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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Colorectal Surgery: Current Concept and Emerging Trends
edited by
submission deadline 20 Mar 2027 | Viewed by 363 | Submission Open
Keywords: colorectal surgery; robotic surgery; neoadjuvant treatment; minimally invasive techniques; enhanced recovery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Optimizing Outcomes in Pancreato-Biliary Care: Integrating Technology, Technique, and Personalized Approaches
edited by
submission deadline 20 Mar 2027 | Viewed by 343 | Submission Open
Keywords: pancreato-biliary care; pancreatic diseases; biliary diseases; hepato-pancreato-biliary (HPB) surgery; interventional endoscopy; interventional radiology; minimally invasive surgery; EUS-guided procedures; ERCP; personalized care/personalized medicine; multidisciplinary care; clinical outcomes; robotics and AI in PB care
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Exercise and Chronic Pain
edited by Nuria Marín-Jiménez and Milkana Borges-Cosic
submission deadline 20 Mar 2027 | Viewed by 321 | Submission Open
Keywords: chronic pain; exercise therapy; physical activity; fitness; pain management; quality of life; non-pharmacological interventions
(This special issue belongs to the Section Sports Medicine)
Game-Changing Advances in Minimally Invasive Spine Surgery
edited by Rouzbeh Motiei-Langroudi
submission deadline 20 Mar 2027 | Viewed by 279 | Submission Open
Keywords: minimally invasive spine surgery (MISS); technological innovation; navigation systems/robotic-assisted; endoscopic techniques; artificial intelligence/machine learning
(This special issue belongs to the Section Clinical Neurology)
Head and Neck Surgery: Immunotherapy’s Role in Shaping Treatment Paradigms
edited by
submission deadline 20 Mar 2027 | Viewed by 276 | Submission Open
Keywords: head and neck surgery; otorhinolaryngology; ENT; transoral surgery; laryngeal surgery; laryngeal carcinoma; sinonasal surgery; oral cancer; oropharyngeal cancer; laryngectomy; immunotherapy; head and neck cancer; cutaneous cancer
(This special issue belongs to the Section Otolaryngology)
Advances in Mental Health: All Ages and Multidisciplinary Clinical Perspectives
edited by Clara González-Sanguino and
submission deadline 20 Mar 2027 | Viewed by 229 | Submission Open
Keywords: stigma; discrimination; mental health; clinical psychology; depression and anxiety
(This special issue belongs to the Section Mental Health)
Clinical Physical Therapy: Current Advances and Future Challenges submission deadline 20 Mar 2027 | Viewed by 206 | Submission Open
Keywords: clinical physical therapy; chronic musculoskeletal disorders; chronic pain management; manual therapy; mind–body medicine; biopsychosocial model; autoimmune diseases; fatigue syndromes; bottom-up and top-down regulation; neurophysiological mechanisms
(This special issue belongs to the Section Clinical Rehabilitation)
Therapies for Heart Failure: Clinical Updates and Perspectives: 2nd Edition
edited by Cristina Tudoran, Stela Iurciuc and
submission deadline 20 Mar 2027 | Viewed by 193 | Submission Open
Keywords: mechanisms of heart failure; new therapies for heart failure; chronic and acute heart failure; new approaches to managing heart failure patients; special populations; clinical outcome
(This special issue belongs to the Section Cardiology)
Recent Advances in Clinical Perspectives on the Diagnosis and Treatment of Endometriosis
edited by Paweł Basta and
submission deadline 20 Mar 2027 | Viewed by 190 | Submission Open
Keywords: endometriosis; deep endometriosis; endometrioma; infertility; laparoscopy; minimally invasive techniques; biomarkers; pain; pelvic pain; adenomyosis; adhesions; dysmenorrhea; dyspareunia
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Updates in Type 2 Diabetes and Related Complications
edited by
submission deadline 20 Mar 2027 | Viewed by 188 | Submission Open
Keywords: type 2 diabetes; chronic complications; microvascular disease; macrovascular disease; treatment
