optic; complication; presbyopia; refractive
(This special issue belongs to the Section Ophthalmology)
Clinical Trends in Cardiomyopathy
edited by Giulia Iannaccone
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4371 | Submission Open
Keywords: cardiomyopathy; genetics; treatment; targeted therapy; prognosis; long-term follow up
(This special issue belongs to the Section Cardiology)
Neurosurgery: Recent Advances and New Perspectives in Skull Base Approaches
edited by Sèbastien Froelich and Matteo De Simone
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4318 | Submission Open
Keywords: skull base; neuroanatomy; tumors; augmented reality; ETOA; EEA; exoscopy; endoscopy; multi-portal approaches
(This special issue belongs to the Section Clinical Neurology)
Clinical Updates in Trauma and Emergency Medicine
edited by Yong-Soo Cho and Hyun Ho Ryu
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4288 | Submission Open
Keywords: emergency medicine; epidemiology; cardiovascular disease
(This special issue belongs to the Section Emergency Medicine)
Pain Management: Current Challenges and Future Prospects
edited by Gian Marco Petroni
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4246 | Submission Open
Keywords: chronic joint pain; radio frequency ablation; adipose-derived mesenchimal stem cells (ADMScs); intrarticular injection; facet joint injection with ADMScs
(This special issue belongs to the Section Anesthesiology)
Innovations in Perioperative Anesthesia: Advancing Non-Operating Room Anesthesia (NORA) and Regional Techniques
edited by Francesco Coppolino and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4001 | Submission Open
Keywords: perioperative medicine; non-operating room anesthesia (NORA); ultrasound-guided regional anesthesia; fascial plane blocks; postoperative pain management
(This special issue belongs to the Section Anesthesiology)
Recent Developments in Hearing and Balance Disorders: 2nd Edition submission deadline 20 Feb 2026 | 2 articles | Viewed by 3897 | Submission Open
Keywords: ear; otology; audiology; hearing disorders; deafness; hearing loss; autoimmunity; ENT; inflammation; vertigo; imbalance
(This special issue belongs to the Section Otolaryngology)
Surgical Precision: The Impact of AI and Robotics in General Surgery
edited by Tamara M. H. Gall
submission deadline 20 Feb 2026 | 4 articles | Viewed by 3848 | Submission Open
Keywords: robotic surgery; artificial intelligence in surgery; surgical training; AR in surgery; 3D imaging; surgical navigation
(This special issue belongs to the Section General Surgery)
Clinical Progress of Spine Surgery
edited by and Gianluca Vadalà
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3688 | Submission Open
Keywords: spine surgery; rehabilitation; robotic surgery; spinal endoscopy; spinal tumor; back pain; minimally invasive surgery; spinal fusion
(This special issue belongs to the Section Clinical Neurology)
New Perspectives in Acute Coronary Syndrome
edited by Makoto Natsumeda
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3557 | Submission Open
Keywords: acute coronary syndrome; PCI; interventional cardiology; coronary imaging; antiplatelet therapy; stentless PCI strategy; CABG; revascularization
(This special issue belongs to the Section Cardiology)
Colorectal Surgery: Innovative Techniques and Enhanced Patient Outcomes
edited by Filippo Carannante and Leandro Siragusa
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3534 | Submission Open
Keywords: colorectal surgery; minimally invasive techniques; artificial intelligence; perioperative patient management; translational research in coloproctology
(This special issue belongs to the Section General Surgery)
Acute Kidney Events in Intensive Care Patients
edited by Kada Klouche
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3436 | Submission Open
Keywords: acute kidney events; ICU; critically ill; RRT; outcome; acute kidney disease; chronic kidney disease; bi-omarkers
(This special issue belongs to the Section Intensive Care)
Clinical Rehabilitation Update on Alzheimer’s Disease and Dementia submission deadline 20 Feb 2026 | 1 articles | Viewed by 3214 | Submission Open
Keywords: cognition; dementia; rehabilitation; exercise; memory; physical activity; Alzheimer’ s disease; non-pharmacological therapies
(This special issue belongs to the Section Clinical Rehabilitation)
Kidney Transplantation: State of the Art Knowledge
edited by , Georgios Geropoulos and Kyriakos Psarras
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3197 | Submission Open
Keywords: kidney transplantation; end-stage renal disease; immunosuppression; organ donation; graft survival; graft rejection
(This special issue belongs to the Section Nephrology & Urology)
New Insights in the Diagnosis, Treatment and Monitoring of Anemia, Inflammation and Infection submission deadline 20 Feb 2026 | 2 articles | Viewed by 3193 | Submission Open
Keywords: anemia; inflammation; infection; diagnostic tools; therapeutic strategies
(This special issue belongs to the Section Hematology)
Management of Pregnancy Complications: 2nd Edition
edited by Ariel Many
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3155 | Submission Open
Keywords: high-risk pregnancy; preterm labor; fetal growth restriction; gestational diabetes; twins; hypertensive disorders during pregnancy; preeclampsia; IUGR; prenatal genetics; congenital anomaly detection; cesarean section; complications of labor and delivery
(This special issue belongs to the Section Obstetrics & Gynecology)
State of the Art in Invasive Vascular Interventions (Second Edition)
edited by and Luca Mezzetto
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3133 | Submission Open
Keywords: coronary artery interventions; non-coronary artery cardiac interventions; open surgical cardiac procedures; endo-vascular interventions; open surgical vascular procedures
(This special issue belongs to the Section Vascular Medicine)
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