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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances and Challenges in Colorectal Cancer
edited by Vignesh Narasimhan
submission deadline 20 Mar 2026 | Viewed by 60 | Submission Open
Keywords: anal fistula; advancement flap; ‎ ligation of intersphincteric tract; haemorrhoid surgery; pilonidal surgery
(This special issue belongs to the Section Oncology)
Rectal Cancer: Screening, Treatment and Prevention
edited by Fernando Mendoza-Moreno
submission deadline 20 Mar 2026 | Viewed by 47 | Submission Open
Keywords: rectal cancer; cancer screening; neoadjuvant therapy; minimally invasive surgery; oncologic outcomes; multidiscipli-nary care; health disparities
(This special issue belongs to the Section Oncology)
Clinical Updates and Perspectives on Subarachnoid Hemorrhage: 2nd Edition
edited by
submission deadline 20 Mar 2026 | Viewed by 43 | Submission Open
Keywords: subarachnoid hemorrhage; outcome of subarachnoid hemorrhage; delayed cerebral ischemia; ruptured cerebral aneurysm; unruptured cerebral aneurysm; artificial intelligence; epidemiology
(This special issue belongs to the Section Clinical Neurology)
Personalized Medicine and Treatment in Inflammatory Bowel Diseases
edited by Carmen Monica Preda and
submission deadline 21 Mar 2026 | Viewed by 100 | Submission Open
Keywords: personalized medicine; inflammatory bowel diseases (IBDs); Crohn’ s disease; ulcerative colitis; biomarkers; pharmacogenomics; microbiome; anti-TNF therapy; precision medicine; machine learning
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Perspectives on Foot and Ankle Surgery
edited by Kenichiro Nakajima
submission deadline 24 Mar 2026 | 3 articles | Viewed by 7228 | Submission Open
Keywords: foot and ankle; minimally invasive surgery; surgical techniques; new technologies; diagnosis; clinical assessment
(This special issue belongs to the Section Orthopedics)
Orthodontics: Current Advances and Future Options submission deadline 25 Mar 2026 | 23 articles | Viewed by 42773 | Submission Open
Keywords: digital orthodontics; functional devices; cranial growth; orthodontic therapy; customized devices
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Musculoskeletal Disorders: Clinical Diagnosis, Treatment and Rehabilitation submission deadline 25 Mar 2026 | 7 articles | Viewed by 26550 | Submission Open
Keywords: musculoskeletal disorders; therapeutic exercise; functional evaluation; rehabilitation protocols; musculoskeletal ultrasound; biomechanical aná lisis; quality of life; functional assessment of the musculoskeletal system; strength training; physical therapy; morphofunctional assessment; conservative treatments; range of motion evaluation; randomized controlled trials
(This special issue belongs to the Section Clinical Rehabilitation)
New Directions for Treatment and Assessment of Ulcerative Colitis submission deadline 25 Mar 2026 | 4 articles | Viewed by 19243 | Submission Open
Keywords: treatment; ulcerative colitis; treatment target; ultrasound assessment; approach
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advancements in Venous Disease Management: From Conservative to Interventional Treatments
edited by and Chiara Lomazzi
submission deadline 25 Mar 2026 | 2 articles | Viewed by 13314 | Submission Open
Keywords: chronic venous disease; varicose veins; venoactive drugs; saphenous vein; venous stent; iliac vein; compression therapy; venous insufficiency
(This special issue belongs to the Section Vascular Medicine)
New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles
edited by , Serdar Dursun and
submission deadline 25 Mar 2026 | 4 articles | Viewed by 11105 | Submission Open
Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD
(This special issue belongs to the Section Mental Health)
