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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Thoracic Radiochemoimmunotherapy for Non-Small Cell Lung Cancer (NSCLC): Evolving Techniques and Clinical Applications

edited by

Franz Zehentmayr

submission deadline 31 Mar 2026 | Viewed by 111 | Submission Open

Keywords: radiotherapy; radiology; oncology; non-small cell lung cancer; real-world data; immunotherapy; radiation dose escalation

(This special issue belongs to the Section Oncology)

Endodontic Diseases: Prevalence, Risk Factors, and Treatment Outcomes

edited by Iris Slutzky-Goldberg, Shlomo Matalon and

Hagay Slutzky

submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open

Keywords: cone beam computed tomography (cbct); diagnostic tools; endodontic therapy; peri-radicular pathologies; regenerative endodontics; risk factors; systemic disease; treatment outcome; vital pulp therapy

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Laser Dentistry: Emerging Therapeutic Concepts

edited by

Satoshi Watanabe

and Risako Mikami

submission deadline 31 Mar 2026 | Viewed by 91 | Submission Open

Keywords: laser dentistry; dental treatment guidelines; refractory endodontic infection; root canal therapy; minimally invasive endodontics; anatomy; cone-beam computed tomography

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Oral Biology: Advances of Translating Experimental Findings into Clinical Dentistry and Oral Medicine

edited by

Andrea Palermo

submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open

Keywords: oral surgery; biomaterials; tissue engineering; regenerative medicine; dentistry dentin graft; growth factors; ad-vances orthodontics; skeletal anchorage with miniscrews; TADS; MADS; MARPE; aligner

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Current Emerging Treatment Options in Atrial Fibrillation

edited by Hoang Nhat Pham and Amitoj Singh

submission deadline 31 Mar 2026 | Viewed by 79 | Submission Open

Keywords: atrial fibrillation; AF ablation; lifestyle intervention; rhythm control; pulsed field ablation; antiarrhythmic drugs; direct oral anticoagulants

(This special issue belongs to the Section Cardiology)

Acute Myocardial Infarction: Diagnosis and Novel Treatment Opportunities

edited by

Danilo Menichelli

and Flavio Giuseppe Biccirè

submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open

Keywords: acute myocardial infarction; atherosclerosis; percutaneous coronary intervention; atherothrombosis; inflammation; dyslipidemia; lipid-lowering therapy

(This special issue belongs to the Section Cardiology)

Glaucoma: Diagnosis and Management Insights

edited by

Stamatios Lampsas

and Eythimios Karmiris

submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open

Keywords: glaucoma; risk factors; progression; novel biomarkers; diagnosis; management

(This special issue belongs to the Section Ophthalmology)

Current Challenges and Updates in Therapeutic Advancements of Prostatectomy

edited by

Luca Lambertini

and

Francesco Lasorsa

submission deadline 31 Mar 2026 | Viewed by 69 | Submission Open

Keywords: radical prostatectomy; robot-assisted surgery; single port; artificial intelligence; complications; same day discharge; learning curve; training models; outcomes

(This special issue belongs to the Section Nephrology & Urology)

New Insights into Cardiovascular Radiology

edited by Amalia Lupi and Riccardo Cau

submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open

Keywords: CMR; tissue characterization; 4Dflow; CCTA; photon counting CT; plaque characterization

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Acute Care Surgery: The Evolution of a Modern Specialty

edited by Mayur Narayan

submission deadline 31 Mar 2026 | Viewed by 63 | Submission Open

Keywords: acute care surgery; emergency surgery; health equity; global surgery; trauma care; surgical workforce; surgical in-novation; decision-making

(This special issue belongs to the Section Emergency Medicine)

Geriatric Diseases: Management and Epidemiology

edited by

Luís Midão

submission deadline 5 Apr 2026 | 9 articles | Viewed by 19596 | Submission Open

Keywords: ageing and health; older care; chronic diseases; preventive health strategies; multidisciplinary approaches; health inequalities; innovation in care; global ageing challenges; epidemiology of ageing; quality of life in older adults

