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New Clinical Perception of Cardiac Rehabilitation
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New Clinical Perception of Cardiac Rehabilitation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Rehabilitation".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 2634

Special Issue Editors

Prof. Dr. Antonello D’Andrea

E-Mail Website
Guest Editor
Department of Cardiology, "Umberto I" Hospital, 84014 Nocera Inferiore, SA, Italy
Interests: advanced cardiovascular imaging; CMR; echocardiography; cardiovascular emergencies
Special Issues, Collections and Topics in MDPI journals
Dr. Mario Pacileo

E-Mail Website
Guest Editor
Unit of Cardiology and Intensive Coronary Care, "Umberto I" Hospital, 84014 Nocera Inferiore, Italy
Interests: cardiovascular; acute coronary syndrome; atherosclerosis; echocardiography; myocardial infarction; heart failure; cardiovascular disease; cardiac rehabilitation

Special Issue Information

Dear Colleagues,

We invite you and members of your research group to submit an article for a Special Issue titled “New Clinical Perception of Cardiac Rehabilitation”.

Cardiac rehabilitation (CR) has evolved significantly since its inception in the mid-20th century, when it was primarily focused on exercise for post-myocardial infarction patients. Today, CR is recognized as a comprehensive, multidisciplinary approach integrating medical evaluation, physical activity, lifestyle modification, and psychosocial support to improve cardiovascular outcomes.

This special issue will redefine and expand the clinical understanding of cardiac rehabilitation by incorporating recent innovations, personalized care strategies, and digital health technologies. It will highlight the evolving role of CR in preventive cardiology and chronic disease management. Cutting-edge research featured will explore topics such as remote and home-based CR programs, AI-driven monitoring tools, integrative mental health interventions, and the role of CR in heart failure and non-traditional populations.

We request original research, clinical reviews, and perspectives that offer novel insights, address current gaps, and/or propose new models of care in cardiac rehabilitation.

Prof. Dr. Antonello D’Andrea
Dr. Mario Pacileo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac rehabilitation
  • digital health
  • exercise therapy
  • cardiovascular prevention
  • chronic disease management
  • psychosocial support
  • personalized medicine

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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18 pages, 553 KB  
Article
Analysis of a Real-World Population Participating in a Cardiac Rehabilitation Program: Cognitive Impairment, Functional Capacity, and Therapy Titration
by Nicola Virtuoso, Francesca Palmieri, Francesco Loria, Antonio Squillante, Carmine Izzo, Martino Fortunato, Floriana Fiorentino, Emilio Sparano, Alessandro De Luca, Ilaria Fucile, Costantino Mancusi, Ornella Ferrigno, Cristina Gatto, Maria Rosaria Rusciano, D. William Molloy, Guido Iaccarino, Albino Carrizzo, Giorgia Bruno, Carmine Vecchione, Michele Ciccarelli and Valeria Viscoadd Show full author list remove Hide full author list
J. Clin. Med. 2026, 15(4), 1413; https://doi.org/10.3390/jcm15041413 - 11 Feb 2026
Viewed by 660
Abstract
Background: Cardiac rehabilitation (CR) is a fundamental pillar in the therapeutic pathway of patients with cardiovascular disease, contributing significantly to improving quality of life and reducing the risk of cardiovascular event recurrence. Over the past decades, this approach has progressively evolved, integrating multidisciplinary [...] Read more.
Background: Cardiac rehabilitation (CR) is a fundamental pillar in the therapeutic pathway of patients with cardiovascular disease, contributing significantly to improving quality of life and reducing the risk of cardiovascular event recurrence. Over the past decades, this approach has progressively evolved, integrating multidisciplinary strategies based on scientific evidence. This study aimed to conduct a detailed analysis of the anthropometric, clinical, and functional characteristics of patients enrolled in the CR Unit of the San Giovanni di Dio and Ruggi D’Aragona University Hospital in Salerno, with particular attention to therapeutic changes, drug titration, and cognitive assessment. Methods: Specifically, the anthropometric, clinical, laboratory, and instrumental data of 95 patients (age 66.56 ± 0.99 years, 75% male) who underwent the CR program between 2023 and 2025 were analyzed. Results: Patients with various diagnoses were enrolled in the CR program: 17% heart failure, 18% cardiac surgery, 20% acute coronary syndrome, 16% chronic coronary syndrome, 29% dyspnea. The patients had numerous comorbidities and risk factors: 73% arterial hypertension, 77% dyslipidemia, 35% diabetes mellitus, 33% smoking, 13% thyroid dysfunction, 47% CAD, 18% CKD, 16% COPD. At baseline, Cardiopulmonary exercise test (CPET) showed a moderately reduced functional capacity (VO2 peak pre-CR: 14.29 ± 0.53 mL/min/kg; VO2% predicted pre-CR: 62.19 ± 2.43%), and a significant improvement was recorded in meters at 6 min walk test (6MWT) post-CR (pre-CR: 306.02 ± 9.93 m vs. post-CR: 378.88 ± 13.37 m; p < 0.05). Notably, 22% of patients had a Qmci score < 49.4 points, indicating an MCI. Finally, the cardiovascular therapy was titrated and adapted; specifically, we recorded a significant increase in the use of SGLT2i therapy (pre-RC 22.00% vs. post-RC 34.00%; p < 0.05). Conclusions: In conclusion, CR proved to be safe and effective in enrolled patients; further studies will be needed to investigate the therapeutic modifications implemented during CR programs in more detail. Full article
(This article belongs to the Special Issue New Clinical Perception of Cardiac Rehabilitation)
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Review

