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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Artificial Intelligence (AI) and Deep Learning (DL) in Medical Imaging

edited by

Francesco Pucciarelli

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5859 | Submission Open

Keywords: artificial intelligence; deep learning; imaging; diagnosis; precision medicine; oncologic

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Endodontic Disease: Prevalence, Risk Factors, and Treatment Outcome

edited by

Razvan Ionut Ghinea

Ioana-Sofia Pop-Ciutrilă

and

Luminita-Maria Nica

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5618 | Submission Open

Keywords: endodontics; apical periodontitis; pulpitis; root canal treatment; risk factors; treatment outcomes; regenerative endodontics

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Eating Disorders: Current Epidemiology and Advances in Diagnosis and Treatment—Second Edition

edited by

Arthur Eumann Mesas

submission deadline 20 Jan 2026 | 4 articles | Viewed by 5580 | Submission Open

Keywords: eating disorder; bulimia nervosa; anorexia nervosa; binge eating disorder; sociocultural context; epidemiology; di-agnosis; treatment; prevention

(This special issue belongs to the Section Mental Health)

Microsurgery: Current and Future Challenges

edited by

Matthias Aitzetmüller-Klietz

submission deadline 20 Jan 2026 | 5 articles | Viewed by 5384 | Submission Open

Keywords: microsurgery; reconstruction; reconstructive surgery; breast reconstruction; extremity reconstruction

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Insights into Pediatric Critical Care

edited by Katherine Biagas and Daniel E Sloniewsky

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5009 | Submission Open

Keywords: PICU; anemia; blood transfusion; critically ill children; traumatic hemorrhage

(This special issue belongs to the Section Intensive Care)

Allergen-Specific Immunotherapy (AIT) for Allergic Diseases of the Respiratory Tract and Food Allergies

edited by

Ralph Mösges

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4902 | Submission Open

Keywords: allergy; allergic rhinitis; allergic conjunctivitis; allergic asthma; food allergy; peptide immunotherapy; allergoids; SLIT; SCIT; OIT

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Advances in Autoimmune Disorders

edited by

Chiara Pellicano

and

Edoardo Rosato

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4778 | Submission Open

Keywords: systemic sclerosis; Raynaud’ s phenomenon; digital ulcers; scleroderma renal crisis; pulmonary arterial hypertension; interstitial lung disease; fibrosis

(This special issue belongs to the Section Immunology & Rheumatology)

Sarcopenia Across the Lifespan: Risk Factors, Mechanisms, and Management in Aging and Disease

edited by

Juan Mielgo-Ayuso

and

Natalia Busto

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4664 | Submission Open

Keywords: sarcopenia; aging; chronic disease; risk factors; muscle physiology; prevention; nutrition; exercise; treatment strategies

(This special issue belongs to the Section Orthopedics)

Sustaining Success Through Innovation in Kidney Transplantation

edited by Junji Uchida

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4475 | Submission Open

Keywords: kidney transplantation; long-term graft survival; immunosuppression; organ shortage; post-transplant complication

(This special issue belongs to the Section Nephrology & Urology)

Recent Clinical Research on Nonalcoholic Fatty Liver Disease: 2nd Edition

edited by Gerond V. Lake-Bakaar

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4411 | Submission Open

Keywords: NAFLD; NASH; cirrhosis; hepatocellular carcinoma; hepatitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Management of Cardiogenic Shock and Cardiac Arrest: 2nd Edition

edited by Jaime A. Hernández-Montfort

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4342 | Submission Open

Keywords: cardiogenic shock; cardiac arrest; temporary mechanical circulatory support; ECMO; transitions; heart recovery; heart replacement

(This special issue belongs to the Section Cardiology)

Long COVID and Cardiovascular Health: Clinical Perspectives on Risk and Management

edited by Mariana Tudoran and

Cristina Tudoran

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4321 | Submission Open

Keywords: long COVID; cardiovascular disease; long COVID therapy; management of long COVID; mechanisms of long COVID

