Hepato-Pancreato-Biliary Surgery in the Era of Immunotherapy
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 15 April 2026 | Viewed by 31
Special Issue Editor
Interests: hepato-pancreato-biliary surgery; abdominal transplant surgery; liver regenration; immune regulation; myeloid derived suppresor cells (MDSC); artificila intelegence in HPB and transplant surgery; molecular genetics; transcriptomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immunotherapy has reshaped oncology by harnessing the immune system to recognize and eliminate cancer cells. In hepatobiliary (HPB) malignancies, where treatment options have traditionally been limited, immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1—often combined with agents such as bevacizumab or tyrosine kinase inhibitors—are creating new therapeutic opportunities. A particularly striking development is the potential for conversion surgery. Tumor regression achieved with immunotherapy can allow patients with initially unresectable disease to undergo curative resection, a scenario rarely possible with older systemic therapies. Moreover, prolonged survival in patients responding to immunotherapy has introduced new clinical situations, such as the resection of additional, unrelated malignancies while metastatic disease remains controlled. These changes highlight an evolving role for surgery in the era of immunotherapy. Questions now arise regarding patient selection, timing of surgery, perioperative outcomes, and the long-term survival of these novel surgical candidates.
This special issue will bring together studies and expert perspectives to explore how immunotherapy is transforming HPB surgery. By examining indications, surgical outcomes, and emerging challenges, we aim to define the opportunities and future directions of surgery for HPB malignancies in the immunotherapy era.
Dr. Niv Pencovich
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hepatobiliary surgery
- immunotherapy
- pancreatic and liver cancer
- conversion surgery
- immune checkpoint inhibitors
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
