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Current Practices in Cardiovascular Perfusion and Recovery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 28 November 2025 | Viewed by 631

Special Issue Editor


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Guest Editor
Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT, USA
Interests: cardiothoracic surgery; coronary artery bypass grafting; cardiovascular interventions; cardiac MRI; heart failure; valvular disorders; myocardial ischemia; arrhythmias

Special Issue Information

Dear Colleagues,

Organ perfusion and recovery have revolutionized transplantation and critical care medicine, offering new opportunities for extending organ viability, improving functional recovery, and optimizing patient outcomes. Advances in ex vivo perfusion technologies, ischemia–reperfusion injury mitigation, and bioengineering approaches have significantly impacted clinical decision-making and organ utilization. This Special Issue aims to highlight current practices, challenges, and future directions in organ perfusion and recovery across multiple organ systems, including the heart, lungs, liver, and kidneys. We invite contributions that explore novel perfusion techniques, machine perfusion strategies and metabolic insights into organ recovery and emerging therapeutic interventions. Clinical and experimental research, as well as expert reviews and technical innovations, are welcomed to provide a comprehensive overview of the state of the field.

Dr. Irbaz Hameed
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • organ perfusion
  • ex vivo perfusion
  • ischemia–reperfusion injury
  • organ recovery
  • transplantation
  • machine perfusion
  • organ preservation

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Published Papers (1 paper)

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22 pages, 2936 KiB  
Systematic Review
Surgical Management Strategies for Pericardial Effusion—A Systematic Review
by Ruman K. Qasba, Busra Cangut, Amnah Alhazmi, Javeria Naseer, Ayesha Mubasher, Sriharsha Talapaneni, Maurish Fatima, Afsheen Nasir, Shanzil Shafqat, Shreya Avilala and Irbaz Hameed
J. Clin. Med. 2025, 14(14), 4985; https://doi.org/10.3390/jcm14144985 - 14 Jul 2025
Viewed by 462
Abstract
Objectives: Pericardial effusion is the accumulation of excess fluid in the pericardial sac. The etiology is multi-factorial and different techniques are used for management, including subxiphoid approaches, anterior and lateral thoracotomies, video-assisted thoracic surgery (VATS), and percutaneous pericardiocentesis. We evaluate the surgical [...] Read more.
Objectives: Pericardial effusion is the accumulation of excess fluid in the pericardial sac. The etiology is multi-factorial and different techniques are used for management, including subxiphoid approaches, anterior and lateral thoracotomies, video-assisted thoracic surgery (VATS), and percutaneous pericardiocentesis. We evaluate the surgical management strategies for pericardial effusion and their outcomes in this systematic review. Methods: A systematic literature review was performed to identify studies on the surgical management of pericardial effusion from inception to February 2024 using PubMed, Cochrane, and Scopus. Articles were independently assessed by two reviewers, with discrepancies resolved by the senior author. Articles were considered for inclusion if they described different pericardial effusion surgical management techniques. Baseline patient characteristics and procedural and outcome variables were extracted. Results: A total of 27 studies comprising 2773 patients were evaluated. The median age was 56.2 years (interquartile range 47–62.2). The most common etiologies of pericardial effusion were malignancy (31.0%), post-cardiac surgery (18.7%), and idiopathic (15.4%). Other causes included uremia (9.6%), infection (9.6%), and autoimmune disease (4.2%). The subxiphoid pericardial window was the most common approach (82.6%), followed by anterior and lateral thoracotomy (12.0%), and median sternotomy (0.6%). At median follow-up of 24 months, the most frequent post-procedural complications were recurrence of effusion (10.5%), arrhythmias (2.7%), and pneumonia (0.7%). Conclusions: Subxiphoid pericardial window is the most common approach for draining pericardial effusions. Prognosis depends on both the underlying etiology and the chosen drainage strategy. Treatment should be tailored to individual patients, considering patient comorbidities and the specific etiology. Full article
(This article belongs to the Special Issue Current Practices in Cardiovascular Perfusion and Recovery)
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