(This special issue belongs to the Section Geriatric Medicine)

Clinical Advances in Inflammatory Bowel Disease: 2nd Edition

edited by

Lorenzo Bertani

submission deadline 5 Apr 2026 | 1 articles | Viewed by 922 | Submission Open

Keywords: inflammatory bowel diseases; IBD; Crohn’ s disease; ulcerative colitis; biomarkers; biologics; anti-JAKs; personalized medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Breaking Barriers in Respiratory Conditions: From Clinical Pathophysiology to Treatment Across the Spectrum of Severity

edited by

Antenor Rodrigues

submission deadline 5 Apr 2026 | Viewed by 119 | Submission Open

Keywords: pulmonary rehabilitation; skeletal muscle; exercise physiology; exercise intolerance; physical activity; respiratory conditions

(This special issue belongs to the Section Respiratory Medicine)

Neurosurgery and Spine Surgery: From Up-to-Date Practitioners, 2nd Edition

edited by

Massimiliano Visocchi

submission deadline 10 Apr 2026 | 7 articles | Viewed by 9576 | Submission Open

Keywords: neurosurgery; spine surgery; surgical techniques; research; advances; patient outcomes; interdisciplinary collaboration; healthcare; medical innovation; clinical practices

(This special issue belongs to the Section Clinical Neurology)

Oral and Maxillofacial Surgery: Recent Clinical Advances and Future Directions

edited by Funda Göker,

Gianluca M. Tartaglia

and

Massimo Del Fabbro

submission deadline 10 Apr 2026 | 2 articles | Viewed by 3977 | Submission Open

Keywords: oral and maxillofacial reconstructive surgery; MRONJ management; temporomandibular joint disorders; sental implants; zygomatic implants; guided surgery; alveolar bone regeneration; maxillofacial deformities; bone regeneration; head and neck cancer

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

COVID-19 and Endocrine Complications

edited by

Kamyar Asadipooya

submission deadline 10 Apr 2026 | 4 articles | Viewed by 1910 | Submission Open

Keywords: adrenal; ACE2; diabetes; gonads; pituitary; SARS-CoV-2; thyroid

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Management of Patients with Heart Failure: 3rd Edition

edited by

Cristina Tudoran

submission deadline 10 Apr 2026 | 1 articles | Viewed by 609 | Submission Open

Keywords: acute heart failure; chronic heart failure; treatment options; management of heart failure; lifestyle changes; diagnosis of heart failure

(This special issue belongs to the Section Cardiovascular Medicine)

Current Updates on Functional Endoscopic Sinus Surgery for Chronic Rhinosinusitis

edited by

Nikolaos Tsetsos

, Georgios Fyrmpas and

Konstantinos Garefis

submission deadline 10 Apr 2026 | Viewed by 122 | Submission Open

Keywords: endoscopic sinus surgery; rhinology; chronic rhinosinusitis management; functional endoscopic sinus surgery (FESS); sinonasal inflammation; transnasal approach; postoperative outcomes

(This special issue belongs to the Section Otolaryngology)

Cesarean Section Versus Vaginal Delivery

edited by

Demetra Gabriela Socolov

Angela Vinturache

and

Liana Ples

submission deadline 10 Apr 2026 | Viewed by 111 | Submission Open

Keywords: cesarean section; vaginal delivery; birth outcomes; birth complications; delivery mode; labor process; obstetric care; trial of labor after cesarean (TOLAC); intrapartum care; obstetric decision-making

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Diagnosis and Treatment for Thymic Pathology

edited by Charalambos Zisis

submission deadline 10 Apr 2026 | Viewed by 62 | Submission Open

Keywords: immunobiology; myasthenia gravis; thymoma; thymic carcinoma; thymic hyperplasia; paraneoplastic disorders; histology; classification; staging; Masaoka; autoimmune disorders

(This special issue belongs to the Section Oncology)

Clinical Therapeutic Innovations in Maternal Fetal Medicine

edited by

Martina Derme

and

Giuseppe Rizzo

submission deadline 10 Apr 2026 | Viewed by 48 | Submission Open

Keywords: maternal-fetal medicine; prenatal screening; artificial intelligence; prenatal imaging; gene therapy

