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Anesthesia and Perioperative Management of Organ Transplants
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Anesthesia and Perioperative Management of Organ Transplants

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: 25 May 2026 | Viewed by 841

Special Issue Editors

Dr. Uzung Yoon

E-Mail Website
Guest Editor
Tomas Jefferson University Hospital, Philadelphia, PA, USA
Interests: liver transplantation; coagulation; reperfusion syndrome; perioperative evaluation; coronary artery disease; CDC; DBD; living donor liver transplant; pulmonary evaluation; hepatorenal syndrome; portopulmonary hypertension
Dr. Ji-Hye Kwon

E-Mail
Guest Editor
Samsung Medical Center, Seoul, Republic of Korea
Interests: liver transplantation; living donor; blood salavate; blood mangement; tranasfusion; CDC; CDB; machine perfusion

Special Issue Information

Dear Colleagues,

Advancements in organ transplantation have significantly improved patient survival and quality of life, with anesthesia and perioperative management playing a crucial role, particularly in liver transplantation. Optimizing anesthetic care and perioperative strategies is essential in ensuring successful surgical outcomes and long-term graft function.

This Special Issue of the Journal of Clinical Medicine will highlight the latest innovations and best practices in anesthesia and perioperative care for organ transplant recipients. Key topics include comprehensive preoperative evaluation, tailored anesthetic techniques, hemodynamic optimization, goal-directed coagulation treatment, perioperative immunosuppression, pain management, and strategies to minimize complications such as ischemia–reperfusion injury.

By bringing together leading experts and groundbreaking research results, this Special Issue will enhance clinical decision-making and improve perioperative outcomes in transplant patients. We welcome contributions from researchers and clinicians, including original studies, reviews, and case reports, to advance knowledge and promote safer, more effective transplant care.

Dr. Uzung Yoon
Dr. Ji-Hye Kwon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver transplantation
  • coagulation
  • reperfusion syndrome
  • perioperative evaluation
  • coronary artery disease
  • CDC
  • DBD
  • living donor liver transplant
  • pulmonary evaluation
  • hepatorenal syndrome
  • portopulmonary hypertension

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

15 pages, 2826 KB  
Article
Effect of Intraoperative Dexmedetomidine Use on Postoperative Liver Function and Graft Outcomes in Laparoscopic Living Donor Hepatectomy: A Propensity Score–Matched Study
by Yan Zhen Jin, Hye-Mee Kwon, Kyoung-Sun Kim, Shi-Yeun Lee, In-Gu Jun, Jun-Gol Song and Gyu-Sam Hwang
J. Clin. Med. 2026, 15(5), 1906; https://doi.org/10.3390/jcm15051906 - 2 Mar 2026
Viewed by 313
Abstract
Background/Objectives: Laparoscopic living donor hepatectomy may compromise hepatic microcirculation and exacerbate ischemia–reperfusion injury. Evidence regarding the effects of dexmedetomidine on donor liver injury and graft outcomes in laparoscopic living donor liver transplantation (LDLT) remains limited. Methods: We conducted a retrospective cohort study of [...] Read more.
Background/Objectives: Laparoscopic living donor hepatectomy may compromise hepatic microcirculation and exacerbate ischemia–reperfusion injury. Evidence regarding the effects of dexmedetomidine on donor liver injury and graft outcomes in laparoscopic living donor liver transplantation (LDLT) remains limited. Methods: We conducted a retrospective cohort study of adult donor–recipient pairs undergoing purely laparoscopic living donor hepatectomy with the Pringle maneuver, categorized by intraoperative dexmedetomidine administration. Primary outcomes were postoperative donor liver function and lactate dynamics. Secondary outcomes included recipient postoperative liver function, perioperative lactate dynamics, early allograft dysfunction (EAD), and graft failure. A 1:1 propensity score matching was performed, and longitudinal laboratory trends were analyzed using linear mixed-effects models. Results: Among 395 donor–recipient pairs, 168 matched pairs (84 per group) were analyzed after PSM. Donors receiving dexmedetomidine had significantly lower postoperative peak aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (both p < 0.01), with significant group-by-time interactions (AST p < 0.001; ALT p = 0.013). Lactate trajectories differed significantly between groups in both donors and recipients (p for interaction < 0.001). In recipients, there were no significant differences between the two groups in EAD (2.4% vs. 8.3%; OR, 0.31; 95% CI, 0.07–1.35; p = 0.168) and one-year graft survival (1.2% vs. 4.8%; HR, 0.36; 95% CI, 0.04–7.20; p = 0.251). Conclusions: Intraoperative dexmedetomidine administration in living liver donors was associated with reduced biochemical evidence of hepatocellular injury and improved perioperative metabolic profiles. These findings suggest a potential donor-level protective effect without demonstrable early clinical benefit in recipients, supporting the need for prospective studies to clarify its clinical significance. Full article
(This article belongs to the Special Issue Anesthesia and Perioperative Management of Organ Transplants)
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