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Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and...
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Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1792

Special Issue Editors

Dr. Elisabeth M.J.P. Mouws

E-Mail
Guest Editor
Department of Anaesthesiology, St. Antonius Hospital, Nieuwegein, The Netherlands
Interests: postoperative atrial fibrillation; cardiac arrhythmia; congenital heart disease; cardiopulmonary bypass; extracorporeal circulation
Prof. Dr. Natasja de Groot

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Guest Editor Assistant
Department of Cardiology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
Interests: atrial fibrillation; arrhythmia; congenital heart disease; electrophysiology; cardiac mapping
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although tremendous therapeutic improvements have been made in recent decades, cardiac arrhythmias currently remain a high burden for patients, health care, and society.

This is partially due to our incomplete understanding of the (individual) underlying mechanisms contributing to arrhythmia development. Currently, various research projects are focused on unraveling these mechanisms and developing more individualized therapeutic (or preventive) options for the future. Moreover, currently available therapeutic options are being further optimized.

The primary objective of this Special Issue of the Journal of Clinical Medicine is to provide insights into the new advances in this field in various patient populations.

This Special Issue is open to studies (original articles, systematic reviews and meta-analyses) investigating the underlying mechanisms of arrhythmia, new diagnostic options, novel therapeutic approaches, therapeutic outcomes and preventive measures. In addition, studies concerning therapeutic options in congenital heart disease may be submitted.

The scope of this Special Issue includes, but is not limited to, the following:

  • The underlying mechanisms of atrial and ventricular arrhythmia;
  • Diagnostic strategies for atrial and ventricular arrhythmia;
  • Therapeutic options for atrial and ventricular arrhythmia;
  • Special cases and therapeutic options for patients with congenital heart disease.

Dr. Elisabeth M.J.P. Mouws
Prof. Dr. Natasja de Groot
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac arrhythmia
  • atrial fibrillation
  • congenital heart disease
  • underlying mechanisms
  • therapeutic options

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Published Papers (2 papers)

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13 pages, 1317 KiB  
Article
Clinical, Electrical, and Mechanical Parameters in Potassium Channel-Mediated Congenital Long QT Syndrome
by Neringa Bileišienė, Violeta Mikštienė, Eglė Preikšaitienė, Ieva Kažukauskienė, Gabrielė Tarutytė, Diana Zakarkaitė, Rita Kramena, Germanas Marinskis, Audrius Aidietis and Jūratė Barysienė
J. Clin. Med. 2025, 14(8), 2540; https://doi.org/10.3390/jcm14082540 - 8 Apr 2025
Viewed by 343
Abstract
Background: Congenital long QT syndrome (LQTS) is a rare cardiac disorder caused by repolarization abnormalities in the myocardium that predisposes to ventricular arrhythmias and sudden cardiac death. Potassium channel-mediated LQT1 and LQT2 are the most common types of channelopathy. Recently, LQTS has been [...] Read more.
Background: Congenital long QT syndrome (LQTS) is a rare cardiac disorder caused by repolarization abnormalities in the myocardium that predisposes to ventricular arrhythmias and sudden cardiac death. Potassium channel-mediated LQT1 and LQT2 are the most common types of channelopathy. Recently, LQTS has been acknowledged as an electromechanical disease. Methods: A total of 87 genotyped LQT1/LQT2 patients underwent cardiac evaluation. A comparison between LQT1 and LQT2 electrical and mechanical parameters was performed. Results: LQT2 patients had worse electrical parameters at rest: a longer QTc interval (p = 0.007), a longer Tpe in lead V2 (p = 0.028) and in lead V5 (p < 0.001), and a higher Tpe/QT ratio in lead V2 (p = 0.011) and in lead V5 (p = 0.005). Tpe and Tpe/QT remained significantly higher in the LQT2 group after brisk standing. Tpe was longer in LQT2 patients compared with LQT1 patients during peak exercise (p = 0.007) and almost all recovery periods in lead V2 during EST. The mid-cavity myocardium mean radial contraction duration (CD) was longer in LQT2 patients (p = 0.02). LQT2 patients had a longer mean radial CD in mid-septal (p = 0.015), mid-inferior (p = 0.034), and mid-posterior (p = 0.044) segments. Conclusions: Potassium channel-mediated LQTS has different effects on cardiac electromechanics with a more pronounced impact on LQT2 patients. Tpe was more prominent in the LQT2 cohort, not only at rest and brisk standing but also during EST exercise and at recovery phases. The altered mean radial CD in the mid-cavity myocardium was also specific for LQT2 patients. Full article
(This article belongs to the Special Issue Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches)
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25 pages, 2927 KiB  
Article
Exploring the Link Between Interoception and Symptom Severity in Premature Ventricular Contractions
by Alena S. Limonova, Irina A. Minenko, Anastasia A. Sukmanova, Vladimir A. Kutsenko, Sofya P. Kulikova, Maria A. Nazarova, Karapet V. Davtyan, Oxana M. Drapkina and Alexandra I. Ershova
J. Clin. Med. 2024, 13(24), 7756; https://doi.org/10.3390/jcm13247756 - 19 Dec 2024
Cited by 1 | Viewed by 1048
Abstract
Background/Objectives: The physiological basis underlying symptomatic versus asymptomatic premature ventricular contractions (PVCs) remains poorly understood. However, symptomatic PVCs can significantly impair quality of life. In patients without structural heart disease, symptom intensity is crucial for guiding management strategies and determining the need [...] Read more.
Background/Objectives: The physiological basis underlying symptomatic versus asymptomatic premature ventricular contractions (PVCs) remains poorly understood. However, symptomatic PVCs can significantly impair quality of life. In patients without structural heart disease, symptom intensity is crucial for guiding management strategies and determining the need for medical or surgical intervention. In this study, we aimed, for the first time, to examine the associations between PVC symptoms and cardiac interoception. Methods: This study included 34 participants with PVCs (20 women; median age = 42 years; 17 participants had asymptomatic PVCs) without concomitant disorders. Interoception was assessed through interoceptive accuracy (IA) probed by two behavioral tests—mental tracking (MT) and heartbeat detection (HBD)—and the neurophysiological marker of cardiac interoception, the heartbeat-evoked potentials (HEPs). Symptom intensity scores reported by patients served as the response variable in the regression analysis, with IA and HEP as predictors. Other factors such as sex, age, percent of body fat, trait anxiety, and alexithymia were added to the models as confounding variables. Results: IAMT was significantly higher in patients with symptomatic PVCs. IAMT and HEP modulation for the HBD task were associated with symptom intensity. A combined regression model incorporating both metrics showed the highest predictive accuracy for symptom severity. Adding confounding variables improved model quality (lower AIC); however, only the male sex emerged as a significant negative predictor for symptom intensity. Conclusions: Our findings confirm a significant association between interoception and PVC symptom severity. Integrating behavioral and neurophysiological interoception measures enhances symptom prediction accuracy, suggesting new ways to develop diagnostic and non-invasive treatment strategies targeting interoception in PVC management. Full article
(This article belongs to the Special Issue Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches)
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