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Management of Skin Cancer: From Pathology Advances to Techniques Applications

edited by Guy Orchard

submission deadline 15 Apr 2026 | 6 articles | Viewed by 18587 | Submission Open

Keywords: skin cancer; surgery; chemotherapy; radiotherapy; photothermal therapy; combination therapy; molecular target strategies

(This special issue belongs to the Section Dermatology)

Clinical Research in Radiation Oncology: Current Status and Future Directions

edited by Paolo Borghetti

submission deadline 15 Apr 2026 | 2 articles | Viewed by 5799 | Submission Open

Keywords: radiation oncology; radiobiology; stereotactic body radiotherapy; multidisciplinary team; integrated treatment; predictive and prognostic biomarkers; cancer treatment

(This special issue belongs to the Section Oncology)

Novel Insights into Neonatal Intensive Care

edited by

Vasilios Giapros

and Maria Baltogianni

submission deadline 15 Apr 2026 | 2 articles | Viewed by 4147 | Submission Open

Keywords: neonatology; neonatal intensive care; neonate; sepsis; nutrition; ventilation; hemodynamic; neurodevelopment

(This special issue belongs to the Section Clinical Pediatrics)

Modern Approaches to the Management of Orthopedic Injuries

edited by

Moshe Salai

submission deadline 15 Apr 2026 | 2 articles | Viewed by 3563 | Submission Open

Keywords: orthopedic trauma; surgical integration; trauma management; modern approaches; rehabilitation advances

(This special issue belongs to the Section Orthopedics)

Diagnosis and Treatment of Sjogren’s Syndrome: 2nd Edition

edited by

Yoshiro Horai

submission deadline 15 Apr 2026 | 1 articles | Viewed by 3197 | Submission Open

Keywords: biological agents; JAK inhibitors; magnetic resonance imaging; noncoding RNA; Sjö gren's syndrome; ultrasound

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Diagnostics and Therapeutic Advances in Pregnancy Complications

edited by

Theresa Reischer

and

Gülen Yerlikaya-Schatten

submission deadline 15 Apr 2026 | 2 articles | Viewed by 1713 | Submission Open

Keywords: prenatal diagnosis; pre-eclampsia; gestational diabetes; pregnancy complications; preterm labor; congenital mal-formations; prenatal genetic testing

(This special issue belongs to the Section Obstetrics & Gynecology)

Oral and Maxillofacial Surgery: Current Trends, Innovations and Techniques

edited by Gabriel Armencea and

Florin Onisor

submission deadline 15 Apr 2026 | Viewed by 1382 | Submission Open

Keywords: maxillofacial; trauma; deformities; cleft lip and palate; OMF surgery; head and neck; head and neck oncology; orthognathic surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Retinal Dystrophies—Structure and Function Relationship

edited by

Katarzyna Nowomiejska

submission deadline 15 Apr 2026 | 2 articles | Viewed by 1081 | Submission Open

Keywords: retinal dystrophies; structural changes; functional impairment; in retinal degenerative diseases; retinitis pigmentosa

(This special issue belongs to the Section Ophthalmology)

Retinal Diseases: Emerging Therapies and Vision Rehabilitation

edited by

Hisanori Imai

submission deadline 15 Apr 2026 | 1 articles | Viewed by 837 | Submission Open

Keywords: vitreoretinal disorder; vitrectomy; digital assisted vitrectomy; intraoperative optical coherence tomography; diabetic retinopathy; epiretinal membrane

(This special issue belongs to the Section Ophthalmology)

Nasopharyngeal Carcinoma: Recent Advances in Clinical Diagnosis and Treatment

edited by

Federico Sireci

submission deadline 15 Apr 2026 | 1 articles | Viewed by 638 | Submission Open

Keywords: nasopharyngeal carcinoma; early diagnosis; radiotherapy advances; immunotherapy; targeted therapy; biomarkers; precision medicine; recurrence and metastasis management