(This special issue belongs to the Section Endocrinology & Metabolism)
Advancing Precision Care in Neuropathic Pain: From Biomarkers to Neuromodulation to Artificial Intelligence
edited by Saurabh Kataria and
submission deadline 20 Mar 2027 | Viewed by 188 | Submission Open
Keywords: neuropathic pain; precision medicine; neuromodulation; spinal cord stimulation; peripheral nerve stimulation; ul-trasound-guided interventions; pain phenotyping; personalized therapeutics; opioid alternatives
(This special issue belongs to the Section Clinical Neurology)
Psychosis Across Disciplines: Emerging Perspectives in Neuroscience, Psychiatry, and Therapy
edited by Inmaculada Peñuelas-Calvo, Roberto Rodríguez-Jiménez and
submission deadline 20 Mar 2027 | Viewed by 186 | Submission Open
Keywords: psychosis; lifespan; neuroimaging; psychotherapy; prevention
(This special issue belongs to the Section Mental Health)
Clinical Challenges and Advances in Hepatobiliary and Pancreatic Surgery submission deadline 20 Mar 2027 | Viewed by 162 | Submission Open
Keywords: pancreatic cancer; pancreatic cancer surgery; neoadjuvant chemotherapy; perioperative management; surgical approaches
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The State of the Art in Robotic Thoracic Surgery: Innovation, Complexity and Outcomes
edited by Michael Zervos
submission deadline 20 Mar 2027 | Viewed by 159 | Submission Open
Keywords: thoracic surgery; robotic surgery; single-port robotic surgery; robotic-assisted thoracic surgery; minimally invasive surgery; lung cancer
(This special issue belongs to the Section General Surgery)
Developmental Transfusion Biology in Neonatal–Perinatal Medicine
edited by Thomas G. Brune
submission deadline 20 Mar 2027 | Viewed by 140 | Submission Open
Keywords: neonatal transfusion; preterm infants; fetal hemoglobin; cord blood; delayed cord clamping; oxygen transport; developmental hematology
(This special issue belongs to the Section Clinical Pediatrics)
Dentistry and Oral Surgery: Current Status and Future Prospects, 2nd Edition submission deadline 20 Mar 2027 | Viewed by 132 | Submission Open
Keywords: dentistry; oral surgery; dental implantology; prosthodontics; restorative dentistry; periodontology; digital dentistry; computer-guided surgery; artificial intelligence
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Diagnostic and Interventional Radiology: Advances in Treatment of Small Tumors
edited by Carolina Lanza
submission deadline 20 Mar 2027 | Viewed by 94 | Submission Open
Keywords: interventional radiology; MRI; contrast-enhanced ultrasound; CT; liver; kidney; lung; prostate; breast; multimodal imaging; diagnostic imaging; tumor
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Sarcopenia: Prevention and Treatment Options
edited by Steven Phu
submission deadline 21 Mar 2027 | 4 articles | Viewed by 2186 | Submission Open
Keywords: sarcopenia; skeletal muscle; ageing; falls; frailty; exercise; rehabilitation; nutrition
(This special issue belongs to the Section Geriatric Medicine)
Clinical Research on Robot-Assisted Thoracic Surgery and Lung Surgery
edited by Marco Scarci
submission deadline 21 Mar 2027 | 1 articles | Viewed by 1046 | Submission Open
Keywords: robot-assisted thoracic surgery; robotic lung surgery; minimally invasive surgery; lobectomy; segmentectomy; thoracic oncology; surgical outcomes; learning curve; clinical research; robotic technology
(This special issue belongs to the Section General Surgery)
Macular Diseases: From Diagnosis to Treatment
edited by
submission deadline 22 Mar 2027 | 3 articles | Viewed by 3131 | Submission Open
Keywords: age-related macular degeneration; retinal vascular diseases; intraocular tumours; retinal imaging; OCT; OCT angiography; anti-VEGF; laser therapy; macular surgery; gene therapy; biomarkers; progression; intravitreal injections; biomarkers
(This special issue belongs to the Section Ophthalmology)
Psychological Affliction in Pregnancy, Delivery and Postpartum Period: A Multidisciplinary Approach submission deadline 24 Mar 2027 | 4 articles | Viewed by 3420 | Submission Open
