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Current and Future Trends in Otorhinolaryngology–Head and Neck Surgery: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Otolaryngology".

Deadline for manuscript submissions: closed (15 April 2026) | Viewed by 798

Special Issue Editor


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Guest Editor
Ear, Nose, and Throat Department, University Hospital of Alexandroupolis, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
Interests: obstructive sleep apnoea; snoring; robotic surgery; thyroid surgery; parathyroid surgery; head and neck; paediatric otorhinolaryngology; rhinology
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Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to contribute to a Special Issue titled “Current and Future Trends in Otorhinolaryngology–Head and Neck Surgery: 2nd Edition”. This is the second edition of a previous issue; for more details on the first edition, please visit

https://www.mdpi.com/journal/jcm/special_issues/HUR1369TMG.

In recent decades, there has been a significant increase in available knowledge in the specialty of otorhinolaryngology–head and neck surgery. Namely, there has been remarkable development in medical treatment modalities, surgical techniques, and technology involved in the management of ENT pathologies. Our Special Issue titled “Current and Future Trends in Otorhinolaryngology–Head and Neck Surgery: 2nd Edition” aims to provide readers with the latest developments in the field of otorhinolaryngology–head and neck surgery and highlight current and future trends.

For this issue, we welcome authors to submit original or review articles related to all aspects of the field of otorhinolaryngology–head and neck surgery, including, but not limited to, oncology, laryngology, rhinology, skull base surgery, sleep-disordered breathing, otology, neurotology, immunotherapy, innovative surgical procedures, robotic surgery, and artificial intelligence.

Dr. Konstantinos Chaidas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • otorhinolaryngology
  • head and neck
  • innovation
  • diagnosis
  • treatment
  • surgery

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Published Papers (1 paper)

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Research

14 pages, 1286 KB  
Article
Presepsin Outperforms Conventional Inflammatory Markers in Distinguishing Malignant from Benign Cervical Lymphadenopathy
by Orhan Tunç, Mustafa Örkmez, Berkay Güzel, Ismail Aytac, Behçet Günsoy and Yusuf Arslanhan
J. Clin. Med. 2026, 15(2), 649; https://doi.org/10.3390/jcm15020649 - 14 Jan 2026
Viewed by 427
Abstract
Objectives: This study aimed to evaluate the diagnostic value of presepsin in differentiating benign and malignant causes of cervical lymphadenopathy and to compare its performance with conventional inflammatory markers, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and neutrophil-to-lymphocyte ratio (NLR). Methods: A [...] Read more.
Objectives: This study aimed to evaluate the diagnostic value of presepsin in differentiating benign and malignant causes of cervical lymphadenopathy and to compare its performance with conventional inflammatory markers, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and neutrophil-to-lymphocyte ratio (NLR). Methods: A total of 76 individuals were enrolled, including 52 patients who underwent excisional biopsy for cervical lymphadenopathy and 24 healthy controls. Serum presepsin, CRP, ESR, and complete blood count parameters were measured preoperatively. Patients were classified according to histopathological diagnosis as reactive, granulomatous, or malignant lymphadenopathy. Correlation and receiver operating characteristic (ROC) analyses were performed to assess the diagnostic performance of biomarkers. Results: Median presepsin, CRP, ESR, NLR, and monocyte-to-lymphocyte ratio (MLR) levels were significantly higher in the patient group compared with controls (all p < 0.001). Presepsin levels correlated positively with CRP (r = 0.42), ESR (r = 0.38), and NLR (r = 0.36). Although subgroup analysis revealed no statistically significant differences in presepsin levels among reactive, granulomatous, and malignant cases (p = 0.50), ROC analysis demonstrated the highest diagnostic accuracy for presepsin (AUC = 0.85), followed by CRP (AUC = 0.78), ESR (AUC = 0.74), and NLR (AUC = 0.72). A presepsin threshold of >210 pg/mL predicted malignancy with 82.4% sensitivity and 78.6% specificity. Conclusions: Presepsin provides an objective and noninvasive tool that complements traditional inflammatory markers in the diagnostic evaluation of cervical lymphadenopathy. Its superior diagnostic performance for malignancy prediction suggests potential utility in guiding biopsy decisions and avoiding unnecessary surgical procedures in benign cases. Full article
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