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Oral and Maxillofacial Surgery: Diagnosis, Management and Future Opportunities
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Oral and Maxillofacial Surgery: Diagnosis, Management and Future Opportunities

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 697

Special Issue Editor

Dr. Federico Gelpi

E-Mail Website
Guest Editor
Head and Neck Department, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, 37129 Verona, Italy
Interests: oral implantology; osseointegration; oral surgery; periodontics; implants; prosthetics; crowns; dental

Special Issue Information

Dear Colleagues,

Maxillofacial surgery has expanded its fields of interest in recent decades from traumatology to head and neck oncology, from preprosthetic surgery to reconstructive microsurgery, from malformative surgery to endoscopy of paranasal sinuses and skull base, covering a wide spectrum of problems and sectoralizing in each specific area.

Huge steps forward have been made in every area, from diagnosis to treatment.

Multidisciplinary work and collaboration with different specialists, oncologists, radiotherapists, radiologists, pathologists, dentists, ophthalmologists, ENT specialists, and dermatologists, has become common clinical practice, leading to a substantial improvement in results.

The aim of this Special Issue is to discuss these innovations and future opportunities in the different areas of interest of maxillofacial surgery in the form of original articles, reviews, or in other forms.

Dr. Federico Gelpi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck oncology
  • free flaps
  • oral surgery
  • malformative surgery
  • traumatology
  • endoscopy
  • preprosthetic surgery
  • reconstructive surgery
  • vascular malformations
  • osteonecrosis

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Published Papers (1 paper)

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19 pages, 1407 KiB  
Systematic Review
Low-Level Laser Therapy in the Management of Bisphosphonate-Related Osteonecrosis of the Jaw
by Vincenzo Bitonti, Rocco Franco, Lorenzo Cigni, Domenico Familiari, Gioele Gravili, Giuseppe Vazzana and Pietro di Michele
J. Clin. Med. 2025, 14(13), 4441; https://doi.org/10.3390/jcm14134441 - 23 Jun 2025
Viewed by 332
Abstract
Background: Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) is a severe complication associated with bisphosphonate therapy, commonly used in the treatment of osteoporosis and metastatic bone diseases. Low-Level Laser Therapy (LLLT) has been proposed as a potential treatment modality for BRONJ, with its [...] Read more.
Background: Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) is a severe complication associated with bisphosphonate therapy, commonly used in the treatment of osteoporosis and metastatic bone diseases. Low-Level Laser Therapy (LLLT) has been proposed as a potential treatment modality for BRONJ, with its anti-inflammatory, analgesic, and regenerative effects being of particular interest. This systematic review aims to critically assess the current evidence regarding the efficacy of LLLT in the management of BRONJ. Methods: This review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search of electronic databases, including PubMed, Scopus, and Web of Science, was performed to identify relevant studies published up to September 2024. The systematic review protocol has been registered on the International Prospective Register of Systematic Reviews (PROSPERO) with the number 423003. All studies considered are observational. Studies were included if they investigated the application of LLLT in BRONJ treatment, reporting clinical outcomes such as pain reduction, lesion healing, and quality of life. The quality of the studies was assessed using the Cochrane Risk of Bias tool, and the data were synthesized descriptively. Results: A total of four studies met the inclusion criteria. The findings indicate that LLLT, particularly when used in conjunction with surgical debridement and pharmacological therapy, significantly may reduce pain and promote soft tissue healing in patients with BRONJ. However, the heterogeneity of study designs, laser parameters, and outcome measures limits the generalizability of these results. Furthermore, most studies were small-scale, with moderate to high risk of bias. Conclusions: The current evidence suggests that LLLT may be a beneficial adjunctive therapy in the treatment of BRONJ. However, conclusions are limited by the lack of randomized controlled trials and methodological heterogeneity, particularly for pain management and soft tissue regeneration. However, further high-quality randomized controlled trials with standardized laser protocols are necessary to establish its efficacy and optimize clinical application. Therefore, one of the limitations of this literature review with meta-analysis is that only four studies were considered and, moreover, they were observational. The results of the meta-analysis showed that there is not enough evidence to declare a statistical correlation; this result will surely be due to the small number of studies and heterogeneity. Full article
(This article belongs to the Special Issue Oral and Maxillofacial Surgery: Diagnosis, Management and Future Opportunities)
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