Keywords: maternal mental health; pregnancy; postpartum depression; perinatal anxiety; midwifery; multidisciplinary care
(This special issue belongs to the Section Mental Health)
Rewriting Metastatic Colorectal Cancer Management: Innovative Frontiers in Clinical Diagnosis and Personalized Oncology submission deadline 24 Mar 2027 | Viewed by 422 | Submission Open
Keywords: molecular profiling; liquid biopsy; targeted therapy; immunotherapy; biomarkers treatment; sequencing; tumor heterogeneity; personalized medicine
(This special issue belongs to the Section Oncology)
Emergency Surgery: Clinical Updates and Key Insights
edited by
submission deadline 24 Mar 2027 | Viewed by 158 | Submission Open
Keywords: minimally invasive emergency surgery; biomarkers; point-of-care imaging (POCI); frailty assessment; surgical decision-making; risk stratification; damage control surgery; enhanced recovery (ERAS); patient outcomes; multidisciplinary care
(This special issue belongs to the Section Emergency Medicine)
Advances in Perioperative Care: Challenges and Perspectives in Enhanced Recovery After Surgery, Perioperative Optimization and Prehabilitation: 2nd Edition
edited by and María Rodríguez Pérez
submission deadline 25 Mar 2027 | 8 articles | Viewed by 11699 | Submission Open
Keywords: perioperative care; enhanced recovery after surgery; prehabilitation; minimally invasive surgery; patient-related outcome measures; colorectal surgery; general surgery; thoracic surgery; vascular surgery; optimal functional recovery
(This special issue belongs to the Section General Surgery)
Contemporary Trends in Cardiovascular Prevention
edited by Alessandro Durante and
submission deadline 25 Mar 2027 | 3 articles | Viewed by 9431 | Submission Open
Keywords: interventional cardiology; coronary artery disease; carotid artery disease; aortic valve disease; left atrial appendage closure; hypercholesterolemia
(This special issue belongs to the Section Cardiovascular Medicine)
Obstructive Sleep Apnea: Advances in Clinical Diagnosis and Management
edited by
submission deadline 25 Mar 2027 | 7 articles | Viewed by 9326 | Submission Open
Keywords: obstructive sleep apnea; sleep disorder breathing; central apnea; apnea–hypopnea index; precision medicine
(This special issue belongs to the Section Respiratory Medicine)
Acute Trauma and Trauma Care in Orthopedics: 2nd Edition submission deadline 25 Mar 2027 | 11 articles | Viewed by 8856 | Submission Open
Keywords: orthopedics; trauma; injury; musculoskeletal; surgery; knee; osteoarthritis; spinal deformity; fracture; joint replacement; hip fractur; fragility fracture; minimally invasive surgery; post-traumatic care and rehabilitation; pain management; emergency assessment
(This special issue belongs to the Section Orthopedics)
Thoracic Surgery: Updates and New Trends
edited by
submission deadline 25 Mar 2027 | 6 articles | Viewed by 7960 | Submission Open
Keywords: minimally invasive surgery; new technology; diagnosis; bronchoscopy; robotic system; artificial intelligence
(This special issue belongs to the Section Respiratory Medicine)
Sleep Disorders: Current Research and Future Directions—Second Edition
edited by Martina Vendrame
submission deadline 25 Mar 2027 | 6 articles | Viewed by 7077 | Submission Open
Keywords: obstructive sleep apnea; parasomnia; idiopathic hypersomnia; periodic limb movement disorder; periodic limb move-ment of sleep
(This special issue belongs to the Section Clinical Neurology)
Update on Acute Severe Respiratory Infections: 2nd Edition submission deadline 25 Mar 2027 | 7 articles | Viewed by 6821 | Submission Open
Keywords: acute severe respiratory infection (ASRI); acute respiratory distress syndrome (ARDS); severe pneumonia; sepsis; ICU; viral respiratory infection; COVID-19; bacterial co-infection; diagnostic technology; treatment strategy; mechanical ventilation; extracorporeal membrane oxygenation (ECMO); antibiotics; non-antibiotics; pulmonary rehabilitation
(This special issue belongs to the Section Respiratory Medicine)
Recent Clinical Perspective in Kidney Transplantation
edited by Nikolina Bašić-Jukić