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18 pages, 951 KB  
Review
Return to Work After a Cardiovascular Event: The Central Role of Cardiac Rehabilitation
by Mario Pacileo, Francesco Giallauria, Gianluigi Cuomo, Giuseppe Vallefuoco, Alfredo Mauriello, Vincenzo Russo and Antonello D’Andrea
J. Clin. Med. 2026, 15(5), 2019; https://doi.org/10.3390/jcm15052019 - 6 Mar 2026
Viewed by 899
Abstract
Background: Return to work (RTW) after acute coronary syndrome (ACS) or acute heart failure (HF) is a pivotal outcome reflecting functional recovery and quality of life (QoL). While survival after cardiac events has improved through reperfusion and guideline-directed pharmacotherapy, sustainable RTW depends on [...] Read more.
Background: Return to work (RTW) after acute coronary syndrome (ACS) or acute heart failure (HF) is a pivotal outcome reflecting functional recovery and quality of life (QoL). While survival after cardiac events has improved through reperfusion and guideline-directed pharmacotherapy, sustainable RTW depends on an integrated set of clinical, psychological, social, and occupational determinants. Objective: This study aimed to synthesize and expand the evidence on predictors of RTW, delineate practical workload-matching rules using METs and CPET, and position multidisciplinary cardiac rehabilitation (CR) as the bridge from clinical recovery to durable vocational reintegration. Key findings: Beyond left ventricular ejection fraction (LVEF), depression, anxiety, illness perceptions, and RTW self-efficacy are robust predictors of vocational outcomes. CPET-guided exercise prescriptions and MET-based job matching ensure adequate metabolic reserve; sustained task demand should remain at ≤35–40% of maximal capacity, with peak capacity ≥2× average job demand. CR (Class IA in the 2023 ESC ACS Guidelines) improves exercise tolerance, medication adherence, psychosocial well-being, and deployment of vocational support, including stepwise reintegration plans and ergonomic adaptations. Telerehabilitation extends monitoring and counseling into the workplace and maintains adherence after RTW. Conclusions: Comprehensive CR that integrates exercise training, psychosocial counseling, lifestyle modification, and vocational interventions offers the most effective pathway to stable RTW, improved QoL, and reduced socio-economic burden. Early identification of vulnerable subgroups and personalized, digitally supported follow-up are essential for long-term job retention. Full article
(This article belongs to the Special Issue New Clinical Perception of Cardiac Rehabilitation)
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9 pages, 379 KB  
Review
Cardiac Rehabilitation After Left Ventricular Assist Device Implantation: A Narrative Review
by Rita Gravino, Luigi Falco, Dario Catapano, Cristiano Amarelli, Fabio Valente, Marina Verrengia, Claudio Marra, Emilio Di Lorenzo, Pierino Di Silverio, Michelle Kittleson and Daniele Masarone
J. Clin. Med. 2026, 15(3), 1089; https://doi.org/10.3390/jcm15031089 - 30 Jan 2026
Viewed by 730
Abstract
Over the past decade, given safety, reduced heart failure-related hospitalizations, and, above all, 5-year mortality rates nearly identical to those of heart transplants, left ventricular assist devices (LVADs) have increasingly become a treatment option for patients with advanced heart failure. However, improvements in [...] Read more.
Over the past decade, given safety, reduced heart failure-related hospitalizations, and, above all, 5-year mortality rates nearly identical to those of heart transplants, left ventricular assist devices (LVADs) have increasingly become a treatment option for patients with advanced heart failure. However, improvements in functional capacity after LVAD implantation are minimal or modest, depending on pre-implantation right ventricular function, the patient’s hemodynamic status, the optimization of guideline-directed medical therapy, and noncardiac factors (physical deconditioning, skeletal muscle alterations, anemia, and alterations in alveolar gas exchange). Therefore, cardiac rehabilitation (CR) is a fundamental element from the early stages after LVAD implantation, as it is not only safe but also highly effective, leading to improved functional capacity and fewer episodes of worsening heart failure, and may be associated with reduced mortality. To perform safe and effective CR in patients with LVADs, it is crucial to account for the unique issues in this group. This includes the difficulty of detecting an arterial pulse with standard tools during CPR and the importance of closely monitoring the transmission line and LVAD controller to prevent unintended damage. Overall, the clinical trial indicates that exercise-based CR has the potential to improve functional capacity. Furthermore, some data suggest that CR is associated with fewer HF-related hospitalizations and may be linked to lower mortality; however, there is no consensus on this matter, partly because most studies supporting this assertion are observational. Full article
(This article belongs to the Special Issue New Clinical Perception of Cardiac Rehabilitation)
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