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Clinical Advances in Therapy of Trauma and Surgical Critical Care
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Clinical Advances in Therapy of Trauma and Surgical Critical Care

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Intensive Care".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1111

Special Issue Editors

Dr. Rabail Chaudhry

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Guest Editor
From the Department of Anesthesiology and Pain Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Interests: trauma postoperative outcomes; prehospital care in trauma; organ reperfusion injury
Dr. George W. Williams

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Guest Editor
Department of Anesthesiology and Critical Care, McGovern Medical School, University of Texas Health Science Center at Houston (UT Health), Houston, TX, USA
Interests: traumatic brain injury; spinal cord injury; critical care outcomes; malnutrition in the ICU
Dr. Tanya Anand

E-Mail Website
Guest Editor
Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA
Interests: trauma surgery outcomes; hypotension in trauma patients; endotheliopathy; trauma resuscitation

Special Issue Information

Dear colleagues,

The landscape of trauma and critical care is rapidly evolving, presenting both new opportunities and ongoing challenges in managing critically ill patients. This Special Issue of the Journal of Clinical Medicine is dedicated to exploring the cutting-edge developments and emerging issues in this dynamic field.

Key focus areas include the progressive role of regional anesthesia in the ICU, aimed at enhancing pain management strategies; modern transfusion practices for patients with thermal injuries, which emphasize precision in transfusion protocols; and innovative approaches in obstetric trauma critical care that ensure both maternal and fetal health. We also revisit balanced resuscitation in trauma, expanding the conversation beyond volume replacement to include the latest insights into endotheliopathy, metabolomics, and the care of distinct subpopulations.

We invite submissions that offer fresh perspectives and novel research findings that can drive forward the standards of care in trauma and critical care settings. Join us in advancing patient management in trauma and critical care.

Best regards,
Dr. Rabail Chaudhry
Dr. George W. Williams
Dr. Tanya Anand
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regional anesthesia
  • critical care
  • trauma resuscitation
  • transfusion strategies
  • thermal injury
  • obstetric critical care
  • epitheliopathy
  • metabolomics
  • ICU pain management
  • trauma care subpopulations

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

18 pages, 935 KiB  
Review
Rethinking Balanced Resuscitation in Trauma
by Tanya Anand, Hannah Shin, Asanthi Ratnasekera, MyDuyen Luong Tran, Rebekah Huckeby, Lindsey Butts, Ivy Stejskal, Louis J. Magnotti and Bellal Joseph
J. Clin. Med. 2025, 14(6), 2111; https://doi.org/10.3390/jcm14062111 - 19 Mar 2025
Viewed by 867
Abstract
Hemorrhagic shock from traumatic injury results in a massive systemic response with activation of the hypothalamic–pituitary–adrenal (HPA) axis, pro-thrombotic and clot-lysis pathways as well as development of an endotheliopathy. With ongoing hemorrhage, these responses become dysregulated and are associated with worsening coagulopathy, microvascular [...] Read more.
Hemorrhagic shock from traumatic injury results in a massive systemic response with activation of the hypothalamic–pituitary–adrenal (HPA) axis, pro-thrombotic and clot-lysis pathways as well as development of an endotheliopathy. With ongoing hemorrhage, these responses become dysregulated and are associated with worsening coagulopathy, microvascular dysfunction, and increased transfusion requirements. Our transfusion practices as well as our understanding of the molecular response to hemorrhage have undergone significant advancement during war. Currently, resuscitation practices address the benefit of the early recognition and management of acute coagulopathy and advocates for balanced resuscitation with either whole blood or a 1:1 ratio of packed red blood cells to fresh frozen plasma (respectively). However, a significant volume of evidence in the last two decades has recognized the importance of the early modulation of traumatic endotheliopathy and the HPA axis via the early administration of plasma, whole blood, and adjunctive treatments such as tranexamic acid (TXA) and calcium. This evidence compels us to rethink our understanding of ‘balanced resuscitation’ and begin creating a more structured practice to address additional competing priorities beyond coagulopathy. The following manuscript reviews the benefits of addressing the additional interrelated physiologic responses to hemorrhage and seeks to expand beyond our understanding of ‘balanced resuscitation’. Full article
(This article belongs to the Special Issue Clinical Advances in Therapy of Trauma and Surgical Critical Care)
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