submission deadline 25 Mar 2027 | 7 articles | Viewed by 6755 | Submission Open
Keywords: kidney transplantation; outcomes; desensitization; xenotransplantation; transplant nephropathology; multiorgan transplantations; post-transplant complications; inequities in transplantation
(This special issue belongs to the Section Nephrology & Urology)
Pregnancy and Delivery Complications: Bridging Research and Clinical Practice
edited by , Andrei Mihai Malutan and Răzvan Ciortea
submission deadline 25 Mar 2027 | 5 articles | Viewed by 6582 | Submission Open
Keywords: maternal–fetal medicine; obstetric complications; perinatal health; pelvic floor disorders; childbirth perineal trauma; risk stratification; patient-reported outcomes; patient-reported outcome measures
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Diagnosis and Management of Corneal Diseases
edited by , and Panagiota Ntonti
submission deadline 25 Mar 2027 | 4 articles | Viewed by 6233 | Submission Open
Keywords: corneal imaging; corneal disease diagnosis; corneal therapeutics; regenerative corneal treatments; artificial intelligence in corneal diagnostics; corneal cross-linking; lamellar keratoplasty
(This special issue belongs to the Section Ophthalmology)
Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications
edited by , Tilo Kölbel and José Ignacio F. Torrealba
submission deadline 25 Mar 2027 | 8 articles | Viewed by 5874 | Submission Open
Keywords: aortic aneurysm; aortic dissection; genetic aortic disease; acute aortic syndromes; endovascular repair; complica-tions; outcomes
(This special issue belongs to the Section Vascular Medicine)
Novel Developments in Dental and Oral Surgery submission deadline 25 Mar 2027 | 4 articles | Viewed by 5483 | Submission Open
Keywords: guided bone regeneration; dental implant osseointegration; laser dentistry; maxillofacial reconstruction; sinus lift techniques
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Prenatal Diagnosis and Fetal Therapy
edited by
submission deadline 25 Mar 2027 | 4 articles | Viewed by 4829 | Submission Open
Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations
(This special issue belongs to the Section Obstetrics & Gynecology)
Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine: 2nd Edition
edited by
submission deadline 25 Mar 2027 | 4 articles | Viewed by 4778 | Submission Open
Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Obesity in the 2020s and Beyond: A Multidisciplinary Overview
edited by
submission deadline 25 Mar 2027 | 2 articles | Viewed by 4545 | Submission Open
Keywords: obesity; anti-obesity pharmacotherapy; clinical pharmacology; pharmacovigilance; cardiometabolic diseases
(This special issue belongs to the Section Pharmacology)
Clinical Strategies for Preventing Healthcare-Associated Infections submission deadline 25 Mar 2027 | 3 articles | Viewed by 3963 | Submission Open
Keywords: healthcare-associated infections; multidrug resistance; prevention; screening scales; polymicrobial infections; oppor-tunistic infections; sepsis
(This special issue belongs to the Section Infectious Diseases)
Endoscopic Management of Pancreaticobiliary Diseases
edited by
submission deadline 25 Mar 2027 | 4 articles | Viewed by 3469 | Submission Open
Keywords: pancreaticobiliary endoscopy; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); biliary drainage; gallbladder drainage; lumen-opposing metal stents; cholangioscopy; pancreatoscopy; confocal laser endomicroscopy; pancreatic cysts; molecular diagnostics; lithotripsy (electrohydraulic and laser); radiofrequency ablation (RFA); photodynamic therapy (PDT); pancreatic and biliary tumors; interventional endoscopy; altered anatomy access; diagnostic and therapeutic endoscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Latest Advances in Minimally Invasive Spine Surgery
edited by Fabian Sommer and
submission deadline 25 Mar 2027 | 2 articles | Viewed by 2011 | Submission Open