(This special issue belongs to the Section Otolaryngology)

Clinical Advances in the Management of Melanoma

edited by

Kelly M. Mahuron

and

Yan Xing

submission deadline 15 Apr 2026 | 1 articles | Viewed by 545 | Submission Open

Keywords: melanoma immunotherapy; targeted therapy; immune checkpoint inhibitors; melanoma subtypes; adjuvant treatment; neoadjuvant treatment; tumor-infiltrating lymphocytes (TILs) therapy; combination therapy; molecular profiling; bi-omarker-driven therapy; clinical decision-making; liquid biopsy

(This special issue belongs to the Section Dermatology)

Orthopedic Surgery: Latest Advances and Future Prospects—2nd Edition

edited by Andrea Marinozzi and

Biagio Zampogna

submission deadline 15 Apr 2026 | 1 articles | Viewed by 515 | Submission Open

Keywords: custom-made; regenerative; prosthetic; noninvasive surgery; robotic surgery; percutaneous surgery; minimally invasive surgery

(This special issue belongs to the Section Orthopedics)

Advances in Gynecological Diseases (Second Edition)

edited by

Guglielmo Stabile

submission deadline 15 Apr 2026 | 1 articles | Viewed by 425 | Submission Open

Keywords: gynecology; women's health; mini-invasive surgery; laparoscopy; hysteroscopy; diagnostic imaging; gynecological oncology; endometriosis; new therapy; urogynecology; female healthcare

(This special issue belongs to the Section Obstetrics & Gynecology)

Management of Intra-Abdominal Infections: Current Challenges and Perspectives

edited by

Alessandro Pasculli

and Carlo Valicelli

submission deadline 15 Apr 2026 | Viewed by 273 | Submission Open

Keywords: intra-abdominal infection; anastomotic dehiscence; acute cholecystitis; acute appendicitis; acute diverticulitis; infected pancreatic necrosis; secondary peritonitis; tertiary peritonitis; intra-abdominal abscess; peptic ulcer perforation; minimally invasive surgery; surgical endoscopy; antimicrobic stewardship; antibiotic therapy; artificial intelligence

(This special issue belongs to the Section General Surgery)

AI-Enhanced Medical Imaging for Cancer Diagnosis

edited by

Aruni Ghose

Sola Adeleke

and

Stergios Boussios

submission deadline 15 Apr 2026 | Viewed by 178 | Submission Open

Keywords: artificial intelligence; imaging; MRI; precise diagnosis; oncology

(This special issue belongs to the Section Oncology)

Innovations in Parkinson’s Disease

edited by

Sneha Mantri

submission deadline 15 Apr 2026 | Viewed by 140 | Submission Open

Keywords: Parkinson’ s disease; parkinsonism; patient-reported outcomes; wearable technology; disease-modifying therapies; non-pharmacological therapies; care delivery; models of care

(This special issue belongs to the Section Clinical Neurology)

Updates and Advances in Aplastic Anemia and Other Bone Marrow Failures

edited by

Alicia Rovo

, Beatrice Drexler and Olaia Naveiras

submission deadline 15 Apr 2026 | Viewed by 109 | Submission Open

Keywords: aplastic anemia; severe aplastic anemia (SAA); bone marrow failures; paroxysmal nocturnal hemoglobinuria (PNH); inherited bone marrow failures

(This special issue belongs to the Section Hematology)

Cardiac Amyloidosis and Heart Failure: Clinical Pathophysiology, Diagnosis, and Therapeutic Strategies

edited by Ilaria Dentamaro and

Laura Fusini

submission deadline 15 Apr 2026 | Viewed by 104 | Submission Open

Keywords: cardiology; cardiac heart failure; cardiac amyloidosis; cardiac imaging; cardiomyopathy

(This special issue belongs to the Section Cardiology)

Current and Future Trends in Otorhinolaryngology–Head and Neck Surgery: 2nd Edition

edited by

Konstantinos Chaidas

submission deadline 15 Apr 2026 | Viewed by 99 | Submission Open

Keywords: otorhinolaryngology; head and neck; innovation; diagnosis; treatment; surgery