Clinical Management for Metabolic Syndrome and Obesity
edited by and Antonio De Arriba-Muñoz
submission deadline 25 Mar 2026 | 5 articles | Viewed by 10808 | Submission Open
Keywords: obesity; metabolic syndrome; estatosis hepatic; diabetes mellitus; children; GLP-1
(This special issue belongs to the Section Endocrinology & Metabolism)
Current Advances in Aortic Valve Stenosis
edited by
submission deadline 25 Mar 2026 | 6 articles | Viewed by 9834 | Submission Open
Keywords: valvular heart diseases; aortic stenosis; prevention; diagnosis; management
(This special issue belongs to the Section Cardiology)
Advances in Stigma and Discrimination in Pediatric Mental Health submission deadline 25 Mar 2026 | 4 articles | Viewed by 8906 | Submission Open
Keywords: stigma; discrimination; childhood; mental health; clinical psychology
(This special issue belongs to the Section Mental Health)
Innovations and Advances in Breast Cancer Research and Treatment
edited by
submission deadline 25 Mar 2026 | 5 articles | Viewed by 8744 | Submission Open
Keywords: breast cancer; early detection; genomics; personalized medicine; targeted therapies; survivorship; quality of life; artificial intelligence; machine learning; immunotherapy
(This special issue belongs to the Section Oncology)
Airway Management: From Basic Techniques to Innovative Technologies
edited by Kunal Karamchandani and Sheila Nainan Myatra
submission deadline 25 Mar 2026 | 5 articles | Viewed by 7872 | Submission Open
Keywords: airway management; physiologically difficult airway; videolaryngoscopy; esophageal intubation; artificial intelligence
(This special issue belongs to the Section Intensive Care)
Psoriasis and Psoriatic Arthritis: How to Treat in the Era of Biologics and Small Molecule Inhibitors: 3rd Edition submission deadline 25 Mar 2026 | 2 articles | Viewed by 6845 | Submission Open
Keywords: psoriasis; psoriatic arthritis; biologics; small molecule inhibitors; conventional therapies
(This special issue belongs to the Section Dermatology)
Innovations in Head and Neck Surgery
edited by and Giovanni Badiali
submission deadline 25 Mar 2026 | 3 articles | Viewed by 6729 | Submission Open
Keywords: reconstructive surgery; head and neck surgery; 3D printing; new technologies; virtual surgical planning; computer-assisted surgery; personalized reconstructive surgery; patient-specific implants; augmented reality; artificial intelligence; robotic surgery; surgical navigation
(This special issue belongs to the Section Otolaryngology)
Biomarkers and Diagnostics in Neurological Diseases
edited by Maria Ioanna Stefanou
submission deadline 25 Mar 2026 | 5 articles | Viewed by 6520 | Submission Open
Keywords: biomarkers; neurological diseases; diagnosis; lipoprotein(a); neurofilament protein; tau peptide; neuroimaging
(This special issue belongs to the Section Clinical Neurology)
Cardiac Surgery: Clinical Advances
edited by Carmelo Dominici, Giovanni Casali and
submission deadline 25 Mar 2026 | 5 articles | Viewed by 5823 | Submission Open
Keywords: cardiac surgery; surgical innovation; minimally invasive techniques; robotic surgery; personalized medicine; advanced surgical technologies
(This special issue belongs to the Section Cardiology)
Clinical Advances in Valvular Heart Diseases
edited by
submission deadline 25 Mar 2026 | 3 articles | Viewed by 5749 | Submission Open
Keywords: prosthetic heart valve; heart valve pathophysiology; structural heart valve interventions; echocardiographic assessment; cardiovascular imaging; valvular heart disease; valvular regurgitation; valvular stenosis
(This special issue belongs to the Section Cardiology)
Aortic Aneurysms: Recent Advances in Diagnosis and Treatment
edited by Marco Virgilio Usai, Giuseppe Asciutto and Michele Piazza
submission deadline 25 Mar 2026 | 5 articles | Viewed by 5329 | Submission Open
