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Clinical Advances in Valvular Heart Diseases
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Clinical Advances in Valvular Heart Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 2914

Special Issue Editor

Dr. Mohammad Kassar

E-Mail Website
Guest Editor
1. Department of Cardiology, Inselspital Bern, Bern University Hospital, 3012 Bern, Switzerland
2. Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, Universitätsklinik (Ruhr-Universität Bochum), Medizinische Fakultät OWL (Universität Bielefeld), 11 32545 Bad Oeynhausen, Germany
Interests: cardiology; echocardiography; valvular heart disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This is a formal invitation to be part of a new Special Issue of the Journal of Clinical Medicine.

Valvular heart disease (VHD) is an increasing cause of cardiovascular morbidity and mortality worldwide. This overall burden is set to rise as the global population ages and access to diagnostic techniques expands. Fortunately, this challenge is being met by renewed interest from the scientific community in the pathophysiology of valve disease, new potential pharmacotherapeutic agents, and novel surgical and minimally invasive techniques. Advances in imaging, such as 3D echocardiography and cardiac MRI, have improved diagnostic accuracy. Innovative treatments like Transcatheter Aortic Valve Replacement (TAVR) and MitraClip are transforming management, particularly for high-risk patients. Enhanced surgical methods, including minimally invasive and robotic-assisted procedures, offer better outcomes and quicker recovery. The Editors of this Special Issue have collated a series of manuscripts detailing key advancements in the diagnosis, management, and treatment of aortic, mitral, tricuspid, and pulmonary valve diseases, highlighting how the medical community is rising to the challenge of VHD.

Dr. Mohammad Kassar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prosthetic heart valve
  • heart valve pathophysiology
  • structural heart valve interventions
  • echocardiographic assessment
  • cardiovascular imaging
  • valvular heart disease
  • valvular regurgitation
  • valvular stenosis

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Published Papers (3 papers)

