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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Treatment and Digital Outcome Assessment in Orthopaedic Trauma
edited by Benedikt Johannes Braun and
submission deadline 25 Nov 2025 | Viewed by 128 | Submission Open
Keywords: orthopaedic trauma; digital outcome assessment; wearable sensors; patient-reported outcomes; machine learning (or artificial intelligence)
(This special issue belongs to the Section Orthopedics)
New Approaches in Open and Minimally Invasive Surgery for Abdominal Oncologic Surgery
edited by and Immacolata Iannone
submission deadline 25 Nov 2025 | Viewed by 118 | Submission Open
Keywords: surgical oncology; early diagnosis; minimally invasive surgery; personalized medicine; combined therapy; gastrointestinal cancer; oligometastatic cancer; peritoneal disease
(This special issue belongs to the Section General Surgery)
Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery submission deadline 27 Nov 2025 | Viewed by 168 | Submission Open
Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology
(This special issue belongs to the Section Otolaryngology)
Management of Complex Infective Endocarditis
edited by Shekhar Saha, Tulio Caldonazo and Mateo Marin-Cuartas
submission deadline 27 Nov 2025 | Viewed by 112 | Submission Open
Keywords: infective endocarditis; imaging; diagnosis; cardiac surgery; pathogens; antibiotic treatment; risk estimation
(This special issue belongs to the Section Cardiology)
Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 2nd Edition
edited by Tsutomu Yasukawa
submission deadline 28 Nov 2025 | 10 articles | Viewed by 10742 | Submission Open
Keywords: age-related macular degeneration; angiography; antivascular endothelial growth factor therapy; choroidal neovascularization; geographic atrophy; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium
(This special issue belongs to the Section Ophthalmology)
New Trends in Mechanical Ventilation
edited by
submission deadline 28 Nov 2025 | 2 articles | Viewed by 7270 | Submission Open
Keywords: positive pressure ventilation; negative pressure ventilation; constant flow ventilation; PEEP; lung recruitment; obesity; laparoscopy; ARDS; atelectasis; total lung compliance
(This special issue belongs to the Section Anesthesiology)
Advances in Spine Surgery: Best Practices and Future Directions
edited by Martin N. Stienen and
submission deadline 28 Nov 2025 | 6 articles | Viewed by 6637 | Submission Open
Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction
(This special issue belongs to the Section Clinical Neurology)
Current Practices in Cardiovascular Perfusion and Recovery
edited by
submission deadline 28 Nov 2025 | 1 articles | Viewed by 2642 | Submission Open
Keywords: organ perfusion; ex vivo perfusion; ischemia– reperfusion injury; organ recovery; transplantation; machine perfusion; organ preservation
(This special issue belongs to the Section Cardiology)
Advancements in Anterior Cruciate Ligament Injury: From Diagnosis to the Return-to-Sports: 2nd Edition
edited by Alexandre Hardy and Nicolas Bouguennec
submission deadline 28 Nov 2025 | 3 articles | Viewed by 2323 | Submission Open
Keywords: anterior cruciate ligament reconstruction (ACLR); timing of ACLR; ramp lesion; meniscal lesion; lateral extra-articular procedure
(This special issue belongs to the Section Sports Medicine)
Clinical Updates in Heart Transplantation
edited by
submission deadline 28 Nov 2025 | 2 articles | Viewed by 1524 | Submission Open
Keywords: heart transplantation; ex vivo heart preservation; immunosuppression; xenotransplantation; pre-clinical models; dilated cardiomyopathy; amyloidosis; congenital heart disease
(This special issue belongs to the Section Cardiology)
Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care submission deadline 28 Nov 2025 | Viewed by 247 | Submission Open
Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine
(This special issue belongs to the Section Respiratory Medicine)
Novel Treatments for Vestibular Migraine
edited by
submission deadline 28 Nov 2025 | Viewed by 215 | Submission Open
Keywords: neuromodulation therapy; sympathetic nerve stimulation; CGRP-targeted therapy; dietary interventions; elimination diets; ketogenic diet; low-glycemic index diet; nutritional supplements; pathophysiology of vestibular migraine; clinical adoption of VM therapies
(This special issue belongs to the Section Otolaryngology)
State of the Art in Hepato-Pancreato-Biliary (HPB) Surgery
edited by and Konstantinos Bramis
submission deadline 28 Nov 2025 | Viewed by 174 | Submission Open
