Clinical Updates and Perspectives on Subarachnoid Hemorrhage: 2nd Edition
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".
Deadline for manuscript submissions: 20 March 2026 | Viewed by 21
Special Issue Editor
Interests: subarachnoid hemorrhage; outcome of subarachnoid hemorrhage; delayed cerebral ischemia, ruptured cerebral aneurysm; unruptured cerebral aneurysm; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is our pleasure to invite you to contribute to a Special Issue titled “Clinical Updates and Perspectives on Subarachnoid Hemorrhage: 2nd Edition”. This is the second edition of the previous Issue; for more details on the first edition, please visit https://www.mdpi.com/journal/jcm/special_issues/BXB7SI9AA3.
Subarachnoid hemorrhage (SAH) is a severe condition with a mortality rate of approximately 35%. However, unlike ischemic stroke, the treatment outcomes for SAH have not significantly improved. The management of post-SAH brain injury and delayed cerebral ischemia (DCI) remains inadequate. The prognosis of SAH is influenced not only by the neurological severity at onset and surgical outcomes but also by the occurrence of delayed cerebral ischemia. Therefore, improving the treatment of DCI is crucial for enhancing the prognosis of SAH.
The etiology of DCI following SAH involves not only cerebral vasospasm but also primary brain injury, increased intracranial pressure, microcirculatory disturbances, microthrombosis, blood–brain barrier disruption, and cortical spreading ischemia. Therefore, a comprehensive prevention and treatment strategy is essential.
As a treatment for DCI, calcium channel blockers have been used in Western countries; however, supporting evidence remains insufficient. Recently, the efficacy of clazosentan has been reported in Japan, but unfortunately, randomized controlled trials (RCTs) conducted in Western countries failed to confirm its effectiveness. While there is no doubt that clazosentan is effective in preventing cerebral vasospasm, complications such as pulmonary edema have been reported, and no improvement in functional outcomes has been demonstrated. Nevertheless, issues such as postoperative management strategies warrant further investigation.
This Special Issue aims to highlight not only conventional pharmacological therapies but also the latest findings regarding the use and efficacy of emerging therapeutic agents.
Dr. Fusao Ikawa
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- subarachnoid hemorrhage
- outcome of subarachnoid hemorrhage
- delayed cerebral ischemia
- ruptured cerebral aneurysm
- unruptured cerebral aneurysm
- artificial intelligence
- epidemiology
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