Keywords: minimally invasive spine surgery (MISS); advances in spine surgery; future directions of MISS; navigation and orientation; intramedullary/extramedullary tumor resections; emerging technologies in MISS (robotics, augmented reality, artificial intelligence, etc.); degenerative spine; patient safety in MISS
(This special issue belongs to the Section Clinical Neurology)
New Advances in Hip and Knee Reconstructive Surgery: 2nd Edition
edited by Senthil Sambandam
submission deadline 25 Mar 2027 | 2 articles | Viewed by 1988 | Submission Open
Keywords: knee; hip; joint arthroplasty; minimally invasive surgery; revision arthroplasty; periprosthetic joint infection; muscle injury; joint alignment; surgical advances; osteotomy; fracture; robotic-assisted surgery; perioperative optimization; telerehabilitation; aseptic loosening
(This special issue belongs to the Section Orthopedics)
Clinical Applications of Echocardiographic Techniques in Cardiovascular Diagnostics
edited by Gianpiero Italiano and
submission deadline 25 Mar 2027 | 3 articles | Viewed by 1708 | Submission Open
Keywords: echocardiography; cardiovascular diagnostics; 3D echocardiography; strain imaging; speckle-tracking echocardi-ography; valvular heart disease; heart failure; interventional echocardiography; stress echocardiography; car-dio-oncology; artificial intelligence
(This special issue belongs to the Section Cardiovascular Medicine)
Corneal Surgery: From Innovation to Clinical Practice
edited by Joanna Wasielica-Poslednik
submission deadline 25 Mar 2027 | 1 articles | Viewed by 1587 | Submission Open
Keywords: keratoplasty; penetrating keratoplasty; DMEK; eye banking; corneal surgery
(This special issue belongs to the Section Ophthalmology)
Treatment and Clinical Management of Necrotizing Pancreatitis submission deadline 25 Mar 2027 | 2 articles | Viewed by 1431 | Submission Open
Keywords: necrotizing pancreatitis; infected necrosis; step-up approach; necrosectomy; minimally invasive surgery; artificial intelligence; lumen-apposing metal stent; pancreatic necrosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Segmentectomy and Lobectomy in Early-Stage Lung Cancer Management
edited by Yujin Kudo
submission deadline 25 Mar 2027 | 1 articles | Viewed by 1289 | Submission Open
Keywords: lung cancer; segmentectomy; lobectomy; thoracic surgery; early-stage NSCLC; oncologic outcomes; pulmonary function; surgical planning
(This special issue belongs to the Section Respiratory Medicine)
Exercise for Healthy Aging: Clinical Physiology, Functional Outcomes, and Implications for Clinical Practice submission deadline 25 Mar 2027 | 1 articles | Viewed by 1127 | Submission Open
Keywords: exercise; healthy aging; functional independence; mitochondrial adaptations; physical activity interventions; neuromuscular function; cardiorespiratory fitness; metabolic health; biomarkers of aging
(This special issue belongs to the Section Sports Medicine)
Innovations in Elbow and Shoulder Surgery: Techniques, Outcomes, and Rehabilitation
edited by Andrea Celli
submission deadline 25 Mar 2027 | 2 articles | Viewed by 998 | Submission Open
Keywords: orthopedic; elbow surgery; shoulder surgery; infection; nonunion; malunion; ligaments injuries; tendon injuries; el-bow and shoulder replacement; arthroscopy
(This special issue belongs to the Section Orthopedics)
Motor Activity and Cognitive Development in Early Childhood: Clinical Implications submission deadline 25 Mar 2027 | Viewed by 554 | Submission Open
Keywords: motor activity; cognitive development; early childhood; neurodevelopmental disorders; autism spectrum disorder; attention-deficit/hyperactivity disorder; developmental coordination disorder; preterm birth
(This special issue belongs to the Section Clinical Neurology)
Minimally Invasive Approaches in Hand Surgery: Optimizing Outcomes and Minimizing Complications
edited by
submission deadline 25 Mar 2027 | 1 articles | Viewed by 458 | Submission Open
Keywords: percutaneous technique; ultrasound-guided procedures; arthroscopic management; robotic surgery in the hand and upper extremity; hand surgery
(This special issue belongs to the Section Orthopedics)
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