Keywords: hepato-pancreato-biliary (HPB) surgery; robotic surgery; laparoscopic surgery; liver resection; liver transplantation; pancreatectomy; liver thermoablation; extrahepatic cholangiocarcinoma; benign biliary disease; pancreatic neuroendocrine tumors; non-colorectal/non-neuroendocrine oligometastatic liver disease
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Novel Diagnostic and Therapeutic Opportunities in Inflammatory and Oncological Diseases in the Gastrointestinal Tract
edited by and Hubert Zatorski
submission deadline 28 Nov 2025 | Viewed by 130 | Submission Open
Keywords: cancer; inflammation; diagnosis; treatment; microbiota; gastrointestinal tract; gastroenterology; immunology
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
New Challenges in Maternal-Fetal Medicine
edited by Marzena Laskowska
submission deadline 29 Nov 2025 | 7 articles | Viewed by 16099 | Submission Open
Keywords: thrombocytopenia in pregnancy; multiple pregnancies; placental abruption; DIC; sepsis; chorioamnionitis; cholestasis; postpartum hemorrhage; emergency cervical cerclage; problems in pregnancy and labor; pregnancy complications; spina bifida; fetal well-being evaluation
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances in Critical Care Medicine
edited by Pietro Caironi
submission deadline 30 Nov 2025 | 14 articles | Viewed by 48289 | Submission Open
Keywords: critical care; artificial intelligence; extra-corporeal life support; mechanical ventilation; sepsis; infection; airway management; acute kidney injury; biomarkers; trauma
(This special issue belongs to the Section Intensive Care)
Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges submission deadline 30 Nov 2025 | 22 articles | Viewed by 43749 | Submission Open
Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Recent Advances in Reconstructive Urology and Prosthetic Surgery
edited by Francisco E. Martins, Maurice Garcia and Jay Simhan
submission deadline 30 Nov 2025 | 4 articles | Viewed by 15221 | Submission Open
Keywords: male and female urogenital reconstruction; urologic trauma; urologic prosthetics; erectile dysfunction; urinary incontinence; artificial urinary sphincter; gender-affirming surgery; transgender; phalloplasty; vaginoplasty
(This special issue belongs to the Section Nephrology & Urology)
What’s New in Cardiomyopathies: Diagnosis, Treatment and Management
edited by
submission deadline 30 Nov 2025 | 6 articles | Viewed by 14644 | Submission Open
Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases
(This special issue belongs to the Section Cardiology)
Advancements in Cornea Transplantation
edited by Giulia Coco and Davide Romano
submission deadline 30 Nov 2025 | 8 articles | Viewed by 11408 | Submission Open
Keywords: corneal transplant; keratoplasty; DMEK; DSAEK; PK; cornea
(This special issue belongs to the Section Ophthalmology)
Pediatric Dentistry: Recent Advances, Current Issues and Future Challenges submission deadline 30 Nov 2025 | 6 articles | Viewed by 11233 | Submission Open
Keywords: pediatric dentistry; recent advances; current issues; future challenges; orthodontic issues; preventive strategies; access to care disparities; behavioral management; multidisciplinary collaboration; oral health
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Personalized Risk Stratification with Diagnostic and Prognostic Relevance for Coronary Artery Disease: New Challenges and Opportunities in a New Era submission deadline 30 Nov 2025 | 4 articles | Viewed by 9166 | Submission Open
Keywords: coronary artery disease; cardiovascular prevention; risk stratification; cardiovascular pathology
(This special issue belongs to the Section Cardiovascular Medicine)
Oral and Maxillofacial Surgery: Diagnosis, Management and Future Opportunities
edited by
submission deadline 30 Nov 2025 | 5 articles | Viewed by 7844 | Submission Open
Keywords: head and neck oncology; free flaps; oral surgery; malformative surgery; traumatology; endoscopy; preprosthetic surgery; reconstructive surgery; vascular malformations; osteonecrosis
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Therapy of Trauma and Surgical Critical Care
edited by Rabail Chaudhry and George W. Williams
submission deadline 30 Nov 2025 | 2 articles | Viewed by 7641 | Submission Open
Keywords: regional anesthesia; critical care; trauma resuscitation; transfusion strategies; thermal injury; obstetric critical care; epitheliopathy; metabolomics; ICU pain management; trauma care subpopulations
(This special issue belongs to the Section Intensive Care)
Recent Progress in Rehabilitation Medicine—3rd Edition
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 7395 | Submission Open
