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Current Challenges in Orthopedic Trauma Surgery
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Current Challenges in Orthopedic Trauma Surgery

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Orthopedics".

Deadline for manuscript submissions: closed (30 November 2025) | Viewed by 4117

Editors

Prof. Dr. Pietro Maniscalco

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Guest Editor
Department of Medicine and Surgery, University of Parma, Parma, Italy
Interests: total knee replacement; femur; hip replacement; nailing
Dr. Fabrizio Quattrini

E-Mail
Guest Editor
1. Department of Medicine and Surgery, University of Parma, Parma, Italy
2. Azienda USL di Piacenza, Piacenza, Italy
Interests: arthroscopy; knee; knee replacement; sport medicine; plating
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Orthopedic surgery focuses on the treatment of trauma, as it addresses a diverse range of intricacies related to fractures and soft tissue injuries, as well as always striving for better patient results. The goal of this Special Issue is to cover the latest research developments, clinical issues, and innovative efforts being made in this area. Advancements in surgical procedures, infection control, novel biomechanical fracture fixation devices, and postoperative rehabilitation are the main focus of this work.

There are still major concerns in orthopedic surgery, such as implant failures, nonunion fractures, and problems associated with comorbid factors that, despite all the progress made, continue to pose critical difficulties. This Special Issue aims to start a conversation among top researchers and clinicians about new evidence-centered solutions and advanced technologies, such as the use of 3D printing, biologics, and AI in trauma surgery.

We welcome papers that cover a broad spectrum, including optimally adapted and other minimally invasive procedures, approaches to patient-specific treatment, and the optimization of surgical techniques and protocols, among others. This open Special Issue seeks to harness the collective skill of orthopedic trauma experts and clinicians to drive change and enhance practices for better health outcomes for patients across the globe.

Prof. Dr. Pietro Maniscalco
Dr. Fabrizio Quattrini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hip replacement
  • knee replacement
  • shoulder replacement
  • ankle replacement
  • trauma surgery
  • femur
  • future chal-lenges
  • surgical innovations

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Published Papers (2 papers)

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Research

13 pages, 1243 KB  
Article
Minimally Invasive Treatment of Three-Part Proximal Humerus Fractures: A Two-Center Comparative Study of Plate Fixation and Intramedullary Nailing
by Calogero Puma Pagliarello, Vito Pavone, Fabrizio Quattrini, Pietro Maniscalco, Virginia Masoni and Corrado Ciatti
J. Clin. Med. 2025, 14(21), 7880; https://doi.org/10.3390/jcm14217880 - 6 Nov 2025
Cited by 1 | Viewed by 1371
Abstract
Background/Objectives: Proximal humerus fractures account for approximately 5% of all skeletal injuries, and their optimal surgical management remains debated. The optimal fixation method for three-part proximal humerus fractures remains a matter of debate. This study aimed to compare the clinical and radiological outcomes [...] Read more.
Background/Objectives: Proximal humerus fractures account for approximately 5% of all skeletal injuries, and their optimal surgical management remains debated. The optimal fixation method for three-part proximal humerus fractures remains a matter of debate. This study aimed to compare the clinical and radiological outcomes of two minimally invasive osteosynthesis techniques—plate fixation and intramedullary nailing—for the treatment of three-part proximal humerus fractures. Methods: Sixty-six patients aged 60–80 years were retrospectively analyzed across two centers adopting different institutional preferences. Thirty-three patients were treated with minimally invasive plate fixation and thirty-three with intramedullary nailing. The mean age was 67.8 ± 4.2 years, and the mean follow-up duration was 27.2 months. Functional and clinical outcomes were evaluated using the Barthel Index, DASH, Simple Shoulder Test (SST), and Visual Analog Scale (VAS). Operative time, hospitalization length, healing time, and postoperative complications were recorded and statistically analyzed. Results: Intramedullary nailing was associated with shorter operative and hospitalization times and fewer complications. Early SST and VAS improvements favored the nailing group, while long-term outcomes were comparable. Conclusions: Intramedullary nailing represents a reliable and less invasive alternative to plate fixation in the treatment of three-part proximal humerus fractures. It offers shorter operative and hospitalization times, fewer postoperative complications, and faster functional recovery while achieving comparable long-term outcomes. Surgeon experience and familiarity with the chosen technique remain key determinants of success. Full article
(This article belongs to the Special Issue Current Challenges in Orthopedic Trauma Surgery)
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10 pages, 223 KB  
Article
Transient Osteoporosis of the Hip: Clinical and Radiological Outcomes After Combined Pharmacologic and Biophysical Therapy
by Calogero Puma Pagliarello, Vito Pavone, Antonio Kory, Luciano Costarella, Antonio Buscema, Gianluca Testa and Corrado Ciatti
J. Clin. Med. 2025, 14(21), 7879; https://doi.org/10.3390/jcm14217879 - 6 Nov 2025
Cited by 1 | Viewed by 1951
Abstract
Introduction: Transient osteoporosis of the hip (TOH) is a rare, self-limiting disorder characterized by acute hip pain and reversible osteopenia. The aim of this study was to evaluate clinical outcomes following treatment with Neridronate, Clodronic Acid, Cholecalciferol, and pulsed electromagnetic field therapy [...] Read more.
Introduction: Transient osteoporosis of the hip (TOH) is a rare, self-limiting disorder characterized by acute hip pain and reversible osteopenia. The aim of this study was to evaluate clinical outcomes following treatment with Neridronate, Clodronic Acid, Cholecalciferol, and pulsed electromagnetic field therapy (PEMF). Materials and Methods: A total of 45 patients presenting with non-traumatic hip pain were screened using a standardized diagnostic protocol. Magnetic resonance imaging (MRI) identified 8 patients (17.8%) with transient osteoporosis of the hip (TOH), who were subsequently enrolled in this analysis. Pain was evaluated using the Visual Analog Scale (VAS). Patients received a three-phase therapeutic protocol, including pharmacological therapy and PEMF. Clinical evaluations using the Harris Hip Score (HHS) were performed monthly, and follow-up MRI was conducted at the end of treatment. Results: We identified 8 cases of TOH (17.8%); the mean baseline HHS for these patients was 68.5 (range 51–83, SD 10.36). Pain reduction became evident within the first month of treatment. At the end of treatment, clinical improvement was observed in 7 patients, with mean HHS increasing to 88.0 (range 67–95, SD 8.84). Post-treatment MRI demonstrated complete resolution of bone marrow edema in all patients. One patient developed avascular necrosis despite therapy and required surgical intervention. Conclusions: TOH remains a controversial condition in terms of diagnosis and treatment. Early diagnosis and timely intervention are essential to progression to osteonecrosis. A combined therapeutic approach using bisphosphonates, vitamin D, and PEMF appears effective in reducing symptoms, promoting bone healing, and ensuring good patient compliance. Full article
(This article belongs to the Special Issue Current Challenges in Orthopedic Trauma Surgery)
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