Keywords: aortic aneurysms; abdominal aortic; thoraco-abdominal aortic aneurysms (TAAAs); complex aortic anatomies; endovascular abdominal aortic aneurysm repair (EVAR); endovascular thoracic aortic aneurysm repair (TEVAR); endovascular treatment
(This special issue belongs to the Section Cardiovascular Medicine)
The Current State of Robotic Surgery in Urology submission deadline 25 Mar 2026 | 5 articles | Viewed by 5281 | Submission Open
Keywords: robotic surgery; urology; surgical technique; multi-port; single port; major urological surgery; reconstructive surgery; robot-assisted radical cystectomy; patients’ selection
(This special issue belongs to the Section Nephrology & Urology)
Obstructive Sleep Apnea: Latest Advances and Prospects submission deadline 25 Mar 2026 | 4 articles | Viewed by 5183 | Submission Open
Keywords: obstructive sleep apnea; sleep medicine; myofunctional therapy; sleep surgery; neurostimulation; personalized treatment; biomarkers; adherence; home sleep testing
(This special issue belongs to the Section Otolaryngology)
Multiple Sclerosis and Demyelinating Diseases: Diagnosis, Treatment and Prognosis
edited by Alberto Gajofatto
submission deadline 25 Mar 2026 | 2 articles | Viewed by 4176 | Submission Open
Keywords: multiple sclerosis; neuromyelitis optica; MOG-antibody disease; diagnosis; prognosis; treatment
(This special issue belongs to the Section Clinical Neurology)
Attention-Deficit–Hyperactivity Disorder (ADHD): Bridging Theory and Clinical Application
edited by Rafał R. Jaeschke
submission deadline 25 Mar 2026 | 2 articles | Viewed by 3868 | Submission Open
Keywords: ADHD; emotional dysregulation; diagnosis and assessment; pharmacological and non-pharmacological treatments; neurobiology; comorbidities
(This special issue belongs to the Section Mental Health)
Imaging and Surgery in Endometriosis—Recent Advances submission deadline 25 Mar 2026 | 2 articles | Viewed by 3330 | Submission Open
Keywords: robotic-assisted surgery; MR imaging; radiomics; transvaginal ultrasound; deep endometriosis; ovarian endometriosis; fluorescence-guided surgery; artificial intelligence; adhesions in endometriosis; infertility; classification systems
(This special issue belongs to the Section Obstetrics & Gynecology)
Hepatobiliary and Pancreatic (HPB) Surgery: Current Status and Future Perspectives
edited by Andrea Benedetti Cacciaguerra and Paolo Vincenzi
submission deadline 25 Mar 2026 | 2 articles | Viewed by 3048 | Submission Open
Keywords: hepatobiliary and pancreatic surgery; laparoscopic surgery; robot-assisted surgery; artificial intelligence; augmented reality; indocyanine green; liver tumors; pancreatic tumors
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Acute Care for Traumatic Injuries and Surgical Outcomes: 2nd Edition
edited by Matthias Fröhlich and Michael Caspers
submission deadline 25 Mar 2026 | 3 articles | Viewed by 2867 | Submission Open
Keywords: trauma injuries; orthopedics; polytrauma; emergency care; coagulation disorders; fractures; surgical outcomes; acute care; diagnostic imaging
(This special issue belongs to the Section Emergency Medicine)
Diagnostic and Therapeutic Challenges in Infective Endocarditis
edited by Lorenzo Bertolino
submission deadline 25 Mar 2026 | 2 articles | Viewed by 2585 | Submission Open
Keywords: infective endocarditis; complications; diagnostic challenges; therapeutic approach; epidemiology; clinical correlates
(This special issue belongs to the Section Cardiology)
Hemophilia: Current Trends and Future Directions submission deadline 25 Mar 2026 | 2 articles | Viewed by 2110 | Submission Open
Keywords: hemophilia; prophylaxis; gene therapy; burden of illness; quality of life; patient reported outcomes; hemarthrosis; women and hemophilia
