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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Perspectives on Physical Activity and Health in Children and Adolescents
edited by , and Rocío Izquierdo-Gómez
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1252 | Submission Open
Keywords: physical activity; sedentary behavior; health promotion; childhood obesity; well-being; fitness
(This special issue belongs to the Section Clinical Pediatrics)
Advancements in Otitis Media Diagnosis and Management
edited by Sharon Ovnat Tamir and Tal Marom
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1111 | Submission Open
Keywords: otitis media; mastoidectomy for cholesteatoma; vaccines; diagnosis; AI; mastoiditis; artificial intelligence; hearing loss
(This special issue belongs to the Section Otolaryngology)
Innovations in the Treatment for Depression and Anxiety
edited by Lucie Bartova
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1081 | Submission Open
Keywords: depression; anxiety; antidepressant; anxiolytic; psychopharmacotherapy; psychotherapy; brain stimulation; treatment; response; resistance
(This special issue belongs to the Section Mental Health)
New Clinical Advances in Minimally Invasive Cardiac Surgery submission deadline 30 Sep 2025 | 2 articles | Viewed by 1079 | Submission Open
Keywords: minimally invasive cardiac surgery; valve surgery; coronary artery bypass grafting; heart failure management; surgical techniques
(This special issue belongs to the Section Cardiology)
New Advances in Musculoskeletal Physiotherapy: Exercise, Manual Therapy and Invasive Physiotherapy
edited by and Ignacio Cancela-Cilleruelo
submission deadline 30 Sep 2025 | 1 articles | Viewed by 948 | Submission Open
Keywords: musculoskeletal disorders; exercise therapy; manual therapy; invasive physical therapy; rehabilitation
(This special issue belongs to the Section Orthopedics)
Pediatric Sleep-Disordered Breathing
edited by Audrey Yoon
submission deadline 30 Sep 2025 | 1 articles | Viewed by 921 | Submission Open
Keywords: pediatric sleep-disordered breathing; growth modification; pediatric obstructive sleep apnea; interdisciplinary management; craniofacial development; obstructive sleep disorders; cognitive behavioral sleep medicine; pediatric dental sleep medicine; pediatric sleep surgery
(This special issue belongs to the Section Clinical Pediatrics)
New Progress in Pediatric Orthopedics and Pediatric Spine Surgery
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 801 | Submission Open
Keywords: pediatric spine; scoliosis; clubfoot; flatfoot; developmental dysplasia of the hip; rare diseases
(This special issue belongs to the Section Clinical Pediatrics)
Multiple Sclerosis: Advances in Therapeutic Approaches
edited by Renata Balnytė
submission deadline 30 Sep 2025 | 1 articles | Viewed by 784 | Submission Open
Keywords: multiple sclerosis; disease modifying treatment; immunomodulating teratment; new therapeutic approaches; neuroinflammation; neurodegeneration
(This special issue belongs to the Section Clinical Neurology)
Management of Inflammatory Bowel Disease: A Multidisciplinary Perspective submission deadline 30 Sep 2025 | 1 articles | Viewed by 712 | Submission Open
Keywords: inflammatory bowel disease management; Crohn's disease; ulcerative colitis; patient-centered care; multidisciplinary management; personalized treatment
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Modern Approaches to the Management of Orthopedic Injuries
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 660 | Submission Open
Keywords: orthopedic trauma; surgical integration; trauma management; modern approaches; rehabilitation advances
(This special issue belongs to the Section Orthopedics)
General Orthopedic Surgery: Trends and Prospects
edited by John T. Riehl