Keywords: neuro-rehabilitation; cognitive rehabilitation; spinal rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; cancer rehabilitation; visceral rehabilitation; cardiac rehabilitation; pulmonary rehabilitation; renal rehabilitation; hepatic rehabilitation; rehabilitation for transplantation; fitness; peak VO2; multimorbidity and multiple disabilities (MMD); adding life to years and years to life
(This special issue belongs to the Section Clinical Rehabilitation)
New Insights into Cardiovascular and Minimally Invasive Cardiac Surgery
edited by Parwis Massoudy and Hilmar C. Dörge
submission deadline 30 Nov 2025 | 4 articles | Viewed by 7132 | Submission Open
Keywords: coronary artery bypass grafting; aortic valve surgery; mitral valve surgery; aortic surgery; minimally invasive cardiac surgery
(This special issue belongs to the Section Cardiology)
Ischemic Stroke: Diagnosis and Treatment submission deadline 30 Nov 2025 | 4 articles | Viewed by 6899 | Submission Open
Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy
(This special issue belongs to the Section Clinical Neurology)
Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches
edited by Elisabeth M.J.P. Mouws and
submission deadline 30 Nov 2025 | 5 articles | Viewed by 6433 | Submission Open
Keywords: cardiac arrhythmia; atrial fibrillation; congenital heart disease; underlying mechanisms; therapeutic options
(This special issue belongs to the Section Cardiology)
Advances in the Diagnosis and Treatment of Ocular Surface Tumors and Diseases
edited by Sotiria Palioura, Carolina L. Mercado and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 5108 | Submission Open
Keywords: ocular surface diseases; anterior segment imaging; chemotherapeutics; immunomodulatory agents; minimally invasive surgical techniques
(This special issue belongs to the Section Ophthalmology)
Clinical Research and Personalized Medicine in Inflammatory Bowel Disease
edited by and Loris Riccardo Lopetuso
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4056 | Submission Open
Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3361 | Submission Open
Keywords: heart; lung; kidney; liver; bone; brain
(This special issue belongs to the Section Clinical Rehabilitation)
Assisted Reproductive Technology and Infertility Treatment: Current Updates and Perspectives—2nd Edition
edited by Nikos Nikolettos and
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2665 | Submission Open
Keywords: assisted reproduction technology (ART); infertility; treatment; reproduction; IVF
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Clinical Updates on Prosthodontics
edited by and Carla Fons-Badal
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2477 | Submission Open
Keywords: dental prosthesis; dental implants; gingival treatment; gingival aesthetics; gingival treatment; dental aesthetics; dental ceramics; BOPT; surgical periodontal treatment
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances of Breast Surgery and Reconstruction
edited by and Emanuele Cigna
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2003 | Submission Open
Keywords: breast reconstruction; autologous breast reconstruction; implant-based breast reconstruction; DIEP; LICAP; breast implant infection
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Novel Aspects of Endocrine Care: From Patient-Centred Management of Endocrine Diseases to Guidelines Standards submission deadline 30 Nov 2025 | 2 articles | Viewed by 1849 | Submission Open
Keywords: endocrine tumour; hormone; biomarker; neuroendocrine tumour; thyroidectomy; parathyroidectomy; bone; ad-renal gland; osteoporosis; pituitary gland; autoimmune; antibody; clinical study; computed tomography
(This special issue belongs to the Section Endocrinology & Metabolism)
Novel Developments on Diagnosis and Treatment of Gastrointestinal Cancer
edited by Bhaumik Patel
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1607 | Submission Open
Keywords: colorectal cancer; gastric cancer; biomarker; novel therapy; immune microenvironment; gut microbiota; molecular mechanisms
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Updates on Rheumatoid Arthritis: 2nd Edition
edited by Francesca Bandinelli
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1489 | Submission Open
Keywords: rheumatoid arthritis; rheumatology; treatment; diagnosis; biomarkers; rheumatic disease
(This special issue belongs to the Section Immunology & Rheumatology)
Orthodontics: State of the Art and Prospects
edited by Beatriz Tarazona-Álvarez and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1461 | Submission Open