(This special issue belongs to the Section Hematology)
Breast Cancer: Advances in Clinical and Personalized Practices
edited by Massimo Lodi and Sébastien Molière
submission deadline 25 Mar 2026 | 2 articles | Viewed by 2036 | Submission Open
Keywords: breast cancer; radiology; surgical oncology; breast reconstruction; personalized medicine; quality of life; multidisci-plinary approach; new technologies
(This special issue belongs to the Section Oncology)
Intracranial Aneurysms: Diagnostics and Current Treatment
edited by Vincenzo Antonelli and
submission deadline 25 Mar 2026 | 2 articles | Viewed by 2020 | Submission Open
Keywords: neurovascular diseases; aneurysms; vascular malformations; diagnostic imaging; minimally invasive approaches; surgical techniques; endovascular interventions; treatment algorithms; subarachnoid hemorrhage; neurorehabiltation
(This special issue belongs to the Section Clinical Neurology)
Recent Advances in Prenatal Diagnosis and Maternal Fetal Medicine submission deadline 25 Mar 2026 | 1 articles | Viewed by 1918 | Submission Open
Keywords: prenatal; obstetrics; fetal abnormalities; intrauterine treatments; genetic disorders; pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Innovations in Laboratory Medicine to Advance Diagnostic and Improve Patient Outcomes
edited by and
submission deadline 25 Mar 2026 | 2 articles | Viewed by 1694 | Submission Open
Keywords: health equity; laboratory diagnostics; near-patient testing; diagnostic access; underserved patient populations; disparities in healthcare; patient outcome
(This special issue belongs to the Section Clinical Laboratory Medicine)
Advances in Treatment and Prognosis for Acute Type A and Type B Aortic Dissections
edited by
submission deadline 25 Mar 2026 | 2 articles | Viewed by 1468 | Submission Open
Keywords: acute aortic dissection; stent graft; false lumen expansion; thoracic endovascular aortic repair; initial surgery for Type A acute aortic dissection; frozen elephant trunk
(This special issue belongs to the Section Cardiovascular Medicine)
Multidisciplinary Approach to the Diagnosis and Treatment of Temporomandibular Disorders: Patient Care Challenges—2nd Edition submission deadline 25 Mar 2026 | 2 articles | Viewed by 1440 | Submission Open
Keywords: multidisciplinary approach; mental health; bruxism; masticatory muscles; temporomandibular joint; orofacial pain; temporomandibular disorders
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances and Challenges in Laparoscopic Surgery
edited by Leonid Barkhatov
submission deadline 25 Mar 2026 | 1 articles | Viewed by 1115 | Submission Open
Keywords: laparoscopic surgery; minimally invasive surgery; surgical outcomes; oncologic surgery; general surgery; learning curve
(This special issue belongs to the Section General Surgery)
From Hyperfunction to Insufficiency: A Comprehensive Look at Adrenal Disorders
edited by and Patricia Y. Fechner
submission deadline 25 Mar 2026 | 1 articles | Viewed by 870 | Submission Open
Keywords: primary aldosteronism; hypoaldosteronism; hypercortisolism; adrenal insufficiency; autonomous cortisol secretion; cushing syndrome
(This special issue belongs to the Section Endocrinology & Metabolism)
Corneal Surgery: From Innovation to Clinical Practice
edited by Joanna Wasielica-Poslednik
submission deadline 25 Mar 2026 | 1 articles | Viewed by 542 | Submission Open
Keywords: keratoplasty; penetrating keratoplasty; DMEK; eye banking; corneal surgery
(This special issue belongs to the Section Ophthalmology)
Translational Immunology in Clinical Medicine: From Preclinical Insights to Therapeutic Impact
edited by
submission deadline 25 Mar 2026 | 1 articles | Viewed by 534 | Submission Open
Keywords: translational immunology; autoimmune disease; autoinflammatory disease; immune-mediated diseases; oncology; preclinical models; immune efficacy and safety; mechanism of action; immunotoxicity assessment