submission deadline 30 Sep 2025 | 2 articles | Viewed by 560 | Submission Open
Keywords: general orthopedic surgery; orthopedic trauma; hand; tumor; foot and ankle; spine; sports medicine; arthroplasty
(This special issue belongs to the Section Orthopedics)
Psoriasis in Focus: Current Research, Treatments, and Future Directions
edited by and Josep Riera-Monroig
submission deadline 30 Sep 2025 | 1 articles | Viewed by 534 | Submission Open
Keywords: psoriasis; biologic therapies; immunopathogenesis; precision medicine; comorbidities in psoriasis; psoriatic arthritis; phototherapy; topical treatments; systemic therapies
(This special issue belongs to the Section Dermatology)
Hemodialysis: Clinical Updates and Advances
edited by
submission deadline 30 Sep 2025 | Viewed by 491 | Submission Open
Keywords: hemodiafiltration; medium cut-off membranes; expanded hemodialysis; vascular calcifications; renal anemia; vas-cular access; arterio-venous fistula; anticoagulation; outcomes
(This special issue belongs to the Section Nephrology & Urology)
Chronic Kidney Disease: Clinical Updates and Perspectives, Opportunities and Challenges, 2nd Edition
edited by Botond Csiky
submission deadline 30 Sep 2025 | 1 articles | Viewed by 460 | Submission Open
Keywords: chronic kidney disease progression; cardiovascular risk factors; diabetes mellitus; obesity; kidney transplantation; survival; pathophysiology of CKD; hemodialysis; peritoneal dialysis; metabolic and mineral bone disease
(This special issue belongs to the Section Nephrology & Urology)
Ventricular Tachycardia: Diagnosis, Treatment and Management
edited by Antonio Dello Russo and
submission deadline 30 Sep 2025 | Viewed by 371 | Submission Open
Keywords: ventricular tachycardia; cardiomyopathy; electroanatomical mapping; intracardiac echocardiography (ICE); radiofrequency ablation; pulsed field ablation; catheter ablation
(This special issue belongs to the Section Cardiology)
Emerging Trends in Cervical Spine Surgery
edited by Daniel Hafez, Rory Murphy and Jacob Greenberg
submission deadline 30 Sep 2025 | 1 articles | Viewed by 367 | Submission Open
Keywords: cervical disk arthroplasty; laminoplasty; hybrid fusion; endoscopic cervical foraminotomy; endoscopic cervical laminectomy; cervical myelopathy; MIS cervical spine fusion; robotic/navigated cervical surgery
(This special issue belongs to the Section Orthopedics)
Advances in Structural Heart Diseases
edited by , and Erwan Donal
submission deadline 30 Sep 2025 | 1 articles | Viewed by 357 | Submission Open
Keywords: valvular heart diseases; transcatheter interventions; TEER; LAA closure; ASD closure; interventional echocardiography; multimodality cardiac imaging; three-dimensional echocardiography
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Sarcopenia Research: Clinical Approaches to Muscle Health and Aging
edited by and Helio José Coelho-Júnior
submission deadline 30 Sep 2025 | Viewed by 234 | Submission Open
Keywords: sarcopenia; functional decline; physical performance; muscle strength; muscle assessment; exercise interventions; nutri-tional strategies; adverse outcomes
(This special issue belongs to the Section Orthopedics)
Latest Advances in Thoracic Surgery: 2nd Edition
edited by
submission deadline 30 Sep 2025 | Viewed by 207 | Submission Open
Keywords: lung cancer; surgical oncology; robotic surgery; thoracic surgery; lung diseases; minimally invasive surgery
(This special issue belongs to the Section Respiratory Medicine)
COVID-19 and Endocrine Complications
edited by
submission deadline 30 Sep 2025 | Viewed by 204 | Submission Open
Keywords: adrenal; ACE2; diabetes; gonads; pituitary; SARS-CoV-2; thyroid
(This special issue belongs to the Section Endocrinology & Metabolism)
Sequelae of COVID-19: Clinical to Prognostic Follow-Up submission deadline 30 Sep 2025 | Viewed by 198 | Submission Open
