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Assisted Reproductive Technology and Infertility Treatment: Current Updates and Perspectives—2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Reproductive Medicine & Andrology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 413

Special Issue Editors


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Guest Editor
Obstetric-Gynecologic Clinic, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Interests: assisted reproduction; infertility; ovarian stimulation; poor responders; fertility preservation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Laboratory of Physiology, Faculty of Medicine, School of Health Sciences, Democritus University of Thrace, 69100 Alexandroupolis, Greece
2. Embryokosmogenesis, Medically Assisted Reproduction Unit, 4th km Alexandroupolis-Borders, Apalos, 68131 Alexandroupolis, Greece
Interests: assisted reproduction; infertility; natural products; immunobiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce the second edition of the Special Issue “Assisted Reproductive Technology and Infertility Treatment: Current Updates and Perspectives”, which we are launching as a result of the success of the first edition, in which we published ten papers. For more details, please visit: https://www.mdpi.com/journal/jcm/special_issues/UK6QD4B928.

ART is used extensively as an aid in overcoming infertility problems. Evidence-based research suggests that 8–12% of couples worldwide are trying to conceive spontaneously despite experiencing fertility problems. A remarkable percentage of people turn to assisted reproduction consultation and help from medical solutions to bring about the conception and birth of a baby of their own. Each ART cycle is complex and consists of several steps. Thus, it is crucial that this system be based on sufficient evidence and detailed guidelines. This Special Issue will discuss the development of assisted reproduction techniques, including their proper indication. Experimental, innovative, and widely used technologies are facilitating inter-professional team collaborations. Contradictions and their subsequent management provide the foundation for personalised assistance in IVF and associated procedures. The success rates, benefits, risks, costs, and ethics of ART are also important aspects of in vitro fertilisation methods and demonstrate the need for surveillance and vigilance in quality control. Our main aim in publishing this Special Issue is to share the most up-to-date evidence on ART, to optimise guidelines and protocols in order to improve assisted reproduction technology practices and outcomes.

Prof. Dr. Nikos Nikolettos
Dr. Angeliki Tiptiri-Kourpeti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • assisted reproduction technology (ART)
  • infertility
  • treatment
  • reproduction
  • IVF

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Published Papers (1 paper)

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Research

11 pages, 213 KiB  
Article
The Effects of Minimal Stimulation Protocol on Preimplantation Genetic Screening
by Gokalp Oner, Enes Karaman, Ferhan Elmali, Suat Altmisyedioglu and Hande Nur Doganay
J. Clin. Med. 2025, 14(12), 4285; https://doi.org/10.3390/jcm14124285 - 16 Jun 2025
Viewed by 291
Abstract
Background/Objectives: Preimplantation genetic screening improves embryo selection in intracytoplasmic sperm injection cycles, especially for women of advanced maternal age. As chromosomal normality declines with age, high-dose gonadotropins are commonly used to enhance follicular response. This study compares minimal and high-dose stimulation protocols in [...] Read more.
Background/Objectives: Preimplantation genetic screening improves embryo selection in intracytoplasmic sperm injection cycles, especially for women of advanced maternal age. As chromosomal normality declines with age, high-dose gonadotropins are commonly used to enhance follicular response. This study compares minimal and high-dose stimulation protocols in terms of euploidy, pregnancy, and live birth rates following single embryo transfer. Methods: In this prospective study, 198 women aged 38–45 years were enrolled and divided into two groups: minimal stimulation (100 mg clomiphene citrate and 75 IU human menopausal gonadotropin) and high stimulation (300–450 IU gonadotropins). Women with severe male factor infertility, endometriosis, or absolute tubal factor were excluded. Clinical outcomes were compared using a t-test or Mann–Whitney U test. Results: Baseline characteristics were similar between groups. The high-dose group had a significantly higher number of retrieved oocytes (p = 0.009) and metaphase II oocytes (p = 0.003). However, there were no significant differences in euploid embryo rates (35.4% vs. 37.4%, p = 0.768), clinical pregnancy rates (67.6% vs. 69.4%, p > 0.999), gestational sac rates (58.8% vs. 58.3%, p > 0.999), or live birth rates (47.1% vs. 50.0%, p = 0.995). Conclusions: This is the first prospective study to compare euploid embryo rates, pregnancy rates, and live birth rates between minimal stimulation protocol and high stimulation protocol in AMA patients. Although there has been no difference in euploid and pregnancy rates, minimal stimulation protocol has advantages in cost and comfort. Full article
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