Keywords: digital orthodontics; clear aligners; 3D printing; accelerated orthodontics; digital treatment plan; nanotechnology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Thrombotic Risk and Its Management Across Diverse Clinical Settings
edited by Samuel Bogdan Todor and Ana Maria Vlǎdǎreanu
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1356 | Submission Open
Keywords: thrombosis; thrombotic risk; hematologic disorders; thrombophilia; myeloproliferative neoplasms; antithrombotic therapy; cardiovascular diseases; biomarkers
(This special issue belongs to the Section Hematology)
Thoracic Surgery Between Tradition and Innovations
edited by Jacopo Vannucci
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1310 | Submission Open
Keywords: thoracic surgery; lung cancer; pulmonary resections; pleural disease; perioperative medicine; mesothelioma; lung transplantation; chest wall resection and reconstruction; esophageal cancer; thoracic trauma; emergency; pulmonary metastasectomy
(This special issue belongs to the Section General Surgery)
Orthopedic Surgery: Latest Advances and Perspectives
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1081 | Submission Open
Keywords: motion preservation; pain management; robotics/computer navigation; degenerative disc disease; orthobiologics; arthroplasty; trauma
(This special issue belongs to the Section Orthopedics)
Multiparametric Ultrasound Techniques for Liver Disease Assessments
edited by Francesco Giangregorio
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1013 | Submission Open
Keywords: ultrasound; multiparametric ultrasound; hepatic ultrasound; contrast-enhanced ultrasound; contrast agents; diffuse hepatic diseases; focal liver lesions; hepatic elastography; liver stiffness; hepatic endosonography; hepatic EUS
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Current Advances and Future Perspectives in Interventional Cardiology
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 974 | Submission Open
Keywords: trans-catheter valve repair and replacement; advanced coronary intervention; AI in decision making for trans-catheter aortic root and arch replacement; LAA occlusion; anti-arrhythmic therapy; right side of the heart
(This special issue belongs to the Section Cardiology)
Current Challenges in Orthopedic Trauma Surgery
edited by Pietro Maniscalco and Fabrizio Quattrini
submission deadline 30 Nov 2025 | 2 articles | Viewed by 944 | Submission Open
Keywords: hip replacement; knee replacement; shoulder replacement; ankle replacement; trauma surgery; femur; future chal-lenges; surgical innovations
(This special issue belongs to the Section Orthopedics)
Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery
edited by and Fabrizio Panaro
submission deadline 30 Nov 2025 | 1 articles | Viewed by 941 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances
(This special issue belongs to the Section General Surgery)
Spine Surgery Innovations: Clinically Advanced Treatment and Technologies
edited by Jang W. Yoon
submission deadline 30 Nov 2025 | 1 articles | Viewed by 912 | Submission Open
Keywords: minimally invasive spine surgery; artificial intelligence; wearable biometrics; big data; smartphone accelerometer
(This special issue belongs to the Section Orthopedics)
New Updates in Pediatric Gastroenterology
edited by , Alina Stanescu-Popp and Oana Belei
submission deadline 30 Nov 2025 | Viewed by 848 | Submission Open
Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Surgical Management of Maxillofacial Fractures and Reconstruction of Facial Deformities
edited by , and Francesco Arcuri
submission deadline 30 Nov 2025 | 1 articles | Viewed by 493 | Submission Open
Keywords: head and neck reconstruction; facial fractures; minimally invasive treatments; facial reconstruction; bioengineering in head and neck disorders; CAD/CAM in maxillo facial trauma and deformities
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care
edited by
submission deadline 30 Nov 2025 | Viewed by 283 | Submission Open
Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging
(This special issue belongs to the Section Cardiology)
Anesthesia and Perioperative Management of Organ Transplants
edited by and Ji-Hye Kwon
submission deadline 30 Nov 2025 | Viewed by 278 | Submission Open
Keywords: liver transplantation; coagulation; reperfusion syndrome; perioperative evaluation; coronary artery disease; CDC; DBD; living donor liver transplant; pulmonary evaluation; hepatorenal syndrome; portopulmonary hypertension
(This special issue belongs to the Section Anesthesiology)
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