(This special issue belongs to the Section Immunology & Rheumatology)
Clinical Insights and Advances in Structural Heart Disease
edited by
submission deadline 25 Mar 2026 | 1 articles | Viewed by 423 | Submission Open
Keywords: TAVR; Mitra-Clip; Tri-Clip; Pascal; TricValve; PFO closure; LAAO closure; cardiac CT; cardiac MRI; transoesopha-geal echocardiography
(This special issue belongs to the Section Cardiology)
Latest Advances in Ocular Surface Diseases
edited by Barbara Burgos-Blasco
submission deadline 25 Mar 2026 | Viewed by 254 | Submission Open
Keywords: cornea; keratitis; ocular surface disease; dry eye; corneal ulcer; keratoplasty; conjunctival disease
(This special issue belongs to the Section Ophthalmology)
Myeloid-Derived Suppressor and Innate Immune Cells in Hematologic, Malignant and Chronic Diseases
edited by
submission deadline 25 Mar 2026 | Viewed by 190 | Submission Open
Keywords: myeloid-derived suppressor cells (MDSCs); macrophages; monocytes; eosinophils; neutrophils; malignancy; cancer; autoimmunity; infection; chronic inflammation; therapeutic target; biomarker; precision medicine; molecular pathways; bone marrow microenvironment
(This special issue belongs to the Section Hematology)
Gastrointestinal Perforations: Diagnosis and Management to Reduce Morbidity and Mortality
edited by
submission deadline 25 Mar 2026 | Viewed by 183 | Submission Open
Keywords: gastrointestinal perforation; diagnosis; surgery; acute peritonitis; sepsis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
State of the Art in Clinical Management of Sedation and Anesthesia Challenges
edited by Basavana Goudra
submission deadline 25 Mar 2026 | Viewed by 156 | Submission Open
Keywords: anesthesia; oxygenation; sedative agents; ventilation; airway management
(This special issue belongs to the Section Anesthesiology)
"Visceral Aneurysm" in 2025: Recent Advances and Treatment (Second Edition)
edited by Enrico Maria Marone
submission deadline 25 Mar 2026 | Viewed by 137 | Submission Open
Keywords: visceral aneurysms; vascular surgery; endovascular treatment; lparoscopic surgery; robotic surgery; embolization; flow-diverting stents; covered stents
(This special issue belongs to the Section Vascular Medicine)
Breast MRI: An Update submission deadline 25 Mar 2026 | Viewed by 123 | Submission Open
Keywords: breast cancer; breast imaging; magnetic resonance imaging; diffusion-weighted imaging; contrast-enhanced sequences; artificial intelligence
(This special issue belongs to the Section Obstetrics & Gynecology)
Meibomian Gland Dysfunction and Dry Eye Diseases
edited by and
submission deadline 25 Mar 2026 | Viewed by 110 | Submission Open
Keywords: meibomian gland; meibomian gland dysfunction; dry eye disease; ocular surface; meibography; lipid layer; tear film; inflammation; therapy; diagnosis; epidemiology; clinical study
(This special issue belongs to the Section Ophthalmology)
Endocarditis: Clinical Updates on Diagnosis, Treatment and Management
edited by Katarzyna Holcman
submission deadline 25 Mar 2026 | Viewed by 95 | Submission Open
Keywords: infective endocarditis; PET; SPECT; echocardiography; antimicrobial therapy; cardiac surgery; multimodality imaging
(This special issue belongs to the Section Cardiology)
Osteosarcoma: New Insights into Diagnosis and Treatment
edited by Lars M. Wagner
submission deadline 25 Mar 2026 | Viewed by 94 | Submission Open
Keywords: osteosarcoma; tyrosine kinase inhibitors; immunotherapy; clinical trial design; intratumoral heterogeneity; liquid biopsy; metastasectomy; deep learning; translational research; targeted therapy
(This special issue belongs to the Section Oncology)
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