(This special issue belongs to the Section Cardiovascular Medicine)

Emerging Treatment Options in Inflammatory Bowel Disease

edited by

Sandro Ardizzone

and Roberta Maselli

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4115 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; biologics; small molecule therapies; personalized medicine; therapeutic drug monitoring; immunology; gut microbiome; clinical practice; endoscopic mucosal resection (EMR); endoscopic submucosal dissection (ESD); endoscopic balloon dilation and endoscopic stent placement; chromoendoscopy; confocal laser endomicroscopy; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Sports Injuries: Recent Advances in Prevention and Rehabilitation, 2nd Edition

edited by

Stasinopoulos Dimitrios

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4002 | Submission Open

Keywords: sports injuries; treatment; musculoskeletal disorders; rehabilitation; physical rehabilitation; exercise science; sports science; injury prevention

(This special issue belongs to the Section Sports Medicine)

Advances and Trends in Pediatric Surgery

edited by

Nikolaos Zavras

and

Anastasia Dimopoulou

submission deadline 20 Jan 2026 | 4 articles | Viewed by 3782 | Submission Open

Keywords: pediatric surgery; minimally invasive surgery; robotics; trends; advances

(This special issue belongs to the Section Clinical Pediatrics)

Current Situation and Challenges of Endovascular Treatment Strategies for Acute Ischemic Stroke

edited by

Fusao Ikawa

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3778 | Submission Open

Keywords: acute ischemic stroke; endovascular treatment; imaging; management of ischemic stroke; system and strategy for acute ischemic stroke; multidisciplinary approach for acute ischemic stroke

(This special issue belongs to the Section Clinical Neurology)

Clinical Application of Radiotherapy in Modern Oncology

edited by

Lukas Käsmann

and

Fabian Weykamp

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3726 | Submission Open

Keywords: brain metastasis; bone metastasis; brain tumors; head and neck cancers; thoracic oncology; breast cancer; prostate cancer; sarcoma

(This special issue belongs to the Section Oncology)

Insights and Innovations in Sports Cardiology

edited by

Garyfallia K. Pepera

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3691 | Submission Open

Keywords: sports cardiology; athlete heart; cardiovascular screening; arrhythmias; sudden cardiac death; cardiac rehabilitation; exercise prescription; mobile health; preventive cardiology; personalized medicine; pediatric fitness

(This special issue belongs to the Section Sports Medicine)

Current and Emerging Therapies for Rheumatoid Arthritis

edited by

Yoshiro Horai

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3484 | Submission Open

Keywords: DMARDs (disease-modifying anti-rheumatic drugs); boDMARDs (biological DMARDs); bsDMARDs (biosimilar DMARDs); csDMARDs (conventional synthetic DMARDs); rheumatoid arthritis; tsDMARDs (targeted synthetic DMARDs)

(This special issue belongs to the Section Immunology & Rheumatology)

Advances in the Treatment of Glaucoma and Ocular Hypertension

edited by Ahnul Ha

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3318 | Submission Open

Keywords: glaucoma; ocular hypertension; intraocular pressure (IOP); minimally invasive glaucoma surgery (MIGS); artificial intelligence (AI); neuroprotection; meta-analysis

(This special issue belongs to the Section Ophthalmology)

Advanced Diagnostic and Therapeutic Strategies for Sarcoidosis

edited by

Małgorzata Sobiecka

and

Monika Szturmowicz

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3208 | Submission Open

Keywords: sarcoidosis; cardiac sarcoidosis; pulmonary fibrosis; magnetic resonance imaging; FDG-PET/CT; echocardiography; neurosarcoidosis; differential diagnosis; hypercalcaemia; IGRA; sarcoidosis-associated pulmonary hypertension; fatigue; corticosteroids; metotrexat; infliximab; antifibrotic treatment; lung transplantation; artificial intelligence; broncho-alveolar lavage; cytokines