(This special issue belongs to the Section Otolaryngology)

Heart Transplantation: Surgery Updates and Complications

edited by Nicola Pradegan

submission deadline 15 Apr 2026 | Viewed by 88 | Submission Open

Keywords: donor heart optimization; antibody-mediated rejection; graft function monitoring; ventricular assist device bridging; post-transplant surveillance

(This special issue belongs to the Section Cardiology)

Prenatal Diagnosis and Intervention: Shaping the Future of Maternal–Fetal Medicine

edited by

Misgav Rottenstreich

submission deadline 15 Apr 2026 | Viewed by 85 | Submission Open

Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Hepato-Pancreato-Biliary Surgery in the Era of Immunotherapy

edited by Niv Pencovich

submission deadline 15 Apr 2026 | Viewed by 82 | Submission Open

Keywords: hepatobiliary surgery; immunotherapy; pancreatic and liver cancer; conversion surgery; immune checkpoint inhibitors

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Antiplatelet Therapy After Cardiovascular Surgery

edited by

Marek T. Tomala

submission deadline 15 Apr 2026 | Viewed by 80 | Submission Open

Keywords: antiplatelet therapy; cardiac surgery; P2Y12 inhibitors; platelet function testing; dual antiplatelet therapy (DAPT); perioperative management; bleeding risk stratification

(This special issue belongs to the Section Cardiovascular Medicine)

Most Advanced Therapeutic Agents Redefining Neurological Health

edited by Clarissa Fantin Cavarsan

submission deadline 15 Apr 2026 | Viewed by 68 | Submission Open

Keywords: disease-modifying therapy; biomarker-guided treatment; gene therapy; neuroprotection; clinical trials; neurological disorders; precision neurology

(This special issue belongs to the Section Clinical Neurology)

Management of Coronary Syndrome for Better Outcome

edited by

Cristina Madaudo

Vincenzo Sucato

and Antonio Luca Maria Parlati

submission deadline 15 Apr 2026 | Viewed by 68 | Submission Open

Keywords: acute coronary syndrome; chronic coronary syndrome; percutaneous coronary intervention; dual antiplatelet therapy; intravascular imaging; risk stratification; secondary prevention; cardiovascular outcomes; artificial intelligence; digital health

(This special issue belongs to the Section Cardiology)

Arrhythmia and Sudden Cardiac Death: Risk Factors, Prevention, and Management

edited by Jitendra Vohra

submission deadline 15 Apr 2026 | Viewed by 61 | Submission Open

Keywords: sudden cardiac death; arrhythmia; cardiac arrest; cardiopulmonary resuscitation; implantable cardioverter-defibrillators; automated external defibrillators

(This special issue belongs to the Section Cardiology)

New Perspectives on Diagnosis, Prognosis and Treatment of Tricuspid Regurgitation According to Etiology

edited by Sergio Moral

submission deadline 15 Apr 2026 | Viewed by 55 | Submission Open

Keywords: tricuspid regurgitation; transcatheter tricuspid intervention; 3D echocardiography; cardiac magnetic resonance; valve repair techniques

(This special issue belongs to the Section Cardiology)

The State of the Art in Adjuvant Breast Irradiation: Technical, Clinical, and Genomic Advances in the Adjuvant and Neo-Adjuvant Fields

edited by Grazia Lazzari

submission deadline 15 Apr 2026 | Viewed by 54 | Submission Open

Keywords: radiation oncology; breast cancer therapy; deep inspiration breath hold; DIBH; stereotactic body radiation therapy; SBRT; intraoperative radiation therapy; IORT; prone positioning; protons; hypofractionation

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Pharmacotherapy and Patient Care in Rheumatoid Arthritis

edited by

Ryu Watanabe

submission deadline 15 Apr 2026 | Viewed by 54 | Submission Open

Keywords: rheumatoid arthritis; pharmacotherapy; patient care; biomarkers; treatment outcomes

(This special issue belongs to the Section Immunology & Rheumatology)

Displaying special issue 951-1000 on page 20 of 31.

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