Keywords: COVID-19; post-COVID-19 syndromes; sequelae of COVID-19; pathophysiological pathways; multiorgan sequelae; long-term management of post-COVID-19 syndromes; quality of life; long-term prognosis of COVID-19
(This special issue belongs to the Section Vascular Medicine)
Multidisciplinary Approach to the Diagnosis and Treatment of Temporomandibular Disorders: Patient Care Challenges—2nd Edition submission deadline 30 Sep 2025 | Viewed by 191 | Submission Open
Keywords: multidisciplinary approach; mental health; bruxism; masticatory muscles; temporomandibular joint; orofacial pain; temporomandibular disorders
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Hepatobiliary and Pancreatic (HPB) Surgery: Current Status and Future Perspectives
edited by Andrea Benedetti Cacciaguerra and Paolo Vincenzi
submission deadline 30 Sep 2025 | Viewed by 190 | Submission Open
Keywords: hepatobiliary and pancreatic surgery; laparoscopic surgery; robot-assisted surgery; artificial intelligence; augmented reality; indocyanine green; liver tumors; pancreatic tumors
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
State of the Art in Management of Aortic Aneurysm in Vascular Surgery
edited by Rana O. Afifi and Eanas Yassa
submission deadline 30 Sep 2025 | Viewed by 169 | Submission Open
Keywords: aortic dissection; complex aortic surgery; endovascular aortic repair; aortic imaging; aortic aneurysm
(This special issue belongs to the Section Vascular Medicine)
New Advances in Retinal Diseases
edited by
submission deadline 30 Sep 2025 | Viewed by 165 | Submission Open
Keywords: retinal diseases; advanced imaging; biomarkers; diabetic retinopathy; macular degeneration; artificial intelligence; clinical outcomes
(This special issue belongs to the Section Ophthalmology)
Imaging and Surgery in Endometriosis—Recent Advances submission deadline 30 Sep 2025 | Viewed by 163 | Submission Open
Keywords: robotic-assisted surgery; MR imaging; radiomics; transvaginal ultrasound; deep endometriosis; ovarian endometriosis; fluorescence-guided surgery; artificial intelligence; adhesions in endometriosis; infertility; classification systems
(This special issue belongs to the Section Obstetrics & Gynecology)
Latest Advances in Ocular Surface Diseases
edited by Barbara Burgos-Blasco
submission deadline 30 Sep 2025 | Viewed by 144 | Submission Open
Keywords: cornea; keratitis; ocular surface disease; dry eye; corneal ulcer; keratoplasty; conjunctival disease
(This special issue belongs to the Section Ophthalmology)
Thrombosis and Haemostasis: Clinical Advances
edited by Hui Yin Lim
submission deadline 30 Sep 2025 | Viewed by 138 | Submission Open
Keywords: venous thrombosis; biomarkers; bleeding; direct oral anticoagulants; pulmonary embolism; factor XI inhibitors; factor XII inhibitors; endovascular treatment
(This special issue belongs to the Section Vascular Medicine)
Clinical Diagnosis and Therapeutic Approaches for Acute and Chronic Coronary Syndromes
edited by Rocco Antonio Montone
submission deadline 30 Sep 2025 | Viewed by 136 | Submission Open
Keywords: coronary artery disease; clinical diagnosis; therapeutic approaches; atherosclerosis; risk factors; percutaneous cor-onary intervention; acute coronary syndrome; MINOCA; INOCA
(This special issue belongs to the Section Cardiology)
Modern Concepts on Acoustic Neuroma
edited by Alessia Rubini and Davide Soloperto
submission deadline 30 Sep 2025 | Viewed by 130 | Submission Open
Keywords: neurotology; neurosurgery; vestibular schwannoma; acoustic neuroma; middle cranial fossa approach; retrosigmoid approach; translabirynthine approach; gammaknife; wait and scan policy
(This special issue belongs to the Section Otolaryngology)
Systemic Autoimmune Disorder with Pulmonary Involvement: Novel Insights from Underlying Mechanisms of Drug Development and Intervention
edited by