(This special issue belongs to the Section Respiratory Medicine)

Advances in Tuberculosis: Comprehensive Insights and Management Strategies

edited by Aliaksandr Skrahin

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2726 | Submission Open

Keywords: pulmonary and extra-pulmonary tuberculosis (TB); TB epidemiology; TB screening; TB prevention; TB diagnostics; TB treatment; TB co-infections (e.g.; HIV; Hepatitis B and C); TB co-morbidities (e.g.; diabetes); host and Mycobacteria genetic; molecular mechanisms and genotype/phenotype correlations

(This special issue belongs to the Section Infectious Diseases)

Glaucoma Surgery: Current Challenges and Future Perspectives

edited by

Tina Tzee Ling Wong

and

Esther M. Hoffmann

submission deadline 20 Jan 2026 | 4 articles | Viewed by 2531 | Submission Open

Keywords: glaucoma; filtration surgery; trabeculectomy; MIGS; scarring; anti-metabolites; wound healing; anti-fibrotics

(This special issue belongs to the Section Ophthalmology)

Acute Myocardial Infarction: Diagnosis, Treatment, and Rehabilitation

edited by

Francesca Giordana

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2519 | Submission Open

Keywords: acute myocardial infarction; coronary angioplasty; acute heart failure; cardiogenic shock; rehabilitation programs

(This special issue belongs to the Section Cardiovascular Medicine)

Endometriosis: Diagnosis and Treatment

edited by

Camran R. Nezhat

and

Ceana Nezhat

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2234 | Submission Open

Keywords: endometriosis; diagnosis; video laparoscopy with and without robotic assistance; chronic pelvic pain; fertility preservation; minimally invasive surgery; biomarkers; artificial intelligence in endometriosis; adenomyosis; and adenomyoma care; multidisciplinary care; personalized medicine

(This special issue belongs to the Section Obstetrics & Gynecology)

Artificial Intelligence (AI) in Dental Clinical Practice

edited by

Eiji Tanaka

and Keiichiro Watanabe

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1327 | Submission Open

Keywords: artificial intelligence; dental diagnostics; machine learning; deep learning; digital dentistry; clinical decision support; diagnostic automation; data transparency; evidence-based dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes

edited by Ivan Krečak, Marko Skelin and Zinaida Perić

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1297 | Submission Open

Keywords: myeloproliferative neoplasms; myelodysplastic syndromes; treatment; risk stratification; prognosis

(This special issue belongs to the Section Hematology)

Neuro-Cardiology: An Obligation for Combined Care of Stress and Heart Diseases

edited by Mario J. Garcia and

Fatih Yalcin

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1266 | Submission Open

Keywords: neuro-cardiology; cardiovascular; segmental remodeling; stressors; hypertension; triple S

(This special issue belongs to the Section Cardiology)

Cardiac and Pulmonary Involvements in High-Risk Neonatal Cohorts: Short- and Long-Term Issues

edited by Arvind Sehgal

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1163 | Submission Open

Keywords: fetal growth restriction; lung disease; cardiac maladaptation; placenta; public health; neurodevelopment; long term; adulthood; Barker’ s hypothesis; newborn; vascular

(This special issue belongs to the Section Clinical Pediatrics)

Cardiac Arrest Research: Neuroprognostication and Improving Outcomes

edited by

Jae Hoon Lee

and Jin-hong Min

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1154 | Submission Open

Keywords: cardiac arrest; prognosis; hypothermia; induced; resuscitation; magnetic resonance imaging; electroencephalography; blood pressure; hypoxia-ischemia; brain; extracorporeal membrane oxygenation

(This special issue belongs to the Section Cardiovascular Medicine)

Idiopathic Pulmonary Fibrosis (IPF): Current Perspectives and Future Directions

edited by Vito D’Agnano

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1107 | Submission Open

Keywords: pulmonary fibrosis; IPF; ILD; antifibrotics; EMT; respiratory physiology; metabolism

