Cardiometabolic Insights into Metabolic Dysfunction: From Mechanisms to Therapeutic Strategies

Dear Colleagues,

Over the past decade, the parallel rise of obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease has been mirrored by a sharp increase in cardiovascular complications. A growing body of experimental and clinical data suggests that these conditions converge on shared inflammatory, metabolic, and profibrotic circuits capable of undermining myocardial integrity long before overt heart disease appears.

This Special Issue seeks to clarify those converging pathways and to translate emerging knowledge into earlier diagnosis and more precise therapy. We welcome manuscripts that probe underlying mechanisms, introduce or validate novel imaging and biomarker platforms, or test interventional strategies—pharmacological, procedural, or lifestyle-based—designed to lessen cardiometabolic risk. Original investigations, robust methodological papers, and critical, up-to-date reviews that draw on the combined expertise of cardiology, endocrinology, and hepatology will all be considered.

Dr. Alessandro Andreis
Dr. Guglielmo Beccuti
Dr. Angelo Armandi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.