submission deadline 30 Sep 2025 | Viewed by 129 | Submission Open
Keywords: rheumatic diseases; pulmonary involvement; connective tissue disorders; systemic autoimmune disorders (SARDs); diagnosis; innovative treatments
(This special issue belongs to the Section Respiratory Medicine)
Risk Prediction in Mechanical Circulatory Support (MCS) and Cardiac Transplantation
edited by
submission deadline 30 Sep 2025 | Viewed by 125 | Submission Open
Keywords: advanced heart failure; mechanical circulatory support (MCS); cardiac transplantation; heart transplantation; risk prediction
(This special issue belongs to the Section Cardiology)
Breast Cancer: Advances in Clinical and Personalized Practices
edited by Massimo Lodi and Sébastien Molière
submission deadline 30 Sep 2025 | Viewed by 123 | Submission Open
Keywords: breast cancer; radiology; surgical oncology; breast reconstruction; personalized medicine; quality of life; multidisci-plinary approach; new technologies
(This special issue belongs to the Section Oncology)
Esophageal and Upper Interventional Endoscopy and Surgery: Latest Advances and Prospects
edited by Giulia Gibiino
submission deadline 30 Sep 2025 | Viewed by 121 | Submission Open
Keywords: gastric preneoplastic and neoplastic lesions; endoscopic submucosal dissection (ESD); endoscopic full-thickness resection (EFTR); subepithelial upper GI lesions; duodenal adenomas; esophageal stenting
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Myeloid-Derived Suppressor and Innate Immune Cells in Hematologic, Malignant and Chronic Diseases
edited by
submission deadline 30 Sep 2025 | Viewed by 105 | Submission Open
Keywords: myeloid-derived suppressor cells (MDSCs); macrophages; monocytes; eosinophils; neutrophils; malignancy; cancer; autoimmunity; infection; chronic inflammation; therapeutic target; biomarker; precision medicine; molecular pathways; bone marrow microenvironment
(This special issue belongs to the Section Hematology)
Advances in Treatment and Prognosis for Acute Type A and Type B Aortic Dissections
edited by
submission deadline 30 Sep 2025 | Viewed by 103 | Submission Open
Keywords: acute aortic dissection; stent graft; false lumen expansion; thoracic endovascular aortic repair; initial surgery for Type A acute aortic dissection; frozen elephant trunk
(This special issue belongs to the Section Cardiovascular Medicine)
Gastrointestinal Perforations: Diagnosis and Management to Reduce Morbidity and Mortality
edited by
submission deadline 30 Sep 2025 | Viewed by 98 | Submission Open
Keywords: gastrointestinal perforation; diagnosis; surgery; acute peritonitis; sepsis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Minimally Invasive Evolutions in Advanced Oncologic Visceral Surgery
edited by
submission deadline 30 Sep 2025 | Viewed by 82 | Submission Open
Keywords: minimally invasive; oncologic surgery; robotic; laparoscopic; outcome
(This special issue belongs to the Section Oncology)
Clinical Advances in Cartilage Repair and Regeneration
edited by Akira Tsujii and Kazunori Shimomura
submission deadline 1 Oct 2025 | 1 articles | Viewed by 1450 | Submission Open
Keywords: cartilage; regenerative therapy; stem cell therapy; scaffold; orthobiologics; osteoarthritis
(This special issue belongs to the Section Orthopedics)
Targeted Diagnosis and Treatment of Maladaptive Developmental Trajectories and Psychopathological Manifestations in Children and Adolescents
edited by , Andrea Baroncelli and Valeria Giostra
submission deadline 1 Oct 2025 | 1 articles | Viewed by 749 | Submission Open
Keywords: maladaptive developmental trajectories; developmental psychopathology; predictors and correlates of distress in children and adolescents; new forms of social-emotional difficulties and distress; clinical and social interventions and preventions; cognitive; affective; expressive and social improvement of children and adolescents; conduct problems; evidence-based practices; early interventions