(This special issue belongs to the Section Respiratory Medicine)

Current Practice and Future Perspectives on Laryngeal Surgery

edited by

Eugenia Allegra

and

Maria Rita Bianco

submission deadline 20 Jan 2026 | 1 articles | Viewed by 954 | Submission Open

Keywords: laryngeal disorders; laryngeal surgery; microsurgery; endoscopic surgery; open surgery; laser surgery

(This special issue belongs to the Section Otolaryngology)

New Perspectives in Chronic Kidney Disease, Transplantation and Immune System

edited by

Maria Daoudaki

and Dimitrios A. Tsakiris

submission deadline 20 Jan 2026 | 1 articles | Viewed by 947 | Submission Open

Keywords: kidney transplantation; HLA; matching at the epitope level; DSAs; complement; kidney disease epigenetics; diabetic nephropathy; hemostasis; graft rejection; B and T cell immunophenotyping; end stage renal disease

(This special issue belongs to the Section Nephrology & Urology)

Aortic Valve Disease: Current Evolution and Future Opportunities

edited by Gianluigi Perri

submission deadline 20 Jan 2026 | 1 articles | Viewed by 916 | Submission Open

Keywords: aortic valve disease; aortic valve repair; Ross procedure; aortic valve replacement; diagnosis of aortic valve disease

(This special issue belongs to the Section Cardiology)

Clinical Advances in Prenatal Diagnosis and Fetal Therapy

edited by

Mar Bennasar

submission deadline 20 Jan 2026 | 1 articles | Viewed by 850 | Submission Open

Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations

(This special issue belongs to the Section Obstetrics & Gynecology)

Rehabilitation and Treatment of Post-COVID-19 Condition

edited by

Indre Bileviciute-Ljungar

submission deadline 20 Jan 2026 | 1 articles | Viewed by 840 | Submission Open

Keywords: post-COVID-19 condition; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); comorbidities; interdisciplinary; multimodal; digital medicine; rehabilitation; treatment; health-related quality of life; disability; return to work

(This special issue belongs to the Section Clinical Rehabilitation)

Multiple Myeloma: Therapeutic and Management Strategies

edited by Terri Parker

submission deadline 20 Jan 2026 | 1 articles | Viewed by 824 | Submission Open

Keywords: multiple myeloma; frontline treatment; monoclonal antibodies; sequencing of treatment; immunotherapy; CAR T; Bi-specific T cell engagers; toxicity management

(This special issue belongs to the Section Hematology)

Shaping Modern Gastroenterology: Bridging Advancements in Digestive Endoscopy and Clinical Research

edited by Manuele Furnari and Stefano Kayali

submission deadline 20 Jan 2026 | 1 articles | Viewed by 813 | Submission Open

Keywords: digestive endoscopy; gastrointestinal disorders; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); therapeutic endoscopy; artificial intelligence; pancreatic and biliary diseases; small bowel pathology; early neoplastic lesions; inflammatory bowel diseases (IBDs); translational gastroenterology; endoscopic submucosal dissection (ESD); per-oral endoscopic myotomy (POEM); endoscopic imaging; gastrointestinal pathophysiology

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Obesity-Related Metabolic and Cardiovascular Disorders

edited by

Lucia Frittitta

and Federica Vinciguerra

submission deadline 20 Jan 2026 | 1 articles | Viewed by 751 | Submission Open

Keywords: obesity; type 2 diabetes mellitus; insulin resistance; metabolic syndrome; cardiovascular disease; lipid disorder; adipose tissue dysfunction; visceral adiposity; cardiometabolic risk; endothelial dysfunction; health disparities; gut microbiota; bariatric surgery; precision medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Cardiopulmonary Resuscitation in the Emergency Care Unit

edited by

Martín Otero-Agra

, Felipe Fernández-Méndez,

Myriam Santos-Folgar

and

María Fernández-Méndez

submission deadline 20 Jan 2026 | 1 articles | Viewed by 641 | Submission Open

Keywords: cardiopulmonary resuscitation; advanced life support; new technologies; special circumstances; emergency care unit