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10 pages, 874 KiB  
Article
Left Ventricular and Atrial Function Analysis Following Transcatheter Edge-to-Edge Mitral Valve Repair
by Timor Linder, Doron Sudarsky, Liza Grosman-Rimon, Jordan Rimon, Mony Shuvy and Shemy Carasso
J. Clin. Med. 2024, 13(23), 7282; https://doi.org/10.3390/jcm13237282 - 29 Nov 2024
Viewed by 606
Abstract
Background: Conventional echocardiography used to assess volumes of the left ventricle (LV) and left atrium (LA) along with mitral regurgitation grade is routine in studies before and after transcatheter edge-to-edge mitral valve repair (Mitral TEER). Previous studies focus on LV parameter changes and [...] Read more.
Background: Conventional echocardiography used to assess volumes of the left ventricle (LV) and left atrium (LA) along with mitral regurgitation grade is routine in studies before and after transcatheter edge-to-edge mitral valve repair (Mitral TEER). Previous studies focus on LV parameter changes and comparison of the functions before and a few months following Mitral TEER implantation, as well as LA reverse remodeling, by assessing LV volumes. However, less is known regarding LA strain changes in the early phase after the procedure. The objective of the study was to assess the effect of Mitral TEER on LA strain early after TEER procedure. Methods: The retrospective study included 44 patients who underwent Mitral TEER. LA strain and volumes were evaluated by speckle tracking echocardiography at the baseline and 24–48 h following the procedure. Demographic, echocardiographic, and clinical characteristics were obtained and statistically analyzed. Results: LA global longitudinal strain (GLS) reservoir improved significantly (from 12.2 ± 7 to 14.7 ± 6.4, p = 0.0079) after Mitral TEER. Significant improvements were also seen in LA volumes (LA maximal and minimal volume), which reduced by 17% and 22.5% respectively. LV GLS was significantly changed (from −9.8% to −12.8%, p < 0.0001) following Mitral TEER, whereas LV stroke volume was not significantly different between the baseline and post-Mitral TEER (p = 0.7798). Conclusions: After successful Mitral TEER, there was a very early improvement in LA function. Two-dimensional speckle tracking echocardiography may contribute to our understanding of LA functional changes immediately post-procedure. Full article
(This article belongs to the Special Issue Clinical Advances in Valvular Heart Diseases)
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12 pages, 12855 KiB  
Case Report
Transcatheter Aortic Valve Replacement Reverses Heyde Syndrome: A Case Report of Severe Aortic Stenosis and Gastrointestinal Bleeding
by Claudiu Florin Rășinar, Alexandru Tîrziu, Rebeca Ionela Rășinar, Florin Gîru, Cristian Mornoș, Dan Gaiță, Constantin Tudor Luca and Daniel Miron Brie
J. Clin. Med. 2025, 14(8), 2819; https://doi.org/10.3390/jcm14082819 - 19 Apr 2025
Viewed by 325
Abstract
Background: Heyde syndrome is a rare condition characterized by the triad of severe aortic stenosis, gastrointestinal bleeding, and acquired type 2A von Willebrand syndrome. This case report highlights the diagnostic and therapeutic approach for a 72-year-old woman presenting with exertional chest pain, dyspnea, [...] Read more.
Background: Heyde syndrome is a rare condition characterized by the triad of severe aortic stenosis, gastrointestinal bleeding, and acquired type 2A von Willebrand syndrome. This case report highlights the diagnostic and therapeutic approach for a 72-year-old woman presenting with exertional chest pain, dyspnea, fatigue, and a history of melena. Methods: The diagnostic workup revealed severe microcytic anemia and a reduced vWF ristocetin-to-antigen ratio. Imaging confirmed severe degenerative aortic stenosis, while video capsule endoscopy identified angiodysplasia and telangiectasias in the small bowel as the source of gastrointestinal bleeding. Following evaluation by a multidisciplinary Heart Team, the patient underwent transcatheter aortic valve replacement (TAVR) with an Evolut Fx self-expanding prosthesis. Results: Post-procedural echocardiography showed mild paravalvular regurgitation. The patient’s clinical course was favorable, with resolution of anemia and no further gastrointestinal bleeding episodes. Conclusions: Heyde syndrome requires a high index of suspicion for diagnosis in patients with severe aortic stenosis and unexplained anemia or gastrointestinal bleeding. TAVR offers an effective treatment option that not only resolves valvular pathology, but also mitigates associated bleeding risks. Full article
(This article belongs to the Special Issue Clinical Advances in Valvular Heart Diseases)
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20 pages, 1793 KiB  
Systematic Review
Echocardiographic Assessment of Mitral Valve Prolapse Prevalence before and after the Year 1999: A Systematic Review
by Andrea Sonaglioni, Gian Luigi Nicolosi, Antonino Bruno, Michele Lombardo and Paola Muti
J. Clin. Med. 2024, 13(20), 6160; https://doi.org/10.3390/jcm13206160 - 16 Oct 2024
Cited by 1 | Viewed by 1426
Abstract
Background: Over the last five decades, a fair number of echocardiographic studies have evaluated the prevalence of mitral valve prolapse (MVP) in various cohorts of individuals, including heterogeneous study populations. The present systematic review has been primarily designed to summarize the main findings [...] Read more.
Background: Over the last five decades, a fair number of echocardiographic studies have evaluated the prevalence of mitral valve prolapse (MVP) in various cohorts of individuals, including heterogeneous study populations. The present systematic review has been primarily designed to summarize the main findings of these studies and to estimate the overall MVP prevalence in the general community. Methods: All echocardiographic studies assessing the MVP prevalence in various cohorts of individuals, selected from PubMed and EMBASE databases, were included. There was no limitation of time period. The risk of bias was assessed by using the National Institutes of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Results: The full texts of 21 studies with 1354 MVP individuals out of 63,723 participants were analyzed. The overall pooled prevalence of MVP was 4.9% (range of 0.6–21%). When dividing the studies in two groups according to the echocardiographic criteria used for MVP diagnosis (less specific old criteria or more specific new criteria, respectively), the estimated pooled prevalence of MVP was 7.8% (range of 2–21%) for the older studies (performed between 1976 and 1998) and 2.2% (range of 0.6–4.2%) for the more recent ones (conducted between 1999 and 2021). Potential selection bias, hospital- or referral-based series, and the use of less specific echocardiographic criteria for MVP diagnosis have been indicated as the main reasons for the higher MVP prevalence detected by the older studies. MVP was commonly associated with a narrow antero-posterior thoracic diameter, isolated ventricular premature beats and nonspecific ST-T-wave abnormalities on a resting electrocardiogram, mild-to-moderate mitral regurgitation (MR), the reduced probability of obstructive coronary artery disease, and a low frequency of serious complications, such as severe MR, infective endocarditis, heart failure, stroke, and atrial fibrillation. Conclusions: MVP has a low prevalence in the general population, regardless of age, gender, and ethnicity, and is associated with a good outcome. Full article
(This article belongs to the Special Issue Clinical Advances in Valvular Heart Diseases)
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