(This special issue belongs to the Section Mental Health)
Urinary Tract Infection: Current Treatment and Future Options
edited by
submission deadline 1 Oct 2025 | Viewed by 480 | Submission Open
Keywords: urinary tract infections (UTIs); antibiotic resistance; probiotics and alternative therapies; diagnostic advancements; urinary infection management
(This special issue belongs to the Section Nephrology & Urology)
Point of Care Sonography, an Essential Tool for Anesthesiology and Acute Care
edited by and Se-Chan Kim
submission deadline 1 Oct 2025 | Viewed by 333 | Submission Open
Keywords: ultrasound; anesthesia; acute care; critical care; regional anesthesia; vascular access; lung ultrasound; echocardiography; gastric ultrasound; point of care
(This special issue belongs to the Section Anesthesiology)
Mitral Valve Surgery: Current Status and Future Challenges
edited by Antonio Lio and Marco Russo
submission deadline 5 Oct 2025 | 8 articles | Viewed by 7136 | Submission Open
Keywords: mitral valve; mitral valve repair; mitral valve replacement; minimally invasive surgery; robotic surgery
(This special issue belongs to the Section Cardiology)
Endovascular Surgery: State of the Art and Clinical Perspectives
edited by and Francesco Squizzato
submission deadline 9 Oct 2025 | 1 articles | Viewed by 592 | Submission Open
Keywords: complex aortic endovascular repair; aortic arch endovascular surgery; endoleaks; PMEG; spinal cord ischemia; endograft-related adverse events
(This special issue belongs to the Section Vascular Medicine)
Current Measures for Diagnosis, Monitoring, and Outcome Assessment in Orthopedics, Traumatology, and Hand Surgery submission deadline 10 Oct 2025 | 8 articles | Viewed by 12454 | Submission Open
Keywords: clinical evaluation; hand surgery; orthopaedics; performance-based measures; physical examination; reliability; traumatology
(This special issue belongs to the Section Orthopedics)
Prevention and Sports Rehabilitation
edited by Sergio Hernandez-Sanchez and
submission deadline 10 Oct 2025 | 3 articles | Viewed by 9717 | Submission Open
Keywords: musculoskeletal pain; sport injury; therapeutic exercise; physiotherapy; load management; psychosocial; quality of life; prevention
(This special issue belongs to the Section Sports Medicine)
Breast Cancer: Clinical Diagnosis and Personalized Therapy
edited by
submission deadline 10 Oct 2025 | 6 articles | Viewed by 6826 | Submission Open
Keywords: breast cancer; imaging biomarkers; molecular biomarkers; precision medicine; loco-regional treatment; breast surgery; breast radiotherapy
(This special issue belongs to the Section Oncology)
Neurosurgery and Spine Surgery: From Up-to-Date Practitioners, 2nd Edition submission deadline 10 Oct 2025 | 5 articles | Viewed by 4180 | Submission Open
Keywords: neurosurgery; spine surgery; surgical techniques; research; advances; patient outcomes; interdisciplinary collaboration; healthcare; medical innovation; clinical practices
(This special issue belongs to the Section Clinical Neurology)
Pediatric Obesity: Causes, Prevention and Treatment
edited by
submission deadline 10 Oct 2025 | 2 articles | Viewed by 2939 | Submission Open
Keywords: 1000 first days of life; childhood obesity; lipids; healthy lifestyle; fetal programming
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Practice Guidelines for the Treatment and Management of Peripartum Depression, 2nd Edition
edited by
submission deadline 10 Oct 2025 | 1 articles | Viewed by 2658 | Submission Open
Keywords: peripartum depression; early detection; clinical health psychology; psychotherapy interventions; parental– infant well-being
(This special issue belongs to the Section Mental Health)
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