(This special issue belongs to the Section Emergency Medicine)

Recent Advances and Future Perspectives of Subarachnoid Hemorrhage

edited by Alexandros Doukas and Athanasios K. Petridis

submission deadline 20 Jan 2026 | 1 articles | Viewed by 627 | Submission Open

Keywords: subarachnoid hemorrhage; neuromonitoring; neurocritical care; neurointerventions; neurointensive care

(This special issue belongs to the Section Clinical Neurology)

Current Status and Future of Urological Surgery

edited by

Filippo Marino

, Davide De Marchi and

Luca Di Gianfrancesco

submission deadline 20 Jan 2026 | 1 articles | Viewed by 585 | Submission Open

Keywords: urological surgery; robotic-assisted surgery; minimally invasive surgery; artificial intelligence; augmented reality; surgical navigation; endourology; laparoscopic urology; reconstructive urology; functional urology; bph treatment; urinary incontinence; prostate cancer surgery; bladder cancer surgery; surgical innovation; digital surgery

(This special issue belongs to the Section Nephrology & Urology)

Cardiometabolic Insights into Metabolic Dysfunction: From Mechanisms to Therapeutic Strategies

edited by Alessandro Andreis,

Guglielmo Beccuti

and

Angelo Armandi

submission deadline 20 Jan 2026 | 1 articles | Viewed by 510 | Submission Open

Keywords: cardiovascular complications; pharmacological; interventional strategies; cardiology; endocrinology; hepatology

(This special issue belongs to the Section Cardiology)

Regional Anesthesia in Pain Management

edited by Jaime L. Baratta

submission deadline 20 Jan 2026 | 1 articles | Viewed by 497 | Submission Open

Keywords: acute pain; perioperative medicine; general anesthesiology; regional anesthesia; orthopedic anesthesia; multimodal analgesia

(This special issue belongs to the Section Anesthesiology)

Clinical Comparisons of Nonpharmaceutical and Pharmaceutical Analgesia

edited by

Sang Hun Kim

and

Yoon Ji Choi

submission deadline 20 Jan 2026 | Viewed by 408 | Submission Open

Keywords: acute pain; chronic pain; postoperative pain; non-pharmaceutical; pharmaceutical; analgesia; clinical

(This special issue belongs to the Section Anesthesiology)

Beyond the Kidney: Managing Chronic Kidney Disease in the Era of Cardio-Metabolic-Kidney Syndrome

edited by

Maria Amicone

and

Antonio Pisani

submission deadline 20 Jan 2026 | Viewed by 365 | Submission Open

Keywords: chronic kidney disease; disease-modifying therapy; physical exercise; cardio-metabolic-kidney syndrome; SGLT2 in-hibitors; MRA; renal nutrition; innovative therapies; low protein diet

(This special issue belongs to the Section Nephrology & Urology)

Clinical Updates and Current Challenges in Obstetrical Anesthesia

edited by Michael Froelich

submission deadline 20 Jan 2026 | Viewed by 361 | Submission Open

Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care

(This special issue belongs to the Section Obstetrics & Gynecology)

Metabolic Dysregulation Across the Spectrum from Anorexia Nervosa to Obesity

edited by Andriana C. Kaliora

submission deadline 20 Jan 2026 | Viewed by 287 | Submission Open

Keywords: metabolic dysregulation; anorexia nervosa; obesity; environmental factors in metabolic health; gut microbiota and metabolism; hormonal regulation of appetite; inflammation and metabolic disorders; dietary influence on metabolism

(This special issue belongs to the Section Endocrinology & Metabolism)

Innovations and Evolution of Extracorporeal Organ Support in Critical Care

edited by