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New Updates in Pediatric Gastroenterology
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New Updates in Pediatric Gastroenterology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (20 May 2026) | Viewed by 2958

Special Issue Editors

Prof. Dr. Laura Trandafir

E-Mail Website
Guest Editor
Pediatrics Clinic, Department of Mother and Child, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: pediatric gastroenterology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; pediatric liver diseases; esophageal diseases; biliary tract diseases; cirrhosis; pediatric digestive endoscopy
Special Issues, Collections and Topics in MDPI journals
Dr. Alina Stanescu-Popp

E-Mail Website
Guest Editor
First Pediatric Clinic, Alfred Rusescu INSMC Bucharest, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
Interests: pediatric gastroenterology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; pediatric liver diseases; esophageal diseases; biliary tract diseases; cirrhosis; pediatric digestive endoscopy
Dr. Oana Belei

E-Mail Website
Guest Editor
1. First Pediatric Clinic, Disturbances of Growth and Development on Children Research Center, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
2. Children’s Emergency Hospital “Louis Turcanu”, 300011 Timisoara, Romania
Interests: pediatric gastroenterology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; pediatric liver diseases; esophageal diseases; biliary tract diseases; cirrhosis; pediatric digestive endoscopy

Special Issue Information

Dear Colleagues,

Pediatric gastroenterology has witnessed remarkable progress over the past decades, driven by advancements in diagnostic tools, therapeutic strategies, and a deeper understanding of the gut–brain axis and microbiome. These developments have significantly improved outcomes for children with gastrointestinal, hepatic, and nutritional disorders.

This Special Issue aims to highlight the latest breakthroughs and emerging trends in pediatric gastroenterology, providing a platform for researchers and clinicians to share innovative findings that address the unique challenges of diagnosing and treating gastrointestinal disorders in children.

We seek contributions that will increase the degree of understanding of the physiopathological mechanisms involved in various pediatric digestive disorders and will allow the launch of new therapeutic directions.

Prof. Dr. Laura Trandafir
Dr. Alina Stanescu-Popp
Dr. Oana Belei
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric gastroenterology and hepatology
  • inflammatory bowel disease
  • celiac disease
  • gastrointestinal diseases
  • esophageal diseases
  • endoscopy
  • gut microbiome
  • inflammatory bowel disease
  • functional GI disorders
  • nutritional management
  • precision medicine
  • gut–brain axis
  • transitional care

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

9 pages, 218 KB  
Article
Clinical, Endoscopic, and Pathologic Spectrum of Pediatric Polyps: A Single-Center Study in the Current Polypectomy Era
by Sevim Çakar, Betül Aksoy, Oğuzhan Akyaz, Tuğçe Tatar Arık, Süleyman Dolu, Mesut Akarsu, Safiye Aktaş and Yeşim Öztürk
J. Clin. Med. 2026, 15(3), 1061; https://doi.org/10.3390/jcm15031061 - 29 Jan 2026
Viewed by 456
Abstract
Background: Pediatric gastrointestinal polyps represent a heterogeneous entity with variable clinical behavior, ranging from solitary benign lesions to syndromic forms associated with significant malignant potential. This study provides contemporary data, including upper GI and small-bowel polyps, with an unusually high syndromic yield (27.6%) [...] Read more.
Background: Pediatric gastrointestinal polyps represent a heterogeneous entity with variable clinical behavior, ranging from solitary benign lesions to syndromic forms associated with significant malignant potential. This study provides contemporary data, including upper GI and small-bowel polyps, with an unusually high syndromic yield (27.6%) compared to prior pediatric cohorts. Methods: This retrospective single-center study included children aged 0–18 years who underwent esophagogastroduodenoscopy and/or colonoscopy and were diagnosed with at least one gastrointestinal polyp between January 2015 and October 2025. Demographic characteristics, presenting symptoms, endoscopic features, histopathology, management strategies, and status of polyposis syndrome were collected. Statistical analyses were performed using IBM SPSS Statistics 27.0, with a significance threshold of p < 0.05. Results: Seventy-six patients (mean age 10.6 ± 5.0 years; 47.4% female) were evaluated. Gastrointestinal bleeding was the most common presenting symptom (37.1%). Solitary (63.2%) and sessile (59.2%) polyps predominated, with a median size of 7.0 mm (IQR 3.2–20.0). Juvenile (28.9%) and inflammatory (22.4%) polyps were the most frequent histologic subtypes. Polyposis syndromes were identified in 27.6% of patients and were significantly associated with multiple polyps (p < 0.001), proximal or intestinal distribution (p < 0.001), and adenomatous or hamartomatous histology (p < 0.001). Endoscopic polypectomy was successful in 94.7% of cases, with no major complications reported. Conclusions: Given the 27.6% prevalence of polyposis syndromes observed in this cohort, pediatric gastrointestinal polyps cannot be assumed to be uniformly benign. Our findings support comprehensive endoscopic evaluation, routine histopathology, and early genetic referral, specifically in patients with multiple, proximal, or mixed-morphology polyps. Full article
(This article belongs to the Special Issue New Updates in Pediatric Gastroenterology)
18 pages, 1193 KB  
Article
Multimodal Management of Extreme Hypertriglyceridemia in a Child with Recurrent Pancreatitis: Clinical Challenges and Solutions
by Elena-Lia Spoială, Carmen Oltean, Ioana Vasiliu, Gabriela Paduraru, Diana-Claudia Danilă, Gabriela Ghiga, Maria Țugui, Lacramioara Ionela Butnariu, Elena Cojocaru and Laura Mihaela Trandafir
J. Clin. Med. 2026, 15(2), 636; https://doi.org/10.3390/jcm15020636 - 13 Jan 2026
Viewed by 1179
Abstract
Background: Severe hypertriglyceridemia (SHTG) in children is a rare but clinically significant disorder associated with recurrent acute pancreatitis and substantial morbidity. Early identification and prompt management are essential to prevent pancreatic and systemic complications. Methods: We report the case of an 11-year-old female [...] Read more.
Background: Severe hypertriglyceridemia (SHTG) in children is a rare but clinically significant disorder associated with recurrent acute pancreatitis and substantial morbidity. Early identification and prompt management are essential to prevent pancreatic and systemic complications. Methods: We report the case of an 11-year-old female with a history of xanthogranulomatous pancreatitis who presented with extreme hypertriglyceridemia, with fasting triglyceride levels exceeding 4000 mg/dL. Results: The patient was treated acutely with continuous intravenous aspart insulin (0.1 U/kg/hour) and adjusted 10% glucose infusion, with hourly glucose and potassium monitoring, leading to a rapid and marked reduction in triglyceride levels—55% reduction within the first 24 h, 76% at 48 h, and 82% after 96 h of treatment. No hypoglycemia or other adverse effects were observed. Nutritional management included a low–long-chain triglyceride (LCT) diet enriched with medium-chain triglycerides (MCTs) and omega-3 fatty acids, providing essential calories while minimizing chylomicron production. Over a 12-month follow-up, the patient remained asymptomatic, with sustained lipid normalization and no recurrence of pancreatitis. Conclusions: This case underscores the therapeutic value of combining pharmacologic and dietary strategies in pediatric SHTG. Evidence from pediatric and adult studies supports the role of insulin infusion for acute triglyceride lowering and MCT-based nutritional therapy for long-term control. Our findings highlight the need for early, individualized, and multidisciplinary management and emphasize the potential future role of emerging targeted therapies in addressing refractory pediatric hypertriglyceridemia. Full article
(This article belongs to the Special Issue New Updates in Pediatric Gastroenterology)
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