jcm-logo

Journal Browser

Journal Browser

Heart Transplantation: Surgery Updates and Complications

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (15 April 2026) | Viewed by 1081

Special Issue Editor


E-Mail
Guest Editor
Cardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy
Interests: heart transplantation; mechanical circulatory support; adult congenital heart disease; cardiac surgery; cardiovascu-lar regenerative medicine

Special Issue Information

Dear Colleagues,

Heart transplantation has undergone remarkable transformations in recent years, revolutionizing outcomes for end-stage heart failure patients. This Special Issue showcases pivotal advances reshaping the field—from cutting-edge organ preservation technologies to AI-driven post-transplant monitoring systems.

Emerging evidence reveals how adult cardiovascular diseases often originate from early post-transplant complications, underscoring the critical need for optimized surgical techniques and vigilant long-term care. The Special Issue particularly examines breakthroughs in:

  1. Novel perfusion systems extending donor organ viability;
  2. Precision immunosuppression strategies minimizing side effects;
  3. Advanced surveillance for cardiac allograft vasculopathy.

We seek contributions that illuminate these transformative approaches, with particular interest in studies demonstrating improved survival rates and quality-of-life outcomes.

Your pioneering research will help establish new standards in heart transplantation care. We eagerly anticipate your submissions to this Special Issue.

Dr. Nicola Pradegan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • donor heart optimization
  • antibody-mediated rejection
  • graft function monitoring
  • ventricular assist device bridging
  • post-transplant surveillance

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 1041 KB  
Article
Heart Transplantation from Donors with Takotsubo Cardiomyopathy: Clinical Outcomes and Early Experience from a Single Center
by Lorenzo Giovannico, Giuseppe Fischetti, Federica Mazzone, Domenico Parigino, Luca Savino, Ilaria Paradiso, Marina Mezzina, Eduardo Urgesi, Claudia Leo, Giuseppe Cristiano, Concetta Losito, Massimiliano Carrozzini, Vincenzo Ezio Santobuono, Andrea Igoren Guaricci, Marco Matteo Ciccone, Massimo Padalino and Tomaso Bottio
J. Clin. Med. 2026, 15(2), 842; https://doi.org/10.3390/jcm15020842 - 20 Jan 2026
Viewed by 498
Abstract
Background: Takotsubo cardiomyopathy (TTC) has been historically considered a contraindication for heart donation due to its transient left ventricular dysfunction. However, emerging evidence supports that hearts from donors with fully recovered Takotsubo Cardiomyopathy can be safely transplanted. Methods: This case series describes seven [...] Read more.
Background: Takotsubo cardiomyopathy (TTC) has been historically considered a contraindication for heart donation due to its transient left ventricular dysfunction. However, emerging evidence supports that hearts from donors with fully recovered Takotsubo Cardiomyopathy can be safely transplanted. Methods: This case series describes seven heart transplantations performed between January 2022 and September 2025 using donors with previously diagnosed Takotsubo cardiomyopathy. Donor characteristics, intraoperative data, echocardiography data and postoperative outcomes were analyzed. Results: The mean donor age was 33.5 years (range 18–58), with a male-to-female ratio of 6:1. All donors exhibited echocardiographic evidence of Takotsubo Cardiomyopathy at the time of brain death, with full or partial recovery before procurement. Coronary angiography excluded obstructive coronary disease. Echocardiographic follow-up demonstrated the mean LVEF increased to 52 ± 6%, reaching 58 ± 4% at 12 months, global longitudinal strain (GLS) improved progressively (from −14.2 ± 2.8% to −18.5 ± 1.9%), confirming normalization of myocardial deformation and the right ventricular function, assessed by TAPSE, rose from 15 ± 3 mm at discharge to 20 ± 2 mm at 12 months. All patients transplanted with donors who had Takotsubo cardiomyopathy are alive at the 12-month follow-up. Conclusions: Hearts from donors with resolved Takotsubo Cardiomyopathy can be safely used for transplantation without compromising early- or mid-term outcomes. Expanding donor eligibility criteria to include selected TTC donors may contribute to mitigating organ shortages in advanced heart failure patients. Full article
(This article belongs to the Special Issue Heart Transplantation: Surgery Updates and Complications)
Show Figures

Figure 1

Back to TopTop