Advances in Antiplatelet Therapy After Cardiovascular Surgery
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".
Deadline for manuscript submissions: 15 April 2026 | Viewed by 2
Special Issue Editor
Interests: antiplatelet therapy optimization; platelet function testing; perioperative cardiovascular management; coronary artery disease; thrombosis and hemostasis; personalized medicine in cardiology; primary PCI; rotational atherectomy (rotablation); cardiology intensive care; noninvasive ventilation in cardiac patients
Special Issue Information
Dear Colleagues,
The purpose of this Special Issue is to gather scientific articles that review advances in the management of antiplatelet therapy after cardiac surgery, along with considerations for improving patient outcomes. The introduction of new P2Y12 receptor antagonists, sophisticated platelet function monitoring, pharmacogenomic profiling, and individualized risk stratification has rapidly led to the creation of a new discipline in the management of antiplatelet therapy after cardiac surgery. The articles included summarize the most significant advances in perioperative management, including the optimization of the duration of dual antiplatelet therapy after complex coronary interventions, the management of patients at high risk of bleeding requiring urgent cardiac surgery, the development of de-escalation strategies to reduce thrombotic and bleeding risks, and the role of point-of-care platelet reactivity testing to guide individualized therapy. The editorial discusses contemporary evidence-based practices and future directions, highlighting areas where research is progressing beyond the basics of antiplatelet therapy. This includes the potential of artificial intelligence and machine learning models to establish optimal antiplatelet regimens based on patient-specific factors and procedural characteristics. Some emphasis is placed on the most challenging clinical situations, including patients with concomitant atrial fibrillation requiring triple therapy, an emergency surgical patient who was on potent P2Y12 inhibitors, and a patient who has a genetic polymorphism impacting drug metabolism. This collection aims to provide readers with a timely and comprehensive overview of a field that is rapidly redefining standards for care, thereby reducing major adverse cardiovascular events while minimizing bleeding complications for the millions of patients undergoing cardiac surgery annually.
Dr. Marek T. Tomala
Guest Editor
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Keywords
- antiplatelet therapy
- cardiac surgery
- P2Y12 inhibitors
- platelet function testing
- dual antiplatelet therapy (DAPT)
- perioperative management